Clinical trials: Reward
Healthy
A Study To Examine Safety, Pharmacokinetics, And Pharmacodynamic Of Pf 06412562 In Healthy Males
This study is designed to investigate the safety, tolerability pharmacokinetics and pharmacodynamic effects of PF-06412562 following multiple dose administration as MR tablets in healthy adult males.
- Trial name
- NCT02306876
- Testing
- PF-06412562 3mg BID, PF-06412562 15mg BID
- Where
- 3 sites in United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Pfizer
Anhedonia, Depression
A Neurobiological Model of Anhedonia
The purpose of this research study is to better understand anhedonia in Major Depressive Disorder by investigating the reward-related neural and inflammatory correlates.
- Trial name
- NCT05629520
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Healthy
The Impact of Reward-induced Dopamine Release on Functional Connectivity: a Combined PET/fMRI Study
The present study would be the first to investigate the relationship between reward- and or social stimuli-induced dopamine (DA) release and neural function using a combined PET/fMRI approach.
- Trial name
- NCT02801643
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Reward, Tetrahydrocannabinol
Investigating the Acute Effects of THC on Functional Brain Systems
The purpose of this study is to determine whether THC, the main psychoactive ingredient in cannabis, affects functional brain systems underlying memory and reward.
- Conditions
- Reward, Tetrahydrocannabinol, Endocannabinoids, Memory
- Trial name
- FIX (NCT00628706)
- Testing
- Delta9-tetrahydrocannabinol (THC)
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Adiposity
Reward System Responses to Food Aromas
Food aromas are a part of foods' flavor, and can promote overeating. Alcohol consumption also stimulates appetite, and contributes to overeating while under alcohol's acute effects.
- Trial name
- NCT02041039
- Where
- United States
- Volunteers
- 332 people, healthy volunteers welcome
- Sponsor
- Robert Considine
Depression in Adolescence, Antidepressant Activity in Healthy Volunteers
Fluoxetine and Understanding Social Experiences
Adolescence is a critical developmental period marked by significant social, cognitive, and emotional changes. Unfortunately, it is also a time when the risk of depression and anxiety rises dramatically.
- Conditions
- Depression in Adolescence, Antidepressant Activity in Healthy Volunteers, Healthy Adult Participants
- Trial name
- FUSE (NCT07456501)
- Testing
- Fluoxetine
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Learning Disabilities
Effects of Oxytocin on Reinforcement Learning
The main aim of the study is to investigate whether intranasal oxytocin (24IU) influences reward sensitivity and performance monitoring during reinforcement learning.
- Trial name
- NCT03846271
- Testing
- intranasal oxytocin
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Depression, Depressive Disorder
Reward Processing and Depressive Subtypes: Identifying Neural Biotypes
Deficits in motivation and pleasure are common in depression, and thought to be caused by alterations in the ways in which the brain anticipates, evaluates, and adaptively uses reward-related information.
- Conditions
- Depression, Depressive Disorder, Major Depressive Disorder, Major Depressive Episode
- Trial name
- NCT06080646
- Testing
- cross-sectional MRI and EEG assessments (NO INTERVENTION)
- Where
- United States
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- San Francisco Veterans Affairs Medical Center
Cocaine Dependence
Study of the Effects of Risperdal Consta on Brain Reward Circuitry Function, Craving and Cocaine Use in Active Cocaine Dependence
The purpose of this study is to examine the effects of the administration of Risperidal-Consta on the brain's reward circuitry using Magnetic resonance Imaging (MRI), behavioral tests and measuring cocaine craving and use among…
- Trial name
- NCT00385801
- Testing
- Risperidone
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Anhedonia
Serotonin-receptor Agonism in Reward Processing
There is growing animal and human evidence for role of 5HT1A receptor agonism in treating depression and reward deficits. The next step is to translate this evidence directly into humans by characterising the effects of…
- Trial name
- SARP (NCT05357547)
- Testing
- Buspirone 20mg
- Where
- United Kingdom
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Obesity
Investigation of the Effects of Bariatric Surgery on Taste Reward in Humans
The investigators hypothesize that some of these changes in the reduced appetite after surgery may be due to alterations in taste.
- Trial name
- NCT01531738
- Where
- United Kingdom
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Healthy
Does Oxytocin Modulate Rewarding Effects in Women and Fluctuating Across the Menstrual Cycle
The aim of the study is to explore how the rewarding effect of men's verbal compliment is modulated by oxytocin and gonadal hormone in a romantic context.
- Trial name
- NCT03144115
- Testing
- Oxytocin
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Vagus Nerve Stimulation in Reward Learning
Pulsed tVNS Protocol and Reinforcement Learning
The aim of this study is to investigate the potential of a phasic taVNS stimulation protocol for reinforcement learning. The investigators will disentangle its effects on learning actions and outcomes through the administration…
- Trial name
- NCT06205108
- Testing
- taVNS stimulation
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Bonn
Healthy
Cognitive, Emotional, and Neural Responses to Acute Inflammation
This study is a pilot study to examine the effects of acute inflammation on cognition and emotion in healthy participants using a between-subjects, randomized, double-blind design.
- Trial name
- NCT03294564
- Testing
- Typhoid Vi Polysaccharide Vaccine
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Esophageal Neoplasms, Stomach Neoplasms
The Effect of Satiety Gut Hormone Modulation on Appetitive Drive After Upper Gastrointestinal Surgery
Improvements to treatment strategies for patients with cancers of the upper gastrointestinal tract have produced a large population of people who remain free from cancer recurrence in the long term following treatment.
- Conditions
- Esophageal Neoplasms, Stomach Neoplasms, Weight Loss, Malnutrition
- Trial name
- NCT02381249
- Testing
- Octreotide
- Where
- 2 sites in Ireland, Sweden
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- St. James's Hospital, Ireland
Type 2 Diabetes
Processed Meat and Brain Regions Related to Reward and Addiction
The purpose of this study is to 1. Compare effects of two isocaloric meals (processed meat hamburger vs. vegetarian sandwich) in response to the postprandial period by using functional brain imaging of reward circuitry implicated…
- Trial name
- RewCrav (NCT02474147)
- Testing
- Processed meat hamburger, Vegan sandwich
- Where
- Czechia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Institute for Clinical and Experimental Medicine
Pre-natal Cocaine Exposure, Risk-Taking
Development of Reward Processing in Prenatally Exposed Adolescents and Young Adults
Reward processing will be examined in prenatally exposed emerging adults in a longitudinal design. Participants will be followed for one year to see if neural markers of reward processing prospectively predict risk-taking…
- Trial name
- NCT03268759
- Testing
- fMRI
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Yale University
Healthy
Stanford Regulating Circuits of the Brain Study - MDMA
This study is a biomarker study designed to characterize how human neural circuits and behaviors are modified during altered states induced by MDMA.
- Trial name
- RBRAIN-MDMA (NCT04060108)
- Testing
- MDMA
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Stanford University
Schizophrenia
The Effects of Aripiprazole on the Processing of Rewards in Schizophrenia
The objective of this study is to determine whether subjects with negative symptoms of schizophrenia have abnormal functioning of brain circuits relevant to reward processing, and to determine whether any such abnormalities are…
- Trial name
- NCT00209027
- Testing
- fMRI, Aripiprazole
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Emory University
Rejection Sensitivity
Endogenous Opioid Mechanisms for Rejection Sensitivity
This project hypothesizes that the brain's opioid system determines rejection sensitivity, a personality trait that is a vulnerability factor and feature of several psychiatric disorders.
- Trial name
- NCT02189785
- Where
- United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Stony Brook University