Clinical trials: Reward
Cannabis Use, Depression
Neural and Psychiatric Consequences of Cannabis Use in Adolescents
The goal of this study is to investigate the effects of cannabis on brain function among adolescents with depression.
- Trial name
- Cann-Teen (NCT06941298)
- Testing
- Neuroimaging Investigation
- Where
- 2 sites in United States
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- University of Miami
Healthy
Lithium Effects on Reward Processing and Reappraisal in Healthy Volunteers
Bipolar disorder has been associated with blunted activity in regions associated with emotional processing, such as striatal activity during reward anticipation as well as prefrontal activity during reappraisal.
- Trial name
- NCT03965247
- Testing
- Lithium
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Anhedonia
Serotonin-receptor Agonism in Reward Processing
There is growing animal and human evidence for role of 5HT1A receptor agonism in treating depression and reward deficits. The next step is to translate this evidence directly into humans by characterising the effects of…
- Trial name
- SARP (NCT05357547)
- Testing
- Buspirone 20mg
- Where
- United Kingdom
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Bulimia Nervosa
Neurobiological and Psychological Maintenance Mechanisms Associated With Anticipatory Reward in Bulimia Nervosa
The purpose of this investigation is to identify the potentially crucial role of anticipatory reward mechanisms maintaining bulimic behavior (i.e., binge eating and purging) in bulimia nervosa (BN).
- Trial name
- NCT04917068
- Where
- United States
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Placebo Effect on Mood Improvement
The Role of Dopamine, Reward Learning and Prefrontal Activity in Expectation-induced Mood Enhancement
Although placebo effects on depressive symptoms are well documented, the underlying mechanisms and moderating factors of expectation effects on mood and depression are poorly understood.
- Trial name
- CRC289A07 (NCT05208294)
- Testing
- Sulpiride 400 MG, High expectation manipulation, Low expectation manipulation
- Where
- Germany
- Volunteers
- 297 people, healthy volunteers welcome
- Sponsor
- Philipps University Marburg
Menstrual Cycle, Hormonal Contraception
Oxytocin and Reward Processing in Women
Oxytocin is a hypothalamic neuropeptide that is best known for its peripheral physiological effects in the female organism i.e., uterine contractions during birth.
- Trial name
- NCT06222749
- Testing
- Intranasal oxytocin administration
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- International Research Training Group 2804
Tobacco Dependence
Varenicline Effects on Cue Reactivity and Smoking Reward/Reinforcement
The purpose of this study was to find out how varenicline works to help people quit smoking. Varenicline, also known as Chantix™, is an U.S.
- Trial name
- NCT00747643
- Testing
- varenicline
- Where
- United States
- Volunteers
- 163 people, healthy volunteers welcome
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Obesity
Investigation of the Effects of Bariatric Surgery on Taste Reward in Humans
The investigators hypothesize that some of these changes in the reduced appetite after surgery may be due to alterations in taste.
- Trial name
- NCT01531738
- Where
- United Kingdom
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Neurocognitive Model, Decision-Making
Motivation, Learning and Decision Making in Changing Environments
The main objective of this study is to develop a models of sequential decision-making, learning and motivation that includes emotions as driving forces of adaptive behaviour.
- Trial name
- MOTILEARN (NCT07314112)
- Where
- France
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hôpital le Vinatier
Obesity, Appetitive Behavior
Regulation of Energy Balance and Metabolism - Mechanisms Behind and Beyond Obesity and Weight Loss
The study aims to investigate homeostatic and hedonic mechanisms regulating appetite, energy balance and metabolism in obesity and the effects of three distinct obesity treatments on these regulatory mechanisms.
- Trial name
- BALANCE (NCT03550339)
- Testing
- SURG, DIET, HAES
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Eastern Finland
Healthy
Food Reward Processing in the Human Brain
The aim of this study is to investigate the influence of different metabolic states and hormonal satiety signalling on responses in neural reward networks.
