Clinical trials: Retinal Function
Rheumatoid Arthritis
Cross-over Study to Investigate Retinal Function Following Administration of a Single Dose of AZD9056
The purpose of the study is to determine whether treatment with a single 800mg dose of AZD9056, a medication which has been developed as a possible treatment for Rheumatoid Arthritis, has an effect on the function of the retina
- Trial name
- NCT00700986
- Testing
- AZD9056
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Regional Blood Flow, Ocular Physiology
Effects of Moxaverine and Placebo on Ocular Blood Flow
A number of common eye diseases such as retinal artery and vein occlusion, diabetic retinopathy, age-related macular degeneration, glaucoma and anterior ischemic optic neuropathy are associated with ocular perfusion…
- Conditions
- Regional Blood Flow, Ocular Physiology, Retina
- Trial name
- NCT00709423
- Testing
- Moxaverine, Moxaverin 150mg, NaCl
- Where
- Austria
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Diabetic Retinopathy
OCT Biomarkers for Diabetic Retinopathy
Diabetic retinopathy (DR) is caused by changes in the blood vessels of the retina associated with long-term Type 1 or Type 2 diabetes mellitus. DR is a leading cause of blindness in the United States.
- Trial name
- NCT02330042
- Where
- United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Choroideremia
The Dark-Adapted Retinal Function Response in Choroideremia (DARC) Study
Choroideremia (CHM) is an inherited retinal disorder that causes progressive vision loss, ultimately leading to complete blindness.
- Trial name
- DARC (NCT05045703)
- Testing
- Vitamin A palmitate
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Duke University
Edema, Varices; Cord
Effect of Intraoperative Taping on the Control of Edema Resulting From Stripping
The aim of the study is to evaluate the effects of the Contensive Taping technique on the control of edema of patients submitted to Phleboextraction Surgery including Saphenectomy.
- Trial name
- NCT05534308
- Testing
- Transoperative taping, No trasoperative taping
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Visual Pathway Disorder, Glaucoma
Assessment of Visual Function in Ophthalmic Disorders Using Virtual Visual Field Analysis
1. To evaluate the accuracy of virtual visual field (VVF) headsets equipped the standard visual field software in its ability to assess visual function in various retinal, glaucoma and neuro-ophthalmic disorders by comparing…
- Conditions
- Visual Pathway Disorder, Glaucoma, Retinal Disease
- Trial name
- proVVF (NCT04110015)
- Testing
- virtual visual field
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- New York City Health and Hospitals Corporation
Healthy
Carotenoid Supplementation and Retinal Health in Healthy Adults
The purpose of this research is to evaluate the effect of oral dietary carotenoid supplements on various aspects of retinal health.
- Trial name
- NCT07314411
- Testing
- other
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Pacific University
Macular Degeneration
A Single-Center Pilot Study to Assess Macular Function
This study seeks to evaluate a novel endpoint for future dry AMD clinical trials.
- Trial name
- NCT01204541
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- ORA, Inc.
Pre Diabetes, Vascular Stiffness
Dietary Exchanges With Avocado and Mango in Pre-diabetes
The research is designed as a randomized, 2-arm, parallel, controlled, human clinical trial to investigate the effects of avocado and mango consumption for 8 weeks on indices of macro- and micro- vascular function in individuals…
- Conditions
- Pre Diabetes, Vascular Stiffness, Vascular Dilation, Cognitive Change
- Trial name
- AVMa (NCT05353790)
- Testing
- Meals + snacks: control, Meals + snacks: Avocado mango
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Age-Related Maculopathy, Diabetic Macular Edema
Validation of a New Methodology for Mapping the Human Blood-Retinal Barrier Function
To validate a new methodology, named Retinal Leakage Analysis (RLA), for mapping the human Blood-Retinal Barrier (BRB) function, in the clinical practice.
- Trial name
- NCT00759044
- Where
- Portugal
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Association for Innovation and Biomedical Research on Light and Image
Ocular Physiology
Data Collection Study of the Nidek Optical Coherence Tomography RS-3000 for 3D Measurements of the Eye
The purpose of this clinical study is to collect and evaluate the data from eye scans using an investigational three-dimensional eye imaging photography device called the Nidek Optical Coherence Tomography (OCT) RS-3000.
