Clinical trials: SARCOIDOSIS
Hepatic Sarcoidosis, Elevated Alkaline Phosphatase
Ursodeoxycholic Acid (UDCA) for Hepatic Sarcoidosis
This study aims to (1) evaluate efficacy of UDCA in improving liver function and quality of life; (2) monitor safety, tolerability of UDCA, as well as progression of hepatic sarcoidosis and liver disease, in patients diagnosed…
- Trial name
- NCT03602976
- Testing
- Ursodeoxycholic Acid
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Ethan Weinberg
Myelodysplastic Syndromes
Sertraline in Treatment of Low-Risk Myelodysplastic Syndrome
This study will investigate the effects of sertraline in people with low-risk myelodysplastic syndrome (MDS). It is hoped that sertraline will decrease disease progression and reduce the need for blood transfusions.
- Trial name
- SS1 (NCT02452983)
- Testing
- Sertraline, Bone Marrow Aspirate/Biopsy
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- Gustavo Rivero
Sarcoidosis
A Study Evaluating the Diagnostic Yield and Safety of the ProCore vs Conventional EBUS-TBNA Needle in Subjects With Suspected Sarcoidosis
This study evaluates the yield and safety of two different needles for performing endobronchial ultrasound guided transbronchial needle aspiration (EBUS-TBNA) in patients with sarcoidosis.
- Trial name
- NCT03656003
- Testing
- Procore biopsy needle, Conventional biopsy needle
- Where
- India
- Volunteers
- 100 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Sarcoidosis
A Trial to Compare Two Methods of Obtaining Tissue for Diagnosis of Sarcoidosis Namely the Conventional Method or the Ultrasound Guided Method
This trial compares the yield of cTBNA (conventional Transbronchial Needle Aspiration) versus the EBUS-TBNA (Endobronchial Ultrasound guided TBNA) for obtaining cytology when they are combined with endobronchial biopsy and…
- Trial name
- NCT02472808
- Testing
- cTBNA without ROSE, cTBNA with ROSE, EBUS-TBNA without ROSE
- Where
- India
- Volunteers
- 80 people
- Sponsor
- All India Institute of Medical Sciences
Pulmonary Arterial Hypertension, Pulmonary Hypertension
Bardoxolone Methyl Evaluation in Patients With Pulmonary Hypertension (PH) - LARIAT
This study assesses the safety and efficacy of bardoxolone methyl relative to placebo in patients with pulmonary hypertension to determine the recommended dose range, evaluate the change from baseline in 6-minute walk distance…
- Conditions
- Pulmonary Arterial Hypertension, Pulmonary Hypertension, Interstitial Lung Disease, Idiopathic Interstitial Pneumonia
- Trial name
- NCT02036970
- Testing
- Bardoxolone methyl
- Where
- 32 sites in United States, Germany
- Volunteers
- 166 people
- Sponsor
- Biogen
Mediastinal Lymphadenopathy, Hilar Lymphadenopathy
Endobronchial Ultrasound Needle Aspiration With and Without Suction
The main purpose of the present study is to compare the diagnostic yield of different aspiration techniques in Ultrasound-guided Transbronchial Needle Aspiration (EBUS-TBNA) in the diagnosis of hilar/mediastinal adenopathy
- Conditions
- Mediastinal Lymphadenopathy, Hilar Lymphadenopathy, Lymphoma, Lung Neoplasms
- Trial name
- NCT05110950
- Testing
- No suction EBUS-TBNA, Passive suction through dedicated EBUS-TBNA syringe, Manual applied suction EBUS-TBNA through a pistol-grip syringe holder
- Where
- Italy
- Volunteers
- 306 people
- Sponsor
- Università Politecnica delle Marche
Sarcoidosis
High-definition Videobronchoscopy in Sarcoidosis
In the last few years, high-definition (HD) videobronchoscopy has become widely available in the market and will progressively become the standard of care for airway inspection and sampling, as it provides substantially higher…
- Trial name
- NCT04743596
- Testing
- High-Definition Videobronchoscopy
- Where
- 5 sites in Italy, Netherlands and 1 more
- Volunteers
- 152 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Sarcoid Uveitis
Lyon Sarcoid Uveitis Cohort
Sarcoidosis is a systemic disease with unknown etiology. Chronicity of the disease is observed in 1/3 of cases. Five percent of the affected patients are expected to die due to pulmonary worsening.
- Trial name
- LUCS (NCT03863782)
- Testing
- No intervention
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Hospices Civils de Lyon
Interstitial Lung Diseases
Monitoring and Evaluation Study of Project ECHO for ILD
The study will utilize pre-post survey measures to evaluate Project ECHO for ILD with respect to an initial set of practice and clinical outcomes and relies on questionnaire data obtained from providers participating in Project…
- Trial name
- NCT05455437
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Pulmonary Care and Research Collaborative Limited
Sarcoidosis
Clinical and Genetic Study of Familial Sarcoidosis (SARCFAM)
Major impacts of air pollution are lung diseases such as granulomatous diseases and mainly sarcoidosis. Understanding the respective role of inorganic / nanoparticles and genetic background in these chronic diseases is a major…
- Trial name
- SARCFAM (NCT02829853)
- Testing
- Genetic analysis by SANGER and WHOLE EXOME NEXT GENERATION SEQUENCING
- Where
- France
- Volunteers
- 800 people
- Sponsor
- Hospices Civils de Lyon
Sarcoidosis, Pulmonary Hypertension
Safety and Efficacy Study of Bosentan in Progressive Pulmonary Sarcoidosis
Progressive pulmonary sarcoidosis occurs in up to twenty percent of patients who require persistent treatment, but available treatment options have shown considerable long-term toxicity and uncertain or unproven efficacy.
