Clinical trials: SARCOIDOSIS
Sarcoidosis
Stromal Gene Expression During Pulmonary Sarcoidosis
to determine the genetic pathways operating at the tissue level to cause granulomatous inflammation in the lungs and lymph nodes of patients with sarcoidosis.
- Trial name
- NCT00837668
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Ohio State University
Pulmonary Sarcoidosis
Study of Efficacy, Safety and Tolerability of ACZ885 (Canakinumab) in Patients With Pulmonary Sarcoidosis
The purpose of this study is to assess if ACZ885 will improve lung function in association with reduction of tissue inflammation in patients with chronic sarcoidosis.
- Trial name
- NCT02888080
- Testing
- ACZ885
- Where
- 8 sites in United States, Germany and 1 more
- Volunteers
- 40 people
- Sponsor
- Novartis Pharmaceuticals
Lymphadenopathy, Lung Cancer
Prevalence and Malignant Involvement of Calcified Intrathoracic Lymph Nodes in Patients Undergoing Endosonography
The presence of calcifications, which is a relatively common feature in intrathoracic lymph nodes, typically contributes to confer them a heterogeneous aspect during endosonographic B-mode examination, but their prevalence and a…
- Conditions
- Lymphadenopathy, Lung Cancer, Sarcoidosis, Tuberculosis
- Trial name
- NCT04743583
- Testing
- Endosonography B-mode examination
- Where
- Italy
- Volunteers
- 362 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Sarcoidosis
Corticosteroid Tapering in Sarcoidosis
Sarcoidosis is an inflammatory condition affecting many different parts of the body but most commonly the lungs. It is not known what causes sarcoidosis.
- Trial name
- SARC-Taper (NCT07498842)
- Testing
- Standard prednisolone taper, Fast prednisolone taper
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Sarcoidosis, Arrhythmogenic Right Ventricular Cardiomyopathy
PET-detected Myocardial Inflammation is a Characteristic of Cardiac Sarcoid But Not of ARVC
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a rare condition in which the heart muscle cells especially of the main pumping chamber (the 'ventricle') is replaced by fat and scar tissue.
- Trial name
- NCT02989480
- Testing
- PET CT, Cardiac MRI
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Aberdeen
Sarcoidosis-associated Ocular Inflammation
Diagnostic Yield of Vitreous Biopsy in Sarcoid Uveitis
The usefulness of diagnostic vitrectomy in patients with suspected sarcoidosis with posterior segment involvement (in whom a diagnosis cannot be determined by conventional methods) has not been well described.
- Trial name
- NCT00609687
- Testing
- Diagnostic Vitrectomy
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Duke University
Sarcoidosis, Pulmonary
Investigation of the Efficacy of Metformin Therapy on Pulmonary Sarcoidosis
This is a double blinded, randomized, placebo controlled clinical trial of 40 participants with pulmonary sarcoidosis. Primary Objective: To assess the steroid-sparing efficacy and safety of oral metformin therapy in participants…
- Trial name
- MetforminTOP (NCT05910554)
- Testing
- Metformin, Cellulose
- Sponsor
- University of Maryland, Baltimore
Sarcoidosis
Patient Reported Outcome Instruments in Sarcoidosis
Evaluate change of quality of life of sarcoiodosis patients over a six months using various quality of life instruments including a monthly smart phone app.
- Trial name
- OSAP-PRO (NCT04342403)
- Testing
- Quality of Life
- Where
- 3 sites in United States
- Volunteers
- 350 people
- Sponsor
- University of Cincinnati
Myelodysplastic Syndromes
Sertraline in Treatment of Low-Risk Myelodysplastic Syndrome
This study will investigate the effects of sertraline in people with low-risk myelodysplastic syndrome (MDS). It is hoped that sertraline will decrease disease progression and reduce the need for blood transfusions.
- Trial name
- SS1 (NCT02452983)
- Testing
- Sertraline, Bone Marrow Aspirate/Biopsy
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- Gustavo Rivero
Giant Cell Arteritis (GCA), Polymyalgia Rheumatica (PMR)
AYLo - AutoimmunitY and Loss of y
The AYLo study (AutoimmunitY and Loss of y - Investigating the Role of Hematopoietic Mutations and Mosaic Mutation in the Y Chromosome in Autoimmune Rheumatologic Diseases) aims to systematically investigate hematopoietic…
- Conditions
- Giant Cell Arteritis (GCA), Polymyalgia Rheumatica (PMR), ANCA Associated Vasculitis (AAV), Idiopathic Inflammatory Myopathies
- Trial name
- AYLo (NCT06696027)
- Testing
- Single nucleotide polymorphisms (SNP), 3'mRNA sequencing, Enzyme-linked immunosorbent assay (ELISA) and Legendplex Array
- Where
- Germany
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Bonn
Sarcoidosis
Sarilumab in Patients With Glucocorticoid-Dependent Sarcoidosis
The purpose of this study is to compare the effectiveness and the safety of sarilumab in patients with glucocorticoid-dependent sarcoidosis.
