Clinical trials: Reward
Cigarette Smoker, Tobacco Use Disorder
Behavioral Activation Therapy and Nicotine Replacement Therapy in Increasing Smoking Cessation
This randomized clinical trial studies how well behavioral activation therapy and nicotine replacement therapy work in increasing smoking cessation.
- Trial name
- NCT02697227
- Testing
- Behavioral Intervention, Laboratory Biomarker Analysis, Nicotine Patch
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Healthy, Brain Insulin Sensitivity
Long-Term Effects of Walnut Consumption on Brain Function
Rationale: Healthy foods, including mixed nuts, may improve brain function, which is essential for cognitive and metabolic health, and may contribute to improved food intake regulation.
- Conditions
- Healthy, Brain Insulin Sensitivity, Cerebral Blood Flow, Brain Vascular Function
- Trial name
- WalBrain (NCT07422220)
- Testing
- Walnuts
- Where
- Netherlands
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Depression, Depressive Disorder
Reward Processing and Depressive Subtypes: Identifying Neural Biotypes
Deficits in motivation and pleasure are common in depression, and thought to be caused by alterations in the ways in which the brain anticipates, evaluates, and adaptively uses reward-related information.
- Conditions
- Depression, Depressive Disorder, Major Depressive Disorder, Major Depressive Episode
- Trial name
- NCT06080646
- Testing
- cross-sectional MRI and EEG assessments (NO INTERVENTION)
- Where
- United States
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- San Francisco Veterans Affairs Medical Center
Schizophrenia
Dopamine Function and Reward Processing In Schizophrenia
Background: Schizophrenia is associated with cognitive impairment in different parts of the brain, including those associated with learning and memory.
- Trial name
- NCT01035996
- Where
- 2 sites in United States
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Obesity
Brain Electrophysiological Patterns in Obesity
There is growing evidence of behavioural and neurobiological overlaps between obesity and drug abuse. Reduction of the amplitude of P300, a component of event-related potentials (ERP) elicited by an oddball paradigm, is an…
- Trial name
- NCT00842569
- Where
- France
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Centre de Recherche en Nutrition Humaine Rhone-Alpe
Anorexia Nervosa
Influence of Reward and Punishment on Goal-directed and Habit Learning in Adolescent Anorexia Nervosa
The proposed study of adolescents with anorexia nervosa (AN) will examine the association of behavioral differences in constructs of decision making, brain structure and connectivity, and eating disorder (ED) symptoms.
- Trial name
- NCT04051879
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Adolescent Development
Monetary Incentive Delay Task for Probing Reward-related Neural Processes
150 males and 150 females ages 14-17 years-old will be enrolled in an observational, longitudinal study. There are three planned in-person visits: a baseline assessment, an 18-month follow-up, and a 36-month follow-up.
- Trial name
- MID (NCT06369623)
- Testing
- Monetary Incentive Delay Task
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Healthy
Cognitive, Emotional, and Neural Responses to Acute Inflammation
This study is a pilot study to examine the effects of acute inflammation on cognition and emotion in healthy participants using a between-subjects, randomized, double-blind design.
- Trial name
- NCT03294564
- Testing
- Typhoid Vi Polysaccharide Vaccine
- Where
- 2 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Binge Eating, Eating Behavior
Effects of LDX on Cognitive Processes and Appetite
This study will investigate the effect of lisdexamfetamine dimesylate (LDX) on the mediating factors of reward and cognition on appetite.
- Trial name
- NCT04181957
- Testing
- Lisdexamfetamine Dimesylate
- Where
- United Kingdom
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Binge Eating Disorder, Obesity
Binge Eating Disorder and Obesity : Functional MRI Study
Obesity, defined as BMI> 30kg / m2, is a major public health problem, with devastating medical and psychological consequences. 30% of obese suffer from BED type of eating disorders.