- Trial name
- BOPSAC (NCT00926627)
- Testing
- bosentan
- Where
- 2 sites in Austria
- Volunteers
- 32 people
- Sponsor
- Daniel Doberer
Peripheral Neuropathy, Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Clinical Trial to Assess the Safety of a Novel Scaffold Biomaterial
This is safety study. Subjects will be undergoing the surgical procedure of nerve biopsy. After routine surgery without grafting, patients develop swelling, redness, tenderness and dysesthesia at the biopsy site.
- Conditions
- Peripheral Neuropathy, Chronic Inflammatory Demyelinating Polyradiculoneuropathy, Vasculitic Neuropathy (Disorder), Amyloidosis
- Trial name
- NCT03584022
- Testing
- Biopsy + Nerve Repair, Biopsy Only
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Sarcoidosis, Sarcoidosis, Pulmonary
The Role of Physical Activity and Diet Within Pulmonary Sarcoidosis
This project focuses on the sub-group population with pulmonary sarcoidosis - a condition that causes red swollen tissue called granulomas to develop in organs such as the lungs.
- Conditions
- Sarcoidosis, Sarcoidosis, Pulmonary, ILD, Interstitial Lung Disease
- Trial name
- NCT03336736
- Testing
- Exercise
- Where
- 2 sites in United Kingdom
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Kingston University
Pulmonary Sarcoidosis
Study of Nicotine Patches in Patients With Sarcoidosis
The purpose of this study is to compare peoples with disease (sarcoidosis) to those without disease. We want to see if people with sarcoidosis have a different immune response to those people without disease.
- Trial name
- NCT00701207
- Testing
- nicotine patch
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Elliott Crouser MD
Lung Cancer,, Mediastinal Tumors,
Virtual Bronchoscopy (VB) vs. Endobronchial Ultrasound (EBUS) Guided Mediastinal Sampling
The study has been designed to evaluate the clinical application of the new virtual bronchoscopy (VB) -based system for transbronchial sampling of the mediastinal masses or enlarged lymph nodes.
- Conditions
- Lung Cancer,, Mediastinal Tumors,, Lymphomas,, Sarcoidosis,
- Trial name
- VB/EBUS-TBNA (NCT01784185)
- Testing
- virtual bronchoscopy guided transbronchial needle aspiration, endobronchial ultrasound guided transbronchial needle aspiration
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- Medical University of Warsaw
Myocarditis, Cardiac Sarcoidosis
Inflammatory Cardiomyopathy Bern Registry
Inflammatory cardiomyopathies are associated with inflammation and impaired function of the heart muscle and encompass myo- and pericarditis and cardiac sarcoidosis.
- Conditions
- Myocarditis, Cardiac Sarcoidosis, Pericarditis
- Trial name
- FlamBer (NCT04774549)
- Where
- Switzerland
- Volunteers
- 1,125 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Suspected Sarcoidosis
Comparing Menghini-type Needle and Franseen-type Needle in EBUS-TBNA for Sarcoidosis
This randomized pilot clinical trial aims to examine whether sample collection with Franseen-type needles are effective for the diagnosis of sarcoidosis, as defined by improved sample quality for pathological diagnosis compared…
- Trial name
- NCT06220526
- Testing
- endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA)
- Where
- Canada
- Volunteers
- 128 people
- Sponsor
- University Health Network, Toronto
Thyroid Pathology, Head and Neck Cancer (H&N)
FAPI PET Imaging - An Exploratory Study
This study is testing a new imaging tracer called [18F]FAPI-74 with PET scans. Researchers want to find out how well this tracer shows certain diseases in the body, including several types of cancer and some non-cancer conditions…
- Conditions
- Thyroid Pathology, Head and Neck Cancer (H&N), Sinonasal Tract Tumor, Sarcoidosis
- Trial name
- FAPIPET (NCT07705074)
- Testing
- [18F]FAPI-74 PET/CT
- Where
- 5 sites in Switzerland
- Volunteers
- 770 people
- Sponsor
- Martin Huellner
SARCOIDOSIS
Sarcoidosis-associated Pulmonary Hypertension
This prospective study was conducted to explore clinical characteristics and outcomes of patients diagnosed with pulmonary sarcoidosis and PH. The investigators also assessed the role of D -dimer levels in these population.
- Trial name
- NCT01139710
- Where
- Israel
- Volunteers
- 75 people
- Sponsor
- Meir Medical Center
Cardiac Sarcoidosis, Myocardial Inflammation
18F-FSPG PET/MRI or PET/CT Imaging of Cardiac Sarcoidosis or Inflammation
The investigators will evaluate the detection of cardiac sarcoidosis or inflammation using 18F-FSPG PET/MRI (or PET/CT for participants with metal implants).
- Trial name
- NCT03103490
- Testing
- 18F-FSPG
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Stanford University