Clinical trials: Ruptured Appendicitis
Appendicitis
Perforated Appendicitis With Delayed Presentation
There is no consensus among pediatric surgeons regarding the optimal treatment for children with complicated appendicitis with delayed diagnosis.
- Trial name
- NCT01068288
- Testing
- Laparoscopic or open appendectomy, Expectant Management
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- The Hospital for Sick Children
Appendicitis Perforated, Appendectomy, Laparoscopic
Piperacillin/Tazobactam Versus Ceftriaxone and Metronidazole for Children With Perforated Appendicitis
The ALPACA-MC trial is a blinded, multicentre randomized controlled trial comparing two postoperative antibiotic treatments for children undergoing laparoscopic appendectomy for perforated appendicitis.
- Conditions
- Appendicitis Perforated, Appendectomy, Laparoscopic, Antibiotic, Pediatric
- Trial name
- ALPACA-MC (NCT07869095)
- Testing
- Piperacillin/Tazobactam, Ceftriaxone + Metronidazole
- Volunteers
- 180 people
- Sponsor
- McMaster Children's Hospital
Acute Appendicitis, Appendicitis Perforated
Bilirubin Levels to Diagnose Appendicitis and Predict Appendiceal Perforation
The goal of this study is to learn if serum bilirubin levels can aid in the diagnosis of acute appendicitis and predict appendiceal perforation
- Trial name
- NCT06956638
- Testing
- Non-interventional
- Where
- Nepal
- Volunteers
- 98 people
- Sponsor
- Nepalese Army Institute of Health Sciences
Acute Appendicitis
Patient Time and In-hospital Delay of Surgery Association With Complicated Appendicitis
This is a retrospective observational study with its main aim of evaluating possible factors associated with complicated appendicitis.
- Trial name
- NCT04689906
- Testing
- surgery
- Volunteers
- 3,137 people
- Sponsor
- Rambam Health Care Campus
Perforated Appendicitis
The Management of Perforated Acute Appendicitis in Adult and Pediatric Populations
Patients admitted at Marshall Health - Cabell Huntington Hospital with the diagnosis of acute perforated appendicitis or appendicular abscess larger than 3cm will be admitted and treated with percutaneous drainage and the IV…
- Trial name
- NCT04253899
- Testing
- Appendectomy, Observation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Marshall University
Perforated Appendicitis
APPI-Cost Trial for Perforated Appendicitis
The purpose of this study to assess the clinical effectiveness and cost-effectiveness of povidone-iodine (PVI) irrigation in perforated appendicitis, to investigate barriers and facilitators to future implementation of PVI…
- Trial name
- NCT06705842
- Testing
- PVI, Usual Care
- Where
- United States
- Volunteers
- 346 people
- Sponsor
- The University of Texas Health Science Center, Houston
Perforated Appendicitis
Hyperbilirubinemia in Acute Appendicitis as a Predictor of Perforation
It has recently been published that hyperbilirubinemia is a reliable marker for the preoperative diagnosis of perforated acute appendicitis.
- Trial name
- NCT00528138
- Testing
- Laboratory Test
- Where
- Chile
- Volunteers
- 132 people
- Sponsor
- Cirujanos la Serena
Acute, Perforated Appendicitis
Povidone-iodine Irrigation for Prevention of Intra-abdominal Abscess in Pediatric Perforated Appendicitis: a Multi-center Stepped Wedge Cluster Randomized Study
The purpose of this study is to determine the effect of intra-abdominal irrigation with povidone-iodine (PVI) versus usual care on the rate of 30-day postoperative intra-abdominal abscesses (IAA) and to determine the effect of…
- Trial name
- PAPPA (NCT04200729)
- Testing
- Irrigation with PVI, Usual care
- Where
- United States
- Volunteers
- 1,750 people
- Sponsor
- The University of Texas Health Science Center, Houston
Appendicitis Perforated
Piperacillin/Tazobactam Versus ceftriAxone and Metronidazole for Children With Perforated Appendicitis (ALPACA)
This study is an internal pilot for a multicenter, blinded randomized controlled trial. The purpose of the multicenter trial is to determine whether post-operative piperacillin/tazobactam is more effective than ceftriaxone and…
- Trial name
- ALPACA (NCT05943223)
- Testing
- Piperacillin/tazobactam, Normal saline, CefTRIAXone Injection
- Where
- Canada
- Volunteers
- 16 people
- Sponsor
- McMaster Children's Hospital
Perforated Appendicitis
Initial Versus Delayed Operation for Treatment of Complicated Appendicitis In Children
To determine the most cost effective way to treat children with perforated appendicitis we will randomize all children presenting with perforated appendicitis to initial operation, with in 24 hours of admission, or to initial…
- Trial name
- NCT00540189
- Testing
- Initial appendectomy, Interval appendectomy
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Michigan
Acute Appendicitis, Acute Appendicitis With Rupture
Prioritisation of Acute Appendicitis Using Appendistat Score
Introduction Although non-operative management of acute appendicitis may be appropriate in selected cases, surgery remains the gold standard treatment.
