Clinical trials: Sedation
Adverse Event
Comparison of the Sedation Effect of Esketamine and Sevoflurane for Pediatric Ophthalmological Procedure
Emergence agitation is the most common reason for post-anesthesia care unit delay. Sevoflurane is used frequently inhalational anaesthetic agent to provide pediatric anaesthesia because of the nonirritant nature.
- Trial name
- NCT05321160
- Testing
- Esketamine, Sevoflurane
- Where
- China
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Eye & ENT Hospital of Fudan University
Healthy
Effect Site Controlled, Reaction Time Safeguarded, Patient Maintained Sedation With Propofol in Healthy Volunteers
Whether patient-maintained sedation (the patient controls his/her degree of sedation using a hand-held device) using the drug propofol is safer and more effective when using deteriorating reaction time as an added safeguard…
- Trial name
- NCT00321360
- Testing
- Propofol, Patient maintained sedation
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Sonia Allam
Colonoscopy
Can Simple and Inexpensive Techniques Enhance Patient Comfort
This research study compares two methods of performing colonoscopy without sedation. The standard method is to insert the colonoscope without adding any water to the colon, and when colonic spasms occur during the examination…
- Trial name
- NCT00747084
- Testing
- Colonoscopy
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Recall Phenomenon
Introducing a New EEG Based Index for Monitoring Recall Under Sedation
This is a single centre prospective observational study that will investigate a new EEG based index in recognizing recall of anesthesia in sedated patients. Awareness under general anesthesia is a dreadful complication.
- Trial name
- NCT03835156
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Hypoxemia
Capnography Monitoring During Intravenous Conscious Sedation Sedation With Midazolam for Oral Surgery
Dentists use sedation to help patients accept difficult procedures and to relieve anxiety. During sedation, the well-being of the patient is monitored by the dental team.
- Trial name
- NCT01949012
- Testing
- Capnography
- Where
- Ireland
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- University College Cork
Pain Relief in Post Operative Patient
Comparison of Pain ReliefofBupivacaineWith Dexmedetomidine and Bupivacaine Alone in TransversusAbdominisPlane Block For Postoperative Anelgesia in Patients Undergoing Abdominal Surgeries
Postoperative pain related to abdominal surgeries poses significant burden on the healthcare system, in terms of increased use of different analgesics, delayed ambulation, pulmonary complications, DVT, and prolonged hospital…
- Trial name
- NCT05244252
- Testing
- dexmeditomidine and bupivacaine, Bupivacaine
- Where
- Pakistan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sheikh Zayed Medical College
Adverse Effects in the Therapeutic Use of Other and Unspecified Agents Primarily Acting on the Respiratory System
Dexmedetomidine Versus Propofol for Sedation in Stereotactic Brain Biopsy
Pre-operative anxiety leads to higher sympathetic stimulation. Propofol in the main drug used during interventional or imaging techniques that need sedation.
- Trial name
- NCT03375385
- Testing
- dexmedetomidine/ propofol
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Pediatric Sedation, Clonidine Sedation
Premedication in Children: a Clinical Trial Comparing Oral Ketamine and Oral Clonidine With Respect to Sedation Level and Opioid Consumption in Pediatrics Undergoing Elective Lower Abdominal Day-case Surgery.
Aim of the work Is to compare between oral ketamine and oral clonidine regarding the level of sedation pre and postoperatively in addition the need of opioids administration intraoperative in children undergoing elective lower…
- Conditions
- Pediatric Sedation, Clonidine Sedation, Ketamine Sedation
- Trial name
- NCT07461376
- Testing
- Oral Clonidine (OC)
- Where
- Egypt
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Cairo University
Analgesic Effects of Music
The Sedative Effects of Music Listening on Pain During Cold Pressor Test
This study aims to understand whether listening to music can reduce pain and anxiety caused by a cold-temperature stimulus in healthy young adults (n = 30).
- Trial name
- ESEMP (NCT07515196)
- Testing
- Phase 1 - Silence (Baseline), Phase 2 - Happy Mode with Measured Rhythm, Phase 3 - Sad Mode with Measured Rhythm
- Where
- Lebanon
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Rawane El Dimachki
Esophagogastroduodenoscopy
Topical Pharyngeal Anesthesia in Sedated Esophagogastroduodenoscopy
At recent, the number of patients who underwent sedated esophagogastroduodenoscopy has been on the increase. For such patients, whether topical pharyngeal anesthesia is needed remains to be controversial.
