Clinical trials: Reward
Depression, Involutional
Function of Catecholamines in the Brain During Depression
This study will explore brain function related to depressive symptoms and will examine DNA for genes that may be involved in depressive disorders, particularly genes that regulate synthesis and metabolism of the brain…
- Trial name
- NCT00082030
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Familial Alcoholism Vulnerability
Functional Neuroimaging of Alcoholism Vulnerability: Probing Glutamate and Reward, Using the mGluR5 Inhibitor Mavoglurant
The purpose of this study is to evaluate the role of Mavoglurant in clarifying the neurobiology of alcoholism risk. This is a one-site, randomized, within subjects, counterbalanced double-blind study of a single dose (200mg) of…
- Trial name
- NCT05203965
- Testing
- Mavoglurant (AFQ056)
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Yale University
Appetitive Behavior, Obesity
Neural Mechanisms for Appetitive Responses to High Reward Foods
This study is aimed at understanding neuroendocrine responses to different types of sugars and how this influences feeding behavior among lean, overweight, and obese individuals.
- Trial name
- NCT02945475
- Where
- United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Major Depressive Disorder (MDD), History of Childhood Sexual Abuse (CSA)
An Investigation of Early Life Stress and Depression
The purpose of this study is to investigate brain pathways within adult females (with a history of CSA that occurred between the ages of 5-14) with and without a current diagnosis of major depressive disorder (MDD).
- Trial name
- NCT01701258
- Testing
- Amisulpride
- Where
- 2 sites in United States
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Structural Racism, Substance Use Risk
Structural Racism, Reward Related Decision Making and Substance Use Risk
The goal of this observational study, which has a pilot phase (R61) and a second, larger phase (R33), is to learn about the impact of indicators of structural racism (SR) on substance use risk in Puerto Rican adolescents living…
- Trial name
- NCT06221839
- Where
- 2 sites in United States, Puerto Rico
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Columbia University
Anorexia Nervosa
Appetitive Conditioning in Anorexia Nervosa
Anorexia nervosa (AN) is characterized by a reduced drive to pursue rewarding experiences and stimuli. Food consumption - which is almost universally experienced as pleasurable - is not described as rewarding by those with AN.
- Trial name
- ACAN (NCT05531604)
- Testing
- appetitive conditioning
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Smoking Cessation
Neuroimaging Studies of Smoking and Treatment
The purpose of this research study is to examine changes in brain regions associated with cognitive control and reward processing during behavioral smoking cessation treatment.
- Trial name
- NCT03085602
- Testing
- Cognitive behavioral therapy, Health education
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Maternal Behavior, Maternal Addiction
Oxytocin and Brain Responses in Maternal Addiction
A prior study by the principal investigator of this project identified dopamine- and oxytocin-related brain pathways that showed a diminished response when addicted mothers viewed the faces of their own vs.
- Trial name
- NCT02979093
- Testing
- Oxytocin, Functional MRI scanning
- Where
- 2 sites in United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Lane Strathearn, MBBS PhD
Tobacco Use Cessation
Reward Sensitivity and Pharmacotherapy for Smoking Cessation
The goal of this clinical research study is learn if varenicline or the nicotine patch can help people with different types of emotion and attention levels to quit smoking.
- Trial name
- NCT02162849
- Testing
- Varenicline, Nicotine Patch, Questionnaires
- Where
- United States
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Substance Dependence
A Study To Assess The Effects Of A Single Dose Of GSK598809 In Modulating Nicotine Reward
GSK598809 is being developed as an innovative treatment for substance dependence and potentially other compulsive behavioral disorders.
- Trial name
- NCT00605241
- Testing
- GSK598809
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Circadian Rhythm
Effect of Circadian Rhythm on Brain NAD Measured by Phosphorus Magnetic Resonance Spectroscopy at 7 Tesla
The Discovery of the circadian clock first established a genetic basis for behavior, and our understanding of circadian rhythm (CIR) has since expanded to provide molecular insights into physiology and disease.
