Clinical trials: Safety Issues
Safety Issues
A Phase I Clinical Study of Hemay808
This is a first-in-human study in health volunteers. The purpose is the local tolerability and systemic safety of Hemay808, which is an ointment made of a novel small molecule Hemay028.
- Trial name
- NCT04100642
- Testing
- Hemay808
- Where
- China
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Tianjin Hemay Pharmaceutical Co., Ltd
Safety Issues
Safety, Tolerability, PK and PD of SSS55 in Healthy Subjects
This study was a single-dose, randomized, double-blind, placebo-controlled study of SSS55 injection to evaluate the safety, tolerability, PK characteristics, immunogenicity and preliminary efficacy characteristics of single-dose…
- Trial name
- NCT07058779
- Testing
- SSS55
- Where
- China
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Shenyang Sunshine Pharmaceutical Co., LTD.
Social Functioning, Addiction, Substance
Pain Clinic Provides Public Health Safety
Chronic pain is associated with psychological disorders; which may affect a patient's socioeconomic, legal, domestic, and employment situations.
- Conditions
- Social Functioning, Addiction, Substance, Safety Issues, Road Injury
- Trial name
- NCT06076512
- Testing
- Behavioral therapy
- Where
- Canada
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Salem Anaesthesia Pain Clinic
Safety Issues
Effect of Evidence Based Teamwork System on Patient Safety Culture
This study aims to evaluate the effect of evidence-based teamwork system on patient safety culture among newly graduate nurses at Main Mansoura University Hospital
- Trial name
- NCT06117800
- Testing
- TeamSTEPPS
- Where
- Egypt
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Asmaa Elwan Mohammed Hassan
Safety and Cosmetic Issues in Endoscopic Thyroidectomy
Evaluation of Endoscopic Thyroidectomy Via Axillo-breast Approach in Thyroid Nodules
Evaluation of Endoscopic Thyroidectomy via Axillo-breast Approach in Thyroid Nodules regarding safety and cosmetic outcomes
- Trial name
- Thyroidectomy (NCT04329455)
- Testing
- Endoscopic thyroidectomy
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Assiut University
Effect of Drugs, Safety Issues
A Clinical Trial to Evaluate the Safety and Tolerability of Dexlansoprazole Injection in Healthy Chinese Adults（Part 2）
This is a single center, open-label, multiple-dose phase 1 clinical trial. This study will determine the pharmacokinetics (PK), pharmacodynamics (PD), safety and side-effect profile of an investigational dexlansoprazole injection…
- Trial name
- NCT03120273
- Testing
- Dexlansoprazole Injection, Lansoprazole Injection
- Where
- China
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Safety Issues
to Assess the Safety of Ga68-Dolacga Injection in Healthy Volunteers
This is a phase 1 study to evaluate the safety of Ga68-Dolacga Injection in healthy volunteers and to assess the normal reference range and inter-individual variability of the Ga68-Dolacga Injection in estimating liver reserve in…
- Trial name
- NCT03908957
- Testing
- Ga68-Dolacga Injection
- Where
- Taiwan
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- National Atomic Research Institute, Taiwan
Safety Issues
Safety and Efficacy of Bleach Baths in Non Critical Hospitalized Patients
Non critical hospitalized patients were bathed daily with 4 substances: bleach at .005%, bleach at .0125%, clorhexidine 2% and soap and water. 76 patients were enrolled and divided 19 subjects per group.
- Trial name
- NCT04904666
- Where
- Mexico
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario Dr. Jose E. Gonzalez
Safety Issues
Effect of Different Ingestion Doses of Celastrol on Human Sperm Motility
Five healthy participants with normal sperm counts and motility will ingest increasing doses of celastrol over a period of several days.
- Trial name
- NCT05413226
- Testing
- Celastrol
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Legend Labz, Inc.
Safety Issues
Tolerance of a Probiotic Formula
Evaluate the tolerance of a probiotic formula in infants
- Trial name
- NCT03925558
- Testing
- Probiotics
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Probi AB
Safety Issues
Phase 1 Study to Evaluate RG002C0106 Injection in Healthy Participants
The goal of this clinical trial is to learn if RG002C0106 is safe in healthy participants . It will also learn about how the drug is absorbed, distributed， metablized and excrited.
