Clinical trials: Retinal Toxicity
Retinal Dystrophies, Age-related Macular Degeneration
Retinal Imaging by Adaptive Optics in Healthy Eyes and During Retinal and General Diseases
Using an adaptive optics imaging device, retinal structures are observed in healthy and diseased subjects.
- Conditions
- Retinal Dystrophies, Age-related Macular Degeneration, Arterial Hypertension, Diabetes
- Trial name
- iPhot (NCT01546181)
- Where
- France
- Volunteers
- 256 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
MEK Inhibitor-Associated Serous Retinopathy
Investigation of Potential Retinal Toxicity Associated With Hair Dye Products Containing pPD Type Aromatic Amines
Hair dye products could induce minimal forms of MEKAR retinopathies (Mitogen-activated Extracellular signal-regulated Kinase - inhibitors associated retinopathies).
- Trial name
- CAPITOX (NCT04222387)
- Testing
- OCT-B scan
- Where
- France
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Asherman Syndrome
Pre-clinical Endometrial Tissular Renovation Study
The endometrium is a tissue with high capacity of renewal ("self-renewal"). This process is regulated by stem cells. Recent studies have shown that bone marrow-derived stem cells (BMDSCs) contribute to tissues and organs…
- Trial name
- PreENTIRE (NCT03665649)
- Testing
- CD133+ cells isolation
- Where
- Spain
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Igenomix
Macular Degeneration
Lutein for Age-Related Macular Degeneration
This study will examine whether taking the vitamin lutein changes lutein blood levels. Lutein, vitamin C, vitamin E and beta-carotene may be useful in treating the eye disease age-related macular degeneration, but more…
- Trial name
- NCT00006202
- Testing
- Lutein
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- National Eye Institute (NEI)
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Maculopathy
" En Face " OCT's Contribution in the Detection of Macular Retinal Toxicity Signs Linked to the Chronic Treatment of Synthetic Antimalarials
The maculopathy induced by the retinal toxicity of the synthetic antimalarials must be detected at the infra-clinical state, when it can still be reversible.
- Trial name
- OCTAPS (NCT02805686)
- Testing
- spectral domain optical coherence tomography, multifocal electroretinogram
- Volunteers
- 45 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Retinoblastoma
Phase I Trial of Periocular Topotecan in Retinoblastoma
This is a dose-escalation study aimed to assess the toxicity (and marginally the activity) of periocular topotecan in patients with relapsed-resistant retinoblastoma.
- Trial name
- NCT00460876
- Testing
- Topotecan
- Where
- Argentina
- Volunteers
- 5 people
- Sponsor
- Hospital JP Garrahan
Idiopathic Epiretinal Membrane, Cataract
Surgical Removal of Idiopathic Epiretinal Membrane With and Without the Assistance of Indocyanine Green.
It was the aim of the present study to prospectively compare the functional and morphological outcome of idiopathic epiretinal membrane surgery with and without the assistance of Indocyanine green (ICG).
- Trial name
- NCT00376857
- Testing
- Surgery with and without the aid of Indocyanine Green (ICG)
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University of Regensburg
Toxicity, Drug, Maculopathy
Studying the Performance of OCT C-scan in the Screening for Retinopathy Related to Synthetic Antimalarials
Maculopathy induced by retinal toxicity of synthetic antimalarials is to be screened at the sub-clinical stage. Indeed, when the first visual symptoms appear, macular damage is already irreversible and the clinical picture may…
- Trial name
- PERFOCTAPS (NCT02719002)
- Testing
- spectral domain optical coherence tomography C-scan and multifocal electroretinogram
- Where
- France
- Volunteers
- 109 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Genotype, Retinal Disease
Genotype-Phenotype Study of Patients With Plaquenil -Induced Retinal Toxicity, With Evaluation of the ABCA4 Gene
Background: Plaquenil (hydroxychloroquine) is an anti-inflammatory drug that is used to treat some autoimmune diseases such as lupus and rheumatoid arthritis.
- Trial name
- NCT01145196
- Where
- United States
- Volunteers
- 320 people
- Sponsor
- National Eye Institute (NEI)
Systemic Lupus Erythematosus
Hydroxychloroquine in Systemic Lupus Erythematosus
A Systemic lupus erythematosus, SLE is disease in which immune system is over-active causing inflammation in joints skin or any organ system. There are many areas where better approaches in SLE could improve outcomes.
- Trial name
- NCT03802188
- Where
- Canada
- Volunteers
- 3,700 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Retinal Toxicity
Structure and Function of Retinal Disease
Current clinical cameras do not allow clinicians to see the cells of the retina. This study will evaluate a new electronic camera's ability to observe the human retina in finer detail.
- Trial name
- NCT05643157
- Testing
- Adaptive Optics - Optical Coherence Tomography (AO-OCT) retinal imaging
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Indiana University
Rhegmatogenous Retinal Detachment, Toxic Effect of Silicone
The Influence of Silicone Oil on Nerve Fiber Layer Thickness After Pars Plana Vitrectomy
The aim of the study is to evaluate the influence of silicone oil on thickness of the retinal nerve fiber layer by using optical coherence tomography (OCT) in patients following pars plana vitrectomy.
- Conditions
- Rhegmatogenous Retinal Detachment, Toxic Effect of Silicone, Glaucoma Due to Silicon Oil
- Trial name
- NCT01255306
- Testing
- Optical coherence tomography, Local medical treatment of raised intraocular pressure
- Where
- Croatia
- Volunteers
- 60 people
- Sponsor
- University Hospital Sestre Milosrdnice