Clinical trials: Retinal Vessels
Retinal Disease, Diabetic Retinopathy
Diagnostic Possibilities in Ophthalmological Diseases Using Swept Source Optical Coherence Tomography
In this pilot study we want to investigate morphological features acquired by the novel image modality and gain information regarding disease pathomechanism, development and future possible influence on disease management for…
- Conditions
- Retinal Disease, Diabetic Retinopathy, Macular Degeneration
- Trial name
- NCT06074731
- Testing
- SS-OCT system Plex Elite 9000
- Where
- Austria
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Johannes Kepler University of Linz
Macular Edema, Central Retinal Vein Occlusion
Ozurdex Versus Ranibizumab Versus Combination for Central Retinal Vein Occlusion
CRVO occurs when the vessels in the back of the eye become blocked. This creates a dangerous condition because the vessels are weak and prone to leakage. This results in the development of macular edema.
- Trial name
- ORION (NCT01827722)
- Testing
- Ozurdex, Ranibizumab, Combination Ozurdex with Ranibizumab PRN
- Where
- 5 sites in United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Valley Retina Institute
Diabetic Retinopathy, DR
Epivascular Glia Regression and Macular Pigment Restoration After Faricimab in Diabetic Retinopathy
The aim of the study is to evaluate in diabetic patients affected by diabetic retinopathy epivascular glia regression and macular pigment restoration after faricimab injection in diabetic retinopathy in a 1 year follow up
- Trial name
- GLIA-MAC (NCT07526857)
- Testing
- Faricimab Injection [Vabysmo], Aflibercept (2.0 mg)
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Federico II University
Diabetic Retinopathy, Age-Related Macular Degeneration
Validation of Bulbicam for DR- and AMD-patients
Aim To investigate repeatability and stability of the six OTH-related Bulbicam tests in patients suffering from a) Diabetic retinopathy (DR), b) Age related macular degeneration (AMD) and matched healthy controls (HC).
- Trial name
- NCT05441072
- Testing
- BulbiCam
- Where
- Norway
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Meddoc
Posterior Vitreous Detachment, Diabetic Retinopathy
Annular Array Ultrasound in Ophthalmology
The objective of this research is to improve the care of ocular disease and disorders, in particular the changes in the eye associated with diabetes, by providing clinicians with dramatically improved ultrasonic images of the…
- Trial name
- NCT01415037
- Testing
- annular array ultrasound exam
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Columbia University
Multiple Sclerosis, Relapsing-Remitting, Optic Neuritis
Retinal Neuro-vascular Coupling in Patients With Multiple Sclerosis
Multiple sclerosis (MS) affects approximately 2.3 million patients worldwide, with a global median prevalence of 33 per 100,000. MS is diagnosed at an average of 30 years and affects twice as many women as men.
- Trial name
- NCT03401879
- Testing
- Dynamic Vessel Analyzer (DVA), Fourier Domain Doppler Optical Coherence Tomography (FDOCT), Optical coherence tomography (OCT)
- Where
- Austria
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Macular Edema, Macular Degeneration
Evaluation of the Retinal Health Monitoring System Thickness Module
Evaluate the ability and accuracy of the Retinal Health Monitoring System - Retinal Thickness Module (RHMS - RTM).
- Trial name
- NCT04499703
- Testing
- RHMS-RTM, SD-OCT
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kubota Vision Inc.
Cataract, Glaucoma
The Effects of a Large Language Model on Clinical Questioning Skills
The researchers have used the ophthalmology textbook, clinical guideline consensus, the Internet conversation data and knowledge base of Zhongshan Ophthalmology Center in the early stage, combined with artificial feedback…
- Conditions
- Cataract, Glaucoma, Diabetic Retinopathy, Keratitis
- Trial name
- NCT06229379
- Testing
- "Digital twin patient", Interaction with real patients
- Where
- China
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Artificial Intelegence, Diabetic Retinopathy Associated With Type 2 Diabetes Mellitus
Application of Artificial Intelligence in Early Detection of Eye Complications in Diabetics
The goal of this pragmatic trial is to test the benefit of using artificial intelligence-based eye screening i.e, a fundus camera device in the early detection of eye complications in diabetics.
