Clinical trials: SARS-COV-2 Infections
COVID-19
Phase 1 Study on Bioavailability, Food Effect, and Drug-Drug Interaction of ALG-097558 Tablets in Healthy Volunteers
The aim of this multi-part Phase 1 study is to evaluate the drug-drug interaction (DDI) potential of ALG-097558 via co-administration with a P-gp substrate (dabigatran) and a CYP3A4 inhibitor/P-gp inhibitor (itraconazole).
- Trial name
- NCT06945276
- Testing
- ALG-097558, Dabigatran, Itraconazole
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Spinal Cord Injuries, Traumatic Spinal Cord Injury
SCIVAX: Biomarkers of Immune Dysfunction and Vaccine Responsiveness in Chronic SCI
The purpose of this observational research study is to better understand immune responses to vaccines against viruses (influenza or SARS-CoV2).
- Conditions
- Spinal Cord Injuries, Traumatic Spinal Cord Injury, Healthy Controls, Flu Vaccine
- Trial name
- SCIVAX (NCT05869968)
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Northwell Health
COVID19
Study to Evaluate the Safety and Efficacy of VIRAZOLE® in Hospitalized Adult Participants With Respiratory Distress Due to COVID-19
This study is a Phase 1, open label, non-randomized, two-arm interventional clinical trial to evaluate the safety and efficacy of Virazole® in hospitalized adult patients who have tested positive for COVID-19 and, as a result…
- Trial name
- NCT04551768
- Testing
- 50 mg/mL Virazole, 100 mg/mL Virazole
- Where
- 4 sites in Greece, Mexico
- Volunteers
- 51 people
- Sponsor
- Bausch Health Americas, Inc.
Mental Health Disorder, Depression
Mobile Phone Based Intervention to Protect Mental Health in Healthcare Workers at Frontline Against COVID19
This study aims at evaluating the effectiveness of a mobile phone based intervention to prevent and manage mental health problems in healthcare workers at the frontline against COVID-19 in Spain.
- Conditions
- Mental Health Disorder, Depression, Posttraumatic Stress Disorder, Burnout
- Trial name
- PsyCovid_App (NCT04393818)
- Testing
- Intervention App
- Where
- Spain
- Volunteers
- 560 people, healthy volunteers welcome
- Sponsor
- Fundació d'investigació Sanitària de les Illes Balears
COVID-19; and High Infection Risk of SARS-CoV-2
Tolerability,Safety,Pharmacokinetic Profile and Immunogenicity of a Recombinant Humanized Anti-SARS-CoV-2 Monoclonal Antibody (JS016) for Injection in Chinese Health Subjects
This is a randomized, double-blind, placebo-controlled, phase I clinical study to evaluate the tolerability, safety, pharmacokinetic profile and immunogenicity of JS016 (anti-SARS-CoV-2 monoclonal antibody) injection in Chinese…
- Trial name
- NCT04441918
- Testing
- JS016 (anti-SARS-CoV-2 monoclonal antibody)
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Shanghai Junshi Bioscience Co., Ltd.
Rheumatoid Arthritis
Antimalarial and Covid 19 in Rheumatoid Arthritis
The antimalarial agent hydroxychloroquine(HCQ) have been used widely used for the treatment of rheumatoid arthritis and systemic lupus erythematosus.
- Trial name
- NCT04389320
- Testing
- Hydroxychloroquine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Covid19, Motility Disorder
Coordination and Locomotor Problems in Patients With Covid-19 Virus
Coordination and Locomotor Problems in Patients With Covid-19 Virus
- Conditions
- Covid19, Motility Disorder, Balance
- Trial name
- NCT04734717
- Testing
- Neurology test
- Where
- Hungary
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Somogy Megyei Kaposi Mór Teaching Hospital
Community-acquired Pneumonia
Awake Prone Positioning of Patients Suffering Community Acquired Pneumonia Requiring Nasal High Flow Therapy
Community acquired pneumonia, in particular when requiring oxygen therapy because of acute hypoxemic respiratory failure and meeting acute respiratory distress syndrome (ARDS) criteria frequently leads to tracheal intubation and…
- Trial name
- PRONECAP (NCT06966310)
- Testing
- Prone position
- Where
- 38 sites in France
- Volunteers
- 1,078 people
- Sponsor
- University Hospital, Tours
Educational Activities
Facilitating COVID-19 Test for Korean Americans Through Korean Schools in Northern California
In collaboration with Korean Schools of Northern California, the investigators will test if a community-based intervention delivered by lay health educators (LHEs) increases testing uptake among Korean Americans.
- Trial name
- NCT05435482
- Testing
- Education, COVID-19 testing kits, Instruction
- Where
- United States
- Volunteers
- 259 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Respiratory Disease
Screening Patients for a Strategic Shift to Pulmonary Telerehabilitation Because of COVID-19
This study applied the Pulmonary Rehabilitation Adapted Index of Self-Efficacy (PRAISE) on respiratory patients who had their on-going ambulatory Pulmonary Rehabilitation program interrupted due to the COVID-19 outbreak.
- Trial name
- PRAISE@COVID (NCT04388579)
- Testing
- Pulmonary Rehabilitation
- Where
- 3 sites in Portugal
- Volunteers
- 100 people
- Sponsor
- University of Lisbon
COVID-19, Pneumonia, Viral
Ultrasonography in Norwegian Emergency Department Patients With Suspected Covid-19 Infection
In light of the ongoing COVID-19 epidemic in Norway, it is paramount to develop and utilize clinical tools for assessing and risk stratifying patients with suspected coronary infection in the emergency departments.
