Clinical trials: SARCOIDOSIS
Acute Myocarditis, Cardiac Sarcoidosis
Somatostatin Receptor Imaging in Acute Myocarditis and Cardiac Sarcoidosis
This prospective imaging study investigates the diagnostic ability of Gallium-68 DOTA-TOC (68Ga-DOTA-TOC) positron emission tomography/computed tomography (PET/CT) in the clinical work-up of patients with 1) clinically suspected…
- Trial name
- NCT04206163
- Testing
- 68Ga-DOTA-TOC PET/CT, Blood sample
- Where
- Sweden
- Volunteers
- 78 people
- Sponsor
- Vastra Gotaland Region
Pulmonary Healthy Controls, Interstitial Lung Disease
Evaluation of Novel Lung Function Parameters in Patients With Interstitial Lung Disease (ILD)
Current diagnostic tools used in interstitial lung disease (ILD) do not meet the challenges set by the complex pathophysiology of this heterogenous group.
- Conditions
- Pulmonary Healthy Controls, Interstitial Lung Disease, Idiopathic Pulmonary Fibrosis, Non-specific Interstitial Pneumonia
- Trial name
- NCT02827734
- Testing
- multiple breath washout tests, impulse oscillometry, body plethysmography
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universitätsmedizin Mannheim
Sarcoidosis, Pulmonary
Acthar Gel in Participants With Pulmonary Sarcoidosis
The purpose of this study is to find out if Acthar Gel is safe and effective to treat pulmonary sarcoidosis. Participants will be randomly assigned (like flipping a coin) to receive a shot under their skin of Acthar Gel or a…
- Trial name
- PULSAR (NCT03320070)
- Testing
- Acthar Gel
- Where
- 29 sites in United States
- Volunteers
- 55 people
- Sponsor
- Mallinckrodt
Sarcoidosis
Prognostic Value of Clinical Cardiovascular MRI
The primary objective of this study is to identify findings on cardiovascular MR imaging (CMR) that are specific to various cardiac or vascular disorders in patients undergoing routine CMR scans.
- Trial name
- NCT01745237
- Where
- United States
- Volunteers
- 27,000 people
- Sponsor
- Duke University
Sarcoidosis, Pulmonary
Pirfenidone for Progressive Fibrotic Sarcoidosis
Study comparing pirfenidone versus placebo for patients with advanced fibrotic sarcoidosis
- Trial name
- PirFS (NCT03260556)
- Testing
- Pirfenidone
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Cincinnati
Renal Sarcoidosis
Treatment of Renal Sarcoidosis by Methylprednisolone Bolus
Renal sarcoidosis treatment is based on steroids, but the dose and duration are unknown. Despite this treatment, most patients will have chronic kidney disease.
- Trial name
- CORTICOIDOSE (NCT01652417)
- Testing
- methylprednisolone bolus IV 15 mg/kg/d for 3 days.
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Inflammatory Cardiomyopathy, Sarcoidosis
PET MRI Study in Patients With Cardiac Sarcoidosis
Myocarditis or inflammatory cardiomyopathy refers to inflammation of the heart muscle (the myocardium). Sarcoidosis is a multisystem granulomatous disorder that may involve the heart, causing inflammation, and potentially…
- Trial name
- NCT03356756
- Testing
- simultaneous combined 18F-FDG PET and cardiac MRI imaging
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University Health Network, Toronto
Juvenile Idiopathic Arthritis, Systemic Lupus Erythematosus
The CARRA Registry
This CARRA Registry study will create a foundational database for rheumatic diseases of childhood using a novel informatics infrastructure developed as part of the larger clinical project.
- Conditions
- Juvenile Idiopathic Arthritis, Systemic Lupus Erythematosus, Mixed Connective Tissue Disease, Juvenile Ankylosing Spondylitis
- Trial name
- CARRA Registry (NCT01697254)
- Where
- United States
- Volunteers
- 9,587 people
- Sponsor
- Duke University
Interstitial Lung Diseases
Monitoring and Evaluation Study of Project ECHO for ILD
The study will utilize pre-post survey measures to evaluate Project ECHO for ILD with respect to an initial set of practice and clinical outcomes and relies on questionnaire data obtained from providers participating in Project…
- Trial name
- NCT05455437
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Pulmonary Care and Research Collaborative Limited
Sarcoidosis-associated Pulmonary Hypertension
A Study in Participants With Sarcoidosis-associated Pulmonary Hypertension (SAPH) to Assess the Efficacy and Safety of Oral Selexipag
Oral selexipag is commercially available in several countries for the treatment of a particular group of pulmonary hypertension (PH) called pulmonary arterial hypertension (PAH).
