Clinical trials: Rheumatic Disorder
Obesity, Osteoarthritis
Reducing Obesity and Cartilage Compression in Knees
OA is a degenerative joint disease that involves the degradation of articular cartilage and underlying subchondral bone. Obesity is identified as a critical and potentially modifiable risk factor for the development and…
- Conditions
- Obesity, Osteoarthritis, Knee Osteoarthritis
- Trial name
- ROCCK (NCT04730557)
- Testing
- Weight Loss
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Duke University
Fibromyalgia
A Study To Assess Esreboxetine's Effect On Concentration, Memory, Decision Making And Problem Solving In Patients With Fibromyalgia.
The study is designed to assess if esreboxetine can improve the cognitive function of patients with fibromyalgia. Cognitive function is defined as the ability to concentrate, remember things and make decisions or problem solve.
- Trial name
- NCT00752505
- Testing
- Esreboxetine
- Where
- 7 sites in United States
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Pfizer
Fibromyalgia
Comparison of the Effects of Fibromyalgia Syndrome
Massage therapy, one of the complementary and alternative treatments, is commonly used for fibromyalgia syndrome (FMS). It may help improve pain, anxiety, depression, and sleep disorders through the complex interaction of…
- Trial name
- NCT07082166
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Temporomandibular Joint Condition Post Longstanding Mouth Opening During Dental Procedure Using Rubber Dam, TMJ Disc Disorder
Evaluation of Temporomandibular Joint Condition Post Longstanding Mouth Opening by Rubber Dam
This Clinical and radiographic study will be designed to evaluate the temporomandibular joint condition post longstanding mouth opening during dental procedure using rubber dam.
- Conditions
- Temporomandibular Joint Condition Post Longstanding Mouth Opening During Dental Procedure Using Rubber Dam, TMJ Disc Disorder, Osteoarthritis, Myofacial Pain
- Trial name
- NCT06487819
- Testing
- Application of a rubber dam during dental treatments for varying durations.
- Where
- Egypt
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Educational Problems, Hip Arthroplasty
VR Simulation and Basic Skills in THA
This prospective randomised clinical trial aims to test if virtual reality (VR) simulation helps acquire basic surgical skills in total hip arthroplasty (THA) by medical students. The main question[s] it aims to answer are: 1.
- Conditions
- Educational Problems, Hip Arthroplasty, Osteoarthritis, Hip, Medical Students
- Trial name
- MD-VR-THA (NCT05807828)
- Testing
- VR simulation on basic THA skills
- Where
- Greece
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Rheumatoid Arthritis
SonoElastography of Median Nerve in Rheumatoid Arthritis
To assess the role of ultrasonography and SE in detecting the median nerve changes before progression to CTS in patients with RA.
- Trial name
- NCT06135129
- Testing
- Sonoelastography
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Assiut University
Osteoarthritis
Wrist Cartilage - High Resolution in Vivo MR T2 Mapping- a Feasibility Study
Purpose:Evaluate the feasibility of T2 cartilage mapping on MRI of the wrist and correlate with T2 mapping of knee cartilage. Study protocol: Phase 1. 10 healthy volunteers, Phase 2.
- Trial name
- NCT00669201
- Where
- 2 sites in Israel
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Arthroplasty, Replacement, Knee, Acute Kidney Injury
After Surgery Acute Renal Failure Incidence in Total Knee Arthroplasty With and Without Tourniquet
This study analize the incidence of acute renal failure after performing total knee arthroplasty with or without use of tourniquet limb cuff (half of patients for each group) in a randomized clinical trial
- Conditions
- Arthroplasty, Replacement, Knee, Acute Kidney Injury, Tourniquets, Knee Osteoarthritis
- Trial name
- NCT03795805
- Testing
- total knee arthroplasty, Tourniquet limb cuff, Intaarticular lidocain
- Where
- Mexico
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Instituto Mexicano del Seguro Social
Knee Osteoarthritis
Using Ultrasonography to Predict Clinical Response to Intraarticular Corticosteroids in Knee Osteoarthritis
The primary purposes of this study are the following: 1. To evaluate whether the presence of inflammatory knee osteoarthritis as determined by ultrasonography can be used as a clinical predictor of patient response to…
- Trial name
- NCT00414427
- Testing
- Intraarticular steroids
- Where
- 2 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Fibromyalgia
A Pilot Study of Small Fiber Neuropathy Prevalence in Fibromyalgia Patients Compared to Healthy Subjects Using Sudoscan®
Fibromyalgia (FM) is characterized by chronic diffuse pain and affects 0.5 to 5% of the population, with a higher prevalence in women1.
