Clinical trials: Reward
Alcohol Use Disorder (AUD), Alcoholism
Assessing Habitual, Goal-Directed, and Pavlovian Influences in Alcohol Use Disorder
The first aim of this study is to establish the role of maladaptive reliance on habits for impaired control in addiction, employing a novel task - the Action-Sequence-Task (AST), which assesses interference between habitual and…
- Conditions
- Alcohol Use Disorder (AUD), Alcoholism, Substance Use Disorders
- Trial name
- ReCoDe (NCT06701500)
- Testing
- Pavlovian-to-instrumental transfer (PIT) paradigm, Action Sequence Task (AST), Basic psychological assessment (interview)
- Where
- Germany
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Technische Universität Dresden
Stroke
Characterizing the Neural Bases of Motivational Disorders After Stroke
The aim of the study is to quantify elementary mechanisms of motivation, with innovative tools adapted to clinical settings, in healthy subjects, and in stroke patients.
- Trial name
- MOTI-stroke (NCT03741140)
- Testing
- Motivation tests
- Where
- France
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Obsessive-Compulsive Disorder
The Neurocircuitry of Relief During Avoidance Learning in Patients With Obsessive-compulsive Disorder
To investigate the neuro-mechanisms underpinning persistent avoidance in OCD patients
- Trial name
- AvoidOCD (NCT04685018)
- Testing
- fMRI acquisition
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Impulsivity, Alcohol Consumption
The Gut-brain Axis in Food Reward and Alcohol Consumption
The aims of this project are to: 1. Determine if 3-weeks dietary supplementation with NOPE-EGCG (PhosphoLEANtm, 85mg NOPE+50mg EGCG per capsule) versus a placebo will improve performance on impulsivity, go/no-go tasks and…
- Trial name
- NCT01902069
- Testing
- Phospholean
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Yale University
Adolescent Obesity
TRUST Study of Adolescent Weight Self-Management
The purpose of this pilot study is to evaluate the effect of the Trust-building weight Self-management Together (TRUST) intervention on weight self-management behaviors and neural processing in overweight/obese adolescents.
- Trial name
- TRUST (NCT03016247)
- Testing
- TRUST Intervention, Enhanced Usual Care
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Major Depressive Disorder, Treatment Resistant Depression
The Impact of Working Memory and Reward Markers on DLPFC Activity in Treatment-resistant Depression
Major Depressive Disorder (MDD) is a very common illness that is usually treated with antidepressant medication. Depression can be caused by many things such as childhood experiences, genetics, and changes in the way the body and…
- Trial name
- NCT06163625
- Testing
- Repetitive Transcranial Magnetic Stimulation, Research Interview, Questionnaires, Brain Scan
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Pediatric Obesity, Inhibition
Brain Mechanisms of Overeating in Children
The proposed research will follow healthy weight children who vary by family risk for obesity to identify the neurobiological and appetitive traits that are implicated in overeating and weight gain during the critical…
- Conditions
- Pediatric Obesity, Inhibition, Decision Making, fMRI
- Trial name
- RO1 (NCT03341247)
- Where
- United States
- Volunteers
- 254 people, healthy volunteers welcome
- Sponsor
- Penn State University
Healthy
7-day Atorvastatin and Emotional Processing
Work in our group has revealed that short-term (7-day) administration of antidepressants produces positive biases in the processing of emotional information in healthy volunteers.
- Trial name
- NCT03966859
- Testing
- Atorvastatin 20mg
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Obesity
Reward Mechanisms in Obesity
The study aims to investigate the effects of 3.0 mg of liraglutide on reward brain circuits in human obesity and to better understand its effects on weight loss (in patients without diabetes).
- Trial name
- LIRAOB (NCT03347890)
- Where
- Switzerland
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Zoltan Pataky
Obesity, Type 2 Diabetes
Effects of Glucagon Like Peptide-1(GLP-1) and Liraglutide on Brain Satiety and Reward Circuits and Feeding Behavior in Diabetes
The aim of this study is to investigate if endogenous Glucagon Like Peptide -1 (GLP-1) has an effect on brain satiety and reward systems and if there are alterations in obese patients with type 2 diabetes (T2DM).