- Trial name
- NCT03070379
- Testing
- Topical lidocaine pharyngeal anesthesia
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Affiliated Hospital to Academy of Military Medical Sciences
Patient Satisfaction, Anxiety State
Effect of Binaural Beats on Level of Anxiety and Toleration in Patients Undergoing Upper Gastrointestinal Endoscopy Without Sedation
To investigate the anxiolytic effects of binaural beat-embedded audio in patients undergoing sedation-free upper gastrointestinal endoscopy
- Conditions
- Patient Satisfaction, Anxiety State, Tolerance
- Trial name
- NCT06114524
- Testing
- binaural music
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Procedural Sedation
Dexmedetomidine and Midazolam Nebulization as Sedation During Cesarean Delivery in Pre-eclampsia
Null hypothesis: There is no difference between the effects of nebulization of dexmedetomidine and midazolam as procedural sedation during cesarean delivery under spinal Anesthesia in pre-eclamptic parturients Alternative…
- Trial name
- NCT04873596
- Testing
- Nebulized dexmedetomidine, Nebulized midazolam
- Where
- Egypt
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Sedation Complication
Comparison Between Sevoflurane and Propofol for Maintenance of Sedation During ERCP
After approval of ethical committee of Sindh Institute of Urology \& Transplantation (SIUT), 86 patients were enrolled for the elective endoscopic retrograde cholangiopancreatography (ERCP).
- Trial name
- NCT05996588
- Testing
- Propofol 1 % Injectable Suspension, Sevoflurane
- Where
- Pakistan
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Sindh Institute of Urology and Transplantation
Pediatric, ED95
The ED95 of Single Intravenous Bolus Remimazolam Besylate in Pediatric Patients During General Anesthesia Induction
Due to the incomplete development of systems and low pain thresholds in the pediatric population, good general anesthesia is required during the perioperative period to ensure the smooth progress of the surgery.Propofol is often…
- Conditions
- Pediatric, ED95, Sedation, General Anesthesia
- Trial name
- NCT06061159
- Testing
- Remimazolam besylate
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Cognitive Dysfunction
Ketamine vs Midazolam on Cognitive Function in Elderly in Elective Surgery Three-Months Postoperatively (ketaminvsMDZ)
Deterioration of posoperative cognitive function (DCPO) is an intermediate state between normal cognitive aging and dementia, defined as a cognitive alteration greater than expected for the patient's age and educational level…
- Trial name
- ketaminvsMDZ (NCT04134052)
- Testing
- ketamine sedation versus midazolam sedation
- Where
- Mexico
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Universidad de Colima
for Post-operative Pain Relief in Spine Surgeries
Low Dose Perioperative Ketamine Infusion and it's Effect on Postoperative Pain Score, Sedation Score and Narcotic Consumption in Patients Undergoing Spine Surgery: A Prospective Randomized Double Blind Control Trial.
Low dose perioperative ketamine infusion and it's effect on postoperative pain score, sedation score and narcotic consumption in patients undergoing spine surgery: A prospective randomized double blind control trial.
- Trial name
- NCT04259476
- Testing
- Ketamine Hydrochloride
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Services Institute of Medical Sciences, Pakistan
Conscious Sedation
Current Procedural Sedation Practices in a Canadian Community Emergency Department
To review current Emergency Department procedural sedation practices in the community hospital setting and the associated drugs used (class of anesthetic and mode of administration).
- Trial name
- NCT04172415
- Testing
- Retrospective cohort
- Where
- Canada
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Amber Graystone
Remimazolam, Dexmedetomidine
Application of Remimazolam, Dexmedetomidine, and Esketamine in Pediatric Preoperative Sedation
By comparing the application effects of three drugs in pediatric preoperative sedation, this study explores the optimal medication regimen, aiming to provide safer, more effective, and more personalized medication options for…
- Conditions
- Remimazolam, Dexmedetomidine, Esketamine
- Trial name
- NCT07050212
- Testing
- remimazolam group, dexmedetomidine group, esketamine group
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Maternal and Child Health Hospital of Hubei Province
Electroencephalography, Melatonin
Sedation and Nursing Management in EEG Recording in Children
Electroencephalogram (EEG) has an important place in establishing the correct diagnosis, providing appropriate intervention, and predicting the prognosis in the long term in children.
- Conditions
- Electroencephalography, Melatonin, Chloral Hydrate, Hydroxyzine
- Trial name
- NCT05492812
- Testing
- Sedation and Nursing Management in EEG Recording in Children, Chloral Hydrate, Hydroxyzine
- Where
- Turkey (Türkiye)
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Suleyman Demirel University
High Flow Nasal Cannula, Body Roundness Index
High Flow Nasal Cannula and Mask Oxygenation in Patients With Visceral Obesity Undergoing Sedated Gastroscopy
During sedated gastroscopy, the insertion of the fiberscope and gastric distension required to perform the examination may induce respiratory depression, airway obstruction, and decreased chest wall compliance.
- Trial name
- NCT07159022
- Testing
- High Flow Nasal Cannula Oxygenation, Face Mask Oxygenation
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Shanghai Zhongshan Hospital