Clinical trials: Rheumatic Disease
Osteoarthritis, Knee, Cruciate Ligament Injury
Basic Research Projects Related to Sports Injuries
Biological samples are important human genetic resources, which can provide great value for medical research, and how to protect and rationally utilize them is of great importance.However, at present, the blood samples after…
- Conditions
- Osteoarthritis, Knee, Cruciate Ligament Injury, Patella Dislocation, Discoid Meniscus of Knee
- Trial name
- NCT04958551
- Testing
- No intervention
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Osteoarthritis
Hydrolyzed Collagen in the Reduction of Osteoarticular Pain and Functional Limitation
This randomised study evaluates the efficacy of an oral dietary supplement of Hydrolyzed Collagen in reducing pain and improving physical function in subjects with osteoarthritis.
- Trial name
- NCT05149053
- Testing
- Hydrolyzed Collagen
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Francisco Jose Rodriguez Velasco
Epstein-Barr Virus (EBV) Infections, Lymphoproliferative Disorders
Expanded Access Protocol for Tabelecleucel for Patients With Epstein-Barr Virus-Associated Viremia or Malignancies
The primary objective of this protocol is to provide expanded access to tabelecleucel to participants with Epstein-Barr virus-associated diseases and malignancies for whom there are no other appropriate therapeutic options, and…
- Conditions
- Epstein-Barr Virus (EBV) Infections, Lymphoproliferative Disorders, EBV+ Associated Lymphoma, EBV+ Associated Post-transplant Lymphoproliferative Disease (EBV+ PTLD)
- Trial name
- NCT02822495
- Testing
- tabelecleucel
- Sponsor
- Atara Biotherapeutics
Osteoarthritis
Evaluation of Diprospan Injection to the Knee on Rehabilitation of Patients After TKR of the Contralateral Knee
This study is performed to assess the influence of intraarticular injection of 2ml Diprospan (wich contains 4mg Betamethasone sodium phosphate and 10mg Betamethasone dipropionate) into osteoarthritic knee in patients who undergo…
- Trial name
- NCT00542139
- Testing
- Betamethasone, Bupivocaine
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Hadassah Medical Organization
Arthritis of Hip, Hip Dysplasia
Nexus Evaluation Primary Trident II Uncemented Shell
This is a prospective cohort study assessing the survival of a new acetabula component which is based on the original Trident acetabular system (cementless shell) which is used for Total Hip Arthroplasty.
- Conditions
- Arthritis of Hip, Hip Dysplasia, Hip Arthropathy, Hip Osteoarthritis
- Trial name
- NEPTUNE (NCT05366712)
- Testing
- Stryker Trident® II HA coated cementless acetabula component
- Where
- United Kingdom
- Volunteers
- 125 people
- Sponsor
- NHS Lothian
Rheumatoid Arthritis, Fibromyalgia
Gut Microbiota: a Player in Chronic Pain in Patients With Rheumatoid Arthritis?
Although rheumatoid arthritis (RA) treatments are very effective in reducing inflammation, chronic pain persists in 20 to 30% of patients.
- Trial name
- MiSenDol (NCT05822856)
- Testing
- Blood sampling and others interventions
- Where
- France
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Osteoarthritis
Effect of Metformin on Patients With Osteoarthritis
This randomized controlled trial aims to investigate if metformin has osteoarthritis protective effects among overweighted knee osteoarthritis patients.
- Trial name
- NCT05034029
- Testing
- Metformin hydrochloride sustained release tablets
- Where
- 5 sites in China
- Volunteers
- 262 people
- Sponsor
- Guangzhou First People's Hospital
Osteoarthritis of the Knee
A Study on the Efficacy of Glucosamine Sulfate Potassium Chloride/Standardized Ginkgo Biloba Leaf Extract in Adults With Osteoarthritis of the Knee.
The primary objective of the study is to assess the effectiveness of alpha-D Glucosamine Sulfate/Standardized Extract of Ginkgo Biloba Leaf versus a comparator product on osteoarthritis pain as assessed by the between group…
- Trial name
- 13GOHJ (NCT02604381)
- Testing
- Glucosamine Sulfate Potassium Chloride/Standardized Ginkgo Biloba Extract
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- KGK Science Inc.
Osteo Arthritis Shoulders, Osteonecrosis
Exactech Shoulder Post Market Clinical Follow-up Study
The objective of this study is to collect and evaluate long-term clinical and radiographic outcomes data in order to better understand the safety and performance of the shoulder arthroplasty over time.
- Conditions
- Osteo Arthritis Shoulders, Osteonecrosis, Rotator Cuff Tears, Rotator Cuff Tear Arthropathy
- Trial name
- NCT05603728
- Where
- 40 sites in United States, Canada and 4 more
- Volunteers
- 20,000 people
- Sponsor
- Exactech
Chronic Fatigue Syndrome, Fibromyalgia
Compare the Medical Conditions of Gulf War Veterans to Non-Deployed Veterans
Primary Hypothesis: Gulf War veterans will have an equal prevalence or mean level of the following medical and psychological conditions frequently reported in the literature compared to a control group of nondeployed veterans…
- Conditions
- Chronic Fatigue Syndrome, Fibromyalgia, Post-Traumatic Stress Disorder, Neurologic Abnormalities
- Trial name
- NCT00032461
- Volunteers
- 2,000 people
- Sponsor
- US Department of Veterans Affairs
Primary Arthrosis
Post-Approval Study to Investigate the Long Term (8 Year) Survivorship of STAR Ankle Among Continued Access Study Patients
The purpose of this study is to examine the long term survivorship of the Scandinavian Total Ankle Replacement (STAR). Specifically, this study focuses on the revision and/or removal rate of any component of the STAR ankle.
