Clinical trials: Saliva Altered
Oral Cavity Squamous Cell Carcinoma, Saliva Altered
Salivary Ap4A, SCCA, TROP2 in Oral Cancer Patients
According to the World Health Organization, oral cancer (OC) is the eighth most common cancer in the world with a five year survival rate of 50%.
- Conditions
- Oral Cavity Squamous Cell Carcinoma, Saliva Altered, Precancerous Lesions
- Trial name
- OCSALTM (NCT03529604)
- Testing
- Saliva sampling, ELISA, HPLC
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Zagreb
Saliva Altered
Salivary Flow Promoted by Sugar-Free Chewing Gum
This was a double-blind, single center in vivo salivary flow rate study. The objective was to compare a marketed sugar-free chewing gum to a clinically-tested sugar-free reference chewing gum, with regards to their ability to…
- Trial name
- NCT05447104
- Testing
- Mastication
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Mars Wrigley
Postprandial Glycemia, Metabolic Stress
WHNRC (Western Human Nutrition Research Center) Honey Study
The purpose of this research is to compare two snacks, one with honey and nuts and the other with sugar and nuts, on glucose levels before and after eating these snacks.
- Conditions
- Postprandial Glycemia, Metabolic Stress, Cognitive Change, Satisfaction, Personal
- Trial name
- NCT06107231
- Testing
- Honey, Sucrose, Honey plus almonds
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- USDA, Western Human Nutrition Research Center
Diet Modification, Insulin Resistance
Saliva Insulin Responses to a Standardized Meal Tolerance Test in Humans
Recent evidence suggests that hyperinsulinemia (i.e., elevated insulin levels) is the primary causative factor in obesity. Insulin promotes fat storage and prevents fat breakdown, suggesting that weight loss would be optimized if…
- Conditions
- Diet Modification, Insulin Resistance, Hyperinsulinemia
- Trial name
- NCT04309071
- Testing
- Dietary intervention
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Chronic Kidney Diseases, Caries,Dental
Assessment of The Oral Health Status of Children With Chronic Kidney Disease
The aim of this study is to compare the oral health findings, salivary parameters and disease-related quality of life of children with different stages of Chronic Kidney Disease(CKD), those undergoing dialysis and…
- Conditions
- Chronic Kidney Diseases, Caries,Dental, Quality of Life, Saliva Altered
- Trial name
- NCT06578832
- Testing
- physical and chemical methods, biochemical methods, biochemical tests
- Where
- Turkey (Türkiye)
- Volunteers
- 167 people, healthy volunteers welcome
- Sponsor
- Marmara University
Alzheimer Disease, Neurodegenerative Diseases
Yogic Breathing Changes Salivary Components
Our aim is to analyze two ancient Tamil practices (chanting and breathing exercise) if they are capable of stimulating saliva containing agents that can be beneficial to the nervous system.
- Conditions
- Alzheimer Disease, Neurodegenerative Diseases, Cancer
- Trial name
- NCT02108769
- Testing
- Yogic Breathing, Attention Control
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Saliva Altered, Oral Hygiene
Comparison of 5 Buffering Agents on Changes in Salivary pH in Individuals Previously Exposed to a Test Fruit Juice
The diurnal variation in the flow of saliva and hence the composition of saliva is an established fact. Consumption of most types of acidic and sweetened foods and beverages are known to reduce the pH of saliva and some of them…
- Conditions
- Saliva Altered, Oral Hygiene, pH, Tooth Structure; Disorder
- Trial name
- SALPH-F (NCT03510962)
- Testing
- Group 1: no intervention, Group 2: tap water gargle, Group 3: 0.2% Chlorhexidine
- Where
- India
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Dr Meru S
Orthodontic Appliances, Removable, Orthodontic Appliances, Fixed
Microbiome and Immunogenity of Saliva During Orthodontic Therapy
There are two essential ways of treatment in the field of orthodontics. The fixed appliance treatment with self-ligating or conventional brackets and treatment with aligners.
- Conditions
- Orthodontic Appliances, Removable, Orthodontic Appliances, Fixed, Oral Microbiome, Cell Culture
- Trial name
- NCT04139538
- Testing
- orthodontic treatment
- Where
- Austria
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Saliva Altered, Taste, Altered
Taste Perception, Salivary Proteins & the Oral Microbiome
Genetic differences in taste are believed to play an important role in food selection, especially for strong-tasting foods and beverages.