- Conditions
- COVID-19, Pneumonia, Viral, Pulmonary Infection
- Trial name
- COVIDUS-NOR (NCT04422691)
- Testing
- Lung ultrasound
- Where
- 9 sites in Norway
- Volunteers
- 5 people
- Sponsor
- St. Olavs Hospital
Mental Health Wellness 1
Jump Start Plus COVID-19 Support
The purpose of the study is to further develop and examine the Jump Start Plus COVID Support (JS+CS) program, which encourages improved psychosocial functioning by promoting resiliency in childcare centers.
- Trial name
- NCT05445518
- Testing
- Jump Start Plus COVID Support, Healthy Caregivers-Healthy Children (HC2)
- Where
- United States
- Volunteers
- 1,505 people, healthy volunteers welcome
- Sponsor
- University of Miami
COVID-19, Infection Viral
A Phase 1/2 Study to Determine Safety and Immunogenicity of Two COVID 19 Vaccines VB10.2129 (RBD Candidate) and VB10.2210 (T Cell Candidate) Previously Vaccinated in Healthy Adult Volunteers
An open label, dose escalation, and dose expansion study to evaluate the safety, reactogenicity and immunogenicity of two SARS-CoV-2 DNA plasmid vaccine candidates, VB10.2129 (C1) and VB10.2210 (C2).
- Conditions
- COVID-19, Infection Viral, Infections
- Trial name
- NCT05069623
- Testing
- VB10.2129, VB10.2210
- Where
- 2 sites in Norway
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Nykode Therapeutics ASA
COVID-19, Low Triiodothyronine Syndrome
The Impact of Pituitary-thyroid and Pituitary-adrenal Axes Function on COVID-19 Clinical Course.
The main focus of the study is the assessment of hormonal function in the course of COVID-19 infection with special regard for trends predicting clinical events defined as primary endpoints of the study.
- Conditions
- COVID-19, Low Triiodothyronine Syndrome, Adrenal Insufficiency, Subacute Thyroiditis
- Trial name
- ENDO-COVID19 (NCT05070091)
- Where
- 2 sites in Poland
- Volunteers
- 180 people
- Sponsor
- Medical University of Gdansk
COVID-19 Vaccine, COVID-19
Evaluation of Safety, Tolerability, Reactogenicity, Immunogenicity of Baiya SARS-CoV-2 Vax 2 as a Booster for COVID-19
The investigational product Baiya SARS-CoV-2 Vax 2 vaccine is a second-generation of protein subunit vaccine from plant to prevent COVID-19 disease.
- Trial name
- NCT05873374
- Testing
- 50 μg Baiya SARS-CoV-2 Vax 2
- Where
- Thailand
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Baiya Phytopharm Co., Ltd.
Corona Virus Infection
Role of Mega Dose of Vitamin C in Critical COVID-19 Patients
Vitamin C (ascorbic acid) is a water-soluble vitamin having anti-inflammatory, immunomodulatory, anti-oxidative, antithrombotic and antiviral properties.
- Trial name
- NCT04682574
- Testing
- Vitamin C
- Where
- Pakistan
- Volunteers
- 278 people
- Sponsor
- University of Lahore
Covid19, Cytokine Release Syndrome
Safety and Efficacy of Dapansutrile for Treatment of Moderate COVID-19 Symptoms and Evidence of Early Cytokine Release Syndrome
The purpose of this study is to assess the safety and efficacy of orally administered NLRP3 inhibitor, dapansutrile, for the treatment of moderate COVID-19 symptoms and early cytokine release syndrome (CRS) in patients with…
- Trial name
- NCT04540120
- Testing
- dapansutrile capsules
- Where
- 10 sites in United States, Switzerland
- Volunteers
- 49 people
- Sponsor
- Olatec Therapeutics, Inc.
COVID-19
The siCoV/KK46 Drug Open-safety Study
This is an open-label, dose-escalation phase I study to assess the safety and tolerability of siCoV/KK46 in healthy volunteers. The purpose of this study is to determine the maximum daily dose of siCoV/KK46 as a single agent in…
- Trial name
- NCT05208996
- Testing
- siCoV/KK46
- Where
- Russia
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- National Research Center - Institute of Immunology Federal Medical-Biological Agency of Russia
COVID-19, COVID-19 Acute Respiratory Distress Syndrome
Study of Cysteamine-pantetheine Disulfide (TTI-0102) in Mild to Moderate COVID-19
This is multi-center, randomized, double-blind, placebo-controlled study to assess the safety, tolerability, pharmacodynamics (PD) and efficacy of TTI-0102 for the treatment of patients with mild to moderate COVID-19.
- Trial name
- NCT05212662
- Testing
- TTI-0102
- Sponsor
- Thiogenesis Therapeutics, Inc.
Cardiovascular Abnormalities, Post-COVID-19 Syndrome
Inspiratory Muscle Strength Training in Post-Covid Syndrome
Patients with post-Covid-19 syndrome are at high risk of developing cardiovascular diseases 12 months after acute infection of COVID-19.
- Conditions
- Cardiovascular Abnormalities, Post-COVID-19 Syndrome, Physical Exercise
- Trial name
- NCT06091384
- Testing
- Inspiratory muscle strength training
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- D'Or Institute for Research and Education
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.