Clinical trials: SNS
Major Depressive Disorder (MDD)
Cardiovascular Effects of Agomelatine and Escitalopram in Patients With Major Depressive Disorder (MDD)
There is strong evidence that patients with major depressive disorder (MDD) are at increased risk of developing coronary heart disease (CHD).
- Trial name
- NCT01483053
- Testing
- Agomelatine, Escitalopram
- Where
- 3 sites in Australia
- Volunteers
- 40 people
- Sponsor
- Baker Heart and Diabetes Institute
Spontaneous Coronary Artery Dissection, Healthy
A Study to Analyze the Role of Sympathetic Nervous System in Spontaneous Coronary Artery Dissection
The purpose of this research is to compare sympathetic function (flight or fight system) and arterial health including structure and mechanics of participants with history of spontaneous coronary artery dissection (SCAD) to age…
- Trial name
- NCT05699200
- Testing
- Arterial Tonometry, Echocardiogram, Carotid Ultrasounds
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Autonomic Nervous System Disease, Healthy
Blood Sampling for Neurochemical and Genetic Testing
This study involves sampling blood from both normal volunteers and patients with diseases known or suspected to involve body chemicals called catecholamines.
- Conditions
- Autonomic Nervous System Disease, Healthy, Hypertension, Pheochromocytoma
- Trial name
- NCT00001147
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Colorectal Polyps, Modified SiNiSan
Efficacy of Modified Si Ni San in Post-Polypectomy Management and Its Impact on Gut Microbiota in Colorectal Polyp Patients
Study Purpose: This study aims to systematically analyze changes in the gut microbiota of colon polyp patients under different intervention models.
- Trial name
- SNS (NCT07442084)
- Testing
- TCM Intervention Group, Patients in this group will receive a combination of glutamine and probiotics for 4 weeks. This control intervention aims to compare the effects on gut microbiota composition and diversity
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Xi'an Hospital of Traditional Chinese Medicine
Osteopathic Manipulative Treatment
Osteopathic Sympathetic Harmonization and Depression
Depression appears to be resistant to the available pharmacological treatments. Autonomic responses accompanied by any psychological stress are sympathetic nervous system (SNS) and neuroendocrine responses are formed by…
- Trial name
- NCT04840043
- Testing
- Osteopathic sympathic harmonization
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people
- Sponsor
- Cumhuriyet University
Ascitic Cirrhosis, Hyperactivation of Sympathetic Nervous System
The Effects of Clonidine on the Diuretic Response in Cirrhotic Patients
To examine the effects of the addition of clonidine to diuretics on the mobilization of ascites at short-term (diuretic response and requirement of diuretics) and long-term (readmissions for tense ascites and requirement of…
- Trial name
- NCT00356226
- Testing
- clonidine
- Where
- Belgium
- Volunteers
- 64 people
- Sponsor
- CHU de Charleroi
Neuroblastoma, Bone Marrow, Sympathetic Nervous System
Anti-GD2 3F8 Antibody and Allogeneic Natural Killer Cells for High-Risk Neuroblastoma
Funding Source - FDA OOPD FDR004128 The goal of this study is to see if it is safe and feasible to give chemotherapy, natural killer (NK) cells, and an antibody called 3F8.
- Trial name
- NCT00877110
- Testing
- cyclophosphamide, vincristine, topotecan ,allogeneic NK cells & 3F8
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Sympathetic Nervous System
Sympathetic Nerve Activity and Strength Gains in Resistance Versus Concurrent Training
This study examines how the body's stress (sympathetic) nervous system responds to 8 weeks of either strength training alone or strength training combined with endurance (treadmill running) training in previously untrained young…
- Trial name
- SKNA-CT (NCT07680387)
- Testing
- Strength-only training, Concurrent training
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Beijing Sport University
Sepsis, Septic Shock
Early Dexmedetomidine and Sympathetic Regulation in Sepsis
The goal of this clinical trial is to learn whether early administration of dexmedetomidine can improve autonomic nervous system regulation and clinical outcomes in adult patients with septic shock.
- Trial name
- DEX-SNS-SEPSIS (NCT07470775)
- Testing
- Dexmedetomidine (DEX)
- Volunteers
- 168 people
- Sponsor
- Sichuan Academy of Medical Sciences
Hypertension, Stress, Psychological
Effectiveness of Prazosin on the Urinary Sodium Excretion Response to Mental Stress
High blood pressure, or hypertension, is a serious problem in the African-American (AA) population which affects nearly 7 of every 10 AAs in our area.
