Clinical trials: SARS
Covid19
Effectiveness of the Adsorbed Vaccine COVID-19 (Coronavac) Among Education and Public Safety Workers With Risk Factors for Severity
This is a quasi-experimental study with risk-based allocation. Public security and education professionals from the state government will be included.
- Trial name
- COVACMANAUS (NCT04789356)
- Testing
- Adsorbed SARS-CoV-2 (inactivated) vaccine
- Where
- Brazil
- Volunteers
- 6,233 people, healthy volunteers welcome
- Sponsor
- Fundação de Medicina Tropical Dr. Heitor Vieira Dourado
COVID-19, SARS-CoV 2
COVID-19: Povidone-Iodine Intranasal Prophylaxis in Front-line Healthcare Personnel and Inpatients
Povidone-iodine (PVP-I) is a broad-spectrum antiseptic with activity against bacteria, fungi, and viruses. It has been previously used in both intranasal preparations against Methicillin Resistant Staphylococcus Aureus (MRSA) as…
- Trial name
- PIIPPI (NCT04364802)
- Testing
- Povidone-Iodine Nasal Spray and Gargle
- Where
- United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Nikita Gupta
SARS-CoV Infection, Polymerase Chain Reaction
Self-Collected Saliva Samples Without Viral Transport Media for COVID-19 Testing Via RT-PCR
This is a study that will attempt to validate the process for detecting SARS-CoV-2 (COVID19) on a non-FDA-approved technology using self-collected saliva as the specimen.
- Conditions
- SARS-CoV Infection, Polymerase Chain Reaction, Laboratory Testing
- Trial name
- NCT04604145
- Testing
- SARS-CoV-2 testing on the Eppendorf Thermal Cycler PCR system using self-collected saliva as the specimen
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- David Grant U.S. Air Force Medical Center
COVID-19 Infection
A Synthetic MVA-based SARS-CoV-2 Vaccine, GEO-CM04S1, for the Prevention of COVID-19 Infection
This phase I trial evaluates the side effects and best dose of GEO-CM04S1 (previously designated as COH04S1), a synthetic modified vaccinia Ankara (MVA)-based SARS-CoV-2 vaccine, for the prevention of COVID-19 infection.
- Trial name
- NCT04639466
- Testing
- Synthetic MVA-based SARS-CoV-2 Vaccine COH04S1
- Where
- 3 sites in United States
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- GeoVax, Inc.
COVID-19, Smoking
Tobacco Use and Uptake of COVID-19 Vaccinations
This is an observational study of participants in two general population health surveys (FinSote 2018 and 2020) who are followed up for their COVID-19 vaccinations or end of follow-up.
- Conditions
- COVID-19, Smoking, Tobacco Use, Vaccination Refusal
- Trial name
- NCT05479383
- Testing
- Not applicable, this is an observational study
- Where
- Finland
- Volunteers
- 42,935 people, healthy volunteers welcome
- Sponsor
- Finnish Institute for Health and Welfare
Pregnancy Related, COVID
Hydroxychloroquine Efficacy and Safety in Preventing SARS-CoV-2 Infection and COVID-19 Disease Severity During Pregnancy and Postpartum
It still unclear how SARS-CoV-2 affects pregnant women and their offspring, as well as which factors may influence obstetrical disease and outcomes, including the timing of maternal viral exposure by gestational age, the effects…
- Conditions
- Pregnancy Related, COVID, Covid-19
- Trial name
- COVID-Preg (NCT04410562)
- Testing
- Hydroxychloroquine
- Where
- 9 sites in Spain
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Barcelona Institute for Global Health
SARS-CoV2 Infection
The School SPIT Study - COVID-19 Testing in Secondary Schools
This study will conduct an evaluation of a program that is being implemented SickKids / Toronto Public health that provides take-home saliva testing kits in schools.
- Trial name
- NCT05060510
- Testing
- Take home saliva kit
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Covid19
Safety, Tolerability, and Pharmacokinetics of Anti-Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Chicken Egg Antibody (IgY) (COVID-19)
The primary objective of Part 1 (Single Ascending Dose) is to assess the safety and tolerability of anti-SARS-CoV-2 IgY when given as single-ascending doses administered intranasally to healthy participants.
- Trial name
- NCT04567810
- Testing
- anti-SARS-CoV-2 IgY
- Where
- Australia
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Stanford University
SARS COV-2 IgG Levels on Health Workers
SARS Cov_2 Incidence of Healthy Health Workers
Since the severe acute respiratory syndrome Coronavirus-2 (SARS-CoV-2) first emerged in Wuhan, China, on 12 December 2019, it has spread rapidly across the world and developed into a pandemic.
- Trial name
- NCT04845880
- Testing
- Spike protein (S) or the nucleocapsid (N) of SARS-CoV-2
- Where
- Turkey (Türkiye)
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Baskent University
COVID-19, Healthy Volunteers
Study of the Kinetics of Antibodies Against COVID-19 (SARS-CoV-2) and of Cellular Subpopulations of the Immune System
Determination of both the degree and duration of the immunity provided after receiving the BNT162b2 vaccine against SARS-Cov-2.
- Conditions
- COVID-19, Healthy Volunteers, Chronic Disease, Hematological Malignancies
- Trial name
- NCT04743388
- Testing
- BNT162b2, Other vaccine against SARS-Cov-2
- Where
- Greece
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
COVID
Caregiver Serological Monitoring Extended Secondarily to Patients With the SARS-CoV-2 Coronavirus
Hospital mortality attributed to SARS-CoV-2 in France increased daily by 28% in the week before confinement. The week following this decision, the daily increase was 30%.