- Trial name
- APEX (NCT07197489)
- Where
- 2 sites in United Kingdom
- Volunteers
- 592 people
- Sponsor
- University College, London
Perforated Appendicitis
Effect of Intraperitoneal Drain Placement on Postoperative Outcomes Following Laparoscopic Appendectomy in Adult Patients With Perforated Appendicitis
Acute appendicitis is the most common acute abdomen, and a small number of patients can progress to perforated appendicitis, which has significantly higher complications than non-perforated appendicitis.
- Trial name
- LADPA (NCT06927765)
- Testing
- No abdominal drain is placed
- Where
- China
- Volunteers
- 500 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Appendicitis, Perforated Appendicitis
Optimal Care of Complicated Appendicitis
When the appendix becomes infected and inflamed, it is called appendicitis. Sometimes, if the infection and inflammation get worse, the appendix can die or burst, leading to a larger infection or even pus pockets around the…
- Conditions
- Appendicitis, Perforated Appendicitis, Ruptured Appendicitis, Complicated Appendicitis
- Trial name
- NCT03159754
- Testing
- Early Appendectomy, Interval Appendectomy, Antibiotics
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Michigan
Acute Appendicitis, Acute Appendicitis With Rupture
Modified Enhanced Recovery Program in Emergency Surgery (MERES)
Laparoscopic appendectomy (LA) is a widespread surgical procedure. Patients may develop considerable postoperative pain and dyspepsia resulting in prolong in-hospital stay.
- Conditions
- Acute Appendicitis, Acute Appendicitis With Rupture, Acute Appendicitis With Peritonitis, Acute Appendicitis Without Peritonitis
- Trial name
- MERES (NCT03754777)
- Testing
- Laparoscopic appendectomy
- Where
- Russia
- Volunteers
- 122 people
- Sponsor
- Pirogov Russian National Research Medical University
Appendicitis
Diagnostic Accuracy of Serum Bilirubin in the Prediction of Perforated Appendicitis
Hyperbilirubinemia is reported to be a positive predictor in diagnosing perforated appendicitis. Therefore we analysed the diagnostic accuracy of serum bilirubin in discriminating between perforated and simple/no appendicitis.
- Trial name
- NCT01698099
- Where
- Germany
- Volunteers
- 500 people
- Sponsor
- University Hospital Tuebingen
Perforated Appendicitis
Prospective Randomized Evaluation of Antibiotic Regimen Following Appendectomy for Perforated Appendicitis
The purpose of this study is to compare traditional triple antibiotic therapy against dual single day dosing antibiotic therapy in the management of perforated appendicitis in children.
- Trial name
- NCT00195923
- Testing
- Ampicillin, gentamicin, clindamycin, flagyl, ceftazidime
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Children's Mercy Hospital Kansas City
Appendicitis
Single Incision Laparoscopic Surgery (SILS) Versus Laparoscopic Appendectomy
This is a prospective trial of single incision versus standard 3-port laparoscopic appendectomy. The hypothesis is that there may a difference in wound infection rates, operative time, doses of analgesics post-operatively, and…
- Trial name
- NCT00981136
- Testing
- Single Incision Laparoscopic Appendectomy, 3 port laparoscopic appendectomy
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- Children's Mercy Hospital Kansas City
Appendicitis
Antibiotic Treatment Alone for Acute Simple Appendicitis in Children
Appendectomy for acute appendicitis has recently been questioned as being the only correct treatment for appendicitis. Appendectomy has been reported to have significant early and late morbidity.
- Trial name
- NCT01356641
- Testing
- Antibiotic treatment alone, Appendectomy
- Where
- 4 sites in Netherlands
- Volunteers
- 50 people
- Sponsor
- Ramon R. Gorter
Complicated Appendicitis, Perforated Appendicitis
Antibiotic Duration in Post-appendectomy Abscess
This is a randomized study of patients 2-17 years old who are diagnosed with perforated appendicitis and develop an abscess after laparoscopy that is subsequently drained.
- Trial name
- NCT03795194
- Testing
- ampicillin/clavulanate
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Phoenix Children's Hospital
Perforated Appendicitis
The Effect of Gum Chewing on Postoperative Ileus
The purpose of this study is to see if chewing gum after surgery for perforated appendicitis will shorten the time of intestinal dysfunction.
- Trial name
- NCT00879294
- Testing
- Motion sickness wristband, Chewing Gum
- Where
- United States
- Sponsor
- Wake Forest University