Clinical trials: Sedation During
Blood Pressure, Dental Anxiety
Hemodynamic Changes During Implant Surgery with Intravenous Conscious Sedation
The goal of this study is to determine whether intravenous sedation would contribute to the stabilization of hemodynamics in adult patients during periodontal/implant surgery compared to receiving local anesthesia during…
- Trial name
- NCT05756439
- Testing
- Intravenous Sedatives with or Without Analgesia, No IV sedation
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Anesthesia, Pain
Memory & Conditioning Under Anesthesia
The purpose of this study is to determine the effects of pain on long-term memory and conditioned physiologic responses in the presence and absence of distinct intravenous anesthetics.
- Trial name
- MCA (NCT04062123)
- Testing
- Dexmedetomidine, Propofol, Fentanyl
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Keith M Vogt
Anxiety
Pre-procedural Anxiety and Sedation.
Colonoscopy is an outpatient procedure performed frequently as a screening test for diagnosis and treatment of a wide range of gastrointestinal problems.
- Trial name
- NCT01958151
- Testing
- State-Trait Anxiety Inventory Scores
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Basak Ceyda MECO
Patient Satisfaction
Use of Virtual Reality Technology as a Sedation Replacement During Colonoscopy
A pilot non-randomized controlled study examined whether the use of VR technology can serve as an appropriate substitute for sedation in a colonoscopy examination.
- Trial name
- NCT05701566
- Testing
- virtual reality headset, colonoscopy with standard sedation.
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Amnesia, Pain
Memory Modulation by Pain During Anesthesia
The purpose of this study is to determine the effects of pain on facilitating long-term auditory memory in the presence and absence of distinct intravenous anesthetics.
- Conditions
- Amnesia, Pain, Anesthesia
- Trial name
- MMA (NCT02515890)
- Testing
- Dexmedetomidine, Midazolam, Peripheral nerve stimulation
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Healthy, Covert Consciousness
Assessing Covert Consciousness During Dexmedetomidine and Ketamine Sedation: An fMRI Study
This research is studying whether mental functions take place during different levels of anesthesia, using a commonly used drug (either dexmedetomidine [with propofol in some participants] or ketamine), which shows areas in the…
- Trial name
- NCT07705022
- Testing
- Dexmedetomidine (+propofol as indicated), Ketamine
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Cognitive Dysfunction
Ketamine vs Midazolam on Cognitive Function in Elderly in Elective Surgery Three-Months Postoperatively (ketaminvsMDZ)
Deterioration of posoperative cognitive function (DCPO) is an intermediate state between normal cognitive aging and dementia, defined as a cognitive alteration greater than expected for the patient's age and educational level…
- Trial name
- ketaminvsMDZ (NCT04134052)
- Testing
- ketamine sedation versus midazolam sedation
- Where
- Mexico
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Universidad de Colima
Propofol, Anesthesia
Investigating Near-Threshold Perception During Anesthetic Sedation
The researchers expect to gain a deeper understanding of mental function during different levels of anesthesia. Propofol is FDA approved for use in patients undergoing an anesthetic for medical treatment but is not approved for…
- Conditions
- Propofol, Anesthesia, fMRI
- Trial name
- NCT06403852
- Testing
- Functional Magnetic Resonance Imaging (fMRI) with propofol
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Dental Pain
Buffered Local Anesthetic
The purpose of this research study is to compare responses in children during dental injections of local anesthetic (used for numbing), while children are under deep sedation (breathing on their own, often with a loss of…
- Trial name
- NCT05757648
- Testing
- Non-buffered Anesthetic, Buffered Anesthetic, Onset
- Where
- 2 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Sedation and Analgesia, Side Effect of Drug
The Effect of Ondansetron During Intramuscular Ketamine Use in Children: A Trial in Emergency Department
The purpose of this study is to evaluate the anti-emetic effect of oral ondansetron. For this evaluation, the investigators will perform a multi-center, double-blind, placebo-controled, randomized study.
- Trial name
- NCT01477242
- Testing
- Ondansetron
- Where
- South Korea
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Colonoscopy
Bispectral Index Monitoring During Anesthesiologist - Directed Sedation in Scheduled Colonoscopies
The aim of the study is to establish and identify the level of sedation that is performed in the endoscopy rooms of Galdakao Hospital.
