Clinical trials: Rhythm
Sleep Deprivation, Metabolic Disturbance
Biorhythms in Metabolic Tissues
Metabolism is increasingly recognized as being highly regulated by anticipatory biological rhythms (circadian rhythms or "biorhythms"), which are driven by molecular feedback loops, and which are approximately 24 hours long…
- Conditions
- Sleep Deprivation, Metabolic Disturbance, Biological Clocks, Healthy
- Trial name
- NCT03276442
- Testing
- Low-fat dietary intervention, High-fat dietary intervention
- Where
- Sweden
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Heart Failure, Atrial Fibrillation
Rhythm Control - Catheter Ablation With or Without Anti-arrhythmic Drug Control of Maintaining Sinus Rhythm Versus Rate Control With Medical Therapy and/or Atrio-ventricular Junction Ablation and Pacemaker Treatment for Atrial Fibrillation
Atrial fibrillation and heart failure are two common heart conditions that are associated with an increase in death and suffering. When both of these two conditions occur in a patient the patient's prognosis is poor.
- Trial name
- RAFT-AF (NCT01420393)
- Testing
- Rhythm control, Rate Control
- Where
- 21 sites in Brazil, Canada and 2 more
- Volunteers
- 411 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Ventricular Tachycardia
Brain Perfusion and Hemodynamic Stability in Patients Undergoing Radiofrequency Ablation of Ventricular Tachycardia
Ventricular tachycardia (VT) is a life-threatening, fast heart rhythm that starts in the lower chambers of the heart (the ventricles). This fast heartbeat is caused by abnormal electrical pathways located in the heart tissue.
- Trial name
- NCT01695551
- Testing
- Data Collection Forms
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Dhanunjaya Lakkireddy, MD, FACC
Suicidal Ideation, Regulation, Emotion
Effect of Morning Light Exposure on Mood
Mood dysregulation and suicidal ideation are closely associated with disruption of sleep and circadian rhythms. Moreover, sleep problems and circadian disruption are commonplace features of military life.
- Trial name
- NCT05616819
- Testing
- Active light exposure
- Where
- United States
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Healthy, Psoriasis
Sleep, Circadian Rhythm & Skin Health
The purpose of this study is to explore the mechanisms behind how sleep quality may affect skin aging, skin integrity and skin disease.
- Conditions
- Healthy, Psoriasis, Eczema, Acne
- Trial name
- NCT02457000
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Sleep Disorders, Circadian Rhythm, Circadian Rhythm Disorders
Validation of Circadian Biomarkers in Patients With Sleep Disorders
Current methods for assessing circadian timing require sampling over hours (or even up to a day) while the patient is in controlled conditions.
- Conditions
- Sleep Disorders, Circadian Rhythm, Circadian Rhythm Disorders, Circadian Rhythm Sleep Disorder, Advanced Sleep Phase Syndrome (ASPS)
- Trial name
- NCT04690504
- Testing
- dim light melatonin onset (DLMO)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Brigham and Women's Hospital
Normal Physiology
Impact of Sex and Age on Non-visual Light Input That Affects Sleep and Circadian Rhythms
The goal of this clinical trial is to learn how the pupil responds to different light stimuli and how that relates to sleep and daily rhythms in healthy people of different ages.
- Trial name
- NCT05829044
- Testing
- Pupillometry, Light box exposure
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Breast Feeding, Breast Milk Collection
Effect of Breast Milk Circadian Properties on Infant's Growth Parameters and Absorption of Nutrients
The most ideal method for providing breast milk is breastfeeding. However, it may be necessary to express breast milk for reasons such as the newborn being in an intensive care unit, the mother being hospitalized for any reason…
- Trial name
- The (NCT06342674)
- Testing
- Giving breast milk to the newborn according to the circadian rhythm, Usual care
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Sakarya University
Atrial Fibrillation, Atrial Flutter
Validation of a Novel Smartphone-based Method for Heart Rhythm Monitoring in the Home Environment
Atrial fibrillation is a heart rhythm disorder with increased risk of stroke, heart failure, dementia and death. The severity of symptoms in atrial fibrillation varies markedly, ranging from no symptoms to those with disabling…
- Conditions
- Atrial Fibrillation, Atrial Flutter, Arrhythmia
- Trial name
- NCT04300270
- Testing
- Smartphone PPG recordings, Smartphone ECG
- Where
- Sweden
- Volunteers
- 480 people
- Sponsor
- Karolinska Institutet
Severe Mental Illness, Bipolar Disorder
A Mobile App to Support Mood, Daily Routines and Medication Adherence in Adults With Severe Mental Illness
The goal of this clinical trial is to learn whether MoodSync, a mobile application for patients and their family caregivers, improves mood stability, medication adherence, daily functioning and early detection of relapse warning…
- Conditions
- Severe Mental Illness, Bipolar Disorder, Schizophrenia, Schizoaffective Disorder
- Trial name
- MoodSync (NCT07879131)
- Testing
- MoodSync, Standard care
- Where
- Bahrain
- Volunteers
- 60 people
- Sponsor
- Alexandria University
Atrial Fibrillation, Heart Failure
Predicting Outcomes in Atrial Fibrillation and Heart Failure
PrOAF-HF will aim to test if rhythm control delivered through catheter ablation in patients in whom it is not clear whether atrial fibrillation or heart failure were the first disease results in a greater improvement in left…
- Trial name
- PrOAF-HF (NCT06417242)
- Volunteers
- 80 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Inflammatory Cytokine, Circadian Rhythm
Acupressure Therapy on Post-stroke Fatigue, Depression, and Sleep Disturbances in Ischemic Stroke Patients
Post-stroke fatigue (PSF) was defined as 'a subjective feeling of physical and/or mental exhaustion that is unrelated to exertion and does not typically improve with rest'.
- Conditions
- Inflammatory Cytokine, Circadian Rhythm, Acupressure, Post-stroke Fatigue
- Trial name
- NCT06401837
- Testing
- Circadian based acupressure application
- Where
- 2 sites in Taiwan
- Volunteers
- 52 people
- Sponsor
- China Medical University Hospital
Alzheimer Disease
Improving Memory in Alzheimer's Disease With Noninvasive Brain Stimulation
The investigators will evaluate the theory that Alzheimer's disease-related memory impairment derives from the inefficient orchestration of rhythmic activity at the level of large-scale cortical networks.
- Trial name
- NCT06094192
- Testing
- High definition transcranial electrical current stimulation
- Where
- United States
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Atrial Fibrillation, Atrial Flutter
Detection of Atrial Fibrillation After Cardiac Surgery
The aim of the SEARCH-AF trial is to evaluate a novel diagnostic tool for detecting post-operative atrial fibrillation or flutter (POAF/AFL) in cardiac surgical subjects during the early, sub-acute post-operative period.
- Conditions
- Atrial Fibrillation, Atrial Flutter, C.Surgical Procedure; Cardiac, Arrhythmias, Cardiac
- Trial name
- SEARCH-AF (NCT02793895)
- Testing
- Medtronic SEEQ™ mobile cardiac telemetry system, Usual Care, CardioSTAT (Icentia Inc.) cardiac rhythm monitoring device
- Where
- 10 sites in Canada
- Volunteers
- 336 people
- Sponsor
- Unity Health Toronto
Atrial Fibrillation, Heart Rate Fast
Portable Measurement Methods Combined With Artificial Intelligence in Detection of Atrial Fibrillation
In Western countries, every sixth person in their lifetime and 15,000 people in Finland have a new stroke each year. About every fourth stroke is based on cardiac embolism.
- Conditions
- Atrial Fibrillation, Heart Rate Fast, Heart Rate Low, Sinus Rhythm
- Trial name
- WB-AF (NCT04917653)
- Testing
- Heart rhythm monitoring with wearable device, Blood samples and biomarkers
- Where
- Finland
- Volunteers
- 100 people
- Sponsor
- Kuopio University Hospital
Advanced Kidney Cancer
The Impact of Time-of-day-Dependent Administration of Nivolumab-Ipilimumab (ICI/ICI) Combination on Overall Survival in Adults With Advanced Kidney Cancer: A Pragmatic Multicenter, Randomized Controlled Trial.
The goal of this clinical trial is to learn if the timing of treatments plays a role in how effective the standard-of-care drugs nivolumab/ipilimumab (ICI/ICI) works to treat adults with advanced kidney cancer.
- Trial name
- NCT07338981
- Testing
- Nivolumab & Ipilimumab, Nivolumab + Ipilimumab
- Where
- Canada
- Volunteers
- 142 people
- Sponsor
- Guliz Ozgun
Cardiac Rhythm Disturbance
Hexoskin Medical System - ECG Performance Testing
The goal of this observational study is to validate the efficacy of the Hexoskin Medical System (HMS) for its intended use (i.e., manual assessment of cardiac rhythm disturbances) in non-critical adult participants who are…
- Trial name
- NCT05970328
- Testing
- Hexoskin Medical System
- Where
- 2 sites in Canada
- Volunteers
- 75 people
- Sponsor
- Carré Technologies Inc.
Shift-Work Sleep Disorder, Insomnia
Fire Fighter Fatigue Management Program: Operation Fight Fatigue
Firefighters frequently work extended duration shifts and long work weeks which have adverse effects on alertness, health, safety and performance.
- Conditions
- Shift-Work Sleep Disorder, Insomnia, Restless Leg Syndrome, Obstructive Sleep Apnea
- Trial name
- NCT01672502
- Testing
- Sleep health education provided via a web-based program, Sleep disorder detection and treatment, Optimization of Sleep in Fire Station
- Where
- United States
- Volunteers
- 620 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Depression, Anxiety
Simulated Dawn Med Students
Medical students score higher than the general population on measures of depression, anxiety, fatigue, poor sleep and sleepiness. Data suggest that disparages in circadian phase might contribute to these problems.
- Conditions
- Depression, Anxiety, Fatigue, Sleepiness
- Trial name
- NCT02088593
- Testing
- Simulated Dawn Light Box, Sleep Hygiene instructions
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Migraine
Mechanistic Studies of Psilocybin in Headache Disorders
In previous clinical trial work, the investigators observed lasting reductions in headache burden after limited dosing of psilocybin. This purpose of this study is to examine potential sources for this observed effect.
- Trial name
- NCT06464367
- Testing
- Psilocybin
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Yale University
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