- Trial name
- CoVid3S (NCT04441710)
- Testing
- Questionnaire
- Where
- 4 sites in France
- Volunteers
- 2,777 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
COVID-19
Phase 2b/3 Trial of VSV-ΔG SARS-CoV-2 Vaccine (BRILIFE) Against Approved Comparator Vaccine.
IIBR-100 (VSV-ΔG) is a self-propagating live virus vaccine that contains the spike protein of the Wuhan wild-type SARS-CoV-2 virus.
- Trial name
- BRILIFE002 (NCT04990466)
- Testing
- IIBR-100, Active Comparator
- Volunteers
- healthy volunteers welcome
- Sponsor
- NeuroRx, Inc.
Annexin A1, Adrenal Cortex Hormones
Annexin A1 Levels in SARS-CoV-2 Infection
The present study aims to determine the clinical predictivity value of blood AnxA1 levels in patients with mild and severe/critical pneumonia induced by COVID-19 and to reveal the alterations of blood AnxA1 levels in patients…
- Trial name
- NCT04948229
- Testing
- Blood serum samples
- Where
- Turkey (Türkiye)
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Kafkas University
SARS-CoV-2 Infection, Varicella
Immunogenicity and Safety of an Inactivated SARS-CoV-2 Vaccine Coadministered With Two Attenuated Vaccines
Eligible participants were randomly assigned (1:1:1), using block randomization stratified, to either 3 groups. Group 1 will be immunized inactivated SARS-CoV-2 vaccine and varicella vaccine in day 0 followed by…
- Conditions
- SARS-CoV-2 Infection, Varicella, Measles, Mumps
- Trial name
- NCT05952505
- Testing
- Inactivated SARS-CoV-2 vaccine coadministered with vricella vaccine, Inactivated SARS-CoV-2 vaccine coadministered with MMR, Inactivated SARS-CoV-2 vaccine administered alone
- Where
- China
- Volunteers
- 540 people, healthy volunteers welcome
- Sponsor
- Shanghai Municipal Center for Disease Control and Prevention
COVID-19 Pneumonia
Evaluation of Immunogenicity and Safety of COVID-19 Vaccine (Produced in Wuhan) in Patients With Hypertension and/or Diabetes
To evaluate the post-marketing immunogenicity and safety of the inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine (Vero cells) in patients aged 60 years or older with hypertension and/or diabetes…
- Trial name
- NCT05065892
- Testing
- COVAX
- Where
- 3 sites in China
- Volunteers
- 1,440 people, healthy volunteers welcome
- Sponsor
- China National Biotec Group Company Limited
COVID-19, SARS-CoV-2 Acute Respiratory Disease
Safety and Immunogenicity of Recombinant Protein RBD Fusion Dimer Vaccine Against the Virus That Cause COVID-19, Known as Severe Acute Respiratoy Syndrome Coronavirus 2 (SARS-CoV-2)
This is a Phase IIb, randomized, controlled, observer-blinded, clinical trial to evaluate safety and immunogenicity of COVID-19 Vaccine HIPRA in adult healthy volunteers in Vietnam
- Trial name
- NCT05142514
- Testing
- COVID-19 Vaccine HIPRA, Cominarty (Pfizer-BioNtech)
- Where
- Vietnam
- Volunteers
- 629 people, healthy volunteers welcome
- Sponsor
- Hipra Scientific, S.L.U
SARS-CoV-2
A Study to Evaluate the Immunogenicity and Safety of mRNA-1283 COVID-19 Vaccine Boosters
The main goal of Part A of this study is to assess the safety, reactogenicity, and immunogenicity of the study vaccine candidates.
- Trial name
- NCT05137236
- Testing
- mRNA-1283, mRNA-1283.211, mRNA-1273
- Where
- 17 sites in United States
- Volunteers
- 540 people, healthy volunteers welcome
- Sponsor
- ModernaTX, Inc.
COVID-19 Acute Respiratory Distress Syndrome, Pregnancy Related
Melatonin Levels on COVID-19 Positive Pregnant Women
This study aimed to investigate the prognostic value of serum melatonin as a biomarker for the determination of severe COVID-19 infection in pregnant women.
- Conditions
- COVID-19 Acute Respiratory Distress Syndrome, Pregnancy Related, Pregnancy Complications
- Trial name
- NCT05318144
- Where
- Turkey (Türkiye)
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- Nazan Yurtcu MD
SARS-CoV-2
A Study to Evaluate the Safety and Immunogenicity of the mRNA COVID-19 Vaccines in Healthy Children Between 6 Months to Less Than 6 Years of Age
This study will evaluate the safety and immunogenicity of the mRNA-1273.214 vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant of concerns (VOCs) in participants aged 6 months to <6 years, when…
- Trial name
- NCT05436834
- Testing
- mRNA-1273.214, mRNA-1273.815
- Where
- 74 sites in United States, Argentina and 5 more
- Volunteers
- 1,807 people, healthy volunteers welcome
- Sponsor
- ModernaTX, Inc.
SARS-CoV-2 Infection, Covid19
Prospective COVID-19 Cohort Study, Dominican Republic
This project will build on an existing CDC funded cooperative agreement in the Dominican Republic with the Brigham and Women's Hospital (2018-2023) that includes (i) prospective COVID-19 and AFI surveillance at two health…
- Trial name
- NCT04898738
- Testing
- Alcohol based hand sanitizer
- Where
- Dominican Republic
- Volunteers
- 1,043 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
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