Clinical trials: STDs
Hiv, Syphilis
The TRIple Elimination Model Of Mother-to-child Transmission Program (TRI-MOM)
The TRI-MOM program aims to implement and evaluate a simplified (based on inexpensive rapid diagnostic tests), integrated (in governmental health facilities) and coordinated (between health care workers) strategy for the triple…
- Conditions
- Hiv, Syphilis, HBV
- Trial name
- TRI-MOM (NCT05951751)
- Testing
- TRI-MOM intervention
- Where
- 2 sites in Burkina Faso, The Gambia
- Volunteers
- 2,800 people, healthy volunteers welcome
- Sponsor
- Institut de Recherche pour le Developpement
Hepatitis C, Hepatitis B
HBV/HCV/HIV in Belgian Prisons
To assess the prevalence of blood-borne viral infections in prisons in Belgium, screening will be executed in several prisons in Flanders, Brussels and Wallonia to obtain a geographical representative distribution.
- Conditions
- Hepatitis C, Hepatitis B, HIV Infections
- Trial name
- NCT04366492
- Testing
- Prevalence of blood borne viral infections (HBV/HCV/HIV)
- Where
- 2 sites in Belgium
- Volunteers
- 3,045 people, healthy volunteers welcome
- Sponsor
- Hasselt University
HIV Infections
A Phase II Safety and Immunogenicity Trial of Live Recombinant Canarypox ALVAC-HIV vCP205 With or Without HIV-1 SF-2 RGP120 in HIV-1 Uninfected Adult Volunteers
To expand the available data regarding the safety and immunogenicity of 2 HIV-1 vaccine strategies: canarypox vector vCP205, or vCP205 with SF-2 rgp120.
- Trial name
- NCT00000871
- Testing
- MN rgp120/HIV-1 and GNE8 rgp120/HIV-1, MN rgp120/HIV-1 and A244 rgp120/HIV-1, ALVAC-HIV MN120TMG (vCP205)
- Where
- 18 sites in United States
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Glaucoma, Cataract
Eye Drop Dispensers: Safety, Efficacy and Comfort.
One aspect to eye drop adherence is successful instillation of the drops; however, it is well known that many patients struggle with this task.
- Conditions
- Glaucoma, Cataract, Healthy Subjects
- Trial name
- NCT03417453
- Testing
- Eye Drop Dispenser TYPE Opticare, Eye Drop Dispenser Autodrop
- Where
- Israel
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Wolfson Medical Center
HIV Infections
A Phase I Multicenter Trial to Evaluate the Safety and Immunogenicity of HIV-1 Recombinant Envelope Glycoprotein gp160
To evaluate the safety and immune response to 160 mcg HIV-1 recombinant envelope glycoprotein gp160. To evaluate the duration of antibody response and its relationship to dose and frequency of inoculation.
- Trial name
- NCT00000757
- Testing
- gp160 Vaccine (MicroGeneSys)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV/AIDS
Evaluation of the Effect of Late Boost on HIV-uninfected Vaccines From EV06 Trial
EV07 is an open label phase I clinical trial to evaluate the effect of late boost on HIV-uninfected vaccinees from EV06 trial. The outcome of the EV06 trial has shown that the vaccine regimen is safe and well tolerated.
- Trial name
- NCT03391375
- Testing
- DNA-HIV-PT123 & AIDSVAX B/E
- Where
- Uganda
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- EuroVacc Foundation
HPV Infection, HPV Vaccine
Intradermal, Fractional Dose of HPV Vaccines:
This randomized phase IV trial compares fractional dose of bivalent HPV vaccine to fractional dose of nonavalent HPV vaccine among men and women aged 27-45 years in Seattle, Washington.
- Trial name
- NCT04235257
- Testing
- HPV vaccine
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Washington
HIV Associated Neurocognitive Disorder, HIV Dementia
SV2A & TSPO PET Imaging Measures to Reveal Mechanisms of HIV Neuropathogenesis During Antiretroviral Therapy
The purpose of this study is to longitudinally characterize and evaluate changes in synaptic density in the brain using novel positron-emission tomography (PET) scans; magnetic resonance imaging (MRI), and clinical laboratory…
- Conditions
- HIV Associated Neurocognitive Disorder, HIV Dementia, HIV Encephalitis, Healthy
- Trial name
- ART (NCT05586581)
- Testing
- SV2A PET, TSPO PET
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Yale University
Human Papillomavirus (HPV) Infection, HPV (Human Papillomavirus)-Associated Carcinoma
Phase IIIb Clinical Trial of Quadrivalent Recombinant Human Papillomavirus Vaccine (Hansenulapolymorpha) for Age/Immunization Schedule Bridging
This vaccine was jointly developed by Chengdu Institute of Biological Products Co., Ltd. and National Vaccine and Serum Institute, China, is co-sponsoring this clinical trial.
- Trial name
- NCT06632912
- Testing
- 2 doses of vaccine Quadrivalent Recombinant Human Papillomavirus Vaccine (Hansenulapolymorpha), 3 doses of vaccine Quadrivalent Recombinant Human Papillomavirus Vaccine (Hansenulapolymorpha)
- Where
- 3 sites in China
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- National Vaccine and Serum Institute, China
HIV Infections
PrEP Impact Trial: A Pragmatic Health Technology Assessment of PrEP and Implementation
HIV pre-exposure prophylaxis (PrEP) is the use of anti-HIV medicines by HIV negative people in order to prevent them from becoming HIV positive if exposed to HIV.
- Trial name
- NCT03253757
- Testing
- This study is non-interventional.
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- St Stephens Aids Trust
Human Papillomavirus Infection
An Observational Study on the Prevalence of Human Papillomavirus Types in Women in the Kingdom of Bahrain
The purpose of this study is to determine the Human Papillomavirus (HPV) prevalence and HPV type distribution among women ≥ 20 years of age attending routine cervical screening and among women ≥ 16 years of age presenting for…
- Trial name
- NCT01205412
- Testing
- Endocervical samples
- Where
- Bahrain
- Volunteers
- 552 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Sexually Transmitted Infections(STIs), HIV/AIDS
Promoting Safer Sexual Dual Protection Behaviors for Female University Students to Reduce Risks of Both STI/HIV and Unintended Pregnancy
Background: Young women are at the greatest risk for STI/HIV infections and unintended pregnancy resulting from unsafe sexual practices.
- Conditions
- Sexually Transmitted Infections(STIs), HIV/AIDS, Unintended Pregnancy
- Trial name
- NCT06952582
- Testing
- The IMB model-based safer sexual dual protection educational intervention
- Where
- Ethiopia
- Volunteers
- 1,020 people, healthy volunteers welcome
- Sponsor
- Jimma University
HIV Infections
HIV Pre-exposure Prophylaxis Implementation Hong Kong Study
While pre-exposure prophylaxis (PrEP) is widely recommended and a number of pilot studies are on-going worldwide, progress of its implementation in the real world setting has been slow, especially in Asia.
- Trial name
- NCT04367688
- Testing
- Tenofovir Disoproxil Fumarate 300 mg / emtricitabine 200 mg
- Where
- Hong Kong
- Volunteers
- 339 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
HIV Infection
A Healthy Volunteer And Patient Study To Assess The Safety, Tolerability And Pharmacokinetics Of GSK1265744
This study is a Phase I single and repeat dose escalation study of GSK1265744 in healthy subjects and a single repeat dose cohort in HIV-1 infected subjects. The study is planned to consist of three parts.
- Trial name
- NCT00659191
- Testing
- GSK1265744
- Where
- 5 sites in United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Infection, Human Immunodeficiency Virus
Relative Bioavailability Study of a Fixed-dose Combination Dolutegravir/Abacavir/Lamivudine Dispersible Tablet
This is an open-label, randomized, crossover study in healthy adult subjects with 5 treatment groups over 5 dosing periods. This study will evaluate pharmacokinetic parameters and relative bioavailability of a dispersible…
- Trial name
- NCT02893488
- Testing
- DTG/ABC/3TC FDC DISPERSIBLE TABLET, EPZICOM (ABC/3TC), TIVICAY (DTG)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- ViiV Healthcare
HIV Prevention, Sexually Transmitted Diseases
STI Care Model to Reduce Genital Inflammation and HIV Risk in South African Women
The goal of this prospective cohort study is to determine if a model of care including point-of-care testing, immediate therapy, expedited partner therapy and test of cure will result in a higher cure rate and a lower recurrence…
- Trial name
- NCT03407586
- Testing
- Point-of-care STI testing
- Where
- South Africa
- Volunteers
- 267 people, healthy volunteers welcome
- Sponsor
- Centre for the AIDS Programme of Research in South Africa
HIV Infections
Safety and Pharmacokinetic Study of Dapivirine Gel (0.05%) Administered Rectally to HIV-1 Seronegative Adults
The purpose of this study is to evaluate the safety and pharmacokinetics (PK) of dapivirine gel (0.05%) administered rectally to HIV-1 seronegative adults.
- Trial name
- NCT03239483
- Testing
- Dapivirine gel
- Where
- 3 sites in United States, Thailand
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
Evaluating the Safety and Immunogenicity of the IHV01 Protein Vaccine Primed and Co-Administered With HIV DNA CON-S Env Vaccine in Healthy, HIV-1-Uninfected Adults
The purpose of this study is to evaluate the safety and immunogenicity of the IHV01 protein vaccine primed and co-administered with HIV DNA CON-S env vaccine in healthy, HIV-1-uninfected adults.
- Trial name
- NCT03505060
- Testing
- DNA CON-S env, IHV01
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Human Immunodeficiency Virus Infection, Hepatitis C
Comparison of Plasma & SMARTplasma for Human Immunodeficiency Virus (HIV) and Hepatitis C Virus (HCV) Antibody Testing
The purpose of this study is to compare the results for HIV and/or Hepatitis C Virus antibody testing when using routine plasma versus SMARTplasma from the same blood sample.
- Trial name
- NCT01447680
- Where
- 7 sites in United States
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- G & W Laboratories Inc.
HIV/AIDS
Demand Creation for Couples' HIV Counseling and Testing
This study aims at assessing the effect of a demand-creation intervention on couples' HIV counseling and testing (couples' HCT) uptake among married couples who have never tested together as a couple.
- Trial name
- NCT02492061
- Testing
- Demand creation for couples' HCT
- Volunteers
- 3,076 people, healthy volunteers welcome
- Sponsor
- Makerere University
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