Clinical trials: Sedation During
Conscious Sedation
Monitored Anesthesia Care: Dexmedetomidine-Ketamine Versus Dexmedetomidine- Propofol For Chronic Subdural Hematoma
Inadequate sedation and analgesia indicated by intraoperative movements are markers of inadequate MAC during burr-hole surgery for chronic subdural hematoma evacuation especially when general anesthesia poses high risk for the…
- Trial name
- NCT04621526
- Testing
- dexmedetomidine- ketamine, dexmedetomidine- propofol
- Where
- Egypt
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Complication
Midazolam With Meperidine and Dexmedetomidine vs. Midazolam With Meperidine and Propofol for Sedation During ERCP
This is a single-center, prospective, randomized, double-blinded study of consecutive patients referred for ERCP. A recent study suggested that the addition of dexmedetomidine to the midazolam-meperidine regimen (MMD)provided…
- Trial name
- NCT02475824
- Testing
- Midazolam®, "Meperidine" (pethidine®), Propofol®
- Where
- South Korea
- Volunteers
- 258 people, healthy volunteers welcome
- Sponsor
- Dankook University
Hypoxia, Endoscopy
Nasal Continuous Positive Airway Pressure Versus Standard Care During Procedural Sedation for Gastrointestinal Endoscopy
This study is a randomized controlled trial comparing oxygen delivery by nasal mask with continuous positive airway pressure versus standard care (nasal cannula or standard facemask) during propofol-based sedation for…
- Conditions
- Hypoxia, Endoscopy, Anesthesia Morbidity
- Trial name
- NCT03369197
- Testing
- Nasal Mask, Control: Nasal Cannula
- Where
- United States
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Anesthesia; Reaction
Dexmedetomidine-Propofol and Ketamine-Propofol During Upper Gastrointestinal System Sedation
Sedation with dexmedetomidine-propofol or ketamine-propofol was planned in patients with upper gastrointestinal endoscopy.
- Trial name
- NCT04399226
- Testing
- Dexmedetomidine
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University
Hypoxia, High Altitude
SJOV vs. HFNO for Hypoxia During Procedural Sedation at High Altitudes
This study aims to compare the effect of the use of supraglottic jet oxygenation and ventilation (SJOV) with high-flow nasal oxygen therapy (HFNO) on reducing the rate of hypoxia during gastrointestinal endoscopic procedures in…
- Trial name
- NCT05474287
- Testing
- SJOV, HFNO
- Where
- China
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital
Anxiety
Melatonin vs Pregabalin for Anxiolysis and Sedation
preoperative melatonin, pregabalin or both will be given to all patients preoperative
- Trial name
- NCT05221151
- Testing
- Melatonin, Pregabalin, Ondansetron 4 MG
- Where
- Egypt
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Menoufia University
Conscious Sedation Failure During Procedure
Remifentanil Effect-site Prediction by Algometry
This study validates the pharmacodynamic analgesic predictions (effect) given by Minto's remifentanil pharmacokinetic and dynamic model in conscious sedation.
- Trial name
- NCT05115578
- Testing
- Remifentanil 1 MG Injection [Ultiva], Midazolam 1 MG/ML Prefilled Syringe, Saline solution
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Apnea During Procedural Sedation
Electric Blower Based Ventilator Used During Procedural Sedation
Conduct human trials in the endoscopy suite of our continuous positive airway pressure (CPAP) ventilator approach using an FDA approved ventilator.
- Trial name
- NCT02621463
- Testing
- Noninvasive Ventilator (V60, Philips)
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Utah
Colonoscopy
Effects of Intravenous Lidocaine During Sedation for Colonoscopy.
This study assesses the benefits of continuous intravenous lidocaine administration during sedation for colonoscopy. Sedation will consist of propofol infusion titrated to provide adequate working conditions to the…
- Trial name
- NCT02784860
- Testing
- Lidocaine, normal saline
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Liege
Kyphoplasty, Prone Position
TCI Versus Manual TIVA for Sedation During Prone Kyphoplasty: Effects on Respiration, Recovery, and EEG
This single-center, prospective, observational study compares target-controlled infusion (TCI) versus manually administered total intravenous anesthesia (TIVA) for sedation in patients undergoing kyphoplasty in the prone…
- Conditions
- Kyphoplasty, Prone Position, Target Controlled Infusion of Propofol, End Tidal Carbon Dioxide
- Trial name
- NCT07745348
- Testing
- Target controlled infusion of propofol, non invasive ETCO2 monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Marmara University Pendik Training and Research Hospital
Conscious Sedation Failure During Procedure
Music Therapy in Procedural Sedation in the Emergency Department
The investigators propose to determine whether listening to classical music during a sedation procedure decreases the need for procedural sedation medication.
