Clinical trials: Scaffolding
Irreversible Pulpitis
Assessment of L-PRF, Nanohydroxyapatite Combined With L-PRF Using Pulpotomy in Mature Mandibular First Molars
Clinical and Radiographic Assessment of L-PRF, Nanohydroxyapatite material combined with L-PRF scaffold in Vital pulp Therapy. Treatments in Mandibular First Molars with Closed Apices, Randomized Controlled Trial.
- Trial name
- NCT06613932
- Testing
- pulpotomy
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Regeneration
Regenerative Ability of Immature Necrotic Permanent Teeth Using Different Scaffolds
The goal of this clinical trial is to compare effect of different scaffolds on the regenerative potential of young permanent immature teeth with necrotic pulp.
- Trial name
- regeneration (NCT06693739)
- Testing
- Platelet rich fibrin, hyaluronic acid, no scaffold
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Preservation of Alveolar Bone Height With PLGA Bioscaffold
Radiographic Assessment of Bone Regeneration in Alveolar Sockets With PLGA Scaffold
After extraction of a tooth, the bony socket heals naturally but due to the absent of the tooth and any presence of support in the socket, bone resorption occur both vertically and bucco lingually or bucco palataly.
- Trial name
- NCT00836797
- Where
- 2 sites in India, Singapore
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Bio-Scaffold International Pte Ltd
Alveolar Ridge Resorption After Extraction
Alveolar Ridge Preservation With Polycaprolactone Scaffold for Implant Site Development
It has been shown through research that alveolar ridges (Part of jaw bone holding teeth) tend to lose width and height after extraction of teeth.
- Trial name
- NCT00466414
- Testing
- Polycaprolactone Scaffold
- Where
- Singapore
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore
Skin Wound
Dermal Regeneration Photosynthetic Matrix
The aim of the study is to demonstrate that dermal regeneration photosynthetic matrix applied in patients with acute clean skin wound is safe.
- Trial name
- HULK (NCT03960164)
- Testing
- Dermal regeneration photosynthetic matrix (DRPM)
- Where
- 3 sites in Chile
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Regenerative Endodontics
Regenerative Endodontics in Mature Permanent Teeth
this study was designed to compare the clinical and radiographic success of REPs after using blood clot scaffold in non-vital mature permanent teeth with or without photobiomodultion therapy
- Trial name
- NCT05892536
- Testing
- dental regenerative endodontics
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Salma fathy
Pulp Necroses
Comparison Between Two Regenerative Scaffolds
This study was performed to compare endodontic regeneration outcome in necrotic mature single rooted teeth with periapical radiolucency using platelet rich fibrin (PRF) \& concentrated growth factor (CGF) as a different natural…
- Trial name
- NCT06227533
- Testing
- Endodontic regeneration using concentrated growth factor compared with Platelet rich fibrin
- Where
- Egypt
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Faculty of Dental Medicine for Girls
Infertility, Intrauterine Adhesions
Treatment of Infertility by Collagen Scaffold Loaded With Autologous Bone Marrow Stem Cells
Study of the treatment of infertility caused by severe intrauterine adhesions or endometrial dysplasia by collagen scaffold loaded with autologous bone marrow stem cells, and to provide clinical evidence for the treatment of…
- Conditions
- Infertility, Intrauterine Adhesions, Endometrial Dysplasia
- Trial name
- NCT02204358
- Testing
- autologous bone marrow stem cells
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Cranioplasty, Craniotomy
Effectiveness of 3D Bone Matrix in Cranioplasty
The objective of this clinical trial is to evaluate the effectiveness of a 3D bone scaffold in relation to a scaffold formed by PCL + β-TCP (polycaprolactone and beta-tricalcium phosphate), compared to the use of PMMA (polymethyl…
- Conditions
- Cranioplasty, Craniotomy, Craniotomy Clipping, Craniotomy Surgery
- Trial name
- OSTEOPRINTCR (NCT06792864)
- Testing
- OsteoprintCR, SMAR SET GMV Endurance Gentamicin
- Where
- Chile
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Universidad Austral de Chile
Necrotic Pulp
Healing Potentiality Of Blood Clot S-PRF and A-PRF in the Treatment Of Necrotic Mature Single-Rooted Teeth With Chronic Peri-Apical Periodontitis
Earlier, it was believed that successful regeneration cannot be achieved once tooth has become infected. However, recent studies suggest that regenerative endodontics may in fact be possible in teeth with pulpal necrosis and…
- Trial name
- NCT04606719
- Testing
- Advanced Platelet Rich fibrin
- Where
- Egypt
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Cairo University
Inguinal Hernia
Neo-nervegenesis in Inguinal Hernia Implant ProFlor
The investigation is aimed at specifically demonstrating the ingrowth of newly formed nervous elements within a 3D dynamic responsive implant for inguinal hernia repair.