- Trial name
- NCT07902245
- Testing
- RG002C0106, 0.9% sodium chloride injection
- Where
- Austria
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Rigerna Therapeutics Co., Ltd.; Rigerna Therapeutics (Beijing) Co., Ltd.
Safety Issues, Post Operative Pain
Safety and Efficacy of Wide Awake Local Anesthesia no Tourniquet Technique (WALANT) in Ankle Removal of Implant Surgery
Safety and efficacy of wide awake local anesthesia no torniquet technique (WALANT) in ankle surgery. Studying risks and benefits from WALANT compared to general anesthesia .
- Conditions
- Safety Issues, Post Operative Pain, Local Anesthetic Complication
- Trial name
- NCT05864664
- Testing
- Wide awake local anaesthesia no tourniquet technique
- Where
- Kuwait
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ali Lari
Opioid; Intoxication, Perception Disturbance (Acute), Acute Pain
Pupillary Unrest in Ambient Light, and Relationship to Opioid-Induced Respiratory Depression
Volunteers will receive a weight-based opioid (remifentanil) infusion for 10 minutes. In the first run, serial pupillary measurements (pupillary unrest, pupil diameter) will be taken at baseline, and at 2.5-minute intervals…
- Conditions
- Opioid; Intoxication, Perception Disturbance (Acute), Acute Pain, Overdose of Opiate, Respiratory Depression
- Trial name
- NCT04301895
- Testing
- Continuous conversational interaction, Remifentanil infusion
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Healthy, Safety Issues
Effect of an Polyphenolic Beverage in Healthy Volunteers
Currently, there are different strategies to prevent the effect of beverages and foods on blood glucose levels after ingestion. In this sense, polyphenols are a promising field; these compounds are secondary metabolites produced…
- Trial name
- PB (NCT05802472)
- Testing
- Polyphenolic beverage from extract of Vachellia farnesiana
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Safety Issues, Healthy Volunteers
Safety and Tolerability of DMT in Healthy Adults
This study aims to evaluate the acute and subacute effects of an inhaled N, N-Dimethyltryptamine (DMT) in healthy individuals.
- Trial name
- NCT05901012
- Testing
- N,N-Dimethyltryptamine
- Where
- Brazil
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Rio Grande do Norte
Safety Issues
Safety, Tolerability, and Pharmacokinetics of EQU-001 in Healthy Volunteers
This is a randomized, placebo-controlled, double-blinded single and multiple ascending dose (SAD and MAD) study of the safety, tolerability, and pharmacokinetics of EQU-001 in healthy volunteers.
- Trial name
- NCT05004571
- Testing
- EQU-001
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Equilibre Biopharmaceuticals B.V.
Poisoning, Safety Issues
Evaluating the Impact of a Safe Medication Storage Device
Despite the initial success of the 1970s Poison Prevention Packaging Act, the incidence of pediatric medication poisonings in the United States remains high.
- Conditions
- Poisoning, Safety Issues, Accidents Injury
- Trial name
- NCT04729894
- Testing
- Medication Lockbox, Education
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Binghamton University
Breastfeeding, Pregnancy Related
The Effect of Modified Pillow on Safety During Breastfeeding
This study will investigate the effectiveness of a modified product "safe breastfeeding pillow" in enhancing the comfort and safety of postpartum women during breastfeeding.
- Conditions
- Breastfeeding, Pregnancy Related, Newborn; Fit, Safety Issues
- Trial name
- NCT05687383
- Testing
- Safe breastfeeding pillow
- Where
- Taiwan
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Effect of Drugs, Safety Issues
Pharmacokinetic Study of Lansoprazole Capsules in Healthy Chinese Volunteer
The objective of this study was to compare pharmacokinetic of Lansoprazole Capsules 30 mg with Lansoprazole Capsules of Takeda 30 mg in healthy adult human subjects.
- Trial name
- NCT03488173
- Testing
- Lansoprazole capsules
- Where
- China
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Safety Issues
Oral Mucosal Effects In Adult Smokers Associated With Two Nicotine Lozenge Formulations
To study the oral mucosal effects in adult smokers associated with the use of two Nicotine Lozenge formulations.
- Trial name
- NCT03087786
- Testing
- Nicotine Bitartrate Lozenge 4mg, Nicotine Polacrilex 4Mg Lozenge
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Niconovum USA