Clinical trials: Scrub Typhus
Scrub Typhus, Cardiovascular Complication
Scrub Typhus Infection Induced Cardiovascular Disease
Scrub typhus infection has been considered as seasonal and endemic infectious disorder with benign feature. However, the increasing mortality rate of scrub typhus has been recently reported in Southeast Asia and cause of death…
- Trial name
- NCT03274869
- Where
- 2 sites in South Korea
- Volunteers
- 100 people
- Sponsor
- Eulji University Hospital
Scrub Typhus
Controlled Trial: 5-day Course of Rifampin Versus Doxycycline for the Treatment of Mild to Moderate Scrub Typhus
New antibiotics are required to have not only the antibacterial activity against doxycyline-resistant O. tsutsugamushi but also lower risk for resistance or any cross-resistance to others.
- Trial name
- NCT00568711
- Testing
- doxycycline, rifampin
- Where
- South Korea
- Volunteers
- 476 people
- Sponsor
- Dong-Min Kim
Scrub Typhus
Clinical Effectiveness of Tigecycline for Scrub Typhus.
This multicenter, randomized, open-label clinical trial evaluated the efficacy and tolerability of intravenous tigecycline compared with oral doxycycline in adults hospitalized with scrub typhus.
- Trial name
- NCT07513103
- Testing
- doxycycline, Tigecycline (Tygacil)
- Where
- 3 sites in South Korea
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Jin Soo Lee
The Prevalence of Scrub Typhus
Scrub Typhus RDT Study
Fever is one of most common presenting complaints in clinics in tropical countries. Rickettsial infections, enteric fever and leptospirosis are common and important causes of undifferentiated fever in Southeast Asia.
- Trial name
- NCT03269266
- Testing
- Scrub Typhus RDT Test
- Where
- 2 sites in Burma
- Volunteers
- 136 people
- Sponsor
- Myanmar Oxford Clinical Research Unit
Scrub Typhus
Controlled Trial: 5-day Course of Telithromycin Versus Doxycycline for the Treatment of Mild to Moderate Scrub Typhus
New antibiotics are required that have antibacterial activity against doxycyline resistant O. tsutsugamushi, that can be safely used in pregnant women and children, that have a low possibility of inducing resistance and that do…
- Trial name
- NCT00351182
- Testing
- Telithromycin, Doxycycline
- Where
- South Korea
- Volunteers
- 92 people
- Sponsor
- Dong-Min Kim
Rickettsioses
Laboratory Diagnosis of of Rickettsial and Rickettsia-like Diseases
The low confirmed rickettsioses cases rate may indicate the presence of rickettsiosis other than scrub typhus, murine typhus, and Q fever.
- Trial name
- NCT01137175
- Where
- Taiwan
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Scrub Typhus
Scrub Typhus Pediatric Immunology Study
This is an observational study of the natural immune response to scrub typhus in patients recruited from Chiangrai Prachanukroh Hospital, N-Thailand.
- Trial name
- NIRPS (NCT02398162)
- Testing
- Multi Blood Collections, Single Blood Collection
- Where
- Thailand
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Rickettsial Disease
Causes of Fever in Bangladeshi Patients
Background: The clinical features and prevalence of tropical rickettsial illnesses such as murine and scrub typhus in Bangladesh are unknown.
- Trial name
- NCT02339259
- Testing
- Observation
- Where
- Bangladesh
- Volunteers
- 416 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Scrub Typhus
QuEST - Quick and Easy Scrub Typhus Diagnostic Tools
Evaluate the performance of insulated isothermal polymerase chain reaction (iiPCR) in the diagnosis of scrub typhus in Chiang Rai Province
- Trial name
- QuEST (NCT06675110)
- Where
- 3 sites in Thailand
- Volunteers
- 345 people
- Sponsor
- University of Oxford
Scrub Typhus
Eschar Investigations in Scrub Typhus
This is an observational study of patients with scrub typhus (rapid diagnostic test/quantitative polymerase chain reaction (RDT/qPCR) positive) and an inoculation eschar present on examination, recruited from Chiangrai…
- Trial name
- EXIST (NCT02915861)
- Testing
- Non-invasive eschar samples + blood, Non-invasive eschar samples+eschar biopsy+blood, Non-invasive eschar samples+eschar biopsy+lymph node fine-needle aspiration biopsy+blood
- Where
- Thailand
- Volunteers
- 44 people
- Sponsor
- University of Oxford
Scrub Typhus, Spotted Fever; India
The Epidemiology of Rickettsial Infections in South India: Cohort Study
There is enough evidence to suggest that scrub typhus and spotted fever group rickettsioses are common causes of febrile illness in India. Serological evidence also exists for murine typhus, but is rarely tested for.
- Conditions
- Scrub Typhus, Spotted Fever; India, Murine Typhus
- Trial name
- NCT04506944
- Testing
- No intervention
- Where
- India
- Volunteers
- 32,566 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Scrub Typhus
Scrub Typhus Antibiotic Resistance Trial
Study type: Randomized Control Treatment Trial Study population: Male and female patients with ≥15 years of age and acute scrub typhus Duration: 2 years Study Design: Prospective, open-label, randomized-controlled treatment trial…
- Trial name
- START (NCT03083197)
- Testing
- Doxycycline 7 days, Doxycycline 3 days, Azithromycin 3 days
- Where
- 5 sites in Thailand
- Volunteers
- 177 people
- Sponsor
- University of Oxford
Scrub Typhus
The Clinical Epidemiology of Scrub Typhus in Humans, Chiggers and Rodents
This study to collect and identify rodents and mites across transects through diverse habitats used by the human community from a localised area identified as a scrub typhus 'hot spot'.
- Trial name
- NCT02876367
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Infectious Disease, Therapeutics
Rickettsia Clearance Study
Murine typhus is a disease caused by Rickettisa typhi, an obligate intracellular bacterium transmitted by rodent fleas. The disease has a worldwide distribution; however the true burden is unknown, related to its non-specific…
- Trial name
- RiCS (NCT05972772)
- Testing
- Doxycyclin, Azithromycin
- Where
- 2 sites in Laos
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Lao-Oxford-Mahosot Hospital Wellcome Trust Research Unit