Clinical trials: Retinal Disorder
Retinal Detachment, Metamorphopsia
Retinal Displacement After Pneumatic Versus Vitrectomy for Retinal Detachment (ALIGN)
This is a prospective cohort study, comparing the functional outcomes and the retinal displacement rates between two techniques for primary rhegmatogenous retinal detachment repair: Pars Plana Vitrectomy (PPV) and Pneumatic…
- Conditions
- Retinal Detachment, Metamorphopsia, Aniseikonia
- Trial name
- ALIGN (NCT04089033)
- Testing
- Pneumatic Retinopexy, Pars Plana Vitrectomy
- Where
- Canada
- Volunteers
- 204 people
- Sponsor
- Unity Health Toronto
Leber Congenital Amaurosis 10, Inherited Retinal Dystrophies
Single Ascending Dose Study in Participants With LCA10
The purpose of this study is to evaluate the safety, tolerability and efficacy of a single escalating doses of EDIT-101 administered via subretinal injection in participants with LCA10 caused by a homozygous or compound…
- Conditions
- Leber Congenital Amaurosis 10, Inherited Retinal Dystrophies, Eye Diseases, Hereditary, Retinal Disease
- Trial name
- NCT03872479
- Testing
- EDIT-101
- Where
- 5 sites in United States
- Volunteers
- 34 people
- Sponsor
- Editas Medicine, Inc.
Glaucoma, Glaucoma Suspect
Philadelphia Telemedicine Glaucoma Detection and Follow-Up Study
The goal is to conduct a 5-year prospective, randomized controlled trial to test an innovative, community-based intervention using posterior and anterior fundus photography of the optic nerve and macula and intraocular eye…
- Conditions
- Glaucoma, Glaucoma Suspect, Diabetic Retinopathy, Ocular Hypertension
- Trial name
- NCT02390245
- Testing
- Free Eye Screenings, Enhanced Intervention, Usual Care
- Where
- United States
- Volunteers
- 906 people, healthy volunteers welcome
- Sponsor
- Wills Eye
Vision Disorders, Refractive Errors
Rapid Computerized Visual Acuity Test
A novel computerized visual acuity test was developed and tested on both healthy persons and patients with ocular conditions. Visual acuity outcomes of the computerized test will be compared to the Early Treatment Diabetic…
- Conditions
- Vision Disorders, Refractive Errors, Retinal Disease, Cataract
- Trial name
- NCT05447845
- Testing
- Computerized visual acuity assessment program
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Retina Disorder, Vitreous Disorder
EVA Nexus Vitrectomy Device Field Observation Study
determine the safety and effectiveness of the device.
- Trial name
- NCT05229094
- Testing
- Eva Nexus
- Where
- Belgium
- Volunteers
- 250 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Blindness, Leber Congenital Amaurosis 10
Natural History Study of CEP290-Related Retinal Degeneration
A prospective natural history study with systematic assessments and uniform follow-up to provide a high-quality dataset for assisting in the design of future clinical treatment trials involving patients with CEP290-related…
- Conditions
- Blindness, Leber Congenital Amaurosis 10, Vision Disorders, Eye Diseases
- Trial name
- NCT03396042
- Where
- 7 sites in United States, France and 2 more
- Volunteers
- 26 people
- Sponsor
- Editas Medicine, Inc.
Autosomal Dominant Retinitis Pigmentosa, Eye Diseases
A Study to Evaluate the Safety and Tolerability of QR-1123 in Subjects With Autosomal Dominant Retinitis Pigmentosa Due to the P23H Mutation in the RHO Gene
This study evaluates the safety, tolerability and efficacy of QR-1123 injection in the eye (intravitreal; IVT) injections (one eye/unilateral) in subjects receiving a single dose or repeat doses.
- Conditions
- Autosomal Dominant Retinitis Pigmentosa, Eye Diseases, Eye Diseases, Hereditary, Retinal Dystrophies
- Trial name
- AURORA (NCT04123626)
- Testing
- QR-1123
- Where
- 5 sites in United States
- Volunteers
- 11 people
- Sponsor
- ProQR Therapeutics
Retinitis Pigmentosa, Usher Syndrome Type 2
Study to Evaluate Safety and Tolerability of QR-421a in Subjects With RP Due to Mutations in Exon 13 of the USH2A Gene
The purpose of this study is to evaluate the safety and tolerability of QR-421a administered via intravitreal injection (IVT) in subjects with Retinitis Pigmentosa (RP) due to mutations in exon 13 of the USH2A gene.
- Conditions
- Retinitis Pigmentosa, Usher Syndrome Type 2, Deaf Blind, Retinal Disease
- Trial name
- Stellar (NCT03780257)
- Testing
- QR-421a
- Where
- 7 sites in United States, Canada and 1 more
- Volunteers
- 20 people
- Sponsor
- ProQR Therapeutics
Retinal Disease, Visual Impairment
Repeatability of Electroretinogram and Visual Evoked Potential
To assess repeatability of electroretinogram and visual evoked potential in clinical practice
- Conditions
- Retinal Disease, Visual Impairment, Vision Disorders
- Trial name
- NCT05334875
- Testing
- Electroretinogram (ERG), Visual evoked potential (VEP)
- Where
- Egypt
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Benha University
Leber Congenital Amaurosis 10, Blindness
An Open-label, Dose Escalation and Double-masked, Randomized, Controlled Trial Evaluating Safety and Tolerability of Sepofarsen in Children (<8 Years of Age) With LCA10 Caused by Mutations in the CEP290 Gene.
