Clinical trials: Rokitansky Kuster Hauser Syndrome
Rokitansky Kuster Hauser Syndrome, Sterility, Female
Uterus Transplantation Procedure From a Live Donor
Absolut uterine factor, meaning the absence of uterus, represents a cause for sterility without the possibility of a present treatment.
- Trial name
- NCT04314869
- Testing
- Uterus transplantation
- Where
- Spain
- Volunteers
- 10 people
- Sponsor
- Hospital Clinic of Barcelona
Mayer Rokitansky Kuster Hauser Syndrome, Quality of Life
Quality of Life and Sexual Function in Vaginal Aplasia Patients After Davydov Procedure
Mayer-Rokitansky-Kuster-Hauser(MRKH) syndrome is described as absence or underdevelopment of vagina and uterus. This condition is extremely rare congenital malformation that affects one in every 5000 female births.
- Conditions
- Mayer Rokitansky Kuster Hauser Syndrome, Quality of Life, Sexual Function Disturbances
- Trial name
- NCT04923217
- Where
- Vietnam
- Volunteers
- 29 people
- Sponsor
- School of Medicine - Vietnam National University at Ho Chi Minh city
Mrk Anomaly, Infertility, Female
Uterus Transplantation LD - Feasibility Study - Sahlgrenska - BMC
Medical know-how concerning uterus transplantation will be transferred to new site by structured process involving theory, animal workshops and a clinical feasibility study on human subjects.
- Trial name
- GOT-BMC-UTx (NCT03590405)
- Testing
- uterus transplantation surgery and IVF
- Where
- 2 sites in Sweden
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Sahlgrenska University Hospital
Mayer Rokitansky Kuster Hauser Syndrome, Uterine Agenesis
The University of Pennsylvania Uterus Transplant for Uterine Factor Infertility Trial
Options for childbearing are limited for the thousands of women in the United States who suffer from absolute uterine factor infertility. Uterine transplantation is an emerging treatment that provides hope for these individuals.
- Conditions
- Mayer Rokitansky Kuster Hauser Syndrome, Uterine Agenesis, Infertility, Female, of Uterine Origin, Uterine Factor Infertility
- Trial name
- UNTIL (NCT03307356)
- Testing
- Uterine Transplant
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Mrkh Syndrome
Evaluation of the Quality of Life and Gynecological Follow-up of Patients Treated for Mayer-Rokitansky-Küster-Hauser (MRKH) Syndrome
Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome affects 1 in 4,500 women and consists of utero-vaginal aplasia in 46 chromosom XX women, most often diagnosed in the presence of primary amenorrhea.
- Trial name
- MOQA (NCT07186764)
- Testing
- Questionnaires, Semi-directed interview
- Where
- France
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Absolute Uterine Factor Infertility, Transplantation
Uterus Transplantation From Deceased Donor - Gothenburg III
Deceased donor uterus transplantation will be offered to patients that have either been excluded from Gothenburg II because of donor criteria or because of early graft failure in Gothenburg I and II
- Conditions
- Absolute Uterine Factor Infertility, Transplantation, Mrk Anomaly
- Trial name
- NCT03581019
- Testing
- uterus transplantation
- Where
- 2 sites in Sweden
- Volunteers
- 1 people
- Sponsor
- Sahlgrenska University Hospital
Mayer Rokitansky Kuster Hauser Syndrome, Absence of Uterus
Uterine Transplant for Women With Absolute Uterine Factor Infertility (AUFI)
Absolute Uterine Factor Infertility (AUFI) is due to congenital or surgical absence of a uterus or the presence of a nonfunctional uterus.
- Conditions
- Mayer Rokitansky Kuster Hauser Syndrome, Absence of Uterus, Infertility of Uterine Origin
- Trial name
- NCT05263076
- Testing
- Uterine Transplant
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- John Goss
Mayer Rokitansky Kuster Hauser Syndrome
Feasibility Study of Uterine Transplantation From Living Donors in Terms of Efficacy and Safety in Patients With Mayer-Rokitansky-Küster-Hauser Syndrome (MRKH)
In France, one in 4500 women is affected by the MayerRokitantskyKüsterHauser (MRKH) syndrome which is characterized by the absence of uterus at birth.
