Clinical trials: Risk of Heat Stress
Obesity, Polycystic Ovary Syndrome
Heat Therapy and Cardiometabolic Health in Obese Women
Traditional medical treatments are often based on research done exclusively in males, and recent research efforts in the physiology community have highlighted critical sex differences in disease presentation and progression.
- Conditions
- Obesity, Polycystic Ovary Syndrome, Prehypertension, PreDiabetes
- Trial name
- CMH (NCT03644524)
- Testing
- Heat therapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Oregon
Heathly Subjects, Primary Health Care
Assessing the Effectiveness of Heat Adaptation Digital Messages From Primary Care Providers to Their Patients on the Change in Behaviour for Heatwave-related Preparedness
Extreme heat events pose a significant health threat in Canada, as demonstrated by the 2021 heat wave that claimed over 600 lives in Western Canada. Most heat-related deaths occur indoors and are preventable.
- Conditions
- Heathly Subjects, Primary Health Care, Climate Change, Public Health
- Trial name
- HeatSmart (NCT07024628)
- Testing
- Heat adaptation digital messaging, Non-heat-related digital messaging
- Where
- Canada
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Hopital Montfort
Thermoregulation
Physiological Responses to Heat Stress During High-risk Events
Exertional heat stroke (EHS) affects ~500 Military Personnel and over 100 Soldiers every year, and it is believed that these numbers are underreported.
- Trial name
- NCT06907225
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Exertional Heat Illness, Hydration Status
Comparing Risk of Heat Illness Based on Peak Core Temps During Preseason Football Camp Across 3 Different Age Levels
To collect field data in professional, collegiate, and high school football players to determine how they respond physiologically to the rigors of preseason training environment.
- Trial name
- NCT01954537
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Risk of Heat Stress
Impact of Pre-cooling in Adolescent Tennis Athletes
Many tennis tournaments are played outdoors in hot and humid conditions, which poses a significant challenge particularly for children athletes.
- Trial name
- NCT04197375
- Testing
- Thermal stress and performance using a pre-cooling protocol, Thermal stress and performance without a pre-cooling protocol
- Where
- Greece
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Petros Dinas
Exertional Heat Illness
Risk Factors for Exertional Heat Illness
The arduous nature of military training and operations require personnel to encounter high heat load, e.g., during intense physical exertion, particularly in the heat.
- Trial name
- NCT04979455
- Testing
- Core temperature monitoring, Questionnaires, Heart rate monitoring
- Where
- United Kingdom
- Volunteers
- 790 people, healthy volunteers welcome
- Sponsor
- Liverpool John Moores University
Obesity & Overweight
Acute Sauna Session and Glucose Control
The goal of this clinical trial is to examine the effect of a single 40-minute sauna session on glucose control in individuals at risk for metabolic impairments.
- Trial name
- NCT07520929
- Testing
- Infrared sauna session, Resting condition
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- University of Prince Edward Island
Hyperthermia, Kidney Injury, Acute
Biomarkers to Assess Acute Kidney Injury Risk During Heat Strain
Prolonged, high intensity work in a hot environment results in significant strain on the body, known as heat strain. Heat strain in hot occupational settings such as agriculture, fire suppression, and military work can lead to…
- Trial name
- NCT05710978
- Testing
- Work Protocol
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Cardiovascular Diseases, Respiratory Diseases
Study on Intervention Effect of Heat-related Health Risk Early Warning Digital Technology for School-age Children
This cluster randomized trial is conducted in Beijing primary schools to evaluate the efficacy of a WeChat mini-program-based high-temperature early warning intervention on the physical and cognitive health of school-age…
- Conditions
- Cardiovascular Diseases, Respiratory Diseases, Mental Health Disorders, Heat Illness
- Trial name
- NCT07643571
- Testing
- WeChat Mini-program Based Heat Health Risk Early Warning Intervention
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention, China
Cardiovascular Diseases, Cancer
Genomic Medicine Risk Assessment Care for Everyone - Implementation Phase
The "Genomic medicine Risk Assessment Care for Everyone" (GRACE)" intervention project will develop a scalable end-to-end solution for risk assessment and management that meets the needs of those populations living in low…
- Conditions
- Cardiovascular Diseases, Cancer, Liver Diseases, Hyperthermia
- Trial name
- GRACE (NCT06278883)
- Testing
- Disease Risk Assessment
- Where
- 4 sites in United States
- Volunteers
- 245 people, healthy volunteers welcome
- Sponsor
- Duke University
Sarcoma,Soft Tissue
Feasibility of Total Neoadjuvant Treatment With HYPErthermia in Patients With High-risk Extremity and Trunk Soft Tissue Sarcoma (TNT-HYPE)
Soft tissue sarcomas (STSs) are rare cancers with a 5-year survival rate of 60%, and there is no standard treatment for high-risk extremity and trunk STSs (eSTS).
- Trial name
- TNT-HYPE (NCT06835049)
- Testing
- Doxorubicin, Ifosfamide, Dacarbazine
- Where
- 8 sites in Switzerland
- Volunteers
- 24 people
- Sponsor
- Swiss Cancer Institute
Breast Neoplasms
Vaccination Against High Risk Breast Cancer Using Tumor Derived Heat Shock Protein 70
Description: The trial is designed to determine the response of the immune system of patients with breast cancer to a vaccine made from their own tumor.
- Trial name
- NCT00027131
- Testing
- Heat Shock Protein 70-peptide complexes (HSP70)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- UConn Health
Risk of Heat Stress
Effect of Aging and Aerobic Fitness Level on Heat Dissipation
In the context of global aging, the health risk factors associated with exercising or working in the heat for aging population are exacerbated by the rising in global surface temperatures.
- Trial name
- NCT04241900
- Testing
- Shuttle run test
- Where
- 2 sites in Greece
- Volunteers
- 431 people, healthy volunteers welcome
- Sponsor
- Petros Dinas
Carrier State, Heat Stroke
Genetic Risk Factor for Heat Stroke
The goal of this observational study is to examine the effect of the Cystic Fibrosis (CF) Carrier state on the risk for dehydration and other CF-specific fluid-and-electrolyte disorders in male and female adults.
- Conditions
- Carrier State, Heat Stroke, Dehydration
- Trial name
- NCT06847256
- Testing
- Heat Challenge
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Iowa
Venous Thromboembolism (VTE), Acute Myocardial Infarction With ST Segment Elevation
Heat Shock Protein 47 in Thrombosis
The goal of this observational study is to learn if the novel biomarker Heat shock protein 47 (HSP47) can be used as a prognostic marker for vascular disease in people with acute venous thromboembolism (VTE), myocardial…
- Conditions
- Venous Thromboembolism (VTE), Acute Myocardial Infarction With ST Segment Elevation, Stroke (in Patients With Atrial Fibrillation)
- Trial name
- NCT06731673
- Where
- 2 sites in Denmark, Germany
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Cardiovascular Risk Factor, Heat Stress
Exercise and Sauna on Blood Pressure and Cardiovascular Health
The study aims to investigate the effects of including regular heat therapy when included to exercise. Specifically, participants in the sauna intervention group will undergo 15 minutes of sauna exposure immediately after a…
- Conditions
- Cardiovascular Risk Factor, Heat Stress, Sedentary Behavior
- Trial name
- ES2019 (NCT04540718)
- Testing
- Exercise, Sauna
- Where
- Finland
- Volunteers
- 47 people
- Sponsor
- University of Jyvaskyla
High-risk Pregnancy
Leg Heating in Pregnant Women With Obesity
Obesity is a major risk factor for hypertensive disorders of pregnancy (HDP). The underlying mechanisms are largely unclear, but maternal vascular endothelial dysfunction is likely involved.
- Trial name
- NCT06932250
- Testing
- Leg heating
- Where
- United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Risk of Heat Stress
Occupational Heat Stress on Workers' Productivity
Workplace heat exposure affects billions of people during their everyday work activities. Occupational heat stress impairs workers' health and capacity to perform manual labour.
- Trial name
- NCT04160728
- Testing
- Work/ rest scenario, Hydration scenario, Clothing scenario
- Where
- Greece
- Volunteers
- 248 people, healthy volunteers welcome
- Sponsor
- Petros Dinas
Weather Risk Perception
Perceptions of Weather Risks and Climate Beliefs Among the Hong Kong General Public
Background: Local abnormal heat events may be used as proxies for communicating the health impacts of climate change when people physically feel the effects to reduce the psychological distance of climate change and improve…
- Trial name
- NCT04919148
- Testing
- Heat risk and pro-environment behavior message
- Where
- Hong Kong
- Volunteers
- 429 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Heat Stroke
Study of Risk Factors for the Occurrence and Severity of Exertional Heatstroke in the Military Environment
Although the circumstances of onset and management of exertional heatstroke have been identified for several years, its pathophysiology remains imperfectly understood. Exertional heatstroke is the result of both extrinsic (i.e.
- Trial name
- EXPLO-CCE (NCT04593316)
- Testing
- Saliva collection, Questionnaires, Ingestible core temperature capsule intake
- Where
- 3 sites in France
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Direction Centrale du Service de Santé des Armées