Clinical trials: Rheumatologic Disorders
Myocarditis, Autoimmune Rheumatologic Disease
CMR Imaging of Autoimmune Diseases
Myocarditis is an important clinical problem which can can occur as a result of viral infections and autoimmune rheumatic diseases. Cardiac MRI is an important non-invasive means of making a diagnosis.
- Trial name
- NCT04673409
- Testing
- Novel Cardiac MRI sequences
- Where
- United Kingdom
- Volunteers
- 123 people
- Sponsor
- King's College London
Tobacco Use Cessation
Smoking Cessation Support for Patients With Rheumatologic Diseases Via WhatsApp
Smoking cessation support for patients with rheumatologist diseases is an underestimated issue. In the previous prospective cohort study the investigators determined that with the brief cessation interventions 63.5% of smokers…
- Trial name
- NCT06219551
- Testing
- Mobile messages via What's App
- Where
- Turkey (Türkiye)
- Volunteers
- 220 people
- Sponsor
- Recep Tayyip Erdogan University Training and Research Hospital
Psoriatic Arthritis, Psoriasis
Psorcast Mobile Study
The purpose of this study is to understand variation in the symptoms of psoriasis and psoriatic arthritis using simple, scalable smartphone-based measurements.
- Conditions
- Psoriatic Arthritis, Psoriasis, Psoriatic Conditions, Dermatologic Disease
- Trial name
- NCT05621369
- Testing
- Participant self-assessment surveys, Psoriasis Draw, Psoriasis Area Photo
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Sage Bionetworks
Juvenile Idiopathic Arthritis, Systemic Lupus Erythematosus
Development of a Therapeutic Endpoint in Pediatric Rheumatologic Conditions
The overarching goal of this study is the development of a physiologic endpoint of pain and treatment effect in three distinct rheumatology populations.
- Conditions
- Juvenile Idiopathic Arthritis, Systemic Lupus Erythematosus, Fibromyalgia
- Trial name
- NCT04833465
- Testing
- No Intervention
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Children's National Research Institute
Narrative Medicine, Chronic Disease
Impact of Early Implementation of Narrative Medicine Techniques on Patient Centered Attitudes of Medical Students
A qualitative study assessing the impact of early narrative medicine practice on Medical Honors Program (MHP) students' attitudes regarding patient-centered interactions, through interviewing patients with chronic or…
- Conditions
- Narrative Medicine, Chronic Disease, Terminal Illness, Cancer
- Trial name
- NCT03041571
- Testing
- Patient Provider Orientation Scale, Interview performed by MHP student
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florida
Rheumatoid Arthritis, Psoriatic Arthritis
A Study of SPY072 in Rheumatic Disease
This is a multi-center, double-blind, placebo-controlled, Phase 2, proof-of-concept basket study with the goal of assessing the efficacy and safety of SPY072 compared to placebo in adults (aged ≥18 years) with rheumatic disease…
- Conditions
- Rheumatoid Arthritis, Psoriatic Arthritis, Axial Spondyloarthritis, Rheumatic Diseases
- Trial name
- SKYWAY-RD (NCT07148414)
- Testing
- SPY002-072
- Where
- 64 sites in United States, Bulgaria and 6 more
- Volunteers
- 285 people
- Sponsor
- Spyre Therapeutics, Inc.
Rheumatoid Arthritis, Inflammatory Bowel Disease
Incidence of Hospitalizations for Serious Infections in Patients Receiving Biologic Anti-Inflammatories for Rheumatologic, Psoriatic, and Gastrointestinal Conditions: A Descriptive Analysis
Purpose: With the existing biologic anti-inflammatory product patents expiring and the FDA approval of new biosimilar and innovator biologics, patients with rheumatologic (RA), psoriatic (PsO-PsA-AS), and gastrointestinal (GI)…
- Conditions
- Rheumatoid Arthritis, Inflammatory Bowel Disease, Psoriasis, Psoriatic Arthritis
- Trial name
- NCT02922192
- Testing
- TNF-α antagonists, non-TNFs, DMARD non-biologics
- Volunteers
- 90,360 people
- Sponsor
- Biologics & Biosimilars Collective Intelligence Consortium
Cardiovascular Diseases, Rheumatologic Disease
Greater Manchester CARDIOvascular Pathology in Immune-Mediated Inflammatory Diseases
The researchers would like to know more about cardiovascular abnormalities in patients with immune-mediated inflammatory diseases (IMID) and with the aim to provide new biomarkers (clinical, blood, imaging) for early diagnosis…
- Trial name
- GM CARDIO-IMID (NCT06600737)
- Where
- United Kingdom
- Volunteers
- 325 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Musculoskeletal Pain, Rheumatologic Disorder
Satisfaction, QoL,Health Status & Clinic Outcomes for Patients Attending MSK Triage Clinics in Rheumatology
The aim of this study is to measure the impact of musculoskeletal (MSK) complaints on the quality of life and general health of MSK Patients attending MSK triage clinics.
- Trial name
- NCT04244968
- Where
- Ireland
- Volunteers
- 325 people, healthy volunteers welcome
- Sponsor
- Health Service Executive, Ireland
Rheumatologic Disease
Systemic Sclerosis (SSc) Vasculopathy: Improved Clinical Monitoring and Treatment
Systemic sclerosis (SSc; scleroderma) is a multi-organ systemic disease characterized by activation of immune cells, which results in vascular dysfunction (vasculopathy) and subsequent scarring (fibrosis).