- Conditions
- Artificial Intelegence, Diabetic Retinopathy Associated With Type 2 Diabetes Mellitus, Macular Edema Due to Type 2 Diabetes Mellitus
- Trial name
- AI (NCT05655117)
- Testing
- AI based eye screening
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- The New Model of Care, Hail Health Cluster
AMD - Age-Related Macular Degeneration, Retinitis Pigmentosa (RP)
Retinal Investigation Using Optos OCT Device
Retinal investigation using OCT with control and diseased eyes
- Conditions
- AMD - Age-Related Macular Degeneration, Retinitis Pigmentosa (RP), Diabetic Retinopathy, Control Patients
- Trial name
- NCT06846151
- Testing
- retinal functional imaging
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Optos, PLC
Diabetic Retinopathy
AI-Powered DIY Screening System for Diabetic Retinopathy
A pragmatic trial will be conducted in two representative clinics in each of the three types of targeted settings. It will be run for 3 months in each clinic to complete data collection of up to 100 patients in SPGC and Optometry…
- Trial name
- NCT06892353
- Testing
- AI-powered fundus camera screening
- Where
- Hong Kong
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Retinal Vascular Disorder, Sport Injury
Analysis of the Variation of the Retinal Vascularization After a Prolonged Effort
The cardiovascular parameters of prolonged physical exercice have been studied, but very little data is available about the retinal vascularization.
- Trial name
- MARETINE (NCT03864380)
- Testing
- Color retinography, OCT-A, Blood pressure measurement
- Where
- France
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Healthy Participants
The Effects of Strength Training Volume, Intensity, and Breathing Techniques on Intraocular Pressure and Retinal Blood Vessels
This study aims to determine the effects of different breathing patterns on ocular vasculature and intraocular pressure (IOP) during isokinetic and isometric strength exercises.
- Trial name
- NCT07326462
- Testing
- Normal Breathing, Valsalva maneuver
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Lithuanian Sports University
Retinal Vein Occlusion, Retinal Vein Thrombosis
Atorvastatin for the Treatment of Retinal Vein Occlusion
The ATORVO study is designed to determine whether atorvastatin (Lipitor) can improve vision, when compared to placebo
- Conditions
- Retinal Vein Occlusion, Retinal Vein Thrombosis, Central Retinal Vein Occlusion, Branch Retinal Vein Occlusion
- Trial name
- ATORVO (NCT00517257)
- Testing
- Atorvastatin
- Where
- Canada
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Diabetic Retinopathy (DR)
Multimodal Biomarkers in Prediction of Diabetic Retinopathy
The goal of this observational study is to enroll diabetic patients with diabetic retinopathy and those without diabetic retinopathy, follow up and observe the long-term changes in ocular structure and function of the subjects by…
- Trial name
- ZOCDR (NCT07098832)
- Where
- China
- Volunteers
- 1,538 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Anterior Ischemic Optic Neuropathy
Retinal Neuro-vascular Coupling in Patients With Non-arteritic Anterior Ischemic Optic Neuropathy
Ischemic optic neuropathy is among the most common causes of serious impaired vision in the middle-aged and elderly population in the western world.
- Trial name
- NCT03401892
- Testing
- Dynamic Vessel Analyzer (DVA), Fourier Domain Doppler Optical Coherence Tomography (FDOCT), Optical coherence tomography (OCT)
- Where
- Austria
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Diabetic Retinopathy, Diabetic Retinopathy Associated with Type 2 Diabetes Mellitus
Early Retinal Neurodegeneration As Risk Factor, Biomarker and Pharmacological Target of Diabetic Retinopathy
Despite the evidence that diabetic retinopathy (DR) remains the first cause of blindness among the working-age population, it lacks a specific preventive treatment.
- Trial name
- 2022-12376008 (NCT06582472)
- Testing
- Ophthalmological examination including imaging assessments, confocal analysis of cornea, Dynamic Vessel Analyzer (DVA)
- Where
- 2 sites in Italy
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- IRCCS Ospedale San Raffaele
Eye Diseases, Ophthalmic Trauma
Mitochondrial DNA in Vitreous Fluid and Blood in Patients With Eye Disease or Ocular Trauma.
This study is to characterize mitochondrial DNA (mtDNA) populations in adults with eye injuries and eye diseases. The eye exam is often hindered by the clouding of tissues involved in injury or disease.
- Conditions
- Eye Diseases, Ophthalmic Trauma, Mitochondrial DNA, Age Related Macular Degeneration
- Trial name
- NCT04334499
- Testing
- Sample collection from tissue discard
- Volunteers
- healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Diabetic Retinopathy
PST/Laser v. Laser Alone for CSME
Prospective randomized clinical trial comparing Laser Alone v. Laser and posterior sub-tenon injection of triamcinolone acetonide for primary and refractory clinically significant macular edema.
- Trial name
- NCT00229918
- Testing
- triamcinolone acetonide
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Edward Hines Jr. VA Hospital
Retinal Hypoxia
The Mechanisms of Diameter Changes in Retinal Vessels During Hypoxia
The primary objective is to study if a stimulation of nitric oxide and/or prostaglandin affect the diameter changes of retinal vessels during hypoxia. Diameter changes are studied using the Dynamic Vessel Analyzer.
- Trial name
- NCT02059018
- Testing
- COX-inhibitor, Nitroglycerin, COX-inhibitor + Nitroglycerin
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Aarhus