Clinical trials: Rhematoid Arthritis
Rhematoid Arthritis
A Phase 1 Study of JADE201 in Participants With Rheumatoid Arthritis
This is a Phase 1, first in human study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of single ascending doses of JADE201 compared to placebo in participants with Rheumatoid Arthritis
- Trial name
- NCT07533955
- Testing
- JADE201
- Where
- 8 sites in Bulgaria, Georgia and 4 more
- Volunteers
- 36 people
- Sponsor
- Jade Biosciences, Inc.
Kinesiophobia (Fear of Movement), Rhematoid Arthritis
Kinesiophobia in Rheumatoid Arthritis: Associations With Functional Disability, Disease Activity, and Related Clinical Factors
Objectives: Impairment of physical function is a core feature of RA, particularly in patients with high disease activity where pain and inflammation directly limit movement.
- Conditions
- Kinesiophobia (Fear of Movement), Rhematoid Arthritis, Rheumatoid Arthritis (RA), Rheumatoid
- Trial name
- NCT07435272
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Minia University
Rhematoid Arthritis
Pharmacogenetics of Leflunomide in the Management of Rheumatoid Arthritis
1. Patients taking leflunomide as the only disease-modifying anti-rheumatic drug (DMARD) will be recruited after consent. 2. Blood sample for DNA extraction will be taken The patient will be followed up till two visits 3 months…
- Trial name
- NCT07388407
- Testing
- Study for the correlation of SNPs with efficacy and toxicity of Leflunomide in RA patients
- Where
- 2 sites in Pakistan
- Volunteers
- 110 people
- Sponsor
- Foundation University Islamabad
Rhematoid Arthritis
Very Low Dose Prednisolone on Newly Diagnosed Rheumatoid Arthritis
Objective To investigate the efficacy of prednisolone 4mg/day added to standard of care in newly diagnosed rheumatoid arthritis (RA) patients with active disease.
- Trial name
- NCT07252271
- Testing
- Prednisolone
- Volunteers
- 112 people
- Sponsor
- Chinese University of Hong Kong
Non-inflammatory Degenerative Joint Disease, Rhematoid Arthritis
Tornier Perform™ Reversed Monopost Study
This study is a Multi-center, Prospective Follow-up, Non-significant risk, Post-Market Clinical Follow-Up (PMCF) study to Evaluate the Safety and Effectiveness of the Tornier Perform™ Reversed MonoPost System.
- Conditions
- Non-inflammatory Degenerative Joint Disease, Rhematoid Arthritis, Correction of Functional Deformity, Fracture of the Humeral Head
- Trial name
- Monarch (NCT07764614)
- Testing
- Tornier Perform™ Reversed MonoPost
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- Stryker Trauma and Extremities
Rhematoid Arthritis, Osteo Arthritis of the Knee
Persona SoluTion PPS Femur PMCF
The goal of this study is to generate clinical evidence and evaluate the safety and performance of the Persona® SoluTion® PPS Femurs in the US market, with data supporting global regulatory submissions, including CE marking under…
- Conditions
- Rhematoid Arthritis, Osteo Arthritis of the Knee, Traumatic Arthritis of Knee (Diagnosis), Polyarthritis
- Trial name
- NCT07286513
- Testing
- Total knee arthroplasty
- Where
- 4 sites in United States
- Volunteers
- 200 people
- Sponsor
- Zimmer Biomet
Rhematoid Arthritis
Wrist Nerve Block as a New Treatment in Patients With Rheumatoid Arthritis
Rheumatoid arthritis is a chronic, systemic, autoimmune inflammatory disease that mainly affects the joints and periarticular soft tissues.[1]
- Trial name
- RA: rheumatoid (NCT07814989)
- Testing
- Wrist local steroid injection
- Where
- Egypt
- Volunteers
- 180 people
- Sponsor
- Sohag University
Rhematoid Arthritis
Evaluation of CCR6 Gene Expression and Circulating CCL20 Levels as Potential Biomarkers in Rheumatoid Arthritis
Rheumatoid arthritis (RA) is characterized as a systemic auto immune disorder linked to a persistent inflammatory process that can harm both joints and extra articular organs.
- Trial name
- NCT07397741
- Testing
- Gene expression by quantitative Real Time PCR
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sohag University
Osteo Arthritis of the Knee, Rhematoid Arthritis
Rehabilitation Approaches Used in Total Knee Replacement
In this study, we will investigate the rehabilitation approaches commonly used by physiotherapists in Pakistan following total knee replacement.
- Trial name
- NCT07375082
- Testing
- Questionnaire
- Where
- Pakistan
- Volunteers
- 384 people, healthy volunteers welcome
- Sponsor
- Bahria University
Rheumatoid Arthritis, Periodontal Diseases
Effect of Periodontal Care on Rhematoid Arthritis in Uganda
this will be an RCT. to determine if non-surgical treatment for periodontitis can improve the disease activity score in 28 joints of rheumatoid arthritis in an African setting.
- Trial name
- NCT03513263
- Testing
- Scaling and polishing, oral hygiene instructions
- Where
- Uganda
- Volunteers
- 152 people
- Sponsor
- Makerere University
Rhematoid Arthritis
LA Function and Dimensions As Predictors of Disease Activity in RA
the aim of this study is to describe subclinical echocardiographic changes of the LA (dimensions and function) in patients with rheumatoid arthritis.
- Trial name
- NCT06593990
- Testing
- echocardography, musculoskeletal ultrasonography, lipid profile test
- Volunteers
- 108 people
- Sponsor
- Assiut University
Rhematoid Arthritis
An Efficacy And Safety Study Evaluating Tofacitinib With And Without Methotrexate Compared To Adalimumab With Methotrexate
To assess the efficacy of tofacitinib monotherapy or tofacitinib with methotrexate as compared to adalimumab with methotrexate. To compare the efficacy of tofacitinib monotherapy compared to tofacitinib combined with…
- Trial name
- ORAL STRATEGY (NCT02187055)
- Testing
- Tofacitinib with methotrexate, Tofacitinib without methotrexate, Adalimumab with methotrexate
- Where
- 215 sites in United States, Argentina and 23 more
- Volunteers
- 1,152 people
- Sponsor
- Pfizer