Clinical trials: Schizophrenia and Disorders With Psychotic Features
Mindfulness Training
MBRS-Based Psychoeducation in Patients With Schizophrenia
This study aimed to determine the effects of mindfulness-based stress reduction training on anger management and functional recovery in patients with schizophrenia.
- Trial name
- NCT07130227
- Testing
- Session 1: Preparatory Session, Session 2: Mindfulness, Session 3: Our Perspectives on Ourselves and the World
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Schizophrenia
The Safety and Efficacy of Lurasidone With Different Initiation Dose in Chinese Acute Phase Patients With Schizophrenia
To evaluate the safety and efficacy of Lurasidone initiated with 40mg and 80mg in treatment with acute phase patients with schizophrenia
- Trial name
- NCT05011669
- Testing
- Lurasidone
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Marubeni Pharmaceuticals (Suzhou) Co., Ltd.
Schizophrenia, Bipolar I Disorder
Multicenter, Randomized, Comparative and Prospective Study Evaluating the Impact on the Care Path of an Editorial Program Accompanied by Advance Directives in Psychiatry (DAP) for People Suffering From Schizophrenia, Bipolar I Disorder or Schizoaffective Disorder
Severe mental illness is accompanied by cognitive fluctuations that can alter decision-making skills and lead to coerced care. Taking into account, on the one hand, the health, social and economic impact of forced…
- Trial name
- DAiP (NCT03630822)
- Testing
- Psychiatric Advanced Directive, Standard care
- Where
- France
- Volunteers
- 399 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Schizophrenia
Investigate Risperidone for the Treatment of Schizophrenia in Adolescents
A clinical study to evaluate the efficacy, safety and tolerability of two dose ranges of risperidone (1 to 3 mg/day, and 4 to 6 mg/day) versus placebo (an inactive substance like a sugar pill) in adolescents (aged 13 to 17 years)…
- Trial name
- NCT00088075
- Testing
- Risperidone
- Volunteers
- 160 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Schizophrenia
Atomoxetine for Treatment of Weight Gain in Olanzapine or Clozapine Patients
The study investigates the use of Atomoxetine in combination with exercise and a diet support group (Weight Watchers)to treat weight gain associated with Olanzapine or clozapine.
- Trial name
- NCT00176436
- Testing
- Diet support group, Group counseling and exercise
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Maryland, Baltimore
Schizophrenia, Schizoaffective Disorder
Clonazepam Effects on Brain Oscillations and Cognition in Schizophrenia
Cognitive deficits are some of the most prominent and disabling symptoms of schizophrenia. Evidence suggests that schizophrenia involves alterations to the functioning of a neural system under the control of a brain chemical…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Schizophreniform Disorder
- Trial name
- KGB (NCT03061136)
- Testing
- Clonazepam
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Palo Alto Veterans Institute for Research
Schizophrenia Spectrum and Other Psychotic Disorders, Periodontal Diseases
Antipsychotic Induced Hyperprolactinemaia as Risk Factor for Periodontitis in Schizophrenic Patients
The aim of the present cohort retrospective study is to explore the effect of antipsychotics on periodontal health and the possible effect of antipsychotic-induced hyperprolactinemia as a risk factor for periodontal disease…
- Trial name
- NCT06040944
- Testing
- antipsychotic drugs inducing hyperprolactinemia
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Fayoum University
Schizophrenia Spectrum
Target Engagement for Oxytocin: Dose Ranging Study
This study will evaluate the effect of 8 doses of intranasal oxytocin or placebo on two proposed measures of target engagement in brain.
- Trial name
- R21Dose (NCT02498236)
- Testing
- Intranasal Oxytocin
- Volunteers
- 51 people
- Sponsor
- University of California, Los Angeles
Schizophrenia
Oxcarbazepine as an Adjunct of Antipsychotic Therapy in Acute Schizophrenia
Over recent years an approach with the adjunctive administration of various anticonvulsant drugs has been discussed and a limited number of open and controlled studies were performed for carbamazepine, valproic acid, and…
- Trial name
- OXC-SCZ (NCT00637234)
- Testing
- Oxcarbazepine
- Where
- 2 sites in Germany
- Volunteers
- 54 people
- Sponsor
- University of Cologne
Psychosis
Neuroplasticity-oriented Cognitive Intervention in Early Onset and First Admission Schizophrenia
The purpose of this study is to reveal the specific effects of computer-aided cognitive training on course and rehabilitation in early onset schizophrenia
- Trial name
- NCT01781364
- Testing
- Brain Fitness Training, Posit Science SF
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University of Konstanz
Schizophrenia, Cardiovascular Disease
Treatment Effects From Aerobic Endurance Training and Maximal Strength Training in Patients Suffering From Schizophrenia
This study investigates treatment effects from aerobic endurance training, maximal strength training and computer game on aerobic capacity, work efficiency and psychiatric symptoms in patients suffering from schizophrenia.
