Clinical trials: Rheumatologic Disease
Epidermolysis Bullosa Dystrophica
Growth Hormone in EB
Growth is extremely affected in epidermolysis bullosa patients
- Trial name
- NCT05390073
- Testing
- growth hormone level and insulin like growth factor 1
- Volunteers
- 50 people
- Sponsor
- Cairo University
Scars, Keloids
Silicone vs Pirfenidone in the Treatment of Hypertrophic Scars and Keloids
Justification: Keloid scars are a major medical and cosmetic problem, especially in darker skin types that predominate in Mexico. It is estimated that hypertrophic scars affecting from 1.5 to 4.5% of the general population.
- Conditions
- Scars, Keloids, Hypertrophic Scar
- Trial name
- NCT06909812
- Testing
- pirfenidone 8% gel, silicon gel
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- Fundación Nacional para la Enseñanza y la Investigación de la Dermatología A.C.
Pomegranate (P. Granatum) Peel Compress
The Effect of Pomegranate (Punica Granatum L.) Peel Compress Application on Pain and Physical Function Status
Osteoarthritis is the most common type of arthritis among rheumatologic diseases. Complementary therapies are one of the effective methods for pain control. This study was planned as a randomized controlled experimental study.
- Trial name
- Pomegranate (NCT06034106)
- Testing
- Pomegranate (Punica granatum) peel compress, Hot compress
- Where
- Turkey (Türkiye)
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Epidermolysis Bullosa, Recessive Dystrophic Epidermolysis Bullosa
Phase 3, Open-label Clinical Trial of EB-101 for the Treatment of Recessive Dystrophic Epidermolysis Bullosa (RDEB)
The purpose of this trial is to evaluate safety and efficacy of surgical application of EB-101 (autologous, gene-corrected keratinocyte sheets) as a treatment of recessive dystrophic epidermolysis bullosa (RDEB).
- Trial name
- NCT04227106
- Testing
- EB-101
- Where
- 2 sites in United States
- Volunteers
- 11 people
- Sponsor
- Abeona Therapeutics, Inc
Psoriatic Arthritis, Hand Rheumatism
Hand Exercises in Psoriatic Arthritis
This study is a randomized controlled study examining the effects of 8-week hand home exercises on grip strength, functionality, disease activity and quality of life in patients with PsA.
- Trial name
- NCT06263634
- Testing
- Hand exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Akdeniz University
Still's Disease Adult Onset
An Efficacy and Safety Study of GNR-086 (Canakinumab Biosimilar) and Ilaris® in Patients With Adult-onset Still's Disease
This is a randomized single-blind comparative parallel group study of the efficacy and safety of canakinumab biosimilar GNR-086 (JSC \"GENERIUM\", Russia) and Ilaris® (Novartis Pharma Stein AG, Switzerland) in the…
- Trial name
- NCT06497491
- Testing
- GNR-086, Ilaris®
- Where
- 17 sites in Russia
- Volunteers
- 118 people
- Sponsor
- AO GENERIUM
Osteogenesis Imperfecta
Safety of Fresolimumab in the Treatment of Osteogenesis Imperfecta
Osteogenesis Imperfecta (OI) is a rare disorder that causes bones to break easily. People with OI may have broken bones with little or no trauma, dentinogenesis imperfecta (DI), and, in adult years, hearing loss.
- Trial name
- NCT03064074
- Testing
- Fresolimumab
- Where
- 2 sites in United States
- Volunteers
- 11 people
- Sponsor
- Baylor College of Medicine
Rheumatologic Disorder
Identifying Novel Biomarkers in Early Rheumatology Patients
Patients new to a rheumatology practice will be asked if they want to consent to their blood sample, medical records, and hand/foot x-rays (with sharp scores) for the analysis and correlation with the diagnosis they will receive…
- Trial name
- NCT03843658
- Testing
- There is no intervention, but a diagnosis.
- Volunteers
- 300 people
- Sponsor
- Arthritis Northwest PLLC
Joint Hypermobility, Ehlers-Danlos Syndrome
Gait Retraining in Patients With Joint Hypermobility Syndrome/Hypermobile Ehlers Danlos Syndrome
This study evaluates the efficacy of gait retraining with biofeedback in the treatment of neuromusculoskeletal symptoms in patients with Joint Hypermobility Syndrome/Hypermobile Ehlers Danlos Syndrome.
- Conditions
- Joint Hypermobility, Ehlers-Danlos Syndrome, Hyperextension Knees
- Trial name
- NCT03575182
- Testing
- Gait retraining program
- Volunteers
- 12 people
- Sponsor
- University of South Florida
Alport Syndrome
Genotype-Phenotype Correlations in Patients With Alport Syndrome
Alport syndrome (AS) is caused by pathogenic variants in the type IV collagen genes COL4A3, COL4A4, and COL4A5. This study aims to enroll families and patients with a history of renal hematuria in 27 hospitals and detect these…
- Trial name
- NCT04947813
- Where
- China
- Volunteers
- 8,165 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Osteogenesis Imperfecta, Rare Bone Disorders
Morphology in Oral Rare Syndromes & Artificial Intelligence for Clinical Diagnosis
MOSAIC aims to determine whether oro-dental morphological anomalies, particularly palatal morphology, associated with rare bone and cartilage diseases can be precisely characterized using 3D digital models analysed through…
- Conditions
- Osteogenesis Imperfecta, Rare Bone Disorders, Hypophosphatemia, X-Linked
- Trial name
- MOSAIC (NCT07666269)
- Testing
- intra-oral 3D optical impression
- Where
- France
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Scar, Cicatrix
Clinical Safety and Scar Prevention Study of a Topical Antifibrotic Compound FS2.
