Clinical trials: Sciatic Neuropathy
Extracorporeal Shock Wave, Radial Shock Wave
Radial Shockwave Versus Low Level Laser Therapy in Patients With Chronic Piriformis Muscle Syndrome
The study aims to compare the effects of radiation shockwave and low-level laser therapy on piriformis muscle thickness, lower extremity function, pain intensity, and hip range of motion in patients with piriformis syndrome.
- Conditions
- Extracorporeal Shock Wave, Radial Shock Wave, Low Level Laser, Piriformis Muscle Syndrome
- Trial name
- NCT06762197
- Testing
- Conventional treatment, shockwave therapy, low level laser therapy
- Where
- Egypt
- Volunteers
- 63 people
- Sponsor
- Cairo University
Lumbosacral Radiculopathy
Procedural Framing and Epidural Steroid Injection Outcomes
Back pain is the leading cause of disability and military medical boards across the globe. Epidural steroid injections (ESI) are the most commonly performed pain procedure in the world.
- Trial name
- PEACE (NCT07498140)
- Testing
- Behavioral manipulation of ESI expectations, No behavioral manipulation of ESI expectations, No behavioral manipulation of pharmacotherapy expectations
- Where
- 4 sites in United States, Thailand and 1 more
- Volunteers
- 210 people
- Sponsor
- Northwestern University
Piriformis Syndrome
McGill Strengthening With and Without Integrated Neuromuscular Inhibition Technique in Piriformis Syndrome
The study was conducted to determine the effects of McGill strengthening exercises program with and without integrated neuromuscular inhibition technique on pain, range of motion and function in patients with piriformis syndrome.
- Trial name
- NCT07403045
- Testing
- McGill strengthening exercises program, Integrated neuromuscular inhibition technique, Standardized physiotherapy treatment
- Where
- Pakistan
- Volunteers
- 56 people
- Sponsor
- Riphah International University
Low Back Pain, Sciatica
Effect of Sciatic Nerve Slider Technique in Different Positions in Low Back Pain Patients
Neural mobilization is a technique that plays an important role in repairing the neural tissue's ability to respond to stress or tension by triggering the reconstruction of normal physiological functioning, pain reduction, and…
- Trial name
- NCT05907356
- Testing
- sciatic nerve slider technique in slump lying position, sciatic nerve slider technique in supine position, Conventional physiotherapy
- Where
- Palestinian Territories
- Volunteers
- 60 people
- Sponsor
- European University of Lefke
Chronic Radicular Back Pain, Lumboischialgia
High-tone External Muscle Stimulation for Pain Reduction
Sciatica is a common pain problem that affects not only the patient but also constitutes a socioeconomic burden and thus affects the whole society. So far, current pharmacologic therapies are inadequate for many patients.
- Conditions
- Chronic Radicular Back Pain, Lumboischialgia, Cervico Brachialgia
- Trial name
- HTEMS (NCT02151565)
- Testing
- HTEMS, TENS
- Where
- 2 sites in Germany
- Volunteers
- 100 people
- Sponsor
- West German Center of Diabetes and Health
Lumbar Disc Herniation With Radiculopathy, Sciatica
FINDISC-Pain, Finnish Discectomy Trial on the Benefits and Harms of Surgery in Patients With Lumbar Disc Herniation
The FINDISC trial studies whether common back operation, microdiscectomy, is effective and safe for treating sciatica caused by a lumbar disc herniation.
- Trial name
- FINDISC-Pain (NCT07418944)
- Testing
- Microdiscectomy
- Where
- Finland
- Volunteers
- 122 people
- Sponsor
- Helsinki University Central Hospital
Lumbar Radiculopathy, Lumbar Disc Herniation
Randomized Evaluation of Lumbar Injection Effectiveness and Function
The goal of this clinical trial is to learn whether the Triojection® System is safe and effective for treating symptomatic lumbar radiculopathy (leg pain caused by nerve irritation or compression) resulting from a contained…
- Conditions
- Lumbar Radiculopathy, Lumbar Disc Herniation, Contained Herniated Lumbar Disc
- Trial name
- RELIEF (NCT07856810)
- Testing
- Triojection® System, Selective Nerve Root Block (SNRB)
- Volunteers
- 300 people
- Sponsor
- SpinaFX Medical Inc.
Sciatica, Sciatica Due to Intervertebral Disc Disorder
Transforaminal Epidural Injection in Acute Sciatica
Patients suffering from sciatica are treated conservatively for the first 8 weeks due to the favourable prognosis. This period is preferably extended up to 14-16 weeks after which patients may opt for surgery.
- Conditions
- Sciatica, Sciatica Due to Intervertebral Disc Disorder, Sciatic Radiculopathy
- Trial name
- TEIAS (NCT03924791)
- Testing
- Lidocaine, Methylprednisolone Acetate, Dexamethasone
- Where
- 2 sites in Netherlands
- Volunteers
- 142 people
- Sponsor
- C.L.A.Vleggeert-Lankamp
Lumbosacral Radicular Pain
Corticosteroid Lumbar Epidural Analgesia for Radiculopathy
This is a research study of SP-102, an experimental medication designed to relieve pain in patients with a specific type of leg pain.
- Trial name
- NCT03372161
- Testing
- SP-102
- Where
- 37 sites in United States
- Volunteers
- 401 people
- Sponsor
- Scilex Pharmaceuticals, Inc.
