Clinical trials: Scheduled Heart Surgery
Prehabilitation, Surgery
'Cardiac and Intramuscular Adaptations Following Short-term Exercise Prehabilitation in Unfit Patients Scheduled to Undergo Hepatic- or Pancreatic Surgery'
Surgery remains an important treatment modality in the treatment of hepatopancreatobiliary (HPB) malignancies, but the physiological stress caused by surgery is at the same time a challenge for the homeostasis of patients.
- Conditions
- Prehabilitation, Surgery, Exercise Prehabilitation, Perioperative Care
- Trial name
- CIRCULATE (NCT05772819)
- Testing
- exercise MRI
- Where
- Netherlands
- Volunteers
- 12 people
- Sponsor
- University Medical Center Groningen
Thrombosis
STRATAGEM: Strategy for Managing Antiplatelet Therapy in the Perioperative Period of Non Coronary Surgery
The STRATAGEM trial is an investigator-driven French nationwide multicenter, randomized, double-blind, placebo-controlled trial comparing perioperative low-dose aspirin therapy versus placebo in the perioperative period in…
- Trial name
- STRATAGEM (NCT00190307)
- Testing
- aspirin 75 mg/day
- Where
- France
- Volunteers
- 293 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Medical Oncology
Transpulmonary Thermodilution Using an Implented Central Venous Access Port
Perioperative hemodynamic optimization requires monitoring adapted to the risks of the surgery and the patient. The investigators currently use a local hemodynamic protocol based on the data of the literature.
- Trial name
- ThermoD-PAC (NCT02357953)
- Testing
- Measurement of cardiac index
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Cardiac Surgery
Ropivacaine Though Laterosternal Catheters After Cardiac Surgery
This is a prospective double-blinded and randomised study involving patients undergoing cardiac surgery with median sternotomy, the effects on postoperative analgesia of a 48-hr continuous infusion of ropivacaine 2 mg.mL-1, at…
- Trial name
- NCT01196767
- Testing
- Ropivacaine (in one arm); catheterization (in both).
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Clermont-Ferrand
Surgery, Cardiac Output, Low
Reliability of a New Pulse Contour Technique for Diagnosing an Increase in Stroke Volume During a Fluid Challenge for Hemodynamic Optimization in Patients Scheduled for High-risk Abdominal Surgery: Comparison With Transthoracic Echocardiography: COMPARE Study
The present study aims at assessing the ability of a new pulse contour device for diagnosing a >15% stroke volume (SV) increase during patient hemodynamic optimization by fluid challenge in high risk abdominal surgery.
- Trial name
- COMPARE (NCT04871620)
- Testing
- >15% SV increase during fluid challenge
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Valvular Heart Disease
Pre-habilitation of Patients Scheduled for Cardiac Valve Surgery
Cardiac rehabilitation (CR) is an integral part of cardiovascular disease management incorporating aspects of scientifically constructed appropriate physical exercise.
- Trial name
- NCT03571906
- Testing
- Tele - Cardiac Pre-Rehabilitation
- Volunteers
- 25 people
- Sponsor
- Sheba Medical Center
Patients With Coronary Artery Disease Scheduled for by Pass Surgery
Atrial Fibrillation and By-pass Surgery
The aim of the study is to evaluate whether combined therapy with beta-blocker, amiodarone and statine is better than beta-blocker alone for the prevention of atrial fibrillation after coronary by-pass surgery.
- Trial name
- NCT01955759
- Testing
- Amiodarone tab 200 mg x 3, rosuvastatin 20 mg tab x1, beta blockers Bisoprolol in adjusted dose
- Where
- Bosnia and Herzegovina
- Volunteers
- 260 people
- Sponsor
- Heart Center BH Tuzla
Cardiac Surgery
Evaluate the Protective Effect of Conditioning With Sevoflurane on the Myocardium
Heart surgery is a considerable source of stress for the myocardium that must be minimized. Troponin Ic is a reliable marker to determine the level of this myocardial stress.
- Trial name
- SUPRA (NCT02851433)
- Testing
- total anaesthesia and postoperative inhaled sedation with Sevoflurane, total intravenous anaesthesia with Propofol.
- Where
- France
- Volunteers
- 82 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
USE OF ARTIFICIAL INTELLIGENCE IN ANESTHESIA, PREOPERATIVE CARDIOLOGY CONSULTATION REQUIREMENT
The Predictability of the Necessity for Cardiology Consultation in Patients Scheduled for Non-Cardiac Surgery Using Artificial Intelligence Models in Preoperative Anesthesia Assessment
Structured Summary Title Predictability of Cardiology Consultation Requirement in Patients Undergoing Non-Cardiac Surgery Using Artificial Intelligence Models Background Preoperative cardiac risk assessment is essential for…
- Trial name
- NCT07395713
- Testing
- Patient scenarios were presented to different AI models (ChatGPT 4.5, ChatGPT 5, Copilot, Deepseek, Grok, Claude, Gemini Flash, Gemini Pro) with and without prompts.
- Where
- Turkey (Türkiye)
- Volunteers
- 183 people
- Sponsor
- Bursa City Hospital
Left Ventricular Assist Device, End-stage Heart Failure
Preoperative Nutritional Optimization and Physical Exercise for Patients Scheduled for Elective Implantation for a Left-Ventricular Assist Device
This is a pilot, randomized, multicenter interventional trial of a combined preoperative oral nutritional support (ONS) and physical exercise therapy in patients planned for elective implantation of a left-ventricular assist…
- Conditions
- Left Ventricular Assist Device, End-stage Heart Failure, Cardiac Surgery
- Trial name
- PROPER-LVAD (NCT04205760)
- Testing
- Nutrition + exercise
- Where
- 5 sites in Germany
- Volunteers
- 40 people
- Sponsor
- RWTH Aachen University
Scheduled Cardiac Surgery, Age Under 85 Years
Administration of Ropivacaine by Bi-laterosternal Multiperforated Catheters Placed Before a Sternotomy for Cardiac Surgery
The sternotomy site is the most painful site after cardiac surgery. Local infiltration of ropivacaine through the multihole catheters in the bilaterosternal position (BLS) after sternotomy significantly reduces pain at rest and…
- Trial name
- Pre-BLS-Sterno (NCT04495504)
- Testing
- Ropivacaine
- Where
- France
- Volunteers
- 32 people
- Sponsor
- University Hospital, Clermont-Ferrand
Oncologic High-risk Surgery
Measurement of Cardiac Index Using an Implanted Central Venous Access Port in Patients Scheduled for Oncologic High-risk Surgery
Perioperative hemodynamic optimization requires monitoring adapted to the risks of the surgery and the patient. We currently use a local hemodynamic protocol based on the data of the literature.
- Trial name
- ThermoD-PAC (NCT02063009)
- Where
- France
- Volunteers
- 33 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Open Heart Surgery
The Effect of Video-supported Education on Anxiety Levels and the ICU Experience
This study was conducted to examine the effects of video-assisted education about the intensive care process on intensive care experiences and anxiety levels of patients scheduled for open-heart surgery.
- Trial name
- NCT06801145
- Testing
- Education with Video
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people
- Sponsor
- Zeynep Turak
Patient Scheduled for Surgery
Evaluation of Pupillometry as a Predictor of Pain Intensity Upon Withdrawal of Sedation in the Postoperative Period Following Cardiac Surgery: A Prospective Cohort Study
Postoperative pain is a significant issue following surgery, and pain that is either inadequately treated or, conversely, overtreated can increase morbidity.
- Trial name
- PUPREA (NCT07648342)
- Testing
- Pupilometry, VAS
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Cognitive Change
Preoperative Risk Factors and Perioperative Neurocognitive Disorders
Perioperative neurocognitive disorders (PND's) remain an important complication after surgery. After many years of speculating about the etiology of this complication, currently studies are pointing to an inflammatory cascade…
- Trial name
- NCT03805685
- Testing
- Non-Cardiac Surgery
- Where
- Belgium
- Volunteers
- 38 people
- Sponsor
- Université Libre de Bruxelles
Scheduled Heart Surgery, Valve Replacement
Postoperative Renal Failure in Cardiac Surgery PMSF-PVC Gradient Study
Acute renal failure is a frequent and severe postoperative complication of cardiac surgery performed under extracorporeal circulation.
- Conditions
- Scheduled Heart Surgery, Valve Replacement, Coronary Artery Bypass
- Trial name
- PMSF-PVC (NCT04062786)
- Testing
- Pmsf-PVC gradient measurement
- Where
- France
- Volunteers
- 130 people
- Sponsor
- University Hospital, Strasbourg, France
Anemia, Iron Deficiency
Nutritional Optimization in Anemic Patients Scheduled for Elective Open-Heart Surgery
1. To test the effect and feasibility of culturally relevant SNP program in Anaemic patients scheduled for elective open-heart surgery versus those getting usual preoperative care in a public sector hospital. 2.
- Trial name
- Prehab_Nutri (NCT07801469)
- Testing
- Immune Modulating Formula, Whey Protein, Multivitamins and Iron Supplements
- Volunteers
- 140 people
- Sponsor
- National Institute of Cardiovascular Diseases, Pakistan
Cardiac Surgery
A Preliminary Study of a New Tranexamic Acid Dosing Schedule for Cardiac Surgery
Tranexamic acid is administered intravenously to prevent bleeding associated with cardiac surgery and cardiopulmonary bypass. We have developed an assay for tranexamic acid.
- Trial name
- NCT00588133
- Testing
- tranexamic acid
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Coronary Artery Disease, Edema
The Efficacy and Safety of Hypertonic Saline in Cardiac Surgery Patients.
The organ dysfunction following cardiopulmonary bypass (CPB) occurs frequently in cardiac surgery patients. Systemic inflammatory response initiated by CPB through releasing of several mediators lead to altered endothelial…
- Trial name
- ESHHS (NCT01675453)
- Testing
- 7.2% NaCl plus 6% hydroxyethyl starch 200/0.5, 0.9% NaCl
- Where
- Russia
- Volunteers
- 40 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Knee Arthroscopy, Spinal Anaesthesia
Investigation of the Effects of Two Different Anaesthesia Methods Applied to Patients Scheduled for Arthroscopic Knee Surgery on the Heart
The study will include 80 patients aged 18-65 years who will undergo elective arthroscopic meniscal surgery. Patients with bleeding disorders, cardiac disease, liver and/or renal failure, arrhythmia and electrolyte imbalance…
- Conditions
- Knee Arthroscopy, Spinal Anaesthesia, Lumbar/Sciatic Block
- Trial name
- NCT07423754
- Testing
- Knee Arthroscopy, Spinal Anaesthesia, Peripheral Nerve Block, Arthroscopic Knee Surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Sanliurfa Mehmet Akif Inan Education and Research Hospital