The study will investigate the safety and effectiveness of daily post surgical scar management, using a moisture-balancing base product containing different amounts of a novel (NCE) antifibrogenic compound FS2, a natural…
- Conditions
- Scar, Cicatrix, Hypertrophic Scar, Skin Graft Scar
- Trial name
- FS2 (NCT04186273)
- Testing
- Fibrosis-Inhibiting-Compound-FS2, Vehicle moisture balancing base
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Systemic Rheumatic Diseases, Intensive Care Unit
Prognosis of SRD Patients in the ICU
Critically ill systemic rheumatic disease (SRD) patients have benefited from better provision of rheumatic and critical care in recent years.
- Conditions
- Systemic Rheumatic Diseases, Intensive Care Unit, Corticosteroids
- Trial name
- ProSyDICU (NCT04398381)
- Where
- France
- Volunteers
- 525 people
- Sponsor
- University Hospital, Montpellier
Chronic Inflammatory Rheumatism
Catastrophism in Chronic Inflammatory Rheumatism
Catastrophic is defined as a negative cognitive and emotional response based on inadequate pain expression. It has three components: rumination, amplification and vulnerability.
- Trial name
- CRIC (NCT04174092)
- Testing
- completing self-questionnaires
- Where
- 2 sites in France
- Volunteers
- 533 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Chronic Pain, Musculoskeletal Pain
The PROmoting Pain Self-Management (PROs) Trial: Holistic Pain Care in the Military Health System
The goal of this study is to improve pain care in the MHS by identifying effective, whole-person, non-pharmacologic interventions for persons with chronic musculoskeletal pain.
- Conditions
- Chronic Pain, Musculoskeletal Pain, Musculoskeletal Pain Disorder
- Trial name
- PROs (NCT06940986)
- Testing
- Empowered Relief, Move to Health, Usual Care as determined by primary care provider
- Where
- 5 sites in United States
- Volunteers
- 608 people
- Sponsor
- Brooke Army Medical Center
Osteoarthritis, Knee, Knee Osteoarthritis
The ATtune Knee Outcome Study
To accomodate dissatisfied patients with a total knee arthroplasty (TKA) and improve outcomes, several knee systems have been developed.
- Conditions
- Osteoarthritis, Knee, Knee Osteoarthritis, Knee Rheumatism, Rheumatoid Arthritis
- Trial name
- ATKOS (NCT04247672)
- Testing
- Total Knee Arthroplasty (uncemented rotating platform ATTUNE)
- Where
- Netherlands
- Volunteers
- 900 people
- Sponsor
- Spaarne Gasthuis
Keloid, Keloid of Ear Lobe
Gene Expression and Biomarker Profiling of Keloid Skin
This study aims to examine both the genetic profile and the biomarkers implicated in keloid scar formation. Hypothesis: 1. Differences in the genetic profiles of lesional and non-lesional skin contribute a given population's…
- Conditions
- Keloid, Keloid of Ear Lobe, Healthy Adults
- Trial name
- NCT03228693
- Testing
- Biopsy and/or triamcinolone injection, Excisional Biopsy
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Epidermolysis Bullosa Dystrophica, Epidermolysis Bullosa Dystrophica, Recessive
A Natural History Study of Corneal Abrasions in Patients With Dystrophic Epidermolysis Bullosa (DEB)
This study is a non-interventional, observational study that will evaluate the natural history of corneal abrasions in patients with Dystrophic Epidermolysis Bullosa (DEB).
- Conditions
- Epidermolysis Bullosa Dystrophica, Epidermolysis Bullosa Dystrophica, Recessive, Epidermolysis Bullosa Dystrophica Dominans
- Trial name
- NCT06563414
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Krystal Biotech, Inc.
Keloid, Stem Cell
Comparison of Keloid Volume and Symptoms Reduction Between Intralesional Umbilical-Cord Mesenchymal Stem Cells, Its Conditioned Medium, and Triamcinolone Acetonide Injection as Keloid Therapy: A Randomised Controlled Trial
This study is a double-blind randomized controlled trial (RCT) examining the effect of intralesional injection of umbilical cord-derived mesenchymal stem cells (UC-MSC), umbilical cord-derived conditioned medium (UC-CM), or…
- Trial name
- NCT05887804
- Testing
- umbilical cord-derived mesenchymal stem cells (UC-MSC), umbilical cord-derived mesenchymal stem cells conditioned medium (UC-CM), Triamcinolone Acetonide (TA)
- Where
- Indonesia
- Volunteers
- 24 people
- Sponsor
- Rumah Sakit Pusat Angkatan Darat Gatot Soebroto
Epidermolysis Bullosa
Allogeneic Stem Cell Transplantation (ALLOSCT) in Recessive Dystrophic Epidermolysis Bullosa (RDEB)
Reduced Intensity Conditioning (RIC) and Allogeneic Stem Cell Transplantation (AlloSCT) from family-related donors and unrelated cord blood (UCB) donors will be safe and well tolerated in selected patients with RDEB.
- Trial name
- RDEB (NCT00881556)
- Testing
- Palifermin, Fludarabine, Busulfan
- Where
- 3 sites in United States
- Volunteers
- 3 people
- Sponsor
- Columbia University