Clinical trials: SBP - Spontaneous Bacterial Peritonitis
Liver Cirrhosis
Faecal Microbiota Transplantation for Liver Cirrhosis
The purpose is to investigate the effect of faecal microbiota transplantation (FMT) on complications, progression, and mortality of patients with liver cirrhosis.
- Trial name
- CHiFT (NCT04932577)
- Testing
- Faecal microbiota transplantation
- Where
- Denmark
- Volunteers
- 220 people
- Sponsor
- University of Aarhus
Spontaneous Bacterial Peritonitis
Ascitic Fluid Calprotectin as an Accurate Diagnostic Marker for Spontaneous Bacterial Peritonitis
Spontaneous bacterial peritonitis (SBP) is an infection of the ascitic fluid in patients with liver cirrhosis and portal hypertension.
- Trial name
- NCT05422118
- Testing
- ascitic fluid calprotectin
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Sohag University
Cirrhosis, Hepatic Encephalopathy
Allopurinol Versus Atorvastatin to Prevent Complications of Liver Cirrhosis
The study aims to compare the potential benefit of allopurinol versus atorvastatin in reducing the risk of developing cirrhosis-related complications, delaying the onset of hepatocellular carcinoma, and improving survival.
- Conditions
- Cirrhosis, Hepatic Encephalopathy, Ascites, Varices
- Trial name
- NCT05511766
- Testing
- Allopurinol 300 MG, Atorvastatin 20mg
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Tanta University
Spontaneous Bacterial Peritonitis
Imipenem Versus Cefepime in Spontaneous Bacterial Peritonitis and to Evaluate the Risk Factors for Treatment Failure
1. All consecutive patients with Cirrhosis and ascites admitted to ILBS (Institute of Liver \& Biliary Sciences) will be evaluated for the presence of SBP (Spontaneous Bacterial Peritonitis) by ascitic fluid examination at…
- Trial name
- NCT01852630
- Testing
- cefepime + Albumin, Imipenem + Albumin
- Where
- India
- Volunteers
- 175 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Ascites Infection
Rifaximin Prophylaxis for Spontaneous Bacterial Peritonitis and Hepatorenal Syndrome in Cirrhotic Patients
Norfloxacin is the most commonly used drug for the prophylaxis against spontaneous bacterial peritonitis (SBP) in patients with liver cirrhosis.
- Trial name
- NCT05621005
- Testing
- Rifaximin 550 milligram Oral Tablet [XIFAXAN]
- Where
- Egypt
- Volunteers
- 104 people
- Sponsor
- Samar Atef Sebaweh Mohammed
Spontaneous Bacterial Peritonitis
Laboratory Diagnosis of Spontaneous Bacterial Peritonitis
This study aims at evaluating the diagnostic accuracy of serum procalcitonin, PEC index, modified Wehmeyer, and Mansoura scoring systems for SBP in cirrhotic patients with ascites
- Trial name
- SBP (NCT05696054)
- Volunteers
- 80 people
- Sponsor
- Sohag University
Spontaneous Bacterial Peritonitis, Cirrhosis
Randomized Comparison of Two Albumin Administration Schedules for Spontaneous Bacterial Peritonitis (SBP)
Spontaneous bacterial peritonitis (SBP) is a common and frequently fatal complication of end-stage liver disease with a mortality of up to 10%, primarily due to the development of kidney failure.
- Trial name
- NCT00761098
- Testing
- Standard Care, Experimental
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Weill Medical College of Cornell University
Spontaneous Bacterial Peritonitis
Rifaximin for the Secondary Prevention of Spontaneous Bacterial Peritonitis Recurrence in Cirrhotic Patients
The aim of this study is to evaluate whether long-term rifaximin administration reduces spontaneous bacterial peritonitis recurrence rate in cirrhotic patients.
- Trial name
- NCT02011841
- Testing
- Rifaximin, Ciprofloxacin
- Where
- South Korea
- Sponsor
- Seoul National University Hospital
Spontaneous Bacterial Peritonitis
Meropenem vs Cefotaxime as Empirical Treatment of SBP
We aimed to evaluate whether meropenem is superior to cefotaxime for treatment of SBP empirically.