- Conditions
- Hypertension, Stress, Psychological, Blood Pressure
- Trial name
- NCT02431936
- Testing
- Prazosin
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Augusta University
Heart Failure, Ischemic Cardiomyopathy
Molecular Pathways of Cardiac Remodellation in Patients With Acute and Chronic Left Ventricular Disfunction
Chronic heart failure represents an extremely complex clinical syndrome, defined as the inability of the heart muscle to generate a volume adequate to the metabolic needs of peripheral tissues, or to do so only in the face of…
- Trial name
- HFrEF (NCT05745571)
- Testing
- Blood sample
- Where
- Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Blood Pressure, Hypertension
Blood Pressure Regulation - Role of Potassium
Project titel: Oral potassium supplementation in healthy men - interactions with the renin-angiotensin-aldosterone system and the sympathetic nervous system Protocol number: KARAASS-1 EudraCT number: 2013-004460-66 Introduction…
- Trial name
- NCT02380157
- Testing
- Kaleorid, 750mg (trade name), Potassium chloride (active substance)
- Where
- Denmark
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Glostrup University Hospital, Copenhagen
Autonomic Nervous System, Heart Rate Variability
Non-invasive Modulation of Autonomic Cardiac Nervous System
To demonstrate the effect of non invasive vagus nerve (VNS) stimulation on heart rate variability and MSNA signal.
- Conditions
- Autonomic Nervous System, Heart Rate Variability, Muscle Sympathetic Nerve Activity
- Trial name
- MSNA (NCT04057508)
- Testing
- Modulation of muscle sympathetic nerve activity
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Université Catholique de Louvain
Light
Cardiometabolic Outcomes With Light Exposure During Sleep
This study tested the hypothesis that acute exposure to light during nighttime sleep adversely affects cardiometabolic function.
- Trial name
- NCT05317559
- Testing
- room light
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Exercise, Cognition
Sympathetic Nervous System Mediation of Acute Exercise Effects on Childhood Brain and Cognition
Today's children have become increasingly inactive and unfit, with >50% of children not meeting the recommended 60 min of moderate-to-vigorous physical activity.
- Trial name
- NCT03592238
- Testing
- Aerobic Exercise Intervention, Trier Social Stress Test for Children, Seated Rest
- Where
- United States
- Volunteers
- 297 people, healthy volunteers welcome
- Sponsor
- Northeastern University
Obesity, Type 2 Diabetes
The Effects of Weight Loss on Neuroadrenergic Function
Elevated subconscious nervous system activity is a characteristic of the obese state and contributes importantly to the risk of heart disease and diabetes.
- Conditions
- Obesity, Type 2 Diabetes, Metabolic Syndrome
- Trial name
- NCT01771042
- Testing
- Dietary weight loss at 25% energy deficit
- Where
- Australia
- Volunteers
- 120 people
- Sponsor
- Baker Heart Research Institute
Erythema
Effect of Thoracic Spine Mobilization on Sympathetic Nervous Systems
This pilot study aims to i) represents the feasibility of the study design and ii) to point out acute effects of thoracic spine mobilization on skin-blood flow, erythema and the sympathetic nervous system.
- Trial name
- NCT02832141
- Testing
- Mobilization anterior, Mobilization posterior
- Where
- Switzerland
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Bern University of Applied Sciences
Hypertension, Renal
Transcatheter Renal Artery Sympathetic Denervation Observational Study
Hypertension is a common health problem that affects millions of people in the world. Poorly controlled blood pressure (BP) leads to cardiovascular, cerebrovascular and renal complications.
- Trial name
- NCT05744986
- Testing
- SYMPICITY Spyral RENAL DENERVATION (RDN) SYSTEMTM
- Where
- 2 sites in Hong Kong
- Volunteers
- 100 people
- Sponsor
- Chinese University of Hong Kong
Whiplash Associated Disorder (WAD)
Transauricular Vagus Nerve Stimulation for Chronic Whiplash Associated Disorders
Approximately 50% of people with chronic whiplash-associated disorders (WAD) continue to report the presence of symptoms 12 months post-injury.
- Trial name
- NCT07055373
- Testing
- Transauricular Vagal Nerve Stimulation
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Calgary
Hepatitis B, Hepatitis
Vaccination Adjuved Against Hepatitis B in SNS Workers Typed as no Responders to Conventional Vaccines
Health workers with biological risk in their tasks, who have been vaccinated as non-responders to conventional vaccination against Hepatitis B.
- Conditions
- Hepatitis B, Hepatitis, Hepatitis, Viral, Human, Hepatitis B Immunization
- Trial name
- NCT03410953
- Testing
- Fendrix suspension for injection Hepatitis B (rDNA) vaccine (adjuvanted, adsorbed).
- Where
- 11 sites in Spain
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León