- Trial name
- NCT01663688
- Where
- 3 sites in United States
- Volunteers
- 279 people, healthy volunteers welcome
- Sponsor
- Nidek Co. LTD.
Flicker-induced Vasodilatation
Effect of Breathing a Mixture of 92% Oxygen (O2) + 8% Carbon Dioxide (CO2) on Flicker Induced Blood Flow Changes in Ocular Perfusion
It has been shown that diffuse luminance flicker increases retinal and optic nerve head blood flow. This indicates that a neuro-vascular coupling between neural activity and blood flow exists in the retina as described previously…
- Trial name
- NCT00719342
- Testing
- Oxygen + Carbondioxide, full field flickering light at 12.5 Hz
- Where
- Austria
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Retinal Degeneration, Retinitis Pigmentosa
Rod and Cone Mediated Function in Retinal Disease
Background: Retinal diseases cause the loss of rod and cone photoreceptors. Symptoms include vision loss and night blindness. Researchers want to learn about rod and cone function in healthy people and people with retinal…
- Conditions
- Retinal Degeneration, Retinitis Pigmentosa, Stargardt's Disease
- Trial name
- NCT02617966
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- National Eye Institute (NEI)
Age Related Macular Degeneration
Study on Visual Function Impairments in Dry Age-related Macular Degeneration
The study hypothesis is that patients with dry age-related macular degeneration experience visual function impairments such as defects in dark adaptation, glare intolerance, poor light transition and reading in low lighting…
- Trial name
- NCT01822873
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Duke University
Glaucoma, Diabetic Retinopathy
A Pilot Study of Functional Optical Coherence Tomography for Ocular Imaging
Growing evidence shows that altered blood flow plays a major role in many vision-threatening diseases including glaucoma, diabetic retinopathy, age-related macular degeneration, Central Retinal Vein Occlusion, and Branch Retinal…
- Conditions
- Glaucoma, Diabetic Retinopathy, Age-Related Macular Degeneration, Central Retinal Vein Occlusion
- Trial name
- NCT00556114
- Testing
- Optical Coherence Tomography
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Fasting, Intermittent, Fasting Hypoglycemia
Electrophysiological Changes With Diet.
Dietary habits may affect our body by certain mechanisms, visual sense is one of the most vital human senses that needs special attention in our daily habits.
- Conditions
- Fasting, Intermittent, Fasting Hypoglycemia, Fasting, Obesity
- Trial name
- NCT05658991
- Testing
- Retinal electrophysiology
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Benha University
Diabetes Mellitus, Diabetic Retinopathy
A Systematic Study of Retinal Structure and Function in Diabetic Macular Oedema
Diabetic retinopathy(DR) is a sight threatening condition that occurs in persons with diabetes. DR arises as a consequence of damage to the retinal blood vessels and is related to the high and fluctuating sugar levels in the…
- Conditions
- Diabetes Mellitus, Diabetic Retinopathy, Diabetic Macular Edema
- Trial name
- NCT02876393
- Where
- United Kingdom
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast
Healthy, Normoxia
Measurement of Retinal Blood Flow, Retinal Oxygenation and Retinal Oxygen Extraction in Healthy Subjects During Normoxia and Systemic Hyperoxia
The inner retina is crucially dependent on an adequate retinal blood supply. When the retina becomes ischemic and hypoxic this results in severe vision loss due to retinal neovascularization.
- Conditions
- Healthy, Normoxia, Systemic Hypoxia
- Trial name
- NCT00914407
- Testing
- Oxygen
- Where
- Austria
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Glaucoma
To Study the Function of the Retina in Glaucoma Patients Using PERG
The purpose of this trial is to evaluate the performance of a new diagnostic device in the diagnosis and management of glaucoma. We will use this new device (PERG) to evaluate the function of the retina in glaucoma patients.
- Trial name
- NCT03330574
- Where
- Switzerland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Swiss Vision Network
Retinitis Pigmentosa, Leber's Hereditary Optic Neuropathy
Pupil Dynamics and Color Vision for the Detection of Eye Diseases
The development of new oculometry techniques allows fine and dynamic measurements of pupillary diameter and use in routine clinical practice.
- Conditions
- Retinitis Pigmentosa, Leber's Hereditary Optic Neuropathy, Stargardt Disease
- Trial name
- PupDyn (NCT04909398)
- Testing
- Dynamic pupillometry sessions
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts