Clinical trials: Screening Strategy
Colorectal (Colon or Rectal) Cancer
Promoting Equity for Cancer Screening and Follow-up
This is a randomized trial to assess the efficacy of reminder mechanisms on colorectal cancer (CRC) screening uptake among a cohort of patients who were previously mailed a multitarget stool DNA (mt-sDNA) test and did not…
- Trial name
- NCT04831827
- Testing
- IVR Reminder, Phone call from research team, EHR Portal message
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mayo Clinic
Human Papillomavirus Infection, Cervical Intraepithelial Neoplasia Grade 2 (CIN2)
Digital Telecytology for Triage of HPV-Positive Women in Cameroon
This study evaluates the diagnostic accuracy and feasibility of a same-day cervical cancer screening strategy using HPV self-sampling followed by digital telecytology triage among HPV-positive women in Cameroon.
- Conditions
- Human Papillomavirus Infection, Cervical Intraepithelial Neoplasia Grade 2 (CIN2), Cervical Cancer Screening Methods
- Trial name
- NCT07550010
- Testing
- HPV testing (self-sampling), Digital telecytology, AI-assisted telecytology
- Where
- 2 sites in Cameroon
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Diabetes Mellitus (Type 2), Prediabetes
Evaluation of the Effectiveness of Implementing a Screening Strategy for the Diagnosis of Prediabetes and Type 2 Diabetes Mellitus in Primary Health Care in a Brazilian Municipality
Primary objective: To evaluate the effectiveness of the ARISE strategy on the proportion of individuals with confirmed T2DM diagnosis, per protocol criteria based on the PCDT-DM2 (Clinical Protocol and Therapeutic Guidelines for…
- Trial name
- ARISE (NCT07846319)
- Testing
- ARISE Strategy
- Where
- 2 sites in Brazil
- Volunteers
- 45,000 people, healthy volunteers welcome
- Sponsor
- epHealth
Digital Eye Strain (DES), Computer Vision Syndrome
Digital Eye Strain in Online Learning and Remote Work Environments: A Systematic Review
This systematic review aims to evaluate the prevalence of digital eye strain (DES) among individuals engaged in online learning and remote work, identify associated demographic, behavioral, environmental, and ocular risk factors…
- Trial name
- DES-OLRW (NCT07707908)
- Testing
- Systematic Literature Review
- Where
- Egypt
- Volunteers
- 8,972 people, healthy volunteers welcome
- Sponsor
- Benha University
Fertility Awareness, Childbearing Intentions
The Effect of Fertility Health Awareness Strategies on Fertility Knowledge and Childbearing in Young Married Couples
Singapore, like many developed countries, is experiencing low birth rates, which is coupled with increasing age at first marriage and birth.
- Trial name
- FertStart (NCT04647136)
- Testing
- Fertility Health Screening, Fertility Awareness Tools
- Where
- 2 sites in Singapore
- Volunteers
- 841 people, healthy volunteers welcome
- Sponsor
- Singapore General Hospital
Sedentary Time, Cardiovascular Diseases
WatchWell: Simple and Practical Strategies to Reduce the Negative Health Impact of Sedentary Screen Time
The purpose of this study is to determine the feasibility, acceptability, efficacy, and participant adherence in using home-based technologies and wearable devices and simple, practical strategies to reduce the negative impact…
- Conditions
- Sedentary Time, Cardiovascular Diseases, Prediabetes, Obesity
- Trial name
- NCT06963736
- Testing
- Blue light, Eating, Standing
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Celiac Disease
Evidence-based Screening Strategies for Celiac Disease
Main aim: To find evidence-based screening strategies for celiac disease in high risk groups and to find new biomarkers or biomarker combinations for celiac disease diagnostics and follow-up.
- Trial name
- NCT03136731
- Testing
- Celiac disease antibody screening
- Where
- Finland
- Volunteers
- 3,517 people, healthy volunteers welcome
- Sponsor
- Katri Kaukinen
Hepatitis C Virus
Acceptance and Feasibility of Hepatitis c Screening Strategies in Social Insertion Centers
Hepatitis C virus (HCV) infection is one of the leading causes of chronic liver disease worldwide. It is a progressive disease that without treatment leads to the development of cirrhosis in approximately 10-20% of patients.
- Trial name
- TGSS_CIS (NCT05756738)
- Testing
- Dried blood spot testing
- Where
- Spain
- Volunteers
- 854 people, healthy volunteers welcome
- Sponsor
- University of La Laguna
Neoplasm, Stomach, H. Pylori Infection
Early Detection and Screening Strategy of Gatric Cancer in Sichuan Province-A Prospective Cohort Study (WCH-GC-SIGES-01)
To establish prospective cohort of healthy population and corresponding serum sample bank in Sichuan province to provide platform for exploring early diagnosis and screening strategy of gastric cancer by a prospective cohort…
- Conditions
- Neoplasm, Stomach, H. Pylori Infection, Chronic Atrophic Gastritis
- Trial name
- SIGES-01 (NCT03597672)
- Where
- China
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- Jian-Kun Hu
Mass Screening, Early Detection of Cancer
Stepwise Strategy to Improve CANcer Screening Adherence: Cervical Cancer
This study aims to assess the effectiveness of a stepwise approach, with increasing complexity and cost, to improve adherence to organized cervical cancer screening: step 1a - customized text message invitation; step 1b …
- Conditions
- Mass Screening, Early Detection of Cancer, Uterine Cervical Neoplasm, Text Message
- Trial name
- SCAN-CC (NCT03122275)
- Testing
- Customized text message invitation ( Step 1a), Customized automatic phone call invitation (Step 1b), Secretary phone call (Step 2)
- Where
- 2 sites in Portugal
- Volunteers
- 1,220 people, healthy volunteers welcome
- Sponsor
- João Firmino Domingues Barbosa Machado
HIV
HIV Screening Take-up: Evaluating Incentives and Opt-out Strategies
Over twenty percent of HIV-positive persons in the United States are unaware of their infection, leading the Institute of Medicine to recently urge further work to compare the effectiveness of HIV screening strategies.
- Trial name
- NCT01377857
- Testing
- Monetary Incentive, Questionnaire Timing, HIV Test Offering
- Where
- United States
- Volunteers
- 8,572 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Sudden Cardiac Death, Cardiomyopathies
Sudden Cardiac Death - Screening Of Risk Factors
The investigators have created a way of quickly collecting information in a large scale young population regarding the presence of some severity indicators that may allow us to classify them into: seemingly "low risk" and…
- Conditions
- Sudden Cardiac Death, Cardiomyopathies, Channelopathies
- Trial name
- SCD-SOS (NCT01845909)
- Testing
- ECG and survey screening
- Where
- Portugal
- Volunteers
- 15,351 people, healthy volunteers welcome
- Sponsor
- University of Coimbra
Audio-Visual Triage System, Anxiety Levels
Innovation of Audio-Visual Triage System in Combating the Spread of COVID-19 Infection and Its Efficacy: A Novel Strategy
During the novel coronavirus pandemic, also known as SARS-CoV-2 or COVID-19 pandemic, frontline healthcare professionals suffered psychological as well as pathological trauma due to the lack of preparation to cope with this…
- Conditions
- Audio-Visual Triage System, Anxiety Levels, COVID-19 Spread, GAD-7 Score
- Trial name
- NCT04621214
- Testing
- Audio-Visual Triage System (AVT)
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Lahore
Heart Failure
Screening Elderly Adults in Rural Communities for Heart Failure Using an NT-proBNP-Guided Strategy in China (SEARCH-HF)
Heart failure (HF) is common among older adults and is associated with substantial morbidity, mortality, and healthcare burden. Early stages of HF may be asymptomatic or present with nonspecific symptoms, making early detection…
- Trial name
- NCT07885488
- Testing
- Symptom-based heart failure screening, NT-proBNP-guided heart failure screening
- Where
- China
- Volunteers
- 2,532 people, healthy volunteers welcome
- Sponsor
- Jiangsu Taizhou People's Hospital
Neoplasms, HPV-Related Anal Squamous Cell Carcinoma
Screening Strategies Among High-risk Populations for Anal Cancer
The goal of the proposed research is to 1) examine the performance of emerging screening methods for anal high-grade squamous intraepithelial lesion (aHSIL), a precancerous condition of anal cancer, among populations at high risk…
- Trial name
- NCT06628570
- Testing
- HRA + Biopsy, Anal Cytology, Genotyping of anal hrHPV infection
- Where
- 4 sites in United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Lisa Flowers
Breast Cancer
Developing Screening Clinical Breast Examination Implementation Strategies in South Africa
The goal of this observational study is to engage with multilevel stakeholders to collaboratively and to systematically develop a suite of strategies for implementing breast cancer screening using clinical breast examination…
- Trial name
- NCT06233383
- Where
- South Africa
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Yale University
Colonic Neoplasms
Artificial Intelligence to Implement Cost-saving Strategies for Colonoscopy Screening Based on in Vivo Prediction of Polyp Histology
This three parallel-arms, randomized, multicenter trial is aimed at investigating the value of AI-assisted optical biopsy for differentiating between neoplastic and non-neoplastic polyps which will lead to the implementation of…
- Trial name
- SAVE (NCT06041945)
- Testing
- Standard, high-definition colonoscopy with the use of CADe assistance, Standard, high-definition colonoscopy with the use of CADe/CADx assistance, no leave-in-situ, Standard, high-definition colonoscopy with the use of CADe/CADx assistance, leave-in-situ
- Where
- 2 sites in Italy
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- Istituto Clinico Humanitas
Cardiovascular Primary Prevention Strategy
Effectiveness of a Proactive Cardiovascular Primary Prevention Strategy, With or Without the Use of Coronary Calcium Screening, in Preventing Future Major Adverse Cardiac Events
The primary objective of this study is to test the effectiveness of a proactive cardiovascular primary prevention strategy, with or without the use of coronary calcium screening, compared to current standard care, in preventing…
- Trial name
- CorCal (NCT03439267)
- Testing
- Coronary Artery Calcium Screening and Statin Treatment, Standard Treatment
- Where
- United States
- Volunteers
- 5,765 people, healthy volunteers welcome
- Sponsor
- Intermountain Health Care, Inc.
Colorectal Cancer
Implementing a Multilevel Intervention to Accelerate Colorectal Cancer Screening and Follow-up
Screening for colorectal cancer (CRC) not only detects disease early when treatment is more effective but also prevents cancer by finding and removing precancerous polyps.
- Trial name
- NCT04514341
- Testing
- Intervention Phase 1: Provider and Staff education, Intervention Phase 2: Provider and staff education + Patient reminder, Intervention Phase 3: Provider and Staff education + Patient reminder + Patient navigation
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
This Study Evaluates Interventions to Increase Surveillance Mammography Uptake for Early Breast Cancer Detection Among Singaporean Women
Trial to Evaluate the Impact of Various Behavioural Interventions to Increase Mammography Uptake Among Singaporean Women
Breast cancer is the leading cancer among women in Singapore, yet mammography screening rates remain critically low at 34.7%, despite the availability of a national program since 2002.
- Trial name
- PROMPT (NCT07283107)
- Testing
- Arm 2: One mailed reminder, Arm 3: Two mailed reminders, Arm 4: Mailed reminder with prescheduled appointment
- Where
- Singapore
- Volunteers
- 8,910 people, healthy volunteers welcome
- Sponsor
- National University Hospital, Singapore