- Trial name
- NCT03689842
- Testing
- Uterine transplantation
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hopital Foch
Mayer Rokitansky Kuster Hauser Syndrome
Vaginal Lactobacillus for Postoperative Microecology and Mucosal Repair in MRKH Syndrome
This study is aimed to evaluate the promoting effects of vaginal Lactobacillus capsule on microecological reconstruction and mucosal repair of the neovagina after biological graft vaginoplasty in patients with MRKH syndrome, …
- Trial name
- NCT07865559
- Testing
- postoperative application of vaginal Lactobacillus capsule, routine care
- Volunteers
- 32 people
- Sponsor
- Obstetrics & Gynecology Hospital of Fudan University
Mayer Rokitansky Kuster Hauser Syndrome
Molecular Genetic Study of Mayer-Rokitansky-Kuster-Hauser Syndrome
In order to understand the molecular mechanisms leading to Mayer-Rokitansky-Kuster-Hauser syndrome (MRKH), the research team has to identify molecular bases of this anomaly.
- Trial name
- MRKH (NCT02967822)
- Testing
- Biological samples for patients, Biological samples for healthy relatives
- Where
- 2 sites in France
- Volunteers
- 410 people, healthy volunteers welcome
- Sponsor
- Imagine Institute
Mayer Rokitansky Kuster Hauser Syndrome, Müllerian Agenesis
Clinical and Imaging Features in MRKH Syndrome
Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is a congenital condition characterized by uterovaginal agenesis in phenotypically normal women with a 46,XX karyotype.
- Trial name
- ROK-US (NCT07321782)
- Where
- Italy
- Volunteers
- 25 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Rokitansky Kuster Hauser Syndrome, Vaginal Neoplasms
Peritoneum Vaginoplasty; Implementation According to IDEAL Framework
This study aims to assess if a single flap peritoneum vaginoplasty is safe and feasible.The IDEAL framework for evaluation and implementation of surgical techniques will be used.
- Conditions
- Rokitansky Kuster Hauser Syndrome, Vaginal Neoplasms, Gender Incongruence, Vaginal Obstruction
- Trial name
- PeriVaS (NCT05925361)
- Testing
- Laparoscopic pedicled single flap peritoneum vaginoplasty
- Where
- Netherlands
- Volunteers
- 13 people
- Sponsor
- Amsterdam UMC, location VUmc
Mayer Rokitansky Kuster Hauser Syndrome
Neovaginoplasty Using Photoinduced-imine-crosslink Hydrogel in MRKH Patients
Evaluating the effectiveness and safety of neovaginoplasty using photoinduced-imine-crosslink hydrogel in patients with MRKH syndrome by comparing the differences in the degree of squamous epithelialization, vaginal length and…
- Trial name
- NCT06508151
- Testing
- neovaginoplasty and vaginal mold spreaded with photoinduced-imine-crosslink hydrogel, neovaginoplasty and vaginal mold
- Volunteers
- 20 people
- Sponsor
- Obstetrics & Gynecology Hospital of Fudan University
Mayer Rokitansky Kuster Hauser Syndrome, Mullerian Aplasia
Uterus Transplantation From Live Donors and From Deceased Donors - Clinical Study
Uterus transplantation (UTx) is the only causative treatment for congenital or acquired uterus absence. Individual cases of UTx from a live donor (LD UTx) with healthy child birth performed so far showed favourable outcomes.
- Conditions
- Mayer Rokitansky Kuster Hauser Syndrome, Mullerian Aplasia, Uterus; Absence, Congenital, Infertility, Female
- Trial name
- UTxLD/DBD (NCT03277430)
- Testing
- Live donor uterus transplantation, Deceased donor uterus transplantation, Tacrolimus
- Where
- Czechia
- Volunteers
- 20 people
- Sponsor
- Institute for Clinical and Experimental Medicine
Mrkh Syndrome
Evolution of the Quality of Life and Experience of Young Women With Utero-vaginal Aplasia (MRKHPSY)
This study aims to evaluate the global evolution of the quality of life on patients diagnosed with MRKH syndrome (Mayer-Rokitansky-Kuster-Hauser), 8 to 10 years after the first research.
- Trial name
- MRKHPSY (NCT05415540)
- Testing
- Questionnaires
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Infertility, Female, Mayer Rokitansky Kuster Hauser Syndrome
Uterus Transplantation From a Multi-organ Donor
Uterus transplantation: screening, in vitro fertilization [IVF] treatment to be able to freeze embryos, uterus transplantation, pregnancy and afterwards removal of the uterus.
- Trial name
- NCT03252795
- Testing
- uterus transplantation
- Where
- Belgium
- Volunteers
- 20 people
- Sponsor
- University Hospital, Ghent