Clinical trials: Rhinovirus
Asthma, Respiratory Disease
Airway Remodeling and Rhinovirus in Asthmatics
Human rhinovirus is also called the "common cold virus" because it causes at least half of all of the common colds experienced each year.
- Trial name
- ARRA (NCT05775952)
- Testing
- HRV-39
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Healthy Adult Participants, Asthma Exacerbation
RIG 101 Trial in Healthy Adults and Adults With Asthma
Nested Phase 1-2 Trial of RIG-101 in Healthy and Asthmatic Participants Assessing Safety, Tolerability and Viral Challenge Efficacy
- Conditions
- Healthy Adult Participants, Asthma Exacerbation, Safety and Efficacy
- Trial name
- NCT07488897
- Testing
- RIG-101
- Where
- 2 sites in United Kingdom
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- RIGImmune Inc.
Rhinovirus Infection in Asthma
Mechanisms of Interplay Between Allergy and Viruses in Asthma
The aim of this study is to investigate the mechanisms of interplay between allergy (IgE and Th2 mediated inflammation) and virus infection in the development of asthma, as well as the risk and severity of acute exacerbations of…
- Trial name
- NCT01773590
- Testing
- Rhinovirus Infection
- Where
- United Kingdom
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Common Cold
Efficacy Trial of 3804-250A in the Prevention of Cold Illnesses
The purpose of this study is to evaluate the efficacy of 3804-250A in the prevention of the common cold. The study will also evaluate whether 3804-250A prevents rhinovirus infection, a virus that causes many common colds.
- Trial name
- NCT00762476
- Testing
- 3804-250A, 3804-291
- Where
- 2 sites in United States
- Volunteers
- 411 people, healthy volunteers welcome
- Sponsor
- The Dial Corporation
Asthma
Early Antiviral Responses to Rhinovirus Infection in Asthma
The bulk of the morbidity and mortality related to asthma is during periods of acutely increased symptomatology called 'exacerbations'. Roughly half of asthma sufferers experience such an exacerbation each year.
- Trial name
- NCT05050903
- Testing
- Rhinovirus infection
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Common Cold
Effect of Probiotic on the Innate and Adaptive Host Response to Rhinovirus (EPIARR)
The study is designed to assess the effect of ingestion of a probiotic on innate and adaptive host responses to rhinovirus infection.
- Trial name
- EPIARR (NCT01669603)
- Testing
- Bifidobacterium lactis Bl-04, Rhinovirus
- Where
- United States
- Volunteers
- 789 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Seasonal Allergic Rhinitis, Rhinovirus
Biomarkers in Nasal Samples of Seasonal Allergic Rhinitics
The purpose of this study is to analyze nasal samples for the presence of biomarkers of allergic inflammation as well as cold and flu infections, and compare these samples both in and out of an individual's active allergy season.
- Trial name
- GSK AR ELF (NCT04670627)
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Upper Respiratory Tract Infections, Rhinovirus
A Trial of Vitamin D and Health Advice for the Prevention of Upper Respiratory Tract Infections
The specific objectives of this investigation are to assess the effectiveness of daily gargling and vitamin D supplementation as preventative measures against incident upper respiratory tract infection (URTI) in students…
- Conditions
- Upper Respiratory Tract Infections, Rhinovirus, Infections
- Trial name
- NCT01158560
- Testing
- cholecalciferol (vitamin D3), Gargling
- Where
- Canada
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- St. Joseph's Healthcare Hamilton
Common Cold
Experimental Human Rhinovirus Infection
Our primary objective is to set up the Human Rhinovirus (HRV)-model in our centre. In addition, to facilitate future clinical trials, we want to determine optimal read-out parameters and read-out time points for experimental HRV…
- Trial name
- EHRVI (NCT01823640)
- Testing
- Human Rhinovirus strain 16 (HRV-16)
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Common Cold
Trial to Evaluate the Use of Pomegranate Concentrate (POMx) for the Prevention of Experimental Rhinovirus Infection
Pomegranate has a long history of use in folk medicine. There is vast data on the health benefits of pomegranate fruit and juice.
- Trial name
- NCT00655031
- Testing
- Pomegranate Concentrate (POMx)
- Where
- 3 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- POM Wonderful LLC
Pulmonary Disease, Chronic Obstructive, Enterovirus Infections
First-in-human Clinical Trial Evaluating CUR-N399 in Healthy Volunteers.
The purpose of the trial is to evaluate CUR-N399, a PI4KB inhibitor, in a first-in-human trial to evaluate the safety, tolerability and pharmacokinetics profile of single and multiple ascending doses in healthy adults.
- Conditions
- Pulmonary Disease, Chronic Obstructive, Enterovirus Infections, Rhinovirus
- Trial name
- NCT05016687
- Testing
- CUR-N399
- Where
- Sweden
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Curovir AB
Acute Viral Bronchiolitis
KL-6 Protein as a Biomarker of Lung Injury in Viral Bronchiolitis
Serum KL-6 protein has been described as a biomarker of epithelial lung injury in Respiratory Syncytial Virus bronchiolitis. The investigators can imagine that epithelial injury intensity has consequences on immediate and later…
- Trial name
- NCT01437956
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Upper Respiratory Tract Infections Due to Influenza or Rhinovirus
Efficacy of Transfer Factor to Prevent Upper Respiratory Tract Infections in Healthy Adults
The goals of our study are to critically evaluate if a healthy population supplemented with Transfer factor experiences fewer incidences of colds and flu, or experience shorter duration of illness compared to an identical…
- Trial name
- NCT01106183
- Testing
- transfer factor
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of Utah
Viral Upper Respiratory Tract Infection
A Study to Examine the Duration of Effect of PrEP-001 in Healthy Subjects Challenged With HRV-16
A study to examine the duration of effect of PrEP-001 in healthy subjects challenged with HRV-16
- Trial name
- NCT03338556
- Testing
- PrEP-001
- Where
- United Kingdom
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Prep Biopharm Limited
Common Cold
Clinical Trial to Optimise Levels of Vitamin D for Rhinovirus Protection
A phase II randomised, placebo-controlled trial to identify the optimal regimen of vitamin D supplementation for rhinovirus protection, determined by host responses to a clinically induced rhinovirus challenge.
- Trial name
- NCT04368520
- Testing
- Vitamin D3
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Common Cold
Effect of Probiotic on Rhinovirus Induced Colds
This is a randomized, double-blind placebo controlled trial to evaluate the effect of a probiotic (Bl-04) on the occurrence of rhinovirus-associated common cold illness in the experimental rhinovirus challenge model.
- Trial name
- MK EPRIC (NCT02679807)
- Testing
- Bifidobacterium animalis subsp. lactis Bl-04, sucrose
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Healthy Volunteers
A First-in-Human Safety and Dose-Finding Study of New Type-16 Human Rhinovirus (RG-HRV16) Inoculum in Healthy Volunteers
This research study will test different doses of RG-HRV16 to find the minimum dose needed to give research subjects cold symptoms of at least moderate intensity. The study will also test the safety of RG-HRV16.
- Trial name
- UWI-02 (NCT01769573)
- Testing
- RG-HRV16
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Asthma
A Study to Evaluate the Safety and Use of Human Rhinovirus in Healthy and Asthmatic Participants (MK-0000-218)
The purpose of this study is to establish the safety and tolerability of Unbiased Biomarkers for the Prediction of Respiratory Disease Outcomes (U-BIOPRED) human rhinovirus 16 (RV16UB) in healthy and asthmatic participants, and…
- Trial name
- NCT01866306
- Testing
- RV16UB, LABA
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Acute Nasopharyngitis
A Controlled Human Rhinovirus Infection Study of 2-Deoxy-D-Glucose in Healthy Adults
2-DG-02 is a randomized, placebo-controlled, double-blind Phase 2 study to investigate the efficacy and safety of 2-Deoxy-D-Glucose as a pre-exposure prophylaxis using the rhinovirus challenge model in healthy study participants.
- Trial name
- NCT06375772
- Testing
- 2-Deoxy-D-glucose
- Where
- Netherlands
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- G.ST Antivirals GmbH
COPD (Chronic Obstructive Pulmonary Disease), Rhinovirus Infection
Using Multiomics to Define Mechanisms of Rhinovirus-induced Chronic Obstructive Pulmonary Disease Exacerbations to Develop Novel Therapies and Therapeutic Targets
The goal of this study is to examine exacerbations of chronic obstructive pulmonary disease (COPD) caused by a common cold virus called rhinovirus, to identify new treatments.
- Conditions
- COPD (Chronic Obstructive Pulmonary Disease), Rhinovirus Infection, Exacerbation of COPD
- Trial name
- MRVCOPD (NCT07112235)
- Testing
- Rhinovirus-A16
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Imperial College London