- Trial name
- LIBRA (NCT01363609)
- Testing
- Liraglutide treatment 12 weeks, insulin glargine treatment, GLP-1 receptor antagonist
- Where
- Netherlands
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Amsterdam UMC, location VUmc
Risk-Taking, Adolescent Behavior
Prevention of Adolescent Risky Behaviors: Neural Markers of Intervention Effects
Adolescence is a time of biological and behavioral changes that can lead to risky and dangerous behaviors, and African-American youth are highly vulnerable to the consequences of risky behavior, including HIV/AIDS and violence…
- Trial name
- NCT03370393
- Testing
- Pathways for African-Americans' Success (PAAS)
- Where
- United States
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Alcohol Use Disorder
The Role of Dopaminergic and Glutamatergic Neurotransmission for Dysfunctional Learning in Alcohol Use Disorders
The aim of this project is to assess reward- based learning behavior and its association with alterations in dopaminergic and glutamatergic transmission in detoxified alcohol-dependent patients and matched controls.
- Trial name
- LeADP5 (NCT02094196)
- Testing
- Alcohol detoxification
- Where
- 2 sites in Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Technische Universität Dresden
Reward Responses, Gastrointestinal Hormones
Assessment of Reward Responses to Erythritol Using Flavor Preference Learning
The aim of this project is to investigate the reward responses to oral erythritol compared to sucrose and sucralose using flavor preference learning in healthy participants.
- Conditions
- Reward Responses, Gastrointestinal Hormones, Glycemic Control, Appetite
- Trial name
- NCT05279183
- Testing
- Erythritol, Sucrose, Sucralose
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Methamphetamine Dependence
Pilot Study of Entacapone for Methamphetamine Abuse
Addiction to methamphetamine is a serious health problem. There are no medications that a doctor can give someone to help them stop using methamphetamine.
- Trial name
- NCT02058966
- Testing
- Entacapone, Methamphetamine
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Cocaine Dependence
Study of the Effects of Risperdal Consta on Brain Reward Circuitry Function, Craving and Cocaine Use in Active Cocaine Dependence
The purpose of this study is to examine the effects of the administration of Risperidal-Consta on the brain's reward circuitry using Magnetic resonance Imaging (MRI), behavioral tests and measuring cocaine craving and use among…
- Trial name
- NCT00385801
- Testing
- Risperidone
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Schizophrenia
Pan European Collaboration on Antipsychotic Naive Schizophrenia (PECANS)
The investigators want to relate disturbances in first-episode schizophrenic patients in (dopaminergic) D2 receptors, brain structure, brain function, and information processing to each other and to psychopathology.
- Trial name
- PECANS (NCT01154829)
- Testing
- amisulpride, aripiprazole
- Where
- Denmark
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Emotional Processing
Losartan and Emotional Learning
This study explores the effects of single-dose losartan (50mg) versus placebo on emotional processing in healthy volunteers.
- Trial name
- NCT06628154
- Testing
- Losartan potassium 50mg
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Binge-Eating Disorder
Binges and Neural Variability
People who suffer from binge eating disorder experience recurrent episodes of binge eating.During these episodes, they consume an unusually large amount of food in a short amount of time and experience loss of control over…
- Trial name
- BEDVAR (NCT04184856)
- Testing
- fMRI
- Where
- Germany
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Healthy
Effect of Oral Oxytocin on Women's Response to Emotional Stimuli
The main aim of the study is to investigate whether orally administered oxytocin (24IU) could modulate females' neural and behavioral responses to affective stimuli including emotional faces and affective scenes.
- Trial name
- NCT05073939
- Testing
- Oral Oxytocin
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Placebo Effect on Mood Improvement
The Role of Dopamine, Reward Learning and Prefrontal Activity in Expectation-induced Mood Enhancement
Although placebo effects on depressive symptoms are well documented, the underlying mechanisms and moderating factors of expectation effects on mood and depression are poorly understood.
- Trial name
- CRC289A07 (NCT05208294)
- Testing
- Sulpiride 400 MG, High expectation manipulation, Low expectation manipulation
- Where
- Germany
- Volunteers
- 297 people, healthy volunteers welcome
- Sponsor
- Philipps University Marburg