PQ-110-005 (BRIGHTEN) is an open-label, dose escalation and double-masked, randomized, controlled study evaluating safety and tolerability of sepofarsen administered via intravitreal (IVT) injection in pediatric subjects (<8…
- Conditions
- Leber Congenital Amaurosis 10, Blindness, Leber Congenital Amaurosis, Vision Disorders
- Trial name
- BRIGHTEN (NCT04855045)
- Testing
- sepofarsen
- Where
- 9 sites in Belgium, Brazil and 5 more
- Volunteers
- 15 people
- Sponsor
- ProQR Therapeutics
Leber Congenital Amaurosis 10, Blindness
A Study to Evaluate Efficacy, Safety, Tolerability and Exposure After a Repeat-dose of Sepofarsen (QR-110) in LCA10 (ILLUMINATE)
The purpose of this double-masked, randomized, controlled, multiple-dose study is to evaluate the efficacy, safety, tolerability and systemic exposure of sepofarsen (QR-110) administered via intravitreal injection in subjects…
- Conditions
- Leber Congenital Amaurosis 10, Blindness, Leber Congenital Amaurosis, Vision Disorders
- Trial name
- ILLUMINATE (NCT03913143)
- Testing
- sepofarsen
- Where
- 14 sites in United States, Belgium and 7 more
- Volunteers
- 36 people
- Sponsor
- ProQR Therapeutics
Ophthalmologic Complication, Epiretinal Membrane
Measuring Subjective Quality of Vision and Metamorphopsia Before and After Epiretinal Membrane and Macular Hole Surgery
Assessing metamorphopsia and quality of vision pre and post epiretinal and macular hole surgery
- Conditions
- Ophthalmologic Complication, Epiretinal Membrane, Metamorphopsia, Macular Holes
- Trial name
- MQUEST (NCT05171621)
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Hayley Westwood
Retinal Disorders
Anesthesia for Pars Plana Vitrectomy (PPV) With Insulin Needle
Periocular blockade with 12.5 mm needle is as effective as block with 25 mm needle for patients undergoing Pars Plana Vitrectomy.
- Trial name
- NCT00735657
- Testing
- needle, Pars Plana Vitrectomy
- Where
- Saudi Arabia
- Volunteers
- 120 people
- Sponsor
- King Khaled Eye Specialist Hospital
Retinal Detachment
Correlation of Metamorphopsia and Aniseikonia to Retinal Shift Following Retinal Detachment Surgery
Individuals operated for rhegmatogenous retinal detachment will be prospectively evaluated for postoperative retinal shift. Fundus autofluorescence will be used to evaluate retinal shift that will be correlated to visual acuity…
- Trial name
- NCT03187613
- Where
- Norway
- Volunteers
- 38 people
- Sponsor
- Helse Stavanger HF
Visual Pathway Disorder, Glaucoma
Assessment of Visual Function in Ophthalmic Disorders Using Virtual Visual Field Analysis
1. To evaluate the accuracy of virtual visual field (VVF) headsets equipped the standard visual field software in its ability to assess visual function in various retinal, glaucoma and neuro-ophthalmic disorders by comparing…
- Conditions
- Visual Pathway Disorder, Glaucoma, Retinal Disease
- Trial name
- proVVF (NCT04110015)
- Testing
- virtual visual field
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- New York City Health and Hospitals Corporation
Retinitis Pigmentosa (RP)
Retrospective Natural History Study of Retinitis Pigmentosa
This is natural history study of rods and cones degenerations in patients with Retinitis Pigmentosa (RP) caused by pathogenic mutations in RHO, PDE6A or PDE6B gene mutations.
- Trial name
- PHENOROD1 (NCT03975543)
- Where
- France
- Volunteers
- 113 people
- Sponsor
- SparingVision
Pediatric Disorder, Vitamin D Deficiency
Retinal Changes in Vitamin D Deficiency
Retinal tissue parameters of pediatric patients with vitamin D deficiency will be evaluated in this prospective case-control study. The patients will be divided into 2 groups according to the vitamin D level.
- Conditions
- Pediatric Disorder, Vitamin D Deficiency, Retinal Disease, Choroidal Disease
- Trial name
- VDD (NCT04891211)
- Testing
- Vitamin D deficiency
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Adiyaman University
Hypertension, Retinal Disorder
DETECT and Retinal Outcomes in Hypertension
The purpose of this study is to study the impact of blood pressure on cognitive performance.
- Conditions
- Hypertension, Retinal Disorder, Cognitive Impairment
- Trial name
- NCT01815567
- Where
- United States
- Volunteers
- 234 people, healthy volunteers welcome
- Sponsor
- Emory University
Retinal Detachment, Metamorphopsia
Effect of Type of Head Positioning on Retinal Displacement in Vitrectomy for Retinal Detachment
Patients may experience metamorphopsia, or image distortion, after having vitrectomy to repair their rhegmatogenous retinal detachments especially those with a detached macula.
- Trial name
- DIAMOND (NCT04035343)
- Testing
- Face down positioning, Supine positioning
- Where
- Canada
- Volunteers
- 324 people
- Sponsor
- Unity Health Toronto
Retinal Detachment, Metamorphopsia
Retinal Displacement Rates in Pneumatic Retinopexy Versus Pars Plana Vitrectomy For Primary Retinal Detachment
Patients may experience metamorphopsia, or image distortion, after having vitrectomy to repair their rhegmatogenous retinal detachments (RRDs) especially those with a detached macula.
- Trial name
- REVEAL (NCT04158622)
- Testing
- PnR + laser/cryotherapy, PPV + laser/cryotherapy
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Unity Health Toronto