- Trial name
- STAR 8 (NCT01288586)
- Testing
- Scandinavian Total Ankle Replacement System (STAR Ankle)
- Where
- 5 sites in United States
- Volunteers
- 87 people
- Sponsor
- Stryker Trauma and Extremities
Fibromyalgia
Fibromyalgia Sleep A to ZZZ Study
This research study is testing whether changes in sleep timing and morning light therapy may have an impact on symptoms related to fibromyalgia.
- Trial name
- NCT06567886
- Testing
- Light Therapy, Sleep Stabilization
- Where
- United States
- Volunteers
- 390 people
- Sponsor
- University of Michigan
Knee Osteoarthritis
Effects of Kinesio-taping in Knee Osteoarthritis Patients.
The main reason to conduct this research is to find the comparison of kinseotaping according to time duration that is 24 hours, 48 hours and 72 hours in knee osteoarthritis patients.
- Trial name
- NCT04585373
- Testing
- kinesio-taping with conventional therapy 24 hours, kinesio-taping with conventional therapy 48 hours, kinesio-taping with conventional therapy 72 hours
- Where
- Pakistan
- Volunteers
- 48 people
- Sponsor
- Riphah International University
Osteoarthritis, Knee, Osteoarthritis, Hip
Efficacy and Safety of a Subcutaneous Tanezumab Titration Dosing Regimen in Subjects With Moderate to Severe Osteoarthritis of the Hip or Knee
The primary purpose of this study is to evaluate the efficacy of a titration arm of tanezumab in which treatment is started at a lower dose (2.5 mg) and increased to a higher dose (5 mg) at Week 8, compared to giving 2 doses of…
- Trial name
- NCT02697773
- Testing
- Tanezumab 2.5 mg, Tanezumab 2.5mg/5mg
- Where
- 87 sites in United States, Canada and 1 more
- Volunteers
- 698 people
- Sponsor
- Pfizer
Osteoarthritis, Knee
Unicompartmental Knee Arthroplasty (UKA) Versus Total Knee Arthroplasty (TKA) of Medial Osteoarthritis
This study allows patients to take part of the decision making between a unicompartment knee (partial ) or a total Knee replacement .
- Trial name
- NCT03457051
- Testing
- Total Knee Arthroplasty (TKA), Unicompartmental Knee Arthroplasty (UKA)
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Fibromyalgia, Chronic Fatigue Syndrome
Complex Chronic Diseases Program Data Registry
The purpose of this data registry is to prospectively collect data from patients referred to an Complex Chronic Diseases Program (CCDP) at BC Women's Hospital + Health Centre to assess the quality of life of the CCDP Patients…
- Conditions
- Fibromyalgia, Chronic Fatigue Syndrome, Myalgic Encephalomyelitis, Chronic Lyme-Like Syndrome
- Trial name
- NCT03409653
- Where
- Canada
- Volunteers
- 1,300 people
- Sponsor
- BC Women's Hospital & Health Centre
Osteoarthritis
Sahastara Remedy Extract Capsule in Primary Osteoarthritis of Clinical Trial Phase II
To study efficacy and safety of Sahastara 95% ethanolic extract capsules compared to treatment Primary osteoarthritis for primary osteoarthritis, it was compared with diclofenac (Phase II).
- Trial name
- NCT04591795
- Testing
- Sahastara remedy extract, Diclofenac
- Where
- Thailand
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Mr NARIN KAKATUM
Hip Osteoarthritis
RSA-measured in Vivo Migration and Micromotion in the DePuy Tri-Lock, Corail and Deltamotion Hip Replacement Components
Hip replacements are being performed on an increasingly active population, who are likely to wear their implants out prematurely. New hip replacements have been devised to minimise the risk of failure.
- Trial name
- DePuy RSA RCT (NCT02696395)
- Testing
- DePuy Tri-Lock® femoral stem + Deltamotion® acetabular component, DePuy Corail® femoral stem + Deltamotion® acetabular component
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Oxford
Osteoarthritis, Knee
Moving Well for Total Knee Arthroplasty (TKA)
The purpose of this study is to assess the efficacy of a behavioral intervention, Moving Well, in improving levels of anxiety and depression for patients undergoing total knee arthroplasty (TKA).
- Trial name
- NCT05217420
- Testing
- Moving Well, Staying Well
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Weill Medical College of Cornell University
Infection, Rheumatoid Arthritis
A Retrospective Cohort Study on the Risk of Serious Infections in Rheumatoid Arthritis Patients Receiving Tocilizumab
The purpose of this study is to evaluate whether the risk of serious infections in rheumatoid arthritis patients with tocilizumab is higher than in those with tumor necrosis factor inhibitors using the nationwide real-world data.
- Trial name
- NCT04115423
- Testing
- Tocilizumab, Tumor Necrosis Factor Inhibitor (etanercept, infliximab, adalimumab, and golimumab)
- Where
- South Korea
- Volunteers
- 9,508 people
- Sponsor
- Sungkyunkwan University