Clinical trials: Sedation
Anesthesia, Sedation
A Study Evaluating the Mass Balance of [14C]HSK3486 Emulsion Injection in Healthy Adults.
This study is designed to evaluate the mass balance and biotransformation pathways of HSK3486 in healthy Chinese male subjects administered with a single intravenous dose of [14C]HSK3486, so as to characterize the drug's general…
- Trial name
- NCT03751956
- Testing
- HSK3486
- Where
- China
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Sichuan Haisco Pharmaceutical Group Co., Ltd
Endotracheal Intubation, Deep Sedation
Inhaled Sedation Using the Anesthetic-conserving Device ( ANACONDA) in Prehospital Emergency Medecine.
Achieving the optimal sedation level for patient management is not always possible using our standard intravenous medications in Pre-hospital Emergency medicine.
- Trial name
- ANACONDA (NCT04141267)
- Where
- France
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Anxiety and Fear, Anesthesia
Evaluating Stress Response and Anxiety Score in Paediatric Patients
To date, there have been no studies done relating serum cortisol levels and intranasal dexmedetomidine sedation. However, there was a behavioral study done on pediatric patients confirming reduction serum cortisol levels with…
- Trial name
- NCT04526652
- Testing
- Dexmedetomidine
- Where
- Malaysia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Procedural Sedation
A Trial of Intranasal Remimazolam Pharmacokinetics, Pharmacodynamics, Safety and Bioavailability
A prospective dose escalation, nine period cross-over trial assessing the safety, pharmacokinetics, bioavailability and pharmacodynamics of escalating doses of Remimazolam when administered intranasally as powder and solution in…
- Trial name
- NCT03329014
- Testing
- Remimazolam
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Paion UK Ltd.
Colonoscopy
Sedation Techniques for Outpatient Colonoscopy
This was a prospective, randomized, single-blind controlled clinical trial comparing three sedative regimens for outpatient colonoscopy.
- Trial name
- NCT04686058
- Testing
- Propofol 10 MG/ML Injection, Midazolam injection, Pethidine Hydrochloride 50 Mg/mL Solution for Injection
- Where
- Malaysia
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
Pharyngeal Dysfunction, Pharyngeal Swallowing
Opioid-Induced Swallowing Dysfunction - The Impact of Bolus Volume
The purpose of the study is to evaluate the impact of different bolus volumes and viscosity on remifentanil-induced swallowing dysfunction in healthy volunteers.Hence, whether swallowing tasks can be done safer during sedation by…
- Trial name
- NCT03283020
- Testing
- RemifentanilMNTX
- Where
- Sweden
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Region Örebro County
Delirium, Sedation Complication
The Relationship Between Fasting Time and Delirium
We investigated the relationship between fasting times and delirium in children undergoing MRI under anesthesia. Paediatric Anaesthesia Emergence Delirium (PAED) scale, last oral intake time and type of food (solid-liquid) and…
- Conditions
- Delirium, Sedation Complication, Magnetic Resonance Imaging, Fasting
- Trial name
- NCT05567718
- Testing
- Paediatric Anaesthesia Emergence Delirium scale
- Where
- Turkey (Türkiye)
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Electroencephalography
EEG Analysis During Light Propofol Sedation
The hypothesis of this study is that propofol sedation does not affect the detectability of a movement intention in the EEG motor cortex signal.
- Trial name
- MOTANA (NCT03362775)
- Testing
- Propofol
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Glioma
Sedatives' Effects on Neurological Function in Patients With Eloquent Area Glioma
Sedation in the operating room, the Post Anesthesia Care Unit and the Intensive Care Unit is common and often necessary for patients with intracranial brain tumor.
- Trial name
- NCT02439164
- Testing
- Midazolam
- Where
- China
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Sleep Apnea Syndrome
Establishment of Ideal IV Sedative Regimen for Successful Fiberoptic Bronchoscopy in Assessing the Site, Severity of Sleep Apnea Syndrome
Venous thromboembolism(VTE) is the third most common cardiovascular complication among hospitalized patients, and can even cause death.
- Trial name
- NCT02148432
- Testing
- dexmedetomidine infusion rate, 0.5 mcg/kg/hr, dexmedetomidine infusion rate, 1.0 mcg/kg/hr
- Where
- South Korea
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Yonsei University
In the Study the Value of Capnography for Avoiding Complications During Sedation for PEG is Evaluated.
