Clinical trials: SARCOIDOSIS
Patient Diagnosed or Treated for Granulomatous Hepatitis Followed in the Internal Medicine (and or) Hepato-gastroenterology Departments
Lyon Granulomatous Hepatitis Study
Granulomatous hepatitis are histopathologically defined by the presence of epithelioid and gigantocellular granulomas within the hepatic parenchyma. Hepatic granulomas are observed in 2 to 15% of liver biopsies.
- Trial name
- LGH (NCT04459897)
- Testing
- Evaluation of epithelioid and gigantocellular granulomas within the hepatic parenchyma by histopathology approach.
- Where
- 3 sites in France
- Volunteers
- 600 people
- Sponsor
- Hospices Civils de Lyon
Sarcoidosis, Tuberculosis
MoMa Signature During Granulomatosis
Sarcoidosis is a systemic inflammatory disease characterized by unspecific granuloma formation. Our hypothesis is that granuloma formation and maintenance mainly relies on the overactivation of monocytes (Mo) and macrophages…
- Trial name
- MOSAR (NCT05916638)
- Testing
- blood sample
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Sarcoidosis, Arrhythmogenic Right Ventricular Cardiomyopathy
PET-detected Myocardial Inflammation is a Characteristic of Cardiac Sarcoid But Not of ARVC
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a rare condition in which the heart muscle cells especially of the main pumping chamber (the 'ventricle') is replaced by fat and scar tissue.
- Trial name
- NCT02989480
- Testing
- PET CT, Cardiac MRI
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Aberdeen
Sarcoidosis
Stromal Gene Expression During Pulmonary Sarcoidosis
to determine the genetic pathways operating at the tissue level to cause granulomatous inflammation in the lungs and lymph nodes of patients with sarcoidosis.
- Trial name
- NCT00837668
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Ohio State University
Sarcoidosis
Testing Hypersensitivity to Metals in Sarcoidosis Patients by Applying the MELISA Test.
The purpose of this study is to apply the MELISA test, that diagnose hypersensitivity to metals, in Sarcoidosis patients with occupational exposure.
- Trial name
- NCT01809145
- Testing
- MELISA test
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Sarcoidosis, Pulmonary Hypertension
Ambrisentan (Letairis) for Sarcoidosis Associated Pulmonary Hypertension
Hypothesis: Ambrisentan (Letairis ®) is safe and effective in treating pulmonary hypertension in patients with Sarcoidosis
- Trial name
- NCT00851929
- Testing
- Ambrisentan
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- Medical University of South Carolina
Sarcoidosis, Dilated Cardiomyopathy
Cardiac Sarcoidosis and FDG-PET
Sarcoidosis is a multi-systemic inflammatory disorder of unknown cause characterized by the formation of non-caseating granulomas in involved organs. Its cardiac involvement may be potentially fatal.
- Trial name
- NCT00958087
- Where
- Japan
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Kurume University
Myocarditis, ANCA Associated Vasculitis
EACVI Study on Multimodality Cardiovascular Imaging of Inflammatory Cardiovascular Diseases
Inflammatory Cardiovascular Diseases and Autoimmune Rheumatic Diseases (ICARDs) encompass cardiovascular involvement in connective tissue diseases, vasculitis, and primary inflammatory cardiac processes affecting all layers of…
- Conditions
- Myocarditis, ANCA Associated Vasculitis, Pericarditis, Systemic Sclerosis
- Trial name
- EACVI-INFLAME (NCT07077304)
- Testing
- observational study
- Where
- France
- Volunteers
- 5,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cutaneous Sarcoidosis, Granuloma Annulare
Open-label Trial of Tofacitinib in Cutaneous Sarcoidosis and Granuloma Annulare
To investigate the ability of tofacitinib, a Janus kinase (JAK) inhibitor, to treat patients with cutaneous sarcoidosis and granuloma annulare during 6 months of therapy.
- Trial name
- NCT03910543
- Testing
- Tofacitinib 5 mg twice daily
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Yale University
IPF, Sarcoidosis
Nasal, Tracheal and Bronchial Mucosal Lining Fluid(MLF) Sampling From Patients With Respiratory Diseases
Nasal, tracheal and bronchial sampling of MLF in patients with idiopathic pulmonary fibrosis(IPF), sarcoidosis, tuberculosis(TB), asthma and COPD. Similar sampling from healthy controls for comparative data.