- Trial name
- NCT04171102
- Testing
- ProFlor Hernia implant
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Cagliari
Pulpotomy
Assessment of I-PRF Versus Nano MTA Combined with I-PRF Scaffold in Vital Pulp Therapy in Mature Mandibular First Molars
Assessment of I-PRF versus Nano Mineral trioxide aggregate Combined with I-PRF in pulpotomy in mature Mandibular First Molars
- Trial name
- NCT06640205
- Testing
- pulpotomy
- Where
- Egypt
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Coronary Occlusion
Optical Coherence Tomography to Improve Outcome for Coronary Revascularisation Using Bioresorbable Vascular Scaffolds
Fully Bioresorbable Vascular Scaffolds (BVS) have been introduced with the objective to preserve native vessel geometry, allow for adaptive vessel remodeling with late lumen gain, restore physiological vasomotion, and avoid late…
- Trial name
- OPTICO-BVS (NCT02683356)
- Testing
- OCT-guided PCI, Angiography-guided PCI
- Where
- Switzerland
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Alveolar Bone Loss
A Clinical Investigation to Evaluate the Healing of Tooth Extraction Sites Filled With BioRestore™
The aim of this study was to evaluate by histology and MSCT scans during a 7-month period, the efficacy of a bioactive glass (Inion BioRestore™) placed in human extraction sockets in the maintenance of alveolar ridge.
- Trial name
- NCT01105026
- Testing
- Alveolar Bone Defect Regeneration Following Tooth Extraction
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Trieste
Randomized Clinical Trial
Clinical and Radiographic Outcome of Regeneration in Immature Permanent Human Teeth Using a New Scaffold
This study aimed to evaluate clinical and radiographic outcome of regeneration in immature permanent human teeth using two different types of scaffolds: 1. Collagen-hydroxyapatite scaffold (Osteon III collagen) after blood clot.
- Trial name
- NCT06812351
- Testing
- Osteon III collagen, Blood clot
- Where
- Egypt
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Localized Gingival Recession
Use of a Collagen Membrane for Soft Tissue Grafting
Is PriMatrix wound dressing capable of regenerating gum tissue inside the mouth?
- Trial name
- NCT02206009
- Testing
- Collagen Membrane
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Lauren M. F. Syrowik
Surgical Incision
Silk Scaffold Surgical Incision Dressing
Interventional Study of the novel clinical application of SERI surgical silk scaffold affixed with dermaFLEX medical adhesive as a wound dressing, compared to two separate current standard of care for surgical incision closure…
- Trial name
- SSSID (NCT05508945)
- Testing
- Dermabond Prineo Skin Closure System, silk, 3M Steri-Strip
- Where
- United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Mehrdad Mark Mofid
Platelet-rich Fibrin, Simvastatin
Effect of Local Application of Platelet-rich Fibrin Scaffold Loaded With Simvastatin on Peri-implant Bone Changes
ACKGROUND: Simvastatin (SIM), a pharmacological drug used for hypercholesterolemia, has been found to have pleotropic effects on bones. Simvastatin together with the appropriate carrier may decrease bone loss around implants.
- Trial name
- NCT05008068
- Testing
- Simvastatin
- Where
- Egypt
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- British University In Egypt
Vital Pulp Treatment in Mature Permanent Teeth With Irreversible Pulpitis
Clinical and Radiographic Assessment of Nano-Bioactive Glass Combined With I-PRF Scaffold in Vital Pulp Treatments in Mandibular Molars With Closed Apices
Clinical, Radiographic and pain assessment of Vital pulp treatment in patients suffering from irreversible pulpitis in mature permanent molars.
- Trial name
- I-PRF (NCT05876520)
- Testing
- Total pulpotomy with I-prf mixed with Nano-bioactive glass
- Where
- Egypt
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Cairo University
Alveolar Ridge Augmentation, Dental Implants
Lateral Ridge Augmentation Using a Volume Maintaining Collagen Scaffold Versus Allograft With Collagen Membrane.
The aim of the current study is to compare lateral bone augmentation using the current gold standard (FDBA plus resorbable collagen membrane) versus Ossix Volumax as a stand-alone material.
- Trial name
- NCT03457298
- Testing
- Ossix Volumax, FDBA with collagen membrane
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus