Clinical trials: Root Canal Treatment
Root Canal Treatment, Post Operative Pain
A First in Human Study to Compare Feasibility of Inertial Cavitation Irrigation to SNI in Root Canal Treatment.
The study design is a single-center 2-arm randomized controlled clinical trial. 10 subjects (teeth) requiring a root canal treatment will be enrolled in 2 groups (5 in each group).
- Trial name
- NCT05374434
- Testing
- Conventional irrigation, Inertial cavitation
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Lumendo AG
High Grade Anal Canal Squamous Intraepithelial Neoplasia, Human Immunodeficiency Virus
Development of a Health-Related Symptom Index for Participants With and Either Treated or Monitored for Anal High-Grade Squamous Intraepithelial Lesions
This trial develops a health-related symptom index for participants with and either treated or monitored for anal high-grade squamous intraepithelial lesions.
- Trial name
- NCT04276935
- Testing
- Interview, Quality-of-Life Assessment, Questionnaire Administration
- Where
- 4 sites in United States
- Volunteers
- 20 people
- Sponsor
- AIDS Malignancy Consortium
Anal Cancer
Intensity-Modulated Radiation Therapy, Fluorouracil, and Mitomycin C in Treating Patients With Invasive Anal Cancer
RATIONALE: Specialized radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue.
- Trial name
- NCT00423293
- Testing
- fluorouracil, mitomycin C, Intensity-modulated radiation therapy
- Where
- 172 sites in United States, Canada
- Volunteers
- 63 people
- Sponsor
- Radiation Therapy Oncology Group
Pain
Comparative Evaluation of Post-endodontic Pain Using Two Rotary Instrumentation Systems
In this study the investigators aim to compare the post-operative pain using two single-file endodontic rotary systems : Reciproc and One shape.
- Trial name
- NCT02621034
- Testing
- Control, Reciproc, One shape
- Where
- Iran
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Zahedan University of Medical Sciences
Skull Base Neoplasms, Skull Neoplasms
Proposal for Intraoperative Administration of Intravenous Indocyanine Green to Evaluate Position of the Optic Canal, Position of the Internal Carotid Arteries, Tumor Vascularization, and Vessel Encasement in Endoscopic Endonasal Cranial Base Surgery
This study is being done to demonstrate the feasibility of using a nasal endoscope to perform intraoperative angiography of surgical field, with the goals to evaluate anatomical landmarks and tumor characteristics during skull…
- Conditions
- Skull Base Neoplasms, Skull Neoplasms, Bone Neoplasm, Neoplasms
- Trial name
- ICG2 (NCT03072186)
- Testing
- near-infrared light nasal endoscope used with ICG
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Ohio State University
HC-BPPV
Treatment of Apogeotropic Horizontal Canal Benign Paroxysmal Positional Vertigo
The purpose of this study was to compare the immediate efficacies of each treatment maneuvers in treatment of apogeotropic horizontal canal benign paroxysmal positional vertigo (HC-BPPV).
- Trial name
- BPPV-HC (NCT00810641)
- Testing
- Gufoni maneuver, Head-shaking maneuver
- Where
- 2 sites in South Korea
- Volunteers
- 157 people
- Sponsor
- Chonbuk National University
Pain, Postoperative Pain
Efficacy of Different Drugs to Control Post Root Canal Treatment Pain
Root canal therapy will ideally eliminate post-endodontic pain but occasionally analgesics are needed to diminish the pain [Owatz et al 2007].
- Conditions
- Pain, Postoperative Pain, Irreversible Pulpitis
- Trial name
- NSAID (NCT02417337)
- Testing
- Paracetamol, Ibuprofen, Mefenamic Acid
- Where
- Sudan
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- University of Khartoum
Root Canal Therapy
Sonendo GentleWave™ System for Treatment in Molar Teeth Requiring Root Canal Therapy
A prospective, literature controlled, clinical study evaluating healing rates for the Sonendo GentleWave System in the treatment of 1st and 2nd molars indicated for root canal therapy.
- Trial name
- SUPREME (NCT02285595)
- Testing
- Sonendo GentleWave™ System
- Where
- 3 sites in United States
- Volunteers
- 69 people
- Sponsor
- Sonendo, Inc.
Anal Canal Squamous Cell Carcinoma, Stage I Anal Cancer AJCC v8
Linear Energy Transfer (LET)-Optimized Intensity Modulated Proton Therapy (IMPT) as a Component of Definitive Chemoradiation for Newly Diagnosed Squamous Cell Carcinoma of the Anal Canal: a Feasibility Trial
This phase II trial studies the side effects of LET-IMPT and standard chemotherapy, and how well they work in treating patients with newly diagnosed stage I-III anal canal squamous cell cancer.
- Conditions
- Anal Canal Squamous Cell Carcinoma, Stage I Anal Cancer AJCC v8, Stage II Anal Cancer AJCC v8, Stage IIA Anal Cancer AJCC v8
- Trial name
- NCT03690921
- Testing
- Cisplatin, Fluorouracil, Linear Energy Transfer-Optimized Intensity Modulated Proton Therapy
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- M.D. Anderson Cancer Center
Human Papillomavirus-16 Positive, Human Papillomavirus-18 Positive
DNA Plasmid-encoding Interleukin-12/HPV DNA Plasmids Therapeutic Vaccine INO-3112 and Durvalumab in Treating Patients With Recurrent or Metastatic Human Papillomavirus Associated Cancers
This phase II trial studies how well deoxyribonucleic acid (DNA) plasmid-encoding interleukin-12/human papillomavirus (HPV) DNA plasmids therapeutic vaccine INO-3112 and durvalumab work in treating patients with human…
- Conditions
- Human Papillomavirus-16 Positive, Human Papillomavirus-18 Positive, Metastatic Malignant Neoplasm, Recurrent Anal Canal Carcinoma
- Trial name
- NCT03439085
- Testing
- DNA Plasmid-encoding Interleukin-12/HPV DNA Plasmids Therapeutic Vaccine MEDI0457, Durvalumab
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- M.D. Anderson Cancer Center
Endodontic Disease, Post Operative Pain
Effect of Post-Operative Anesthetics on Post-Operative Pain in Patients Receiving Endodontic Treatment
This study will assess the efficacy of two local anesthetics (2% lidocaine 1:100,000 epinephrine and 0.5% bupivicaine 1:200,000 epinephrine) in reducing post-operative pain in patients receiving endodontic treatment.
- Conditions
- Endodontic Disease, Post Operative Pain, Symptomatic Irreversible Pulpitis
- Trial name
- NCT05338671
- Testing
- Local anesthetic
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Washington
ACL Surgery
Optimal Location of Nerve Block to Minimize Perioperative Opioid Administration in ACL Surgery: Comparing True Adductor Canal to Proximal Block
This is a prospective, randomized, single blinded trial involving human subjects. The goal of this study is to determine an optimal location (proximal or distal) for the nerve block and whether it will make a difference in how…
- Trial name
- NCT03401450
- Testing
- ACB within true AC with bupivacaine 0.5% 20cc, ACB proximal to true AC with bupivacaine 0.5% 20cc
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- NYU Langone Health
Anal Cancer
Capecitabine, Oxaliplatin, and Radiation Therapy in Treating Patients With Stage II or Stage III Anal Cancer
RATIONALE: Drugs used in chemotherapy, such as capecitabine and oxaliplatin, work in different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00093379
- Testing
- Capecitabine, Oxaliplatin, Radiation Therapy (XRT)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- M.D. Anderson Cancer Center
Root Canal Obturation
Root Canal Obturation With a Ready-to-use Root Canal Sealer (PA1704) Versus BioRoot™ RCS: a Randomized Controlled Trial
The study design is a multicentric randomized controlled non-inferiority trial. 160 subjects (teeth) requiring a primary or a secondary root canal treatment will be enrolled in 2 groups (80 in each group).
- Trial name
- OPTIFILL (NCT04757753)
- Testing
- ready-to-use root canal sealer: PA1704, root canal sealer: BioRoot™ RCS
- Where
- 5 sites in Belgium, France
- Volunteers
- 160 people
- Sponsor
- Septodont
Anal Cancer
Cetuximab, Cisplatin, Fluorouracil, and Radiation Therapy in Treating Patients With Anal Cancer
RATIONALE: Monoclonal antibodies, such as cetuximab, can block tumor growth in different ways. Some find tumor cells and kill them or carry tumor-killing substances to them.
- Trial name
- NCT00316888
- Testing
- cetuximab, cisplatin, fluorouracil
- Where
- 125 sites in United States
- Volunteers
- 63 people
- Sponsor
- ECOG-ACRIN Cancer Research Group
Root Canal Infection, Endodontic Disease
Occurrence of Post-op Pain Following Gentlewave
This is a clinical study that will investigate the occurrence of post-operative discomfort following the use of the Gentlewave System for root canal disinfection and irrigation.
- Conditions
- Root Canal Infection, Endodontic Disease, Endodontic Inflammation, Post-Operative Pain
- Trial name
- NCT03635515
- Testing
- Gentlewave, Standard Endodontic Protocol
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Cancer
Advanced MRI Sequences for Radiation Therapy Treatment Planning
The purpose of this study is to determine if it would be helpful to use advanced MRI imaging techniques to take additional views of the tumor target for radiation treatment planning or treatment follow-up MRI.
- Trial name
- NCT02340715
- Where
- United States
- Volunteers
- 158 people
- Sponsor
- Medical College of Wisconsin
Otomycosis
Efficacy and Safety Study of Miconazole Oil Versus Vehicle on Fungal Infection of the Ear Canal (Otomycosis)
This study involves two portions, a randomized, double-blind portion and an open-label portion, to evaluate the efficacy and safety of Miconazole oil 2% versus its Vehicle in the treatment of fungal infection of the outer ear…
- Trial name
- NCT04432376
- Testing
- miconazole 2% oil, vehicle oil
- Where
- 12 sites in United States
- Volunteers
- 382 people, healthy volunteers welcome
- Sponsor
- Hill Dermaceuticals, Inc.
Dental Anxiety
Comparing Brief Relaxation Period to Virtual Reality Period in Reducing Dental Anxiety Prior to Root Canal Treatment
The goal of this study is to evaluate non-drug approaches to reducing dental anxiety prior to non-surgical root canal treatment.
- Trial name
- NCT05720897
- Testing
- Auditory Alone, Relaxation Virtual Reality
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Indiana University
Radiodermatitis, Injury, Radiation
Study Using Spray Skin Protector Versus Conventional Treatment to Prevent Acute Radiodermatitis.
This is a randomized, open-label, single-institution trial designed to evaluate the effectiveness of a spray skin protector in preventing moist desquamation caused by radiotherapy treatment.
- Trial name
- NCT04067310
- Testing
- Spray skin protector, moisturizer Dnativ Revita derm
- Where
- Brazil
- Volunteers
- 72 people
- Sponsor
- Instituto Nacional de Cancer, Brazil