Clinical trials: Rhinosinusitis
Chronic Rhinosinusitis (Diagnosis), Nasal Polyposis
Mometasone vs Budesonide in CRS With Polyposis
The principal objective is to compare the use of mometasone nasal spray to budesonide irrigations in patients suffering from CRSwNP who have never been operated.
- Trial name
- NCT03323866
- Testing
- Budesonide 0.5 MG/ML, Mometasone nasal spray
- Where
- Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
Upper Airway Inflammation and Olfaction: Mechanisms of Loss and Recovery
The goal of this clinical trial is to understand the mechanisms leading to olfactory dysfunction (OD) in chronic rhinosinusitis (CRS).
- Trial name
- IMMUNODOR (NCT06776042)
- Testing
- Nasal brushing of the olfactory cleft, Smell testing
- Where
- Belgium
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Sinusitis in Children
Pediatric Chronic Rhinosinusitis in Asthmatic Children
The objectives of this study would be to determine the most effective treatment for children with PCRS and asthma who fail medical management.
- Trial name
- NCT06194097
- Testing
- adenoidectomy versus endoscopic sinus surgery with adenoidectomy
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- State University of New York - Upstate Medical University
Sinonasal Disorder, Chronic Rhinosinusitis (Diagnosis)
The Sinonasal Microbiome
Chronic rhinosinusitis is an inflammatory disease of the sinonasal mucosa with significant impact and limited treatment options.
- Trial name
- NCT06822725
- Testing
- Control Group, Chronic rhinosinusitis (CRS) with and without Nasal Polyposis
- Where
- United States
- Volunteers
- 285 people, healthy volunteers welcome
- Sponsor
- University of Chicago
Acute Rhinosinusitis, Sore Throat
The Development and Testing of a Scaling Strategy for a Community-Based Primary Care Antimicrobial Stewardship Program
Antibiotic resistant infections are expected to cause 10 million deaths worldwide by 2050, and exceed cancer deaths. Reducing antibiotic use can reduce resistance levels.
- Conditions
- Acute Rhinosinusitis, Sore Throat, Acute Cystitis, Acute Bronchitis
- Trial name
- PC-ASP 2 (NCT03517215)
- Testing
- Enhanced CB-ASP, Standard CB-ASP
- Where
- 3 sites in Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Endoscopic Sinus Surgery, Chronic Rhinosinusitis
Large Scale Cerebral Oximetry During Sinus Endoscopy
Deliberate hypotension, reverse Trendelenburg position, and hyperventilation are techniques utilized during functional endoscopic sinus surgery to attempt to reduce surgical bleeding.
- Trial name
- NCT02692794
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
AERD - Aspirin Exacerbated Respiratory Disease
Effect of Dupilumab on Aspirin Intolerance
To test the efficacy of dupilumab in patients with AERD regarding the intolerance to salicylic acid after 6 months. This will be evaluated by oral drug provocation testing with low dose salicylic acid after 6 months of dupilumab…
- Trial name
- NCT04442256
- Testing
- Dupilumab
- Where
- Austria
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Chronic Sinusitis, Rhinosinusitis
Chronic Rhinosinusitis With or Without Nasal Polyps Steroid Study
This is a study to evaluate the cause of chronic sinus disease. Oral steroids have long been used in the treatment of inflammatory conditions including chronic sinusitis, asthma, and arthritis.
- Conditions
- Chronic Sinusitis, Rhinosinusitis, Nasal Polyps
- Trial name
- NCT00841802
- Testing
- Prednisone
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Northwestern University
Chronic Rhinosinusitis Without Nasal Polyps, Asthma
Adherence in Global Airways - Steroid Intake and Effects on Chronic Rhinosinosinutis
The purpose of this study is to investigate the relationship between long-term use of systemic steroids in patients with upper and lower respiratory tract diseases and their own production of cortisol (cross-sectional), as well…
- Conditions
- Chronic Rhinosinusitis Without Nasal Polyps, Asthma, Chronic Rhinosinusitis With Nasal Polyps, Steroid-Induced Osteopenia (Diagnosis)
- Trial name
- AGAS 2023 (NCT05843019)
- Where
- Denmark
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Christiane Haase
Chronic Maxillary Rhinosinusitis
Using Navigation to Improve Accuracy of Maxillary Balloon Sinusotomy
The purpose of the research is to examine the effectiveness of navigation in maxillary sinus balloon dilation for the treatment of chronic maxillary rhinosinusitis.