- Trial name
- SPHINX (NCT03942211)
- Testing
- Selexipag
- Where
- 38 sites in United States, Belgium and 8 more
- Volunteers
- 10 people
- Sponsor
- Actelion
Sarcoidosis, Pulmonary
A Study to Estimate the Effect Sizes of HRCT Endpoints in Response to Glucocorticoid Induction Therapy in Subjects With Pulmonary Sarcoidosis
This is a multicenter, single-arm, unblinded/open-label study of the effect size of HRCT endpoints in response to glucocorticoid induction therapy in subjects with a diagnosis of pulmonary sarcoidosis who have not received…
- Trial name
- NCT03324503
- Testing
- Glucocorticoid (prednisone or prednisolone)
- Where
- 20 sites in United States, Netherlands and 1 more
- Volunteers
- 8 people
- Sponsor
- Celgene
Sarcoidosis, JAK-STAT Pathway Deregulation
Expression and Role of the JAK/STAT Pathway in Sarcoidosis Granuloma Cells
Recent studies suggest that the JAK/STAT signaling pathway constitutes a new step in the clinical and therapeutic progress of sarcoidosis.
- Trial name
- JAK-SARC (NCT04751279)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sarcoidosis, Pulmonary
RCT of Nintedanib in Fibrotic Sarcoidosis
Sarcoidosis is generally managed with outdoor immune modulatory drugs, most commonly oral steroids and at times drugs like methotrexate or azathioprine as a steroid sparing agent.
- Trial name
- NINSARC (NCT06479603)
- Testing
- Nintedanib, Standard of care
- Where
- India
- Volunteers
- 120 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Sarcoidosis, Fatigue
Fatigue and Exercise Training in Patients With Sarcoidosis
The aims of the current study is to explore if different exercise training protocols affect fatigue post-exercise, and if sarcoidosis-related fatigue and maximal and sub-maximal cardiopulmonary exercise test (CPET) variables…
- Trial name
- NCT02735161
- Testing
- Muscle strength training, Endurance exercise training
- Where
- Norway
- Volunteers
- 40 people
- Sponsor
- LHL Helse
Sarcoidosis
Inspiratory Muscle Training in Sarcoidosis
Respiratory muscle weakness results with decreased exercise capacity, worse fatigue, dyspnea and quality of life in patients with sarcoidosis.
- Trial name
- NCT02270333
- Testing
- Inspiratory muscle training
- Volunteers
- 30 people
- Sponsor
- Gazi University
Mediastinal Lymphadenopathy, Sarcoidosis, Pulmonary
Diagnostic Yield of Intranodal Forceps Biopsies in Mediastinal Adenopathy
The investigators will compare endobronchial ultrasound transbronchial needle aspiration (EBUS-TBNA) with intranodal forceps biopsy (EBUS-IFB) as it relates to the rate of diagnosis of suspected sarcoidosis.
- Conditions
- Mediastinal Lymphadenopathy, Sarcoidosis, Pulmonary, Mediastinal Diseases
- Trial name
- NCT05374447
- Testing
- Endobronchial Ultrasound-Guided Intranodal Forceps Biopsy
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- George Washington University
Interstitial Lung Disease, Idiopathic Pulmonary Fibrosis
University of Virginia Natural History Study
Data and specimens will be collected longitudinally from patients seen in the UVA Interstitial Lung Disease (ILD) clinic in order to describe the phenotypic expression of various interstitial lung diseases.
- Conditions
- Interstitial Lung Disease, Idiopathic Pulmonary Fibrosis, Sarcoidosis, Connective Tissue Diseases
- Trial name
- NCT04896138
- Testing
- Interstitial Lung Disease
- Where
- United States
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Sarcoidosis
ACE and HLA Genotypes Predict Severity and Disease Progression in Danish Sarcoid Patients
Sarcoidosis is a multisystem granulomatous disease of unknown cause histologically characterized by noncaseating granulomas. Genetic factors affect disease course, which is highly variable and difficult to predict.
- Trial name
- NCT04462068
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- University of Aarhus
Sarcoidosis
Worldwide Sarcoidosis Research Study
The aim of this study is to collect information about the clinical course and characteristics of sarcoidosis patients around the world through web-based surveys.
- Trial name
- WISE (NCT01610843)
- Testing
- Survey
- Where
- United States
- Volunteers
- 2,200 people
- Sponsor
- Alicia Gerke
Medication Adherence, Sarcoidosis
Medication Adherence in Patients With Sarcoidosis
The goal of the study is to look at the relationship between how individuals with Sarcoidosis take the sarcoidosis medicines and how it affects the disease, to evaluate any factors that may make individuals not want to take the…
- Trial name
- MAPS (NCT05438095)
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- Johns Hopkins University