Clinical trials: SNS
Obstructive Sleep Apnea Syndrome
Effects of Obstructive Sleep Apnea Treatment by Fixed CPAP and by Auto-CPAP (Somnosmart2)
The main purpose of this study is to investigate if treatment of obstructive sleep apnea syndrome (OSAS) by continuous positive airway pressure (CPAP) given by a traditional CPAP device administering a fixed air pressure, or by…
- Trial name
- NCT00633711
- Testing
- Automatic (variable, automatically controlled) pressure CPAP, fixed continuous positive airway pressure (CPAP)
- Where
- Italy
- Volunteers
- 17 people
- Sponsor
- Fondazione C.N.R./Regione Toscana "G. Monasterio", Pisa, Italy
Urinary Urgency Incontinence
Neuspera's Implantable Sacral Nerve Stimulation System in Patients With Symptoms of Urinary Urgency Incontinence (UUI)
Prospective, multi-center, single-arm, seamless phase-pivotal study conducted in participants diagnosed with UUI who have failed or could not tolerate more conservative treatment. The trial will be conducted in two phases.
- Trial name
- NCT04232696
- Testing
- Neuspera Implantable Sacral Nerve Stimulation System
- Where
- 34 sites in United States, Belgium and 1 more
- Volunteers
- 331 people
- Sponsor
- Neuspera Medical, Inc.
OBESITY, HYPERTENSION
The Autonomic Nervous System and Obesity
In its simplest terms, obesity is the results of a positive balance between food intake and energy expenditure (EE). I.e., we take in more energy, in the form of food, than we expend, e.g., by exercise.
- Conditions
- OBESITY, HYPERTENSION, PURE AUTONOMIC FAILURE, SHY-DRAGER SYNDROME
- Trial name
- NCT00179023
- Testing
- Trimethaphan, Pseudoephedrine
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Cancer, Sequels
Assessment of Cardiac Autonomic Function in Adulthood After Chemotherapy or Radiotherapy in Childhood
The SALTO-SNA study is an ancillary study of the SALTO study (Suivi À Long Terme en Oncologie des enfants guéris d'un cancer pédiatrique en régions Rhône-Alpes et Auvergne) coordinated by Dr.
- Conditions
- Cancer, Sequels, Complications, Autonomic Nervous System
- Trial name
- SALTO-SNA (NCT01574196)
- Testing
- Autonomic nervous system activity records
- Where
- 4 sites in France
- Volunteers
- 83 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Rheumatoid Arthritis
Role of the ANS Dysregulation in the Persistence of Fatigue in Rheumatoid Arthritis Patients Treated With Anti-TNF
Despite the large therapeutic arsenal available since one decade allowing a strong reduction of inflammation process, rheumatoid arthritis (RA) patients claimed pain, fatigue, sleep problems and other quality of life outcomes.
- Trial name
- ANSRA (NCT02475486)
- Testing
- VistaO2
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Hypertension
Melatonin and Nighttime Blood Pressure in African Americans-8 mg Study
This purpose of this study is to test the effect of oral melatonin supplementation (8 mg per night for 4 weeks) on nighttime blood pressure in African Americans with a history of elevated nighttime blood pressure.
- Trial name
- NCT01114360
- Testing
- Melatonin
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Emory University
Major Depressive Disorder
Major Depressive Disorder - Understanding The Link Between The Brain And The Heart
There is strong evidence that patients with major depressive disorder (MDD) have an increased risk of developing coronary heart disease (CHD).
- Trial name
- MDD (NCT01568307)
- Testing
- Participants will be prescribed an approved selective serotonin re-uptake inhibitor (SSRI) antidepressant.
- Where
- 4 sites in Australia
- Volunteers
- 80 people
- Sponsor
- Baker Heart and Diabetes Institute
COPD, Sympathetic Nervous System Diseases
Sympathetic Nerve Activity Predictors in Patients With Chronic Obstructive Pulmonary Disease
The project will be pursued in our respiratory, autonomic nervous system physiology laboratory (Respiratory, autonomic nervous system physiology laboratory, Department of Pneumology and Intensive Care Medicine, RWTH Aachen…
- Conditions
- COPD, Sympathetic Nervous System Diseases, Catecholamine; Overproduction
- Trial name
- SNAP-COPD (NCT04849806)
- Testing
- Assessments of the sympathetic nerve activity axis, OSA severity, Determination of PH and right HF severity
- Where
- Germany
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- RWTH Aachen University
Sympathetic Nervous System
Sympathetic Neural Outflow During Xenon Anesthesia in Humans
The purpose of this study is to test the hypothesis that sympathetic neural outflow to muscles as well as a sympathetic baroreflexes are not altered during xenon anesthesia in Healthy Volunteers.
- Trial name
- NCT01043419
- Testing
- xenon
- Where
- Germany
- Volunteers
- 8 people
- Sponsor
- Air Liquide Santé International
Parkinson Disease, Gait Disorders, Neurologic
SNS for Treatment of PD Gait Disorder
Parkinson's disease (PD) is a progressive disease, characterized by dopaminergic neurons degeneration in the substantia nigra. Postural and gait disorders usually occur in advanced PD patients.
