Clinical trials: Rheumatic Disorder
Knee Osteoarthritis
Comparison of Aquatic and Land-Based Mulligan Mobilization With Movement in Knee Osteoarthritis
This study aims to compare the effects of aquatic and land-based Mulligan mobilization with movement in individuals with knee osteoarthritis, with particular focus on their impact on pain and functional outcomes.
- Trial name
- NCT07484529
- Testing
- Aquatic Mobilization with Movement, Land Mobilization with Movement
- Where
- Pakistan
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Rheumatoid Arthritis
A Phase Ⅰ Clinical Trial to Evaluate the Safety, Tolerance, Pharmacokinetics and Pharmacodynamics of SHR-3045 in Healthy Subjects
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of SHR-3045 in healthy subjects.
- Trial name
- NCT06883695
- Testing
- SHR-3045 Injection
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Guangdong Hengrui Pharmaceutical Co., Ltd
Fibromyalgia
Postural Exercises in Women With Fibromyalgia
In the current study, the investigators aimed to study: The proprioception status of patients with FMS. The effectiveness of a postural exercise program in women with fibromyalgia for 8 weeks (2 sessions per week), compared to a…
- Trial name
- NCT03166995
- Testing
- Low impact aerobic exercise, Postural exercises
- Where
- Spain
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Valencia
RA - Rheumatoid Arthritis
GAS5 Gene Expression and IL-6 in Rheumatoid Arthritis
This study aims to investigate the expression of Growth Arrest-Specific 5 (GAS5) , a long non-coding RNA , in patients with Rheumatoid Arthritis compared with healthy individuals.
- Trial name
- NCT07796841
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Sohag University
Rheumatoid Arthritis
Orofacial Evaluation in Women With Rheumatoid Arthritis
Rheumatoid arthritis (RA) can affect any synovial joint. Unlike the hand, ever so valued in the physical examination of patients with RA, the joints in the area of the jaw and neck may also be affected in this disease and have…
- Trial name
- NCT01616641
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Knee Osteoarthritis
Effectiveness of a Knee Brace When Combined With Viscosupplementation in the Treatment of Knee Osteoarthritis
Hypothesis: Viscosupplementation when combined with an off-loading knee brace is more effective in treating the symptoms of knee OA then treating with viscosupplementation alone
- Trial name
- NCT01478386
- Testing
- Orthovisc, DonJoy HA lite knee brace, Orthovisc injections and DonJoy HA lite knee brace
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- OAD Orthopaedics
Knee Osteoarthritis
Knee Pain Phenotypes in the Community Study
The focus of the study is to determine the prevalence and variance of self-reported knee pain characteristics in a community-derived sample of adults aged 40 years and over.
- Trial name
- NCT02098070
- Where
- United Kingdom
- Volunteers
- 40,000 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Juvenile Idiopathic Arthritis
Assessment of Pharmacokinetics of a Single Oral Dose of VIMOVO in Healthy Adult Volunteers
This is an assessment of Pharmacokinetics of a single oral dose of VIMOVO in healthy adult volunteers.
- Trial name
- NCT01358383
- Testing
- naproxen, esomeprazole
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Rheumatoid Arthritis
Study of Venous Endothelial Cells in Rheumatoid Arthritis
Heart disease is the major contributor of early death in rheumatoid arthritis (RA) and is not influenced by traditional risk factors.
- Trial name
- NCT02468986
- Where
- 2 sites in United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Rheumatoid Arthritis, Periodontitis
Evaluation of Non-surgical Periodontal Therapy in Patients With Rheumatoid Arthritis
Some clinical and epidemiological studies have revealed a high prevalence of periodontitis and tooth loss in patients with rheumatoid arthritis.
- Trial name
- NCT02379975
- Testing
- Non-surgical Periodontal Therapy
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- CAIO VINICIUS GONÇALVES ROMAN TORRES
Osteoarthritis
Mesenchymal Stromal Cells and Osteoarthritis
Osteoarthritis (OA) is one of the most frequent musculoskeletal disorders and represents the main indication for total joint arthroplasty.
- Trial name
- NCT01038596
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Technische Universität Dresden
Rheumatoid Arthritis
Study of Some Risk Factors for Developing RA
Introduction Rheumatoid arthritis (RA), a chronic autoimmune disease of unknown etiology, .If not managed early , RA can result in irreversible, painful, and disabling joint damage.
- Trial name
- NCT03624179
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assiut University
Knee Osteoarthritis
Lysyl Oxidase and Lysyl Hydroxylase Levels in Knee Osteoarthritis
The aim of this study is to investigate the serum levels of lysyl hydroxylase, lysyl oxidase, and the lysyl oxidase-like enzymes in patients with different stages of knee osteoarthritis and to compare these findings with those of…
- Trial name
- KNEELOX (NCT07875296)
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Afyonkarahisar Health Sciences University
Osteoarthritis, Knee
Role of Bone in Knee Osteoarthritis (OA)
The purpose of the study is to investigate protein and gene expression among damaged knee tissues. We will perform MRI's on subjects prior to total knee replacement to identify the location of bone marrow lesions.
- Trial name
- NCT00850538
- Testing
- MRI, Primary Total Knee Replacement
- Where
- Australia
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- The New England Baptist Hospital
SLE, Rheumatoid Arthritis
Role of DcR3 in T Cell Activation in SLE and RA
Decoy receptor 3 (DcR3), a new member of tumor necrosis factor receptor (TNFR) superfamily, is a decoy receptor for FasL and could inhibit FasL-induced apoptosis, has recently been shown to induce costimulation of T cells.
- Trial name
- NCT00275899
- Where
- Taiwan
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Knee Osteoarthritis
Chronic Knee Pain Study
Specific Aims: 1) To examine differences between AA and white patients with knee OA in willingness to consider knee joint replacement.
- Trial name
- JRPIT (NCT00776932)
- Where
- United States
- Volunteers
- 852 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Axial Spondyloarthritis, Arthritis, Rheumatoid
The Role of Microbiome on Biological Therapy Efficacy in axSpA and RA
Spondyloarthritis (SpA) and Rheumatoid arthritis (RA) are among the most common chronic inflammatory rheumatic diseases. Introduction of Tumor Necrosis Factor alpha inhibitors (TNFi) to the therapeutic strategy improved acute…
- Trial name
- MicroSpA & RA (NCT04973787)
- Testing
- biological disease-modifying antirheumatic drugs (bDMARDs)
- Where
- 10 sites in Portugal
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Universidade Nova de Lisboa
Fibromyalgia
Risk Factors of Primary Fibromyalgia
Fibromyalgia (FM) is a condition with a different non-specific symptoms which lead to a difficult diagnosis. Study suggests that osteopathy can help in improving FM symptoms, nevertheless, it can be difficult to identify which…
- Trial name
- NCT05295316
- Testing
- Life Stressor Checklist Revised (LSC-R) (Appendix 1)
- Where
- Italy
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Studio Osteopatico Busto Arsizio
Psoriasis, Coronary Artery Disease
Premature Coronary Artery Disease (CAD) in Severe Psoriasis
The purpose of this study is to compare the prevalence and severity of CAD (coronary artery disease) in patients with and without severe psoriasis, otherwise matched for cardiovascular risk factors.
- Trial name
- NCT00893126
- Testing
- CCTA Scan (Coronary CT Angiogram)
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Osteoarthritis, Degenerative Joint Disease
Efficacy of Intraoperative Injections on Postoperative Pain Control During Total Hip Replacement
The purpose of this study is to clarify the efficacy of a multidrug versus single drug periarticular injection when only standard operative and postoperative pain management protocols used and the control group is exposed to what…
- Trial name
- NCT03119038
- Testing
- Bupivicaine + epinephrine, Bupivacaine, Ropivacaine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Rush University Medical Center
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