Clinical trials: Rheumatoid Arthritis (RA, open to volunteers
Rotator Cuff-related Shoulder Pain, Shoulder Osteoarthritis
Could a Feedback Device Help Manage Work-related Shoulder Disorders?
Work-related shoulder pain is a common problem with significant socio-economic repercussions. The impact of these disorders on workers is considerable, particularly in terms of pain, disability and reduced quality of life.
- Conditions
- Rotator Cuff-related Shoulder Pain, Shoulder Osteoarthritis, Rheumatoid Arthritis (RA)
- Trial name
- NCT06693479
- Testing
- Shoulder watch load (SWL) feedback, Education
- Where
- Canada
- Volunteers
- 42 people
- Sponsor
- Laval University
Rheumatoid Arthritis (RA
A Study of Iguratimod in Combination With Tofacitinib in RA Patients
Rheumatoid arthritis (RA) is a common chronic inflammatory autoimmune disease characterized by synovitis, which can cause joint pain, deformity, and extra-articular symptoms, seriously affecting the quality of life and lifespan…
- Trial name
- NCT06945666
- Testing
- Combined therapy of Iguratimod and tofacitinib
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Jie Chang
Giant Cell Arteritis (GCA), Polymyalgia Rheumatica (PMR)
AYLo - AutoimmunitY and Loss of y
The AYLo study (AutoimmunitY and Loss of y - Investigating the Role of Hematopoietic Mutations and Mosaic Mutation in the Y Chromosome in Autoimmune Rheumatologic Diseases) aims to systematically investigate hematopoietic…
- Conditions
- Giant Cell Arteritis (GCA), Polymyalgia Rheumatica (PMR), ANCA Associated Vasculitis (AAV), Idiopathic Inflammatory Myopathies
- Trial name
- AYLo (NCT06696027)
- Testing
- Single nucleotide polymorphisms (SNP), 3'mRNA sequencing, Enzyme-linked immunosorbent assay (ELISA) and Legendplex Array
- Where
- Germany
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Bonn
Rheumatoid Arthritis (RA)
Changes in MTX-PG Concentrations During Subcutaneous MTX Therapy in Patients With Rheumatoid Arthritis(COSMOS Study)
Methotrexate is known to exist intracellularly as methotrexate polyglutamate, which is formed by the addition of glutamic acid after absorption into the body.
- Trial name
- NCT06913907
- Testing
- Methotrexate (MTX)
- Where
- Japan
- Volunteers
- 100 people
- Sponsor
- Keio University
Rheumatoid Arthritis (RA)
Long-term Outcomes of Patients with Rheumatoid Arthritis in Remission
The goal of this multi-center prospective observational study is to develop knowledge on how to best personalize treatment and follow-up strategies for patients with RA in remission, with the intention to prevent relapse of…
- Trial name
- NCT06783322
- Where
- 10 sites in Norway
- Volunteers
- 259 people
- Sponsor
- Diakonhjemmet Hospital
Rheumatoid Arthritis (RA, 6 Minutes Stepper Test
An Alternative Assessment in Patients with Rheumatoid Arthritis: 6 Minute Step Test
Although joint involvement is predominant, RA is a systemic disease that can affect many organs. RA is a disease that includes changes such as inflammation, joint pain, fatigue, increased risk of coronary and heart disease.
- Trial name
- NCT06838884
- Testing
- 6 minutes step test and bicycle ergometer
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Firat University
Systemic Sclerosis Associated Interstitial Lung Disease, Rheumatoid Arthritis Associated Interstitial Lung Disease (RA-ILD)
A Randomized, Double-blind, Placebo-controlled Phase II Clinical Study to Evaluate the Safety, Tolerability, Efficacy, and Pharmacokinetic Profile of Genakumab Injection in Patients With Connective Tissue Disease-associated Interstitial Lung Disease
This study was conducted in a randomized, double-blind, placebo-controlled design to evaluate the efficacy and safety of Genakumab injection in the treatment of CTD-ILD including Rheumatoid Arthritis associated Interstitial Lung…
- Conditions
- Systemic Sclerosis Associated Interstitial Lung Disease, Rheumatoid Arthritis Associated Interstitial Lung Disease (RA-ILD), Systemic Sclerosis Associated Interstitial Lung Disease (SSc-ILD)
- Trial name
- NCT06189495
- Testing
- GenSci048
- Where
- 4 sites in China
- Volunteers
- 30 people
- Sponsor
- Changchun GeneScience Pharmaceutical Co., Ltd.
Rheumatoid Arthritis (RA)
L-carnitine Supplementation in Rheumatoid Arthritis Patients
This study aims to evaluate the effect of l-carnitine as add- on therapy for improving the outcome in rheumatoid arthritis patients.
- Trial name
- NCT06753565
- Testing
- Carnitine, Disease-modifying anti-rheumatic drugs
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- German University in Cairo
Rheumatoid Arthritis (RA)
Effect of Silymarin in Rheumatoid Arthritis Patients Treated With Methotrexate
The goal of this clinical trial is to evaluate the anti-rheumatic activity and the role of silymarin in attenuating methotrexate toxicity in patients with rheumatoid arthritis.
- Trial name
- NCT06724952
- Testing
- MTX S.C or IM and Silymarin 140 mg tab, MTX S.C or IM
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- Tanta University
Rheumatoid Arthritis (RA, Diabetes Mellitus
The Impact of Glycemic Control on Rheumatoid Arthritis Disease Activity on Diabetic Patients
The incidence of DM is unclear in RA but most prior data suggest that DM or insulin resistance in RA has risen because of activation of the immune system and/or RA therapy .
- Trial name
- NCT06691997
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Rheumatoid Arthritis (RA), Methotrexate Induced Nephrotoxicity
The Possible Efficacy and Protective Effect of Empagliflozin in Rheumatoid Arthritis Patients Treated with Methotrexate
The primary aim of this clinical trial is to Evaluate the Possible Efficacy and Protective Effect of Empagliflozin in Rheumatoid Arthritis Patients Treated with Methotrexate.
- Conditions
- Rheumatoid Arthritis (RA), Methotrexate Induced Nephrotoxicity, Methotrexate Adverse Reaction
- Trial name
- NCT06641128
- Testing
- MTX SC or IM, Empagliflozin 25mg tab
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- Tanta University