- Trial name
- NCT04137146
- Testing
- Sacral Nerve Stimulation
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Ruijin Hospital
Heart Failure, Congestive
Statin Therapy in Heart Failure: Potential Mechanisms of Benefit
The goal of the investigators' study is to further understand the potentially beneficial effects of statin therapy in patients with heart failure.
- Trial name
- NCT00233480
- Testing
- atorvastatin
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of California, Los Angeles
Uncontrolled Hypertension
EuroNetrod HTN OFF-Med Study of Renal Denervation With NetrodTM Six-electrode Radiofrequency RDN System
This randomized controlled investigation aims to evaluate the efficacy and safety of the Netrod™ RDN system in patients with uncontrolled primary hypertension in the absence of antihypertensive medication, comparing the outcomes…
- Trial name
- EuroNetrod (NCT06722651)
- Testing
- Netrod™ six-electrode radiofrequency renal denervation system
- Where
- Switzerland
- Sponsor
- Shanghai Golden Leaf MedTec Co. Ltd
Breastfeeding, Preterm Infant
The Effect of the SNS-Based Feeding on Transition to Exclusive Breastfeeding in Preterm Infants
This study investigated the effect of the Supplemental Nursing System (SNS)-based feeding on the time to transition to exclusive breastfeeding, sucking success, and the time to discharge in preterm infants
- Conditions
- Breastfeeding, Preterm Infant, Sucking Behavior
- Trial name
- NCT05815706
- Testing
- MEDELA Supplemental nursing system
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Istanbul Medeniyet University
Metabolic Syndrome, Obesity
Cortisol and Nutritional Sympathetic Responsiveness
This project will examine whether short-term (over a 12-hour period) pharmacological lowering of the stress hormone 'cortisol' improves the nervous system response to food intake in overweight or obese individuals who have…
- Conditions
- Metabolic Syndrome, Obesity, Insulin Resistance
- Trial name
- NCT01620684
- Testing
- metyrapone
- Where
- Australia
- Volunteers
- 24 people
- Sponsor
- Baker Heart Research Institute
Unrecognized Condition
Deep Diaphragmatic Breathing: Neurobiological and Anti-inflammatory Effects
The exposure to acute and\or chronic stress can produce an activation of sympathetic nervous system (SNS), leading to an increased level of cortisol and pro-inflammatory cytokines.
- Trial name
- NCT04102813
- Testing
- Functional Therapy
- Where
- Italy
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone Palermo
Low Back Pain
Dry Needling at the Thoracolumbar Junction on Measures of Sympathetic Outflow and Flexibility
Dry needling (DN) is becoming more frequently performed by physical therapists around the world to treat musculoskeletal pain. Dry needling is a form of trigger point therapy that evolved from using injections of local…
- Trial name
- NCT03630172
- Testing
- Dry needling
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Nova Southeastern University
Obesity, Prehypertension
Vascular Dysfunction in Human Obesity Hypertension
The purpose of the study is to test the effects of blocking sympathetic nerve activity with a drug called clonidine on blood vessel function and muscle nerve activity in adults who are obese and have high blood pressure.
- Conditions
- Obesity, Prehypertension, Hypertension
- Trial name
- VANISH (NCT01983462)
- Testing
- Clonidine, Hydrochlorothiazide
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Gary L. Pierce
Obstructed Defecation Syndrome, Rectocele
Stapled TransAnal Rectal Resection (STARR) With Contour® TranstarTM
The stapled transanal rectal resection (STARR procedure) is an effective treatment for obstructed defecation syndrome (ODS) caused by intussusception and rectocele.
- Conditions
- Obstructed Defecation Syndrome, Rectocele, Intussusception, SNS
- Trial name
- STARR (NCT00673400)
- Testing
- Stapled transanal rectum resection
- Where
- Switzerland
- Volunteers
- 52 people
- Sponsor
- Cantonal Hospital of St. Gallen
Sinusitis
Application of Ectoin® Rhinitis Nasal Spray in Patients With Acute Rhinosinusitis
This is a comparative, open label, parallel group, non interventional study to further demonstrate the effectiveness and tolerability of Ectoin® Rhinitis Nasal Spray.
- Trial name
- SNS01 (NCT01684540)
- Testing
- Medical Device, Drug-like, Sinupret forte
- Where
- 6 sites in Germany
- Volunteers
- 66 people
- Sponsor
- Bitop AG
Fecal Incontinence, Anal Incontinence
Medical and Economic Evaluation of a Magnetic Anal Sphincter for Patients With Severe Anal Incontinence
The purpose of this study is to compare 2 surgical treatments of severe fecal incontinence (defined as more than a major leak per week).
- Trial name
- MOS STIC (NCT01920607)
- Testing
- magnetic anal sphincter, sacral nerve stimulation
- Where
- France
- Volunteers
- 71 people
- Sponsor
- Nantes University Hospital