- Conditions
- IPF, Sarcoidosis, Tuberculosis, Asthma
- Trial name
- RESPI-SAM (NCT02807025)
- Where
- United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Imperial College Healthcare NHS Trust
Pulmonary Sarcoidosis, Chronic Beryllium Disease
Study Comparing Chronic Beryllium Disease to Pulmonary Sarcoidosis
Inhalation of beryllium can induce specific sensitization and diffuse pulmonary granulomatosis called chronic beryllium disease (CBD).
- Trial name
- BERYSARC (NCT06113991)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pulmonary Sarcoidosis
Study of Efficacy, Safety and Tolerability of ACZ885 (Canakinumab) in Patients With Pulmonary Sarcoidosis
The purpose of this study is to assess if ACZ885 will improve lung function in association with reduction of tissue inflammation in patients with chronic sarcoidosis.
- Trial name
- NCT02888080
- Testing
- ACZ885
- Where
- 8 sites in United States, Germany and 1 more
- Volunteers
- 40 people
- Sponsor
- Novartis Pharmaceuticals
Sarcoidosis
Nicotine Treatment for Pulmonary Sarcoidosis: A Clinical Trial Pilot Study
The purpose of this study is to determine if nicotine treatment is beneficial for the treatment of sarcoidosis. Sarcoidosis is a disease of unknown cause that leads to inflammation. This disease affects your body's organs.
- Trial name
- NCT02265874
- Testing
- Habitrol
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Ohio State University
Sarcoidosis
Validation of a Non-invasive Diagnostic Method for Sarcoidosis Using Exhaled Breath
Sarcoidosis is a chronic lung disease that is characterized by fatigue, shortness of breath, chest pain and reduced lung function. Suffering from these diseases has a very negative effect on the quality of life.
- Trial name
- NCT02361281
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Maastricht University
Sarcoidosis, Mediastinal Diseases
Endobronchial Ultrasonography in the Diagnosis of Sarcoidosis
Sarcoidosis is a benign, inflammatory condition which will typically involve the lungs and lymph glands in the chest. Diagnosis is often confirmed with bronchoscopic biopsy.
- Trial name
- NCT00373555
- Testing
- Bronchoscopy
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of Calgary
Sarcoidosis
The Lung Microbiome in Sarcoidosis
The objective of this study is to determine the presence of bacterial species, and the immunologic and molecular mechanisms of granuloma formation that might be involved in the pathogenesis of sarcoidosis.
- Trial name
- NCT02520323
- Testing
- Blood draw, Bronchoscopy, Questionnaires
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Optic Neuritis, Transverse Myelitis
Swiss Pediatric Inflammatory Brain Disease Registry (Swiss-Ped-IBrainD)
The Swiss-Ped-IBrainD is a national patient registry that collects information on diagnosis, symptoms, treatment, and follow-up of pediatric patients with an inflammatory brain disease in Switzerland.
- Conditions
- Optic Neuritis, Transverse Myelitis, Acute Disseminated Encephalomyelitis, Multiple Sclerosis
- Trial name
- NCT05017142
- Where
- 13 sites in Switzerland
- Volunteers
- 500 people
- Sponsor
- University of Bern
Pulmonary Sarcoidosis
An Efficacy Study of XTMAB-16 in Patients With Pulmonary Sarcoidosis With or Without Extrapulmonary Manifestations
A study of XTMAB-16 in patients with pulmonary sarcoidosis
- Trial name
- NCT07680166
- Testing
- XTMAB-16
- Volunteers
- 182 people
- Sponsor
- Xentria, Inc.
Juvenile Idiopathic Arthritis, Systemic Lupus Erythematosus
The CARRA Registry
This CARRA Registry study will create a foundational database for rheumatic diseases of childhood using a novel informatics infrastructure developed as part of the larger clinical project.
- Conditions
- Juvenile Idiopathic Arthritis, Systemic Lupus Erythematosus, Mixed Connective Tissue Disease, Juvenile Ankylosing Spondylitis
- Trial name
- CARRA Registry (NCT01697254)
- Where
- United States
- Volunteers
- 9,587 people
- Sponsor
- Duke University
Pulmonary Disease, Oropharyngeal Disease
Role of Helicobacter Pylori and Its Toxins in Lung and Digestive System Diseases
This study will examine bacteria and toxins in the mouth, lung and digestive system that may be the cause of various diseases or symptoms. H.
- Conditions
- Pulmonary Disease, Oropharyngeal Disease, Lymphangioleiomyomatosis, Pulmonary Fibrosis
- Trial name
- NCT00366509
- Where
- United States
- Volunteers
- 157 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)