- Trial name
- NCT06567821
- Testing
- RELIEVA SPINPLUS® NAV Balloon Sinusplasty System
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Sinusitis, Nasal Polyps
The Polymerase Chain Reaction (PCR) Analysis of Nasal Polyps for Fungal DNA
The objective of this study is to determine whether the amount or type of fungal DNA present in the nose and home environment can be correlated with the outcomes of the following quality of life (QOL) instruments: Medical…
- Trial name
- NCT00739921
- Testing
- Nasal swab under endoscopic guidance
- Where
- United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Rhinosinusitis Acute
The Effect of Facial Effleurage on Acute Rhinosinusitis
Rhinosinusitis accounts for 12% of the total antibiotic prescriptions filled in the United States annually; however, the majority of rhinosinusitis cases have been proposed to have a viral etiology, or are capable of…
- Trial name
- NCT04642989
- Testing
- Facial Effleurage, Antibiotics
- Where
- United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Edward Via Virginia College of Osteopathic Medicine
Chronic Rhinosinusitis With Nasal Polyps
The Role of Budesonide Intrapolyp Injection in the Management of Type 2 Chronic Rhinosinusitis
To investigate the usage of budesonide as an agent in the injection of Type 2 chronic rhinosinusitis with nasal polyps
- Trial name
- NCT05931744
- Testing
- Budesonide, Prednisone, Saline
- Where
- Egypt
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Kafrelsheikh University
Chronic Sinus Infection, Chronic Sinusitis
Impact of Budesonide Irrigations on Patients With Chronic Rhinosinusitis and Impact on Sinus Surgery Rates
This study is intended to assess the impact of a 90 day course of high volume budesonide irrigations for patients who have failed other medical therapy and assessing the impact of the budesonide irrigations on the need for sinus…
- Conditions
- Chronic Sinus Infection, Chronic Sinusitis, Chronic Sinusitis - Ethmoidal, Posterior, Chronic Sinus Congestion
- Trial name
- NCT03519061
- Testing
- Budesonide
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Chronic Rhinosinusitis (Diagnosis)
Nasal Microbiota Transfer Therapy in Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP)
Chronic Rhinosinusitis (CRS) is a chronic inflammatory condition of the nasal passage and paranasal sinuses that places significant burden on affected patients and global healthcare systems.
- Trial name
- NCT05400616
- Testing
- Microbiome Transplant
- Where
- 3 sites in Australia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The University of Queensland
Allergic Fungal Rhinosinusitis
Sinonasal Risk Factors for Occurrence of Unilateral Versus Bilateral Allergic Fungal Rhinosinusitis .
This study aims to assess Sinonasal risk factors for occurrence of unilateral versus bilateral allergic fungal rhino sinusitis regarding:: 1. anatomical variations and correlate radiological finding with intraoperative finding.
- Trial name
- NCT06376071
- Testing
- functional endoscopic sinus surgery
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Assiut University
Rhino Sinusitis
Safety Evaluation of Intranasal Use of DSM 32444 Postbiotic in Humans
Rhinitis is a type of upper respiratory infection with a common nasal pathology especially in Southeast Asia, which is characterized by the presence of one or more of the following symptoms: itchy nose, sneezing, runny nose, and…
- Trial name
- NCT05984004
- Testing
- 0.9% NaCl isotonic saline solution, Bacillus subtilis DSM32444, inactivated
- Where
- Vietnam
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Huro Biotech Joint Stock Company
Rhinosinusitis Chronic, Bleeding
This Study Aims to Assess the Impact of 50°C Saline Irrigation on the Overall Intraoperative Blood Loss and Surgical Visualization During Endoscopic Sinus Surgery for Rhinosinusitis.
Objectives: Intraoperative bleeding during endoscopic sinus surgery for severe rhinosinusitis may significantly compromise the surgical field.
- Trial name
- NCT07627789
- Testing
- Hot saline irrigation, Room-temperature saline irrigation
- Where
- Poland
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Military Institute of Aviation Medicine
Allergic Fungal Rhinosinusitis
Dupilumab in Allergic Fungal Rhinosinusitis (AFRS)
Primary Objective: To evaluate the efficacy of treatment with dupilumab to reduce sinus opacification in a population with allergic fungal rhinosinusitis (AFRS) Secondary Objectives: To evaluate the efficacy of treatment with…
- Trial name
- AIMS (NCT04684524)
- Testing
- Dupilumab SAR231893
- Where
- 47 sites in United States, Argentina and 7 more
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Sanofi
Nasal Polyps, Sinusitis
Study to Compare Resection Versus Preservation of the Middle Turbinate in Surgery for Nasal Polyps
Endoscopic sinus surgery (ESS) has become the standard of care for patients suffering of chronic rhinosinusitis with nasal polyposis (CRSwP) who have failed medical therapy.
- Trial name
- NCT02855931
- Testing
- Middle turbinate resection
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke