Clinical trials: Retrocochlear Pathology
Auditory Perceptual Disorders, Age-related Hearing Loss
Objective Measurement of Hearing Aid Benefit
Hearing loss is a critical health concern in the rapidly aging population, affecting approximately 22 million older individuals in the United States.
- Trial name
- NCT04431622
- Testing
- Hearing aid amplification algorithms
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Maryland, College Park
Central Auditory Disease, Auditory Processing Disorder, Central
taVNS Effect on Central Auditory Processing
The behavioral effects of vagus nerve stimulation (VNS) and observed activation in the auditory cortex with transcutaneous auricular VNS (taVNS) raise questions about their potential impact on auditory processing.
- Conditions
- Central Auditory Disease, Auditory Processing Disorder, Central, Auditory Processing Disorders, Vagus Nerve Stimulation
- Trial name
- NCT06970444
- Testing
- transcutaneous auricular vagus nerve stimulation (taVNS)
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Medipol University
Auditory Processing Disorders
Contribution of Functional MRI in Assessment of Auditory Processing Disorders
Auditory Processing Disorder (APD) affects 0.5-7% of the pediatric population. This disorder is responsible for a child's low hearing ability.
- Trial name
- IRMf-TTA (NCT03887182)
- Testing
- functional MRI, Automated Cortical Brainstem Auditory Evoked Potential, whole exome sequencing
- Where
- France
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Auditory Diseases, Central
Comparing Hearing Aid Fitting Methods in Blast-exposed Veterans
Since 2000, at least 250,000 U.S. Service members have experienced a blast-related mild traumatic brain injury. A retrospective analysis of over 100,000 post-9/11 Veterans shows that blast injury more than doubles the risk of a…
- Trial name
- SBA (NCT06309264)
- Testing
- Phonak Lumina P90
- Where
- 3 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Mild Concussion, Post Concussion Syndrome
Clinical Evaluation of a Novel Balance, Vestibular and Oculomotor Assessment Tool
The iDETECT (Integrated Display Enhanced Testing for Concussion and mild traumatic brain injury) system is a novel portable, open access platform that enables immediate and rapid assessment of multimodal neurologic function.
- Conditions
- Mild Concussion, Post Concussion Syndrome, Vestibular Neuritis
- Trial name
- NCT02171312
- Testing
- iDETECT Assessment, Routine Balance and Vestibular Testing
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Emory University
Progesterone, Estrogens
Neural Changes in the Aging Auditory System
The purpose of this study was to determine the effects of hormone replacement therapy (HRT) on hearing in post-menopausal women.
- Conditions
- Progesterone, Estrogens, Hearing, Psychoacoustics
- Trial name
- NCT00264407
- Testing
- Hormone Replacement Therapy - HRT
- Where
- 2 sites in United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Auditory Perceptual Disorders, Aging Problems
Auditory Temporal Processes in Aging
Older people experience great difficulty understanding speech, especially accented English, and this problem is expected to increase with the influx of immigrants who provide services to the elderly population.
- Trial name
- NCT03468660
- Testing
- Auditory training with feedback, Listening paradigm with no feedback
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University of Maryland, College Park
Auditory Processing Disorder
Auditory Processing in Spanish-English Bilinguals: Is Performance Better When Tested in Spanish or English?
The purpose of this study is to learn more about how bilingual individuals process sound in challenging listening environments and how testing language may impact results on auditory processing assessments.
- Trial name
- NCT05452486
- Testing
- English APD assessment, Spanish APD assessment
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Migraine, Vestibular Migraine
Analysis of Vestibular Compensation Following Clinical Intervention for Vestibular Schwannoma
Multiple sensory cues are typically generated by discrete events, and while they do not reach the cerebrum simultaneously, the brain can bind them temporally if they are interpreted as corresponding to a single event.
- Conditions
- Migraine, Vestibular Migraine, Vestibular Schwannoma, Motion Sickness
- Trial name
- NCT04196933
- Testing
- Temporal Binding Adaptation - PSS training, Temporal Binding Adaptation - PSS adaptation with VI stimulation, Chronic Motion-modulated Stimulation
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Massachusetts Eye and Ear Infirmary
Healthy Individuals, Hearing Loss, Central
The Contributions of Age Related Changes in the Sound Localization Pathway to Central Hearing Loss
Age-related hearing loss, presbycusis, affects up to 50% of American adults. There are two main causes for presbycusis: 1) Progressive death of hair cells in the inner ear, and 2) Central hearing loss, or the reduced ability to…
- Trial name
- NCT04513782
- Testing
- Audiological Assessments
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Hearing Impairment, Hearing Aid Fitting
Blast Exposed Veterans With Auditory Complaints
The purpose of this study is to study blast-exposed Veterans who report hearing handicap but show normal or near normal results on standard audiometric testing.