- Trial name
- NCT04008069
- Testing
- Sarilumab
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Stanford University
Sarcoidosis, Dilated Cardiomyopathy
Cardiac Sarcoidosis and FDG-PET
Sarcoidosis is a multi-systemic inflammatory disorder of unknown cause characterized by the formation of non-caseating granulomas in involved organs. Its cardiac involvement may be potentially fatal.
- Trial name
- NCT00958087
- Where
- Japan
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Kurume University
Pulmonary Sarcoidosis
Imaging of Active Granulomas With [18F]FDG and Selected Inflammatory PET Tracers in Pulmonary Sarcoidosis
The goal of the current study is to evaluate the potential of the selected PET tracers to detect sarcoidotic lesions in lungs. The tracers are already in clinical use for the detection of certain inflammatory processes or…
- Trial name
- NCT02824419
- Testing
- Methionine, DOTANOC
- Where
- Finland
- Volunteers
- 5 people
- Sponsor
- Turku University Hospital
Non-infectious Uveitis
Safety and Efficacy of AIN457 in Noninfectious Uveitis
This study was performed to evaluate the efficacy and safety of AIN457 for patients with active uveitis that requires systemic immunosuppression.
- Trial name
- NCT00685399
- Testing
- AIN457, AIN 457
- Where
- 23 sites in United States, Germany
- Volunteers
- 76 people
- Sponsor
- Novartis Pharmaceuticals
Sarcoidosis
Sarcoidosis and Immune Cells in Lung, Lymph Nodes and Blood
Background: Sarcoidosis is an inflammatory disease, most commonly affecting the lungs and intrathoracic lymph nodes but can affect virtually any organ, sometimes manifesting as life threatening cardiac arrythmias.
- Trial name
- NCT05751447
- Testing
- Lymph node puncture, bronchoscopy
- Where
- Sweden
- Volunteers
- 560 people
- Sponsor
- Region Stockholm
Interstitial Fibrosis, Pulmonary Disease
Inspiratory Muscle Training in Patients With Interstitial Lung Disease
The aim of this study is to evaluate the effects of inspiratory muscle training program in inspiratory muscle endurance, breathlessness, inspiratory muscle strength, functional capacity and quality of life in patients with…
- Conditions
- Interstitial Fibrosis, Pulmonary Disease, Interstitial Lung Disease, Sarcoidosis
- Trial name
- IMT-ILD (NCT04481074)
- Testing
- Inspiratory muscle training
- Where
- 2 sites in Brazil
- Volunteers
- 14 people
- Sponsor
- Federal University of Minas Gerais
Sarcoidosis
Trial of Adalimumab in Progressive Sarcoidosis
Sarcoidosis is a rare disease that can affect any organ in the body. It is characterized by the buildup of immune-system (fights off infection in the body) cells in organs.
- Trial name
- NCT00311246
- Testing
- Adalimumab
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Chicago
Cardiac Sarcoidosis
Interleukin-1 Blockade for Treatment of Cardiac Sarcoidosis
Sarcoidosis is a heterogeneous disorder of unknown etiology whose signature lesions are granulomatous inflammatory infiltrates in involved tissues. Tissue commonly affected are lungs, skin, eyes, lymph nodes and the heart.
- Trial name
- MAGiC-ART (NCT04017936)
- Testing
- Anakinra
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- Virginia Commonwealth University
Pulmonary Hypertension
Tadalafil for Sarcoidosis Associated Pulmonary Hypertension
This study is designed to assess safety and efficacy of tadalafil in patients with Sarcoidosis Associated Pulmonary Hypertension.
- Trial name
- SAPH (NCT01324999)
- Testing
- Tadalafil
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- University of North Carolina, Chapel Hill
Sarcoidosis
A Study of Infliximab in Patients With Sarcoidosis
The purpose of this study is to evaluate the safety and effectiveness of infliximab (Remicade) in patients with Chronic Sarcoidosis.
- Trial name
- NCT00073437
- Testing
- Infliximab
- Volunteers
- 139 people
- Sponsor
- Centocor, Inc.