- Trial name
- NEFI (NCT03347669)
- Testing
- Sudoscan®
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Rheumatoid Arthritis, Healthy Control
Adipokines as Predictors of Foot Function, Pain, and Disability in Patients With Rheumatoid Arthritis
Significant increase in the levels of serum adiponectin, ADA, and hsCRP was reported in all RA patients compared to controls. Compared to patients with early RA, the increase in these markers significantly correlated with disease…
- Trial name
- NCT04036669
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- King Saud University
Osteoarthritis, Knee
Outcomes After Standard and High-Flexion Posterior Stabilized Rotating-Platform Mobile-Bearing Total Knee Arthroplasty
The aim of this prospective study is to compare the clinical and radiographic outcomes of standard and high-flexion posterior stabilized (PS) rotating-platform mobile-bearing (RP-MB) total knee arthroplasty.
- Trial name
- NCT00954954
- Testing
- Standard PS RP-MB (P.F.C Sigma Rotating Platform knee), High-flexion PS RP-MB (P.F.C Sigma Rotating Platform Flex)
- Where
- South Korea
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Osteoarthritis, Articular Cartilage Disorder of Knee
Serum Cartilage Oligomeric Matrix Protein Levels After 12 Weeks of Different Exercises
Acute effects of physical exercise on the deformational behavior of articular cartilage and changes in cartilage oligomeric matrix protein (COMP) are definite.
- Conditions
- Osteoarthritis, Articular Cartilage Disorder of Knee, Degenerative Lesion of Articular Cartilage of Knee
- Trial name
- NCT01576159
- Testing
- Running exercise, Cycling exercise, Swimming Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Middle East Technical University
Fibromyalgia
The Effects of Self Directed Exercise on People With Fibromyalgia
The purpose of this study is to determine the effects of self directed exercise on pain and function reported in patients with Fibromyalgia both in the short term and long term.
- Trial name
- NCT03400527
- Testing
- Exercise
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Shenandoah University
Osteoarthritis
Visual Feedback Non-weight Bearing Exercise on the Elderly With Knee Osteoarthritis.
Degenerative knee arthritis is the most common chronic arthritis disease. Once the elderly suffer from this disease, it will accelerate the loss of body function and autonomy.
- Trial name
- NCT04919486
- Testing
- visual feedback with non-weight bearing exercise, elastic band exercise
- Where
- Taiwan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Knee Osteoarthritis
Risk and Risk Perception of Knee Osteoarthritis in the US
The investigators have created an interactive knee osteoarthritis (OA) risk calculator that estimates a user's risk of developing symptomatic knee OA as well as the user's risk for undergoing a total knee replacement (TKR) within…
- Trial name
- NCT02704286
- Testing
- Internet-Based Osteoarthritis Risk Calculator, Generic osteoarthritis information
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Physical Activity, Functional Performance
Additional Effects of Triamcinolone to Hyaluronic Acid on Knee Osteoarthritis
Using a double-blind, randomized controlled design to investigate the additional therapeutic effects of 3 times of combined triamcinolone and hyaluronic acid injections to 3 times of hyaluronic acid injections to patients with…
- Trial name
- NCT02949466
- Testing
- Triamcinolone, Hyaluronic acid
- Where
- Taiwan
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Osteoarthritis, Knee
Evaluatıon of Nutrıtıonal Status and Total Antıoxıdant Capacıty in Osteoarthritis
This is a descriptive cross-sectional study conducted to evaluate the nutritional status and total antioxidant/oxidant capacity of individuals diagnosed with osteoarthritis.
- Trial name
- NCT05214469
- Where
- Turkey (Türkiye)
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Osteoarthritis, Knee, Cruciate Ligament Injury
Basic Research Projects Related to Sports Injuries
Biological samples are important human genetic resources, which can provide great value for medical research, and how to protect and rationally utilize them is of great importance.However, at present, the blood samples after…
- Conditions
- Osteoarthritis, Knee, Cruciate Ligament Injury, Patella Dislocation, Discoid Meniscus of Knee
- Trial name
- NCT04958551
- Testing
- No intervention
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Rheumatoid Arthritis (RA)
Safety, Tolerability, and PK/PD of CIGB-814 in Chinese Health Participants
The purpose of this study is to evaluate the safety, tolerability, and pharmacokinetics (PK) of CIGB-814 for injection after single and multiple administrations in healthy participants.
- Trial name
- NCT07182656
- Testing
- CIGB-814 (single-dose group), CIGB-814 (multiple-dose group)
- Where
- China
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Yi Fang
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