- Trial name
- NCT03081585
- Testing
- Satiety State
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Heidelberg Medical Center
Reward Value Level
Stress and Anxiety Effects on Valuation
The purpose of this study is to understand how stress, anxiety, and negative affect change learning and decision-making processes.
- Trial name
- NCT07252947
- Testing
- Socially Evaluated Cold Pressor Task (SECPT), Non-Stressful Control Task
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Alcohol Use Disorder
The Role of Dopaminergic and Glutamatergic Neurotransmission for Dysfunctional Learning in Alcohol Use Disorders
The aim of this project is to assess reward- based learning behavior and its association with alterations in dopaminergic and glutamatergic transmission in detoxified alcohol-dependent patients and matched controls.
- Trial name
- LeADP5 (NCT02094196)
- Testing
- Alcohol detoxification
- Where
- 2 sites in Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Technische Universität Dresden
Depression, Parent-Child Relations
Parent Encouragement And Coaching of Happiness in Youth
The goal of this mechanistic clinical trial is to examine whether parent-coaching aimed at increasing child positive affect will increase child neural response to reward. The main questions it aims to answer are: Aim 1.
- Trial name
- PEACHY (NCT06725160)
- Testing
- Parent Coaching, Active Control
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Bulimia Nervosa, Eating Disorders
Neural Response to Catecholamine Depletion in Subjects Suffering From Bulimia Nervosa in Their Past and Healthy Controls
Bulimia nervosa is a severe psychiatric disorder characterized by recurrent binge eating episodes followed by inappropriate compensatory behavior to prevent weight gain such as self-induced vomiting.
- Conditions
- Bulimia Nervosa, Eating Disorders, Dopamine, Reward
- Trial name
- NCT02179814
- Testing
- AMPT/ Demser, Diphenhydramine
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Bern
Major Depressive Disorder
Imaging Dopamine Release in Depression
This study aims to determine whether ventral striatal dopamine release is a mechanism of reward motivation in major depression, whether dopamine release is low in depression, and whether DA release and reward motivation predict…
- Trial name
- NCT02033369
- Testing
- Pramipexole
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Healthy Volunteers
Magnetic Prefrontal Stimulation for Studying the Role of the Cortex in High-level Cognition Processes and Reward System
The investigators intend to study the role of the cortex in high- level cognition processes and sensory adaptation, by the use of non-invasive Transcranial Magnetic stimulation and various cognitive tests.
- Trial name
- NCT00912522
- Testing
- TMS
- Where
- Israel
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Caffeine
Does Caffeine Facilitate Human Reward Learning Behaviors?
"Learning from the rewards" is underlying the formulation of knowledge and habits in daily life. Caffeine is the most commonly used "psychoactive" substance that could change one's mind state by affecting the brain and nervous…
- Trial name
- ADoRe (NCT05325502)
- Testing
- caffeine, mannitol
- Where
- Switzerland
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Yu-Shiuan Lin
Overweight and Obesity
The Role of Altered Nutrient Partitioning in Food Reward
Obesity remains a public health epidemic despite substantial advances in treatment strategies and therapies in the last decade. Effective strategies to support maintenance of improved metabolic health and reduced body weight are…
- Trial name
- NCT05200845
- Testing
- Conditioned Stimulus + (CS+): Flavored beverage solution with 75 calories of sucrose, Conditioned Stimulus - (CS-): Flavored beverage solution with sweetness-matched sucralose, High-Fat Test Meal Inside a Metabolic Chamber
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Alcohol Dependence
Multimodal Neuroimaging of Stress and Reward Cues to Assess Alcoholism Risk and Relapse
Extending previous findings, and applying a novel multi-method translational approach, this project hypothesizes that there are alcohol-related neuroendocrine and neural changes observable in acute and protracted abstinence, and…
- Trial name
- NCT02616094
- Testing
- Multi-method Neuroendocrine and Neuroimaging Procedure Scan 1, Multi-method Neuroendocrine and Neuroimaging Procedure Scan 2
- Where
- United States
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Yale University