- Trial name
- Scleroderma (NCT02530996)
- Testing
- BH4, Vasculopathy assessment
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Inflammatory Bowel Diseases, Rheumatologic Disease
EFFICACY AND SAFETY OF S.C. INFLIXIMAB IN PATIENTS SWITCHED FROM I.V. FORMULATION OF INFLIXIMAB
Phase-IV, national, multicentric, non-randomized, observational real-life study. The goal of this stud is to investigate the patient's benefits in terms of quality of life and work ability resulting from the switch from…
- Trial name
- NCT05719389
- Testing
- CT-P13
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- IRCCS San Raffaele
Meibomian Gland Dysfunction, Dry Eye Syndromes
Ocular Surface Changes and Meibomian Gland Dysfunction in Rheumatologic Patients
This observational study aims to assess the frequency and severity of Meibomian Gland Dysfunction (MGD) and associated ocular surface changes in patients with systemic autoimmune rheumatic diseases compared with healthy…
- Conditions
- Meibomian Gland Dysfunction, Dry Eye Syndromes, Rheumatoid Arthritis, Systemic Lupus Erythematosus
- Trial name
- NCT07810569
- Volunteers
- 150 people
- Sponsor
- Assiut University
Cardiovascular Diseases
Reexamining Her Cardiovascular Risk - Ottawa WomeN's Longitudinal Cohort Study
The full HER CROWN will be a prospective cohort study to propose a novel, women-specific cardiovascular risk score/ algorithm in the prediction of hard cardiovascular outcomes (myocardial infarction, unstable angina, coronary…
- Trial name
- HER-CROWN (NCT05632601)
- Testing
- PET scan
- Where
- Canada
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Ottawa Heart Institute Research Corporation
Rheumatologic Disease, Autoimmune Diseases
Testimonials and Navigation in Rheumatology
The overall goal of this study is to determine whether a novel, multi-modal, patient-directed behavioral intervention initiated in rheumatology clinics is an effective approach to improve uptake of updated COVID-19 vaccine.
- Trial name
- TANGO (NCT06469788)
- Testing
- Video comprised of AIRD patient narratives on COVID-19 vaccination thoughts and experiences, Video on the importance of good oral health for patients with AIRD, Brochure on COVID-19 vaccination in AIRD patients
- Where
- 4 sites in United States
- Volunteers
- 1,170 people
- Sponsor
- University of Alabama at Birmingham
Hematologic Disorders, Oncologic Disorders
Rapid Infusion Rituximab, Hematologic, Oncologic, and Rheumatologic Disorders
Rituximab is frequently used in adult and pediatric cancers, blood disorders, lymphoma (a cancerous growth made up of lymphoid tissue), graft-versus-host-disease (complication that can occur after a stem cell or bone marrow…
- Conditions
- Hematologic Disorders, Oncologic Disorders, Rheumatologic Disorders
- Trial name
- NCT02484053
- Testing
- Rituximab
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Baylor College of Medicine
Joint Diseases, Joint Inflammation
Evaluating Replacement of Standard-of-care Low Dose Computer Tomography (CT) Scans With Radiation-free Bone Imaging by Deep-learning Augmented Zero Echo Time (DL-ZTE) Magnetic Resonance Tomography (MRT)
The goal of this clinical trial is to determine how effectively bone structures of the human skeleton can be visualized using Deep Learning (DL) augmented Magnetic Resonance Imaging (MRI) in individuals with inflammatory and…
- Trial name
- DLZTECT (NCT06579547)
- Testing
- Low Dose Computer Tomography
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- Roman Guggenberger
Giant Cell Arteritis (GCA), Polymyalgia Rheumatica (PMR)
AYLo - AutoimmunitY and Loss of y
The AYLo study (AutoimmunitY and Loss of y - Investigating the Role of Hematopoietic Mutations and Mosaic Mutation in the Y Chromosome in Autoimmune Rheumatologic Diseases) aims to systematically investigate hematopoietic…
- Conditions
- Giant Cell Arteritis (GCA), Polymyalgia Rheumatica (PMR), ANCA Associated Vasculitis (AAV), Idiopathic Inflammatory Myopathies
- Trial name
- AYLo (NCT06696027)
- Testing
- Single nucleotide polymorphisms (SNP), 3'mRNA sequencing, Enzyme-linked immunosorbent assay (ELISA) and Legendplex Array
- Where
- Germany
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Bonn
Scleroderma
Scleroderma ARFI Imaging of the Skin
Scleroderma and other rheumatologic conditions can affect the skin. Scleroderma in particular involves skin thickening and hardening.
- Trial name
- ARFI (NCT02006420)
- Testing
- ARFI-SVI Ultrasound
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Autoimmune Rheumatologic Disease, Kidney Disease
Traditional Chinese Medicine Constitution Study and the Diagnosis and Treatment of Chronic Disease in Taiwan Population
Several questionnaires have been developed for clinical research in Traditional Chinese Medicine. The objective of this study is to evaluate the consistency and relevance of two questionnaires, the Constitution in Chinese…
- Conditions
- Autoimmune Rheumatologic Disease, Kidney Disease, Endocrine, Metabolic or Nutritional Diseases or Conditions
- Trial name
- NCT02678546
- Testing
- Other
- Where
- Taiwan
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Inflammatory Bowel Disease, Crohn Disease
Prevalence and Clinical Course of Chronic Hep B Infection in IBD and Rheumatologic Disease
This study aims to determine the prevalence of HBV infection in patients with IBD and rheumatologic disease, and to assess the impact of immunosuppressive therapy on viral load and clinical course of IBD patients.
- Conditions
- Inflammatory Bowel Disease, Crohn Disease, Ulcerative Colitis, Rheumatic Diseases
- Trial name
- NCT02128503
- Testing
- HBV DNA level monitoring
- Where
- Hong Kong
- Volunteers
- 430 people
- Sponsor
- Chinese University of Hong Kong