Capnography During Percutaneous Endoscopic Gastrostomy (PEG)
In this randomized controlled trial the utility of capnography gets evaluated. Hypoxemia may occur during sedation with midazolam and propofol.
- Trial name
- PEG (NCT01242358)
- Testing
- Capnography, Standard monitoring
- Where
- 3 sites in Germany
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Ruhr University of Bochum
Effect of Sedation on Heart Rate Variability
EFFECT OF DEXMEDETOMİDİNE AND MİDAZOLAM SEDATİON ON HEART RATE VARİABİLİTY AFTER CORONARY ARTERY BYPASS GRAFT SURGERY
The parasympathetic tone reduction and sympathetic tone enhancement, which are components of the autonomic nervous system (ANS) activity, increase the likelihood of malignant arrhythmias leading to ventricular fibrillation.
- Trial name
- NCT03601091
- Testing
- Precedex 200 MCG in 2 ML Injection, DORMICUM 5MG/5 ML
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
Sedation and Analgesia, Side Effect of Drug
The Effect of Ondansetron During Intramuscular Ketamine Use in Children: A Trial in Emergency Department
The purpose of this study is to evaluate the anti-emetic effect of oral ondansetron. For this evaluation, the investigators will perform a multi-center, double-blind, placebo-controled, randomized study.
- Trial name
- NCT01477242
- Testing
- Ondansetron
- Where
- South Korea
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Shoulder Dislocation
Propofol Target-Controlled Infusion in Emergency Department Sedation
There exists continued controversy over the use of propofol in Emergency Department procedural sedation, this is despite its widespread existence in clinical practice for at least a decade.
- Trial name
- ProTEDS (NCT03442803)
- Testing
- Target-Controlled Infusion
- Where
- 4 sites in United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- NHS Greater Glasgow and Clyde
Anesthesia
VR Sedation in Third Molar Surgery
Anaesthesia or sedation for dental surgery is Challenging. Over-sedation, leading to upper airway obstruction, desaturation and apnoea, is very common.
- Trial name
- NCT04540666
- Testing
- Propofol
- Where
- Hong Kong
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Sedation Complication
Comparison of High-Flow Nasal Cannula Oxygen Application and Classic Nasal Cannula Oxygen Application
Recently, sedation practices have increased for diagnostic and interventional procedures for children in non-operating rooms. On the other hand, the rate of respiratory complications especially in non-operating room sedation…
- Trial name
- NCT04472273
- Testing
- high-flow nasal cannula / classic nasal cannula
- Where
- Turkey (Türkiye)
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Kocaeli Derince Education and Research Hospital
Sedation in ERCP
Ketamine- Propofol Versus Pethidine- Propofol in ERCP
The investigators aim to investigate the differences between ketamine propofol and pethidine propofol during ERCP in respect to endoscopist satisfaction.
- Trial name
- NCT02651792
- Testing
- ketamine- propofol, pethidine- propofol
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Arthritis Knee, Arthritis Hip
Ideal Dosage for Sedation of Obese Patients Undergoing Knee or Hip Arthroplasty Under Spinal Anesthesia
This study aims to compare ideal body weight- and total body weight-based dosage for remimazolam sedation of obese patients undergoing knee or hip arthroplasty under spinal anesthesia.
- Trial name
- NCT05760534
- Testing
- Remimazolam
- Where
- South Korea
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Stress, Job
Stress Level Among Dentists in Performing Treatment
Purpose: To evaluate the stress levels of dentists working under clinical, deep sedation, or general anaesthesia. Methods: Blood pressure (Systolic, Diastolic blood pressure), Pulse value, O2 saturations were measured, and saliva…
- Trial name
- NCT05394480
- Testing
- Blood pressure (Systolic, Diastolic), Pulse value, O2 saturations were measured.
- Where
- Turkey (Türkiye)
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Healthy
Effect Site Controlled, Reaction Time Safeguarded, Patient Maintained Sedation With Propofol in Healthy Volunteers
Whether patient-maintained sedation (the patient controls his/her degree of sedation using a hand-held device) using the drug propofol is safer and more effective when using deteriorating reaction time as an added safeguard…
- Trial name
- NCT00321360
- Testing
- Propofol, Patient maintained sedation
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Sonia Allam