- Trial name
- ChronoBrain (NCT05093088)
- Where
- Switzerland
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Ecole Polytechnique Fédérale de Lausanne
Major Depressive Disorder, Bipolar Disorder
Brain Mechanisms of Human Motivation
This study aims to investigate reward learning across the mood disorder spectrum and to investigate the predictive validity of reward learning for subsequent symptom severity.
- Trial name
- NCT01976975
- Where
- United States
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Children's Nutrition Intake
The Nutritional Effect of Parental Use of Food as a Reward
Control rules are common parental practices that use food as reward to encourage children to conduct parents' preferred behaviors.
- Trial name
- NCT02354157
- Testing
- no intervention
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- McGill University
Healthy Volunteers
Feedbacks' Influence on Decision Making Processes
The purpose of this research is to identify and probe the neural networks involved in feedback processing. It aims at translating this knowledge to clinical populations in which this network is disrupted or compromised.
- Trial name
- Feedbacks (NCT02816632)
- Testing
- mRI, Effect of Galvanic Vestibular Stimulation on decision making processes
- Where
- France
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Addiction
Dopamine and Opioid Receptor Antagonists Reduce Cue-induced Reward Responding and Reward Impulsivity
The purpose of this study is to determine how the dopamine and opioid system is involved in reward processing, specifically in cue-induced reward responding and reward impulsivity, using dopamine and opioid receptor antagonists…
- Trial name
- NCT02557984
- Testing
- Amisulpride, Naltrexone
- Where
- Switzerland
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Depression Mild, Depression Moderate
Long-term Effects ReSet Your Mind - Mechanisms
See: ClinicalTrials.gov ID: NCT05402150 Relevant for this Paper: This investigation aims to evaluate the stability of the effectiveness of different two-week online interventions in a four months follow-up regarding reward…
- Trial name
- NCT06072209
- Testing
- Behavioral Activation, Mindfulness and Gratitude, Combination of Behavioral Activation and Mindfulness and Gratitude
- Where
- Germany
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Philipps University Marburg
Cigarette Smoking, Nicotine Dependence
Nicotine Withdrawal and Reward Processing
This study is designed to find out how smoking affects the way the brain responds to pleasure and how this impacts smokers' behavior. Participants will complete three sessions.
- Conditions
- Cigarette Smoking, Nicotine Dependence, Nicotine Withdrawal
- Trial name
- NicWith (NCT05041959)
- Testing
- Smoking Abstinence, Ad Lib Smoking
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Healthy
Reward Circuit Modulation Via fMRI-informed-EEG-based Musical Neurofeedback
The goal of this study is to test whether voluntary up-regulation of mesolimbic reward system activation is possible, and to examine the neurobehavioral effects of specific neuromodulation of this circuit on reward processing.
- Trial name
- NCT04876170
- Testing
- Brain-computer-interface: EEG-based musical Neurofeedback task
- Where
- Israel
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Transdiagnostic Psychopathology, Attrition
Digital Rewards and Retention in a M-health App
Attrition and user engagement are two challenges that eHealth interventions struggle with. Attempts to address this have been previously made through gamification, instructional design and using different types of incentives.
- Conditions
- Transdiagnostic Psychopathology, Attrition, Engagement, Depression, Anxiety
- Trial name
- DIGITALRCT (NCT06883773)
- Testing
- Multipurpose Online Tool, No intervention
- Where
- Romania
- Volunteers
- 177 people, healthy volunteers welcome
- Sponsor
- University of Bucharest
Opiod Use Disorder
The Influence of ANS-6637 on Midazolam Pharmacokinetics in Healthy Volunteers
Background: Opioids are medicines that control pain. But they are often misused, which can lead to illness and death. Opioids increase dopamine to the brain, which makes people feel good and often causes them to crave drugs…
- Trial name
- NCT03831971
- Testing
- ANS-6637
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)