- Trial name
- NCT02676206
- Testing
- Classical music
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Healthy Participants
Characterizing Transcranial Focused Ultrasound Neuromodulation During Sedation
The goal of this clinical trial is to learn if focused ultrasound delivered to the brain influences the effects of the anesthetic medication propofol.
- Trial name
- NCT07161518
- Testing
- Low-intensity transcranial ultrasound, Propofol
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Stanford University
Bronchoscopy
Narcotrend Versus Bispectral Index Monitoring During Sufentanil-Midazolam Anesthesia for Bronchoscopy
This study was aimed to determine whether narcotrend monitoring was better than bispectral index monitoring during sufentanil-midazolam anesthesia for bronchoscopy under conscious sedation.
- Trial name
- NCT03738137
- Testing
- Narotrend, BIS, Sufentanil
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Guangzhou Institute of Respiratory Disease
Pediatric, ED95
The ED95 of Single Intravenous Bolus Remimazolam Besylate in Pediatric Patients During General Anesthesia Induction
Due to the incomplete development of systems and low pain thresholds in the pediatric population, good general anesthesia is required during the perioperative period to ensure the smooth progress of the surgery.Propofol is often…
- Conditions
- Pediatric, ED95, Sedation, General Anesthesia
- Trial name
- NCT06061159
- Testing
- Remimazolam besylate
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Pain, Anxiety
Estimation of Analgetic Effect and Cooperability of Pediatric Patients During Application of Gass Mixture of Oxygen:Nitrogen Suboxide 50%:50% for Minimal Invasive Procedures
The goal of this observational study is to observe analgetic and anxiolytic effect of gass mixture of oxygen:nitrigen suboxide 50%:50% in pediatric patients sujected to minimal invasive procedures.
- Conditions
- Pain, Anxiety, Sedation
- Trial name
- NCT07159425
- Where
- Serbia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mother and Child Health Institute of Serbia Dr Vukan Cupic
Propofol, Anesthesia
Investigating Near-Threshold Perception During Anesthetic Sedation
The researchers expect to gain a deeper understanding of mental function during different levels of anesthesia. Propofol is FDA approved for use in patients undergoing an anesthetic for medical treatment but is not approved for…
- Conditions
- Propofol, Anesthesia, fMRI
- Trial name
- NCT06403852
- Testing
- Functional Magnetic Resonance Imaging (fMRI) with propofol
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Hypoxemia During Surgery
Prediction Model of Hypoxemia in Gastrointestinal Endoscopy Sedation
The incidence of hypoxemia during gastrointestinal endoscopy sedation is high, but there is still a lack of perfect prediction model of hypoxemia, which often leads to unpredictable respiratory complications.
- Trial name
- NCT06016998
- Where
- China
- Volunteers
- 1,023 people, healthy volunteers welcome
- Sponsor
- Sichuan Provincial People's Hospital
Oocyte Retrieval, Sedation, Conscious
Respiratory Depression During an Analgosedation Combining Remifentanil and Ketamine in TCI for Oocyte Retrieval
This study evaluates the effect of the addition of ketamine to a conscious sedation protocol including remifentanil during oocyte retrieval.
- Conditions
- Oocyte Retrieval, Sedation, Conscious, Ventilatory Depression
- Trial name
- NCT03458143
- Testing
- Ketamine 150 ng/ml, Remifentanil, Oocyte retrieval
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Erasme University Hospital
Morbid Obesity, Noninvasive Ventilation
Use of High Flow Nasal Cannula During Sedation of Morbidly Obese Patients in the Endoscopy Suite
This study evaluates the ability of high flow nasal cannula versus nasal cannula to oxygenate morbidly obese patients undergoing moderate to deep sedation for gastrointestinal procedures.
- Conditions
- Morbid Obesity, Noninvasive Ventilation, Deep Sedation
- Trial name
- NCT02859597
- Testing
- High flow nasal cannula, Nasal Cannula
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Conscious Sedation
Ondansetron Reduce Vomiting Associated With Ketamine PSA
Ondansetron, a commonly used anti-vomiting medication, may reduce the occurrence of vomiting associated with ketamine during procedural sedation in the pediatric emergency department.
- Trial name
- NCT00387556
- Testing
- Ondansetron
- Where
- United States
- Volunteers
- 268 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver