Clinical trials: Risk for Colorectal Cancer
Colorectal Cancer Screening
Optimization of the Bowel Preparation Regimen for the PillCam® COLON 2 Capsule Endoscopy Procedure
This study is designed to determine the optimal bowel preparation regimen for PillCam® COLON 2 Capsule Endoscopy System (CCE) procedures in average risk patients.
- Trial name
- NCT02481219
- Testing
- PillCam® COLON 2 procedure-CONTROL, Senna tablets, PEG
- Where
- 6 sites in United States
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Medtronic - MITG
Colorectal Cancer, Colorectal Polyp
Predicting Risk for Post-polypectomy Colorectal Cancer
This originated as an observational study of Kaiser Permanente Northern California (KPNC) patients with a history of adenoma diagnosed by colonoscopy who received a subsequent surveillance colonoscopy between 2014 and 2019.
- Conditions
- Colorectal Cancer, Colorectal Polyp, Colorectal Adenoma, Neoplasm, Colorectal
- Trial name
- PREDICT (NCT05606081)
- Testing
- Logistic regression risk model
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Colorectal Cancer, Colorectal Adenoma
The Implementation of Genetic Risk for Colorectal Cancer Screening
The goal of this study is to investigate genetic risk for colorectal cancer utilizing polygenic risk scores (PRS) for adults over 45 who have not received their first colonoscopy. The main questions it hopes to address are: 1.
- Conditions
- Colorectal Cancer, Colorectal Adenoma, Colorectal Polyp
- Trial name
- PRO-GENE-COLON (NCT07621757)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Colorectal Cancer
I-Scan Versus High-definition White Light
The purpose of the study is to assess whether the use of I-scan during colonoscopy leads to an increased yield of adenomas in the colon among a population at increased risk for CRC.
- Trial name
- NCT01617278
- Testing
- I-Scan 1, HD Colon, I-Scan 2
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Adenomatous Polyps
Non-invasive Risk Stratification of CR AMN/SSP
The purpose of this study is to determine the clinical utility of stool and blood methylation tests for detection of advanced mucosal neoplasia (AMN) and sessile serrated polyps (SSP).
- Trial name
- FIT (NCT02476682)
- Testing
- blood or stool samples will be collected
- Where
- Australia
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- Professor Michael Bourke
Artificial Intelligence, Deep Learning
Development and Demonstration of Intelligent Assessment Based on Multi-modal Information Fusion for Tumor Risk and Diagnosis and Treatment
To improve the accuracy of risk prediction, screening and treatment outcome of cancer, we aim to establish a medical database that includes standardized and structured clinical diagnosis and treatment information, image features…
- Conditions
- Artificial Intelligence, Deep Learning, Lung Cancer, Lung; Node
- Trial name
- NCT06653478
- Testing
- No Intervention
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Colorectal Cancer, Adenomatous Polyps
Multitarget Stool FIT-DNA Study for Colorectal Cancer Early Screening in China
The primary objective is to determine the diagnostic sensitivity and specificity of the newly developed multitarget FIT-DNA Colorectal Cancer (CRC) screening test (ColoClear) for detecting advanced neoplasia (including colorectal…
- Conditions
- Colorectal Cancer, Adenomatous Polyps, Adenoma, Advanced Adenoma
- Trial name
- CLEAR-C (NCT04287335)
- Testing
- Multitarget stool FIT-DNA test - ColoClear, FIT, Colonoscopy
- Where
- 8 sites in China
- Volunteers
- 4,758 people, healthy volunteers welcome
- Sponsor
- Zhejiang University
Colorectal Cancer Screening
Performance Study of the Invendo C20 Colonoscope System in Colorectal Cancer Screening
The purpose of the study is to evaluate efficacy (i.e. reaching the cecum) and safety of the Invendo C20 Colonoscopy System
- Trial name
- NCT01054924
- Where
- 2 sites in Germany
- Volunteers
- healthy volunteers welcome
- Sponsor
- Invendo Medical GmbH
Colorectal Carcinoma, Advanced Adenomas (AA)
Development and Validation of a Blood Test for Early Diagnosis of Colorectal Cancer
This is a prospective, multicenter, case-control study. The aim is to develop an optimized algorithm by combining the levels of molecular markers in plasma together with risk factors for developing colorectal cancer and clinical…
- Trial name
- ColoDix (NCT06889883)
- Where
- 9 sites in Spain
- Volunteers
- 510 people, healthy volunteers welcome
- Sponsor
- ADVANCED MARKER DISCOVERY S.L.
Stage IV Melanoma, Advanced Lung Cancer
Improving Patient and Caregiver Understanding of Risks and Benefits of Immunotherapy for Advanced Cancer
The purpose of this study is to refine and pilot test educational material developed to educate and support patients receiving immunotherapy for advanced cancer.
- Conditions
- Stage IV Melanoma, Advanced Lung Cancer, Stage IV Non-Small Cell Lung Cancer, Unresectable Non-Small Cell Lung Carcinoma
- Trial name
- UPLIFT (NCT04670445)
- Testing
- Educational Video and QPL List, Usual Care
- Where
- United States
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Patients Aged 50-75 and Requiring Colonoscopy
The French Gut-colo
Colorectal cancer (CRC) is the second most common type of cancer worldwide. The European Union recommends national CRC screening for people aged between 50 and 74.
- Trial name
- NCT06174233
- Where
- France
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
Colorectal Cancer
Colorectal Cancer Screening French Organizations for the Follow-up After Colonoscopy
France is one of the European countries where the incidence of colorectal cancer is the highest among cancers for both sexes. Fecal occult blood screening has been implemented since 2008.
- Trial name
- Tempo-colo (NCT03383367)
- Testing
- Tempo Colo
- Where
- France
- Volunteers
- 33,000 people, healthy volunteers welcome
- Sponsor
- Association pour le Dépistage Organisé des Cancers dans le Rhône
Artificial Intelligence, Deep Learning
Artificial Intelligence System for Assessment of Tumor Risk and Diagnosis and Treatment
To improve the accuracy of risk prediction, screening and treatment outcome of cancer, we aim to establish a medical database that includes standardized and structured clinical diagnosis and treatment information, image features…
- Conditions
- Artificial Intelligence, Deep Learning, Lung Cancer, Lung; Node
- Trial name
- NCT05426135
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Mindfulness, Colon Cancer
Targeting Chronic Stress for Reducing Risk Factors for Colorectal Cancer
Many neighborhoods in Chicago experience daily exposure to stressors including economic inopportunity and violent crime in public spaces.
- Conditions
- Mindfulness, Colon Cancer, Females
- Trial name
- MindCRC (NCT06323421)
- Testing
- Mindfulness
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Type 2 Diabetes Mellitus
The Effect of Resistant Starch Bagels on Risk Factors of Type 2 Diabetes and Colorectal Cancer
The purpose of this study is to determine if consumption of bagels made with resistant starch for 8 weeks can improve markers of type 2 diabetes, colon cancer and satiety in adults.
- Trial name
- NCT02129946
- Testing
- Resistant Starch
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Guelph
Neuroendocrine Neoplasm of Lung, Neuroendocrine Neoplasm of Gastrointestinal Tract (Disorder)
Risk Factors for Neuroendocrine Neoplasms
Recent studies show an increase in neuroendocrine neoplasms, especially for the digestive tract. Previous studies suggest various risk factors that were observed for various tumor sites, e.g.
- Trial name
- NCT06282016
- Testing
- Case-control study (no intervention)
- Where
- Germany
- Volunteers
- 14,250 people, healthy volunteers welcome
- Sponsor
- Bavarian Cancer Registry
Colorectal Cancer, Colorectal Neoplasms
Clinical Performance of the Mainz Biomed Colorectal Cancer Screening Test for Colorectal Cancer and Advanced Adenoma
This study is to determine how the Mainz Biomed Colorectal Cancer Screening Test works when used in people aged ≥45 years of age and at an average risk of developing colorectal cancer.
- Conditions
- Colorectal Cancer, Colorectal Neoplasms, Colorectal Polyp, Colorectal Adenoma
- Trial name
- reconAAsense (NCT05636085)
- Testing
- Mainz Biomed Colorectal Cancer Screening Test
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- Mainz Biomed
Gastrointestinal Disease, Colorectal Cancer
Randomized Controlled Study Comparing Colon Evaluation With The Pure-Vu System To A Standard Colonoscopy In Patients Who Are High Risk For Inadequate Bowel Preparation
The primary objective of this multi-center, prospective, randomized controlled trial is to evaluate the bowel cleansing after Pure-Vu use in outpatient subjects at high risk for inadequate colon preparation as compare to standard…
- Trial name
- RESCue (NCT04285008)
- Testing
- Pure-Vu System
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Motus GI Medical Technologies Ltd
Colorectal Cancer, Colorectal Adenoma
Volatile Markers in Digestive Cancer
The study is aimed to determine the potential of volatile marker testing for identification of gastrointestinal cancers (in particular - colorectal and gastric cancers), the related precancerous lesions in the stomach and colon.
- Conditions
- Colorectal Cancer, Colorectal Adenoma, Gastric Cancer, Peptic Ulcer Disease
- Trial name
- VOLGACORE (NCT02332213)
- Testing
- Breath sampling for volatile marker detection, Upper endoscopy with biopsies, Colonoscopy with biopsies or lesion removal when required
- Where
- 2 sites in Latvia, Lithuania
- Volunteers
- 2,022 people, healthy volunteers welcome
- Sponsor
- University of Latvia
Colonic Neoplasms
Comparison of Oral Lactulose Versus Polyethylene Glycol for Bowel Preparation in Low-risk Patients
Adequate quality of bowel preparation(BP) is essential for colonoscopy. In recently, Kang suggested that for low-risk patients, single dose of 2L PEG is an effective regimen for bowel preparation.However, due to the poor…
- Trial name
- NCT05648318
- Testing
- Lactulose oral solution, PEG
- Where
- China
- Volunteers
- 255 people, healthy volunteers welcome
- Sponsor
- Zhang Xiaofeng,MD