- Trial name
- NCT00286299
- Testing
- Aerobic high-intensity interval training (AIT), Computer game training (CG), Maximal strength training
- Where
- Norway
- Volunteers
- 33 people
- Sponsor
- Norwegian University of Science and Technology
22q11 Deletion Syndrome
Indicated Prevention With Long-chain Polyunsaturated Omega-3 Fatty Acids in Patients With 22q11 Microdeletion Syndrome.
The purpose of the present trial is to investigate the effects of omega-3 PUFAs in individuals aged 12-26 years with 22q11DS at ultra-high risk for developing a first episode of psychosis.
- Trial name
- NCT02070211
- Testing
- omega-3 PUFAs, Standard care
- Where
- Holy See
- Volunteers
- 80 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Schizophrenia
A Dose-finding Trial of OPC-34712 in Patients With Schizophrenia
To investigate the efficacy and safety of OPC-34712 in comparison with placebo in patients with schizophrenia.
- Trial name
- NCT01451164
- Testing
- OPC-34712
- Where
- Japan
- Volunteers
- 459 people
- Sponsor
- Otsuka Pharmaceutical Co., Ltd.
Schizophrenia, Gluten Sensitivity
Confirmatory Efficacy Trial of a Gluten-Free Diet in a Subgroup of Persons With Schizophrenia Who Have High Levels of IgG Anti-Gliadin Antibodies (AGA IG)
This study purpose is to conduct a confirmatory double-blind randomized controlled trial in an inpatient setting of the effects of a tightly controlled gluten-free diet (GFD) to improve negative symptoms in people with…
- Conditions
- Schizophrenia, Gluten Sensitivity, Schizo Affective Disorder
- Trial name
- NCT03183609
- Testing
- Gluten Flour in Protein Shake, Rice Flour in Protein Shake
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Maryland, Baltimore
Schizophrenia
Efficacy and Functional Recovery After Switching From Paliperidone Palmitate Injection to Oral Antipsychotics in Schizophrenia
To evaluate the efficacy of Paliperidone Palmitate Injection in replacing oral antipsychotics for the treatment of schizophrenia and its impact on social function
- Trial name
- NCT07075237
- Testing
- Paliperidone Palmitate Injection (PP1M)
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Jiangsu Province Nanjing Brain Hospital
Mental Health, Oral Health Care
The Mouth Matters in Mental Health Trial -2
This clinical trial will evaluate the effectiveness and cost-effectiveness of a link work intervention for supporting people with severe mental health difficulties to attend a routine dental appointment.
- Conditions
- Mental Health, Oral Health Care, Psychosis
- Trial name
- NCT07470437
- Testing
- Link work intervention
- Where
- 5 sites in United Kingdom
- Volunteers
- 480 people
- Sponsor
- Lancashire and South Cumbria NHS Foundation Trust
Schizophrenia, PreDiabetes
Bromocriptine for Patients With Schizophrenia and Prediabetes
This is a multicenter open-label, pilot study to evaluate the safety and tolerability of bromocriptine, a dopamine D2/D3 receptor and serotonin 5-HT2C receptor agonist, as an adjunct to preexisting standard-of-care antipsychotic…
- Trial name
- NCT03575000
- Testing
- Bromocriptine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- VA Pittsburgh Healthcare System
Schizophrenia
A Study of Plasma Concentrations, Metabolism and Excretion of 14C-paliperidone After a Single Oral Dose
The purposes of this study are to investigate the metabolic pathways of paliperidone and excretion of paliperidone and its metabolites in healthy adult male volunteers, both CYP2D6 poor and extensive metabolizers, after…
- Trial name
- NCT00796029
- Testing
- 14C-paliperidone
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
At Risk Mental State (ARMS), Psychosis
Minocycline and/or Omega-3 Fatty Acids Added to Treatment as Usual for At Risk Mental States
This is a randomized double-blind placebo controlled trial which aims to evaluate the efficacy and tolerability of minocycline and Omega-3 fatty acids for patients with ARMS.
- Trial name
- NAYAB (NCT02569307)
- Testing
- Minocycline, Omega-3 fatty acids, Minocycline Plus Omega-3 fatty acids
- Where
- 7 sites in Pakistan
- Volunteers
- 326 people
- Sponsor
- Pakistan Institute of Living and Learning
Psychosis, Schizophrenia and Other Psychotic Disorders
What is the Feasibility of Narrative Exposure Therapy (NET) for People Experiencing Psychosis?
The goal of this interventional study is to evaluate the feasibility of Narrative Exposure Therapy (NET) for people experiencing psychosis.
- Trial name
- NCT07237529
- Testing
- Narrative Exposure Therapy (NET)
- Volunteers
- 1 people
- Sponsor
- University of Nottingham
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