Clinical trials: Rheumatic Heart Disease
Diabetes Mellitus, Hypertension
Evidence-based Laboratory Test Order Sets in Primary Care
Cluster randomised controlled trial to evaluate what the effect is of evidence-based order sets aimed at five indications on the appropriateness of laboratory test ordering in primary care.
- Conditions
- Diabetes Mellitus, Hypertension, Cardiovascular Diseases, Fatigue
- Trial name
- NCT02950142
- Testing
- CPOE with order sets for lab testing, CPOE without order sets for lab testing
- Where
- Belgium
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Neurodegenerative Diseases, Osteoarthritis
Safety and Clinical Outcomes Study: SVF Deployment for Orthopedic, Neurologic, Urologic, and Cardio-pulmonary Conditions
To evaluate for any adverse effects that may be related to the administration and reception of autologous adipose derived stromal vascular fraction (SVF).
- Conditions
- Neurodegenerative Diseases, Osteoarthritis, Erectile Dysfunction, Autoimmune Diseases
- Trial name
- NCT01953523
- Testing
- Administration of autologous adipose derived SVF
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Elliot Lander
Rheumatic Heart Disease, Rheumatic Fever
The Genetic Basis of Acquired Heart Disease in Africa
Background: An acquired heart disease is one that a person gets after they are born. Two of these are rheumatic heart disease (RHD) and endomyocardial fibrosis (EMF).
- Conditions
- Rheumatic Heart Disease, Rheumatic Fever, Endomyocardial Fibrosis, Acquired Heart Disease
- Trial name
- NCT02124109
- Where
- 2 sites in Nigeria, Uganda
- Volunteers
- 736 people, healthy volunteers welcome
- Sponsor
- National Human Genome Research Institute (NHGRI)
Cardiac Rehabilitation, Rheumatoid Arthritis
The Effects of Cardiac Rehabilitation Programme in Hypertensive Rheumatoid Arthritis Patients
The aim of this study is to investigate the beneficial impacts of the 6-week standardized CR program applied to hypertensive RA patients whose disease activity is under control with regular pharmacological treatment.
- Conditions
- Cardiac Rehabilitation, Rheumatoid Arthritis, Hypertension
- Trial name
- CARDIRA (NCT06295848)
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kayseri City Hospital
Rheumatoid Arthritis, Systemic Lupus Erythematosus
The Effect of Deep Breathing and Transcutaneus Electrical Nerve Stimulation on Heart Rate Variability
This interventional study aims to investigate the effect of deep breathing (DB) and transcutaneous electrical vagus nerve stimulation (tVNS) on heart rate variability (HRV) in healthy participants and patients with rheumatoid…
- Conditions
- Rheumatoid Arthritis, Systemic Lupus Erythematosus, Healthy Participants
- Trial name
- NCT05157334
- Testing
- Non-invasive auricular electrical transcutaneous vagus nerve stimulation, Deep breathing
- Where
- Denmark
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Aalborg University Hospital
Rheumatic Heart Disease, Acute Rheumatic Fever
Rheumatic Heart Disease in Peru: Prevalence and Cardiovascular Outcomes Among Schoolchildren
Rheumatic heart disease remains a major challenge in low and middle income countries. Early detection of clinically silent valvular lesions by screening echocardiography allows timely implementation of secondary antibiotic…
- Trial name
- NCT02353663
- Testing
- Echocardiography
- Where
- 2 sites in Peru, Switzerland
- Volunteers
- 1,023 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Pulmonary Arterial Hypertension, HIV Infection
Auto-immunity and Pulmonary Arterial Hypertension
The investigators have recently evidenced the presence of antibodies to endothelial cells and fibroblasts in patients with idiopathic or SSc-associated PAH.
- Conditions
- Pulmonary Arterial Hypertension, HIV Infection, Congenital Heart Defect, Systemic Sclerosis
- Trial name
- Auto-HTAP (NCT01208792)
- Testing
- skin biopsy, Blood Sample
- Where
- 3 sites in France
- Volunteers
- 629 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Tumor, Cardiovascular Diseases
Application of [68Ga]Ga-NI-FAPI-04 PET/CT Imaging in Fibroblast Activation Protein Related Diseases
The purpose of this study is to conduct clinical research on [68Ga] Ga-NI-FAPI-04 PET/CT imaging and further investigate its diagnostic value in fibroblast activation related diseases.
- Conditions
- Tumor, Cardiovascular Diseases, Pulmonary Fibrosis, Rheumatic Immune Diseases Involving Large Blood Vessels
- Trial name
- NCT07464132
- Testing
- Injection of 68Ga-NI-FAPI
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Arthritis, Rheumatoid, Activities of Daily Living
Adaptation of EDAQ Into Turkish, Examining The Reliability and Validity For People With RA
The aim of the study is to adapt the Evaluation of Daily Activity Questionnaire into Turkish language, and to examine the reliability and validity for people with rheumatoid arthritis.
- Trial name
- NCT05244824
- Testing
- Adaptation into Turkish, Examining The Reliability and Validity for People with RA
- Where
- Turkey (Türkiye)
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Fibromyalgia
Effects of Hydrotherapy on Physical Function and Quality of Life of Women With Fibromyalgia
Fibromyalgia Syndrome (FS) is one condition that most affects functional performance, especially in women, due to alterations in the entire musculoskeletal system.
- Trial name
- NCT01839305
- Testing
- Hydrotherapy
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mariana Arias Avila
Neonatal Lupus, Systemic Lupus Erythematosus
The Research Registry for Neonatal Lupus
Women with lupus and other related disorders produce certain antibodies in the blood. Some women have these antibodies even if they have not yet developed symptoms of lupus or Sjogren's syndrome.
- Conditions
- Neonatal Lupus, Systemic Lupus Erythematosus, Sjogren's Syndrome, Congenital Heart Block
- Trial name
- NCT00074373
- Testing
- No intervention; observational
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Congestive Heart Failure
Exercise-based Cardiac Rehabilitation in Congestive Heart Failure With Coexisting Knee Osteoarthritis
Exercise-based cardiac rehabilitation (CR) has been shown to significantly improve cardiovascular health and overall well-being in patients with congestive heart failure (CHF).
- Trial name
- NCT07440914
- Testing
- Exercise Based Cardiac Rehabilitation, Controlled Group
- Where
- Pakistan
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Hyperuricemia, Gout
Thorough QT (TQT) Study to Evaluate the Effect of LC350189 on Cardiac Repolarization in Healthy Male and Female Subjects
This is a Phase 1, single-center, randomized, partially double-blind, placebo- and positive controlled, 4-way crossover study to evaluate the effect of a therapeutic and a supratherapeutic dose of LC350189 on the QTcF in healthy…
- Conditions
- Hyperuricemia, Gout, Qt Interval, Variation in
- Trial name
- NCT04966325
- Testing
- LC350189 200mg, Moxifloxacin 400mg, LC350189 600mg
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- LG Chem
Fibromyalgia Syndrome
Palpitations and Tachycardia in Fibromyalgia Syndrome
Clinically Characterized by the presence of chronic widespread pan and tenderness, Fibromyalgia (FM) is one of the most common "functional" syndromes. FM is currently conceived of as representing a prototype of central pain, i.e.
- Trial name
- NCT01147263
- Testing
- Evaluation of autonomic parameters
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Rheumatic Heart Disease in Children
Penicillin to Prevent Early Rheumatic Heart Disease in School-Aged Children
This study will look at whether children ages 5-8 who take Penicillin V by mouth twice a day are less likely to develop rheumatic heart disease (RHD) over a 3-year period compared to children who do not take the medicine.
- Trial name
- MEERCATS 2 (NCT07798232)
- Testing
- Oral Penicillin V
- Where
- Uganda
- Volunteers
- 9,622 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Rheumatic Heart Disease
Testing a Registry-Based Strategy (ACT+) to Reduce Loss to Follow-Up in Rheumatic Heart Disease Screening in Uganda
This study aims to improve follow-up care after positive rheumatic heart disease (RHD) screening in Northern Uganda. It will identify barriers and co-develop an enhanced ACT+ strategy, then evaluate its effectiveness in…
- Trial name
- SHIELD 2 (NCT07606131)
- Testing
- The ACT+ Strategy
- Where
- Uganda
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Rheumatic Heart Disease
Train the Trainer Curriculum to Scale up AI Supported Echo for RHD Screening in a Public Health System
The first primary objective of this study is to determine the diagnostic performance (sensitivity and specificity) of primary MOH nurses who have completed certification in focused echocardiography acquisition and interpretation…
- Trial name
- ADD-RHD 2B (NCT05668611)
- Testing
- Primary Training Phase, Primary Assessment Phase, Primary Screening Phase
- Where
- Uganda
- Volunteers
- 1,628 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Rheumatoid Arthritis, Coronary Artery Disease
Effects of Interleukin-1 Inhibition on Vascular and Left Ventricular Function in Rheumatoid Arthritis Patients With Coronary Artery Disease
Inhibition of interleukin-1 (IL-1) activity in patients with RA without CAD ameliorates vascular and LV function. Moreover, data from species shows beneficial effect of this treatment on LV function after experimental myocardial…
- Conditions
- Rheumatoid Arthritis, Coronary Artery Disease, Inflammation
- Trial name
- NCT01566201
- Testing
- anakinra
- Where
- Greece
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Athens
Fetal Distress
Evaluation of Fetal Cardiac Function in Rheumatic Heart Disease (RHD) Patients
The goal of this study is to evaluate fetal myocardial performance in patients with heart diseases in comparison to normal pregnant patients.
- Trial name
- RHD (NCT03095937)
- Where
- Egypt
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- Assiut University
Hypertriglyceridemia, Gout
Apolipoprotein CIII Reduction Via Colchicine
The aim of this trial will be to determine an effect-size for the administration of chronic low-dose colchicine in the reduction of serum levels of triglycerides (TG), very-low density lipoproteins (VLDL), and apolipoprotein CIII…
- Conditions
- Hypertriglyceridemia, Gout, Pericarditis
- Trial name
- NCT02083510
- Testing
- Colchicine
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Scripps Translational Science Institute