- Trial name
- NCT05427747
- Testing
- cefotaxime
- Volunteers
- 286 people
- Sponsor
- Assiut University
SBP - Spontaneous Bacterial Peritonitis
N-Acetylcysteine in the Management of Spontaneous Bacterial Peritonitis
Spontaneous bacterial peritonitis (SBP) is one of the most serious infectious complications of liver cirrhosis and ascites. It affects approximately 10-30% of hospitalized patients with decompensated cirrhosis and carries an…
- Trial name
- NCT07803952
- Testing
- NAC
- Volunteers
- 60 people
- Sponsor
- Tanta University
Cirrhosis
Predictors of Spontaneous Bacterial Peritonitis Among Patients with Cirrhosis
Prevalence of spontaneous bacterial peritonitis (SBP) varies from approximately 4% among asymptomatic patients to 30% among those hospitalized [1, 2].Previous studies explored the role of several biomarkers, such as tumor…
- Trial name
- NCT06884306
- Volunteers
- 200 people
- Sponsor
- Assiut University
Spontaneous Bacterial Peritonitis
Cefotaxime Resistance in Treatment of Spontaneous Bacterial Peritonitis
Spontaneous bacterial peritonitis (SBP) is a serious complication in cirrhotic patients, and the changes in the microbiological characteristics reported in the last years are impacting the choice of antibiotic used in the…
- Trial name
- NCT02388035
- Testing
- Cefotaxime
- Where
- Egypt
- Volunteers
- 254 people
- Sponsor
- Dr Ahmed Ali Elbaz
Cirrhosis With Ascites
Evaluation of Safety & Efficacy of Synbiotic on the Incidence and Recurrence of Spontaneous Bacterial Peritonitis (SBP) in Cirrhotics
Background: Spontaneous bacterial peritonitis (SBP) is a serious complication in patients of cirrhosis with ascites and may occur despite antibiotic prophylaxis.
- Trial name
- NCT00947336
- Testing
- Norfloxacin + Synbiotic
- Where
- India
- Volunteers
- 110 people
- Sponsor
- Govind Ballabh Pant Hospital
Cirrhosis With Spontaneous Bacterial Peritonitis
Clinical Study on the Effectiveness of Antibiotics Combined With Bifidobacterium Quadruple Live Tablets in Treating Cirrhosis With Spontaneous Bacterial Peritonitis and Preventing Recurrence
This is a prospective, randomized, double-blind, placebo-controlled multicenter clinical study targeting cirrhosis patients with Spontaneous Bacterial Peritonitis(SBP), aiming to evaluate whether adding Bifidobacterium quadruple…
- Trial name
- NCT07686861
- Testing
- Bifidobacterium quadruple live tablets
- Where
- 30 sites in China
- Volunteers
- 360 people
- Sponsor
- Peking University First Hospital
Adverse Reaction to Other Drugs and Medicines
Norfloxacin Versus Ciprofloxacin for Spontaneous Bacterial Peritonitis (SBP) Prevention
For the prevention of spontaneous bacterial peritonitis (SBP) in patients with liver cirrhosis, norfloxacin 400mg per day is a standard regimen. Ciprofloxacin 750 mg per week is also known to be effective for prevention of SBP.
- Trial name
- NCT01542801
- Testing
- Norfloxacin, ciprofloxacin
- Where
- 7 sites in South Korea
- Volunteers
- 124 people
- Sponsor
- Korea University
Spontaneous Bacterial Peritonitis
Norfloxacin With Itopride Versus Norfloxacin in Secondary Prophylaxis of Spontaneous Bacterial Peritonitis
Norfloxacin versus Norfloxacin with Itopride in Secondary Prophylaxis of Spontaneous Bacterial Peritonitis
- Trial name
- NCT04161768
- Testing
- Norfloxacin, Itopride
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Tanta University
Proton Pump Inhibitor Adverse Reaction, Liver Cirrhosis
Proton Pump Inhibitors in Cirrhotic Patients
Proton pump inhibitors (PPIs) inappropriate use, in patients with cirrhosis, presents a significant clinical challenge. This study evaluates overprescription and misuse of PPIs in cirrhotic patients.
- Trial name
- NCT06384443
- Where
- Egypt
- Volunteers
- 1,000 people
- Sponsor
- National Liver Institute, Egypt
Cirrhosis, Liver
Platelet Indices Could Predict Spontaneous Bacterial Peritonitis in Cirrhotic Ascitic Patients
Spontaneous bacterial peritonitis (SBP) is an ascitic fluid infection in cirrhotic patients
- Trial name
- NCT03172013
- Testing
- Platelet indices
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tanta University
Spontaneous Bacterial Peritonitis
MPV and NLR as Predictors of SBP Diagnosis
The aim of the study is to investigate the clinical utility of mean platelet volume (MPV) and neutrophil to lymphocyte ratio (NLR) as diagnostic markers for spontaneous bacterial peritonitis (SBP).
- Trial name
- NCT04775420
- Testing
- Measurement of mean platelet volume (MPV) and blood neutrophil to lymphocyte ratio (NLR)
- Where
- Egypt
- Volunteers
- 332 people
- Sponsor
- Sohag University
Spontaneous Bacterial Peritonitis
Nitazoxanide in Prevention of Secondary Spontaneous Peritonitis
the study is to evaluate the possible efficacy and safety of nitazoxanide as an adjuvant therapy in the secondary prevention of SBP in patient with cirrhosis.
- Trial name
- NCT04746937
- Testing
- Nitazoxanide, Norfloxacin
- Volunteers
- 60 people
- Sponsor
- Tanta University