- Trial name
- NCT04107688
- Testing
- Control, CPE
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Rutgers University
Saliva Altered, Oral Hygiene
Comparison of 5 Buffering Agents on Changes in Salivary pH in Individuals Previously Exposed to a Test Carbonated Drink
The diurnal variation in the flow of saliva and hence the composition of saliva is an established fact. Consumption of acidic and sweetened food and beverage is known to reduce the salivary pH and some of them reduce it to…
- Conditions
- Saliva Altered, Oral Hygiene, pH, Tooth Structure; Disorder
- Trial name
- SALPH-C (NCT03526770)
- Testing
- Group 1: no intervention, Group 2: tap water gargle, Group 3: 0.2% Chlorhexidine
- Where
- India
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Dr Meru S
Dental Plaque, Saliva Altered
Effects of Two Sugar Substituted Chewing Gums on Caries and Gingivitis Variables
The purpose of this study is to determine the effect of three times a day mastication, during a follow-up period of 4 weeks, of two sugar-substituted chewing gums on various factors associated with dental caries and gingivitis.
- Conditions
- Dental Plaque, Saliva Altered, Gingivitis
- Trial name
- NCT01578603
- Testing
- xylitol, casein phosphopeptide amorphous calcium phosphate complex
- Where
- Colombia
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Universidad de Antioquia
Healthy Male Adults
Effects of Intranasal Administration of a Single Dose of Oxytocin Using a Novel Device in Healthy Adults
Oxytocin (OT) is a small, naturally occurring peptide currently in clinical use to stimulate lactation in breastfeeding women. The intranasal administration of OT has recently attracted attention as a potential novel treatment in…
- Trial name
- NCT01983514
- Testing
- 8IU intranasal oxytocin, 24 IU intranasal oxytocin, 1 IU intravenous oxytocin
- Where
- Norway
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- OptiNose AS
Spinal Disease, Spinal Radiculopathy
This Study is to Determine if Degenerative Spinal Pain and Disorders Cause the Levels of Substance P to Change in a Patients Saliva, Blood and/or Cerebrospinal Fluid.
The objective of this pilot study is to determine if degenerative spinal disorders such as acute radiculopathy, myelopathy, stenosis, or disc and facet disease cause detectable alterations in Substance P levels in saliva, serum…
- Conditions
- Spinal Disease, Spinal Radiculopathy, Myelopathy, Neurogenic Claudication
- Trial name
- Substance P (NCT01458938)
- Testing
- treatment plan
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Carolina Neurosurgery & Spine Associates
Fat Sensitivity
Saliva Modification Related to Fat Perception in Human
The perception of fat represents major scientific and nutritional issues. This research aims to identify salivary markers that could predict and possibly explain this perception in healthy human being.
- Trial name
- SensInFat (NCT01532778)
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
Periodontal Diseases, Saliva Altered
The Role of Periodontal Diseases and Stimulation of Saliva Secretion in the Acute Phase of Ischemic Stroke
Methods: 100 consecutive patients with their first ever ischemic stroke were enrolled in the study. 56 randomly selected patients were subjected to stimulation of salivation, the remaining patients were not stimulated.
- Conditions
- Periodontal Diseases, Saliva Altered, Stroke
- Trial name
- NCT05394090
- Testing
- saliva stimulation
- Where
- Poland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Pomeranian Medical University Szczecin
Primary Ciliary Dyskinesia, Caries,Dental
Assessment of Oral Health Status of Children With Primary Ciliary Dyskinesia
The aim of this study is to compare the oral health findings, salivary parameters and pediatric oral health related quality of life of children with Primary Ciliary Dyskinesia (PCD) with healthy children
- Conditions
- Primary Ciliary Dyskinesia, Caries,Dental, Quality of Life, Saliva Altered
- Trial name
- NCT06618209
- Testing
- physical and chemical methods, biochemical methods, Oral Findings
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Marmara University
Tooth Erosion
Intra Oral Kinetics of Fluoride Containing Dentifrices
The aim of this study is to assess the impact of formulation differences on fluoride retention clearance with US levels of fluoride (1150 ppm of fluoride) by evaluating and comparing between treatments the concentrations of…
- Trial name
- NCT02548156
- Testing
- Test Dentifrice, Reference Dentifrice, Comparator Dentifrice
- Where
- United Kingdom
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Streptococcal Infections, Saliva Altered
Efficacy of Propolis Varnish Against Oral Biofilm
This study aims to evaluate the effectiveness of a varnish containing 15% of green propolis on Streptococcus mutans in saliva and biofilm.
- Trial name
- NCT02052973
- Testing
- Propolis varnish
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Federal University of Minas Gerais
Healthy
Factors Controlling the Formation of Salivary Films
The aim of this study is to determine how different ingredients which are found in food and other consumer products affect the ability of saliva to form surface films.
- Trial name
- SalFilm (NCT01167504)
- Testing
- Saliva sample collection
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Quadram Institute Bioscience
Diet Habit, Diet Modification
Interaction of Salivary Proteins and Polyphenols
Participants will be chosen through an initial sensory test to find high and low-perceivers of astringency. Selected participants will drink a chocolate milk or milk substitute beverage for one week each with washout weeks in…
- Conditions
- Diet Habit, Diet Modification, Taste, Altered, Saliva Altered
- Trial name
- NCT03501238
- Testing
- Chocolate Milk, Chocolate milk substitute, Chocolate milk substitute with gelatin
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Purdue University