- Trial name
- BED (NCT02868619)
- Testing
- Functional MRI, ADO-BEDS scale, R-CMAS scale
- Where
- France
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Smoking
Effects of Quitting Study A Test of Pre-clinical Findings
The most widely-accepted animal model of nicotine withdrawal states stopping nicotine makes rewarding events become less rewarding. The current study will test if this is true in humans.
- Trial name
- NCT01824511
- Testing
- Smokers cease smoking
- Where
- 2 sites in United States
- Volunteers
- 287 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Cannabis Use Disorder
Effects of THC on Alcohol Consumption and Neural Correlates of Reward
Alcohol and cannabis are often used together such that their effects overlap, but little is known about the neural mechanisms that underlie simultaneous use.
- Trial name
- NCT06446479
- Testing
- Dronabinol Pill
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Eating Behavior, Hunger
Effect of Consumption on Cognitive Processes
To get a better understanding of the interaction between metabolism, neural responses, cognitive processes and appetite the investigaters will examine the effect of food consumption on cognitive processes.
- Conditions
- Eating Behavior, Hunger, Inhibition, Functional Magnetic Resonance Imaging
- Trial name
- NCT03472703
- Testing
- Break-Lunch time
- Where
- United Kingdom
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Reward Value Level
Stress and Anxiety Effects on Valuation
The purpose of this study is to understand how stress, anxiety, and negative affect change learning and decision-making processes.
- Trial name
- NCT07252947
- Testing
- Socially Evaluated Cold Pressor Task (SECPT), Non-Stressful Control Task
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Healthy Human Male Subjects
The Influence of Liraglutide on the Reward Properties of Food: an fMRI Study on Healthy Volunteers
Clinical experience has confirmed the anorexic effect of Glucagon-like-peptide 1 (GLP-1) mimetics in comparison to DPP-4 inhibitors.
- Trial name
- NCT01695109
- Testing
- Liraglutide
- Where
- Austria
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Depression Mild, Depression Moderate
Long-term Effects ReSet Your Mind - Mechanisms
See: ClinicalTrials.gov ID: NCT05402150 Relevant for this Paper: This investigation aims to evaluate the stability of the effectiveness of different two-week online interventions in a four months follow-up regarding reward…
- Trial name
- NCT06072209
- Testing
- Behavioral Activation, Mindfulness and Gratitude, Combination of Behavioral Activation and Mindfulness and Gratitude
- Where
- Germany
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Philipps University Marburg
Obesity, Body Weight
The Effect of Alcohol on Food Reward
Rationale It has been shown in several studies that alcohol increases subsequent food intake. However, moderate alcohol consumption has no clear effects on hunger and satiety hormones.
- Trial name
- NCT01738906
- Testing
- Orange juice, maltodextrin, Vodka
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Henk FJ Hendriks
Major Depressive Disorder
Effects of a Single Dose of Amisulpride on Functional Brain Changes
This study is designed to investigate effects of a single dose of amisulpride on functional brain changes during reward- and motivation-related processing and at rest in healthy volunteers (HV) and in patients with Major…
- Trial name
- NCT05347199
- Testing
- Amisulpride Pill
- Where
- Germany
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- Simone Grimm
Schizotypy
Neural Mechanisms of Social Feedback Evaluation in Young Adults Across the Schizotypy Spectrum: An EEG Social Judgment Study
This study will examine how young adults with different levels of schizotypal traits process social acceptance and rejection. Participants between 18 and 35 years old will complete a single laboratory session that includes…
- Trial name
- NCT07823621
- Testing
- Social Judgment Paradigm
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Central Connecticut State University
Menstrual Cycle, Hormonal Contraception
Oxytocin and Reward Processing in Women
Oxytocin is a hypothalamic neuropeptide that is best known for its peripheral physiological effects in the female organism i.e., uterine contractions during birth.
- Trial name
- NCT06222749
- Testing
- Intranasal oxytocin administration
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- International Research Training Group 2804