- Trial name
- NCT02122458
- Testing
- mild-gain hearing aids with high-frequency emphasis over 6-months
- Where
- 3 sites in United States
- Volunteers
- 363 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Acute Vestibular Syndrome, Vertigo
Quantitative Eye Movement Measurements in Patients with Acute Vestibular Syndrome
BACKGROUND: A chief complaint of acute vertigo/dizziness is related to about 2.1-7.1% of all emergency department (ED) visits. About 25% of all patients with acute prolonged vertigo meeting diagnostic criteria of AVS (acute…
- Conditions
- Acute Vestibular Syndrome, Vertigo, Stroke Acute, Acute Unilateral Vestibulopathy (AUV)
- Trial name
- NCT06668857
- Testing
- video-oculography
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Alexander Tarnutzer
Auditory Processing Disorder
An 'Off-the-shelf' Assistive Listening Device: Normal-hearing Children.
The cochlea, the sensory organ of hearing, is a structure of the temporal bone on the skull. In everyday life sounds are heard via air conduction.
- Trial name
- NCT03695575
- Testing
- Bone-conduction headset
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Children's Hearing Evaluation and Amplification Resource, Ltd.
Sensorineural Hearing Loss, Noise Induced Hearing Loss
ABR Characteristics and Salivary Cortisone Concentration in Noise-exposed Workers
The aim of the research: Investigate the association of auditory evoked brainstem response characteristics with salivary cortisone concentrations in noise-exposed workers. Purpose of the research: 1.
- Conditions
- Sensorineural Hearing Loss, Noise Induced Hearing Loss, Auditory Nerve; Lesion
- Trial name
- NCT04183361
- Testing
- ABR and salivary cortisone testing
- Where
- Croatia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital Sestre Milosrdnice
Sensorineural Hearing Loss
Investigation of Anatomical Correlates of Speech Discrimination
Understanding speech is essential for good communication. Individuals with hearing loss and poor speech discrimination often have little success with hearing aids because amplifying sound improves audibility, but not clarity of…
- Trial name
- NCT01781039
- Testing
- Hearing Aid fitting
- Where
- United States
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- Steward St. Elizabeth's Medical Center of Boston, Inc.
Vestibular Schwannoma, Inner Ear Disease
Vestibular Precision: Physiology & Pathophysiology
This project will investigate the role of noise in the vestibular system, and in particular its effects on the variability (precision) of vestibular-mediated behaviors.
- Conditions
- Vestibular Schwannoma, Inner Ear Disease, Dizziness, Neurofibromatosis 2
- Trial name
- NCT04890132
- Testing
- VOR precision training
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Massachusetts Eye and Ear Infirmary
Peripheral Vestibular Disorder, Benign Paroxysmal Positional Vertigo
Effect of Peripheral Vestibular Disease Location on Outcomes Following Home-based Virtual Reality Vestibular Therapy
This parallel-group randomized controlled trial aims to determine if the location of the lesion(s) in the vestibular system (unilateral versus bilateral, lateral semi-circular canal versus otolith) impacts the effectiveness of…
- Conditions
- Peripheral Vestibular Disorder, Benign Paroxysmal Positional Vertigo, Meniere Disease, Vestibular Neuritis
- Trial name
- VR-PVD-RCT (NCT05424302)
- Testing
- Standard Vestibular Rehabilitation with Adjunct At Home Virtual Reality Vestibular Rehabilitation, Standard Vestibular Rehabilitation with Adjunct Auditory Intervention
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Diabetic Peripheral Neuropathy, Diabetes
Diabetes, Falls, and Fractures
Comparing severity of diabetic peripheral neuropathy (small and large fibers including autonomic neuroapthy) to postural control and vestibular measurements
- Conditions
- Diabetic Peripheral Neuropathy, Diabetes, Balance; Distorted, Vestibular Neuropathy
- Trial name
- DIAFALL (NCT05389566)
- Testing
- Quantative Sensory Testing, NCStat-DPN-Check, Composite Autonomic Symptom Score 31
- Where
- Denmark
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Aalborg University Hospital
Acoustic Neuroma, Labyrinthitis Ossificans
Maintaining Cochlear Patency After VIIIth Nerve Surgery
Tumors arising from the VIIIth Nerve (vestibulo-cochlear nerve) typically present with progressive unilateral hearing loss and tinnitus.
- Conditions
- Acoustic Neuroma, Labyrinthitis Ossificans, Profound Hearing Impairment
- Trial name
- NCT03261726
- Testing
- MedEl Test Electrode Placer
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Brain Mapping, Intracranial Central Nervous System Disorder
Connectivity Analysis for Investigation of Auditory Impairment in Epilepsy
Background: People with epilepsy often have auditory processing disorders that affect their ability to hear clearly and may cause problems with understanding speech and other kinds of verbal communication.
- Conditions
- Brain Mapping, Intracranial Central Nervous System Disorder, Epilepsy, Auditory Perceptual Disorder
- Trial name
- NCT01212068
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- National Institute on Deafness and Other Communication Disorders (NIDCD)