- Trial name
- NCT03461029
- Testing
- BIS monitor
- Where
- Spain
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Hospital Galdakao-Usansolo
Kyphoplasty, Prone Position
TCI Versus Manual TIVA for Sedation During Prone Kyphoplasty: Effects on Respiration, Recovery, and EEG
This single-center, prospective, observational study compares target-controlled infusion (TCI) versus manually administered total intravenous anesthesia (TIVA) for sedation in patients undergoing kyphoplasty in the prone…
- Conditions
- Kyphoplasty, Prone Position, Target Controlled Infusion of Propofol, End Tidal Carbon Dioxide
- Trial name
- NCT07745348
- Testing
- Target controlled infusion of propofol, non invasive ETCO2 monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Marmara University Pendik Training and Research Hospital
Analgesia
Methoxyflurane for Analgesia During Hysteroscopy
This study is to assess the non-inferiority of using inhaled methoxyflurane (MOF) versus intravenous conscious sedation with fentanyl and midazolam on women's perception of pain, during hysteroscopy and/or polypectomy in an…
- Trial name
- NCT06899724
- Testing
- Anesthetics, Inhalation, Intravenous Sedatives with or Without Analgesia
- Where
- Canada
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Dr. John A. Thiel Medical Professional Corporation
In the Study the Value of Capnography for Avoiding Complications During Sedation for PEG is Evaluated.
Capnography During Percutaneous Endoscopic Gastrostomy (PEG)
In this randomized controlled trial the utility of capnography gets evaluated. Hypoxemia may occur during sedation with midazolam and propofol.
- Trial name
- PEG (NCT01242358)
- Testing
- Capnography, Standard monitoring
- Where
- 3 sites in Germany
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Ruhr University of Bochum
Hypoxia, High Altitude
Supraglottic Jet Oxygenation and Ventilation for Gastrointestinal Endoscopy at High-altitude
This study aims to determine whether the use of SOJV could reduce the rate of hypoxia during gastrointestinal endoscopic procedures in deeply sedated patients sedated at high altitude comparing to the supplemental oxygen…
- Trial name
- NCT05304923
- Testing
- Supraglottic jet oxygenation and ventilation, Nasal cannula oxygen supply
- Where
- China
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital
Electroencephalography
EEG Analysis During Light Propofol Sedation
The hypothesis of this study is that propofol sedation does not affect the detectability of a movement intention in the EEG motor cortex signal.
- Trial name
- MOTANA (NCT03362775)
- Testing
- Propofol
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Continuous Positive Airway Pressure, Endoscopy
Nasal CPAP - The Treatment IMpact on Oxygenation in High-risk Patients During Deep Sedation for Endoscopy
Deep sedation during gastrointestinal endoscopy in patients with cardiopulmonary risk factors such as respective co-morbidities or also morbid obesity is challenging.
- Conditions
- Continuous Positive Airway Pressure, Endoscopy, Oxygenation, Obesity
- Trial name
- NAPTIME (NCT06168682)
- Testing
- SuperNO2VA™ Et by Vyaire Medical, Inc., nasal oxygen cannula
- Where
- Germany
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Minimally Sedated Patient Undergoing Colonoscopy
Comparing Maximal and Half-maximal Suction Pressure Applied During Water Exchange in Colonoscopy
This prospective, randomize, controlled trial will compared maximal to half-maximal suction pressure applied during water exchange in patients undergoing minimally sedated colonoscopy.
- Trial name
- NCT01948284
- Testing
- half-maximal pressure, maximal pressure, Suction Unit
- Where
- Taiwan
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Dalin Tzu Chi General Hospital
Magnesium, Intraoperative Analgesia
Magnesium Sulfate as an Adjuvant to Propofol During Consious Sedation in Colonoscopy
Colonoscopy is one of the most commonly performed outpatient procedures throughout the world as a screening, diagnostic, and therapeutic tool to evaluate the large intestine from the distal rectum to the cecum.Propofol is the…
- Trial name
- NCT06131905
- Testing
- Magnesium Sulfate, Propofol
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assiut University
Conscious Sedation
Ondansetron Reduce Vomiting Associated With Ketamine PSA
Ondansetron, a commonly used anti-vomiting medication, may reduce the occurrence of vomiting associated with ketamine during procedural sedation in the pediatric emergency department.
- Trial name
- NCT00387556
- Testing
- Ondansetron
- Where
- United States
- Volunteers
- 268 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver