Clinical trials: Rheumatic Disorder
Rheumatoid Arthritis
First-in-Human Single Ascending Dose of SHR0302
The purpose of the study is to evaluate the safety and tolerability of single ascending (SAD) oral doses of SHR0302 compared to placebo.
- Trial name
- NCT02423538
- Testing
- SHR0302
- Where
- China
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Arthritis, Rheumatoid
BAY1830839: First in Man, Single Dose Escalation, Safety & Tolerability and Pharmacokinetics
The primary objectives of this study are to investigate the safety and tolerability of increasing single oral doses of BAY 1830839 versus placebo under fasted conditions the pharmacokinetics after single ascending oral doses of…
- Trial name
- NCT03540615
- Testing
- BAY1830839
- Where
- Germany
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Bayer
Sjogren's Syndrome, Dry Eye Syndromes
Salivary Conductivity Screening for Dry Eye Disease and Sjögren's Syndrome
Dry eye disease, or keratoconjunctivitis sicca, is one of the most common diseases encountered at ophthalmologic clinics. Patient with dry eye disease commonly presented foreign body sensation, red eye, blurred vision, etc.
- Trial name
- NCT06406933
- Testing
- Carbomer Gel/Jelly
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Preeclampsia, Immunologic Disease
Patients Pregnant Women With or Without Primary Antiphospholipid Antibody Syndrome
The purpose of the study is to evaluate the ability of placental angiogenesis markers to predict the risk of PE in pregnancy in women with primary APS.
- Conditions
- Preeclampsia, Immunologic Disease, Antiphospholipid Antibody Syndrome Primary, Pregnancy Complications
- Trial name
- NCT05786235
- Testing
- Collection of epidemiological and anamnestic data and collection of biological material (peripheral blood)
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Rheumatoid Arthritis
A Randomized Placebo- and Active Comparator-controlled Study to Evaluate the Photosafety of SAR441566
This is a single center randomized parallel-group partially-blinded, 4-arm Phase 1 study to evaluate the phototoxic potential of two dose levels of SAR441566 treatment compared to placebo and the active comparator, ciprofloxacin…
- Trial name
- NCT05844735
- Testing
- SAR441566, Ciprofloxacin
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sanofi
Rheumatic Disease, Cardiac Disease
Comparing Modes of Telehealth Delivery: Phone vs. Video Visits (ASSIST)
Given the current public health crisis the use of telehealth consultation visits including phone-only and video visits has exponentially increased.
- Conditions
- Rheumatic Disease, Cardiac Disease, Primary Care, Infectious Disease
- Trial name
- NCT04616118
- Testing
- Phone Visit, Video Visit
- Where
- United States
- Volunteers
- 269 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Knee Osteoarthritis
Feasibility of High Intensity Interval Training in Knee Osteoarthritis
The focus of this pilot study is to evaluate the feasibility of utilizing an evidenced-based high intensity interval training program (HIIT) to improve physical function in patients with knee osteoarthritis (OA).
- Trial name
- NCT03281668
- Testing
- High intensity interval training (HIIT)
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Rheumatoid Arthritis
Effects Of CP-690,550 (Tasocitinib) On Cholesterol Metabolism In Patients With Active Rheumatoid Arthritis
The purpose of study is to explore the effect of CP-690,550 (tasocitinib) on cholesterol metabolism in patients with active rheumatoid arthritis (RA).
- Trial name
- NCT01262118
- Testing
- CP-690,550 (tasocitinib)
- Where
- 11 sites in United States, Hungary
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Pfizer
Rheumatoid Arthritis, Healthy Volunteers
A Study in Normal Healthy People, Testing Different Versions of a Pill That Will be Used to Treat Rheumatoid Arthritis.
The study will try, in 2 separate parts, each using 12 research subjects, to see how a new form of the pill CE 224,535 gets released into the bloodstream and whether that is affected by food.
- Trial name
- NCT00838058
- Testing
- CE-224,535, CE 224,535
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Pfizer
Septic Arthritis, Inflammatory Arthritis
Differentiate Children Septic and Inflammatory Arthritis by Comparative Analysis
The purpose is to found new biomarker that differentiate septic arthritis and Juvenile Idiopathic Arthritis in children. Synovial liquid and blood samples with proteomic, MiRNA searching, multiplex cytokine analysis and cellular…
- Conditions
- Septic Arthritis, Inflammatory Arthritis, Children
- Trial name
- DIANE (NCT03827759)
- Where
- 5 sites in France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Rheumatoid Arthritis (RA)
The Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics Study of SHR-3045 in Healthy Subjects
The study is being conducted to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of a single-dose subcutaneous injection of SHR-3045 in healthy subjects.
- Trial name
- NCT07200596
- Testing
- SHR-3045 Injection
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Guangdong Hengrui Pharmaceutical Co., Ltd
Knee Osteoarthritis
Integrated Trunk Stabilization With Osteoarthritis Rehabilitation in Knee-Spine Syndrome
This study aims to evaluate the effects of integrating trunk stabilization exercises with conventional rehabilitation in patients with knee-spine syndrome.
- Trial name
- NCT07484594
- Testing
- Trunk Stabilization exercises with conventional Rehab, Conventional Rehabilitation
- Where
- 2 sites in Pakistan
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Arthritis, Rheumatoid
Safety, Tolerability, and Pharmacokinetics of Multiple Ascending Doses of SKI-O-703 in Healthy Volunteers
This double-blind, placebo-controlled, multiple ascending dose study is designed to evaluate the safety, tolerability, and pharmacokinetics (PK) of SKI-O-703 in healthy volunteers.
- Trial name
- NCT03315494
- Testing
- SKI-O-703 capsule
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Oscotec Inc.
Fibromyalgia, Exercise
Cardiovascular Autonomic Function and Endogenous Pain Modulation
The study has three aims: 1. To investigate the influence of cardiovascular autonomic function on pain sensitivity at rest in patients with fibromyalgia and age- and sex-matched controls 2.
- Conditions
- Fibromyalgia, Exercise, Pain, Autonomic Dysfunction
- Trial name
- NCT03911609
- Testing
- Exercise, Cognitive Task
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Marquette University
Neuropathic Pain, Osteo Arthritis Knee
WHIRLPOOL FOR OSTEOARHRITIS
Both neuropathic and nociceptive mechanisms may contribute to the OA pain experience. Aims: The aim of this study was to determine the efficacy of warm whirlpool on pain, disability, quality of life (QoL) and sleep for patients…
- Conditions
- Neuropathic Pain, Osteo Arthritis Knee, Sleep Disorder
- Trial name
- NCT03299114
- Testing
- Whirlpool
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ufuk University
Rheumatoid Arthritis, Musculoskeletal Ultrasound
Musculoskeletal Ultrasound with Elastography in the Evaluation of Muscle State in Rheumatoid Arthritis Patients
Evaluation of muscle state in rheumatoid arthritis patients. Application of elastography in the detection of muscle stiffness in rheumatoid arthritis
- Trial name
- NCT06620484
- Testing
- Musculoskeletal Ultrasound with elastography
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Assiut University
Osteoarthritis
Testing APPA-1 in Healthy Subjects and Osteoarthritis Patients
To determine the safety and tolerability of ascending single and multiple oral doses of APPA-1 in healthy subjects and osteoarthritis patients.
- Trial name
- APPA (NCT07429565)
- Testing
- APPA-1
- Where
- 2 sites in United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Liverpool
Knee Osteoarthritis
Femoral Cartilage Thickness in Knee Osteoarthritis
The aim of the study to investigate the relationship between femoral cartilage thickness in Ultrasonographic evaluation and inflammatory parameters, pain severity and functionality in participants with Knee Osteoarthritis
- Trial name
- NCT05456711
- Testing
- ultrasonographic measurement for femoral cartilage thickness VAS for pain severity WOMAC for functionality
- Where
- Turkey (Türkiye)
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Fibromyalgia, Foot Core
Foot Core Intervention for Fibromyalgia
This quasi-experimental study was designed to evaluate the effects of an eight-week foot core training program on foot pain, foot function, and pressure pain sensitivity in individuals with fibromyalgia.
- Trial name
- FOOTCORE-FM (NCT07388199)
- Testing
- Foot Core
- Where
- Spain
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Diabetes Mellitus, Gout
Pharmacogenetics of SGLT2 Inhibitors
Sodium-dependent glucose transporter-2 (SGLT2) inhibitors are a new class of anti-diabetic drugs, which increase urinary glucose excretion thereby promoting weight loss and decreasing plasma glucose levels.
- Conditions
- Diabetes Mellitus, Gout, Hyperuricemia
- Trial name
- SGLT2iPGx (NCT02462421)
- Testing
- Canagliflozin
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
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