Sciatica
Comparison of Intravenous Ibuprofen and Paracetamol in Patients With Sciatica Presented to the Emergency Department
Currently, Paracetamol and Ibuprofen are widely used by emergency physicians in Turkey for the pain treatments. The objective of the study was to assess whether intravenous Paracetamol has superior Sciatica pain reduction will…
- Trial name
- NCT02777320
- Testing
- paracetamol, Ibuprofen
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Pamukkale University
Sciatica
Evaluate the Safety, Tolerability and Pharmacokinetics of BG00010 (Neublastin) Administered to Sciatica Participants
The primary objective of the study is to determine the safety/tolerability profile, systemic PK behavior, and immunogenicity of single IV and SC administrations of BG00010 to sciatica participants.
- Trial name
- NCT00961766
- Testing
- BG00010 (Neublastin)
- Where
- Australia
- Volunteers
- 48 people
- Sponsor
- Biogen
Piriformis Syndrome
Comparative Presence of Piriformis Syndrome in Patients With Lumbar Disc Bulging and Protrusion
Clinicians consider lumbar disc herniation more prominently in the differential diagnosis than piriformis syndrome, as it is the most common cause of sciatica, and this canalizes them to overlook that the sciatic nerve may be…
- Trial name
- NCT06435169
- Testing
- Lasegue's, Freiberg's and, FAIR (Flexion Adduction Internal Rotation) tests.
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people
- Sponsor
- Yuzuncu Yil University
Piriformis Muscle Syndrome, Anthropometry
Pelvic and Hip Morphometry in Piriformis Syndrome
In this case-control study, 23 patients diagnosed as PS by diagnostic injection with ultrasound guidance were selected as the study group.
- Trial name
- NCT04600024
- Testing
- Ultrasound guided diagnostic injection
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Lumbar Radiculopathy
Comparative Effects of Dynamic Stretching Versus Slider Neurodynamic Technique In Patients With Lumbar Radiculopathy
This study will be a randomised clinical trial conducted at the University of Lahore Teaching Hospital, Lahore, Pakistan. A total of 72 participants will be selected and randomly allocated into two treatment groups (36…
- Trial name
- NCT07384832
- Testing
- Dynamic stretching, slider neurodynamic mobilization, Routine physiotherapy
- Where
- Pakistan
- Volunteers
- 72 people
- Sponsor
- University of Lahore
Lumbar Disc Degeneration, Lumbar Disc Disease
Total Lumbar Disc Prosthesis and Subsequent Work Activity at at Least Five Years After Total Lumbar Disc Replacement
Lumbosciatica is a very prevalent pathology. When conservative treatments fail, surgery should be considered. The traditional surgical treatment is lumbar arthrodesis.
- Conditions
- Lumbar Disc Degeneration, Lumbar Disc Disease, Sciatica, Lumbar Disc Herniation
- Trial name
- NCT06989632
- Testing
- Total lumbar disc prosthesis (Baguera®L, Spineart, Switzerland)
- Where
- Spain
- Volunteers
- 130 people
- Sponsor
- University of Valencia
Sciatica
Pain Relief by Platelet-rich Plasma (PRP) Treatment
Past PRP therapy is not sufficient for some part of patients.In this clinical research, The integrated application of PRP with extracellurar matrix and some type of stem cell technique.
- Trial name
- NCT01749839
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Saint Bernard Mission University
Piriformis Syndrome, Musculoskeletal Abnormalities
Comparing Two Soft Tissues Technique on Piriformis Syndrome Patients
Piriformis Syndrome is a neuromuscular condition with symptoms of pain, numbness and tingling tracing the route of the sciatic nerve, due to the nerve impingement by the piriformis muscle.
- Conditions
- Piriformis Syndrome, Musculoskeletal Abnormalities, Sciatica
- Trial name
- MPR-PIR (NCT07661485)
- Testing
- Myofascial Release, Post Isometric Relaxation
- Where
- Pakistan
- Volunteers
- 26 people
- Sponsor
- University of Faisalabad
Piriformis Muscle Syndrome, Myofacial Pain Syndromes
The Importance of Gluteus Maximus Muscle in Patients With Preliminary Diagnosis of Piriformis Syndrome
Literature shows different pathologies or combination pathologies can cause gluteal region pain and it can be difficult to diagnose.
- Conditions
- Piriformis Muscle Syndrome, Myofacial Pain Syndromes, Piriformis Syndrome
- Trial name
- NCT05271071
- Testing
- Ultrasound guided piriformis muscle and gluteus maximus muscle lidocaine injection
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Istanbul University - Cerrahpasa
Diabetic Foot
Sciatic Nerve Blocks With or Without Femoral Block Versus Spinal Anaesthesia in Patients Undergoing Diabetic Foot Surgery
Background: Dysautonomia refers to the abnormal function of the autonomic nervous system including sympathetic and parasympathetic nervous system. Diabetes mellitus causes secondary dysautonomias (1).
- Trial name
- NCT02727348
- Testing
- Sciatic with or without femoral block, Spinal anaesthesia
- Where
- Malaysia
- Volunteers
- 120 people
- Sponsor
- University of Malaya
Lumbar Radiculopathy, Sciatica
Dose Dependent Steroid Injections
This study aims to evaluate the efficacy of interlaminar steroid injections at treating pain in lumbar radiculopathy at varying doses, to evaluate the efficacy of interlaminar steroid injections at improving quality of life and…
- Conditions
- Lumbar Radiculopathy, Sciatica, Back Pain With Radiation
- Trial name
- NCT07494136
- Testing
- Triamcinolone 10 Mg/mL Injectable Suspension, Triamcinolone 40 Mg/mL Injectable Suspension, Triamcinolone 80 Mg/mL Injectable Suspension
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Miami