Clinical trials: Sedation During
Anesthesia, Spinal, Sedation, Conscious
Paradoxical Excitement Response During Sedation Between Dexmedetomidine and Propofol in Hazardous Alcohol Drinker
1. Adequate sedation with classical sedative agents, propofol 2. Sedation with propofol may induce paradoxical excitement response in heavy alcohol drinkers 3.
- Conditions
- Anesthesia, Spinal, Sedation, Conscious, Dexmedetomidine, Alcohol Drinking
- Trial name
- DEX (NCT02197403)
- Testing
- Dexmedetomidine, Propofol
- Where
- South Korea
- Volunteers
- 110 people
- Sponsor
- Chonnam National University Hospital
Pregnancy, Unplanned
Use of an Algorithm to Determine IV Sedation Dosing During First-trimester Surgical Abortion
This study aims to compare an algorithm for IV sedation dosing to the current standard of care in patients undergoing first trimester surgical abortion.
- Trial name
- NCT01994317
- Testing
- Algorithm, Standard care
- Where
- United States
- Volunteers
- 196 people, healthy volunteers welcome
- Sponsor
- Planned Parenthood League of Massachusetts
Sedation During GI Endoscopy
Comparison Between Two Drugs in Sedation of Upper GI Endoscopy
The goal of this clinical trial is to compare time of sedation between two drugs administered to patients undergoing upper gastrointestinal endoscopy Primary outcome : Time of sedation : is the time to reach sedation score of 5…
- Trial name
- NCT07423676
- Volunteers
- 52 people
- Sponsor
- Zagazig University
Benign Thyroid Nodule
Intravenous Sedation and Analgesia Versus Local Anesthesia During Microwave Ablation of Benign Thyroid Nodules
The participants will be randomized into 2 equal groups by a computer-generated random numbers table, named group A and B. An independent data manager of computer-generated software will be responsible for randomization…
- Trial name
- NCT07235605
- Testing
- Moderate to deep sedation, Perithyroidal local anesthesia
- Volunteers
- 52 people
- Sponsor
- Suez University
OSA - Obstructive Sleep Apnea
Characterizing Bilateral Hypoglossal Nerve Stimulation During Drug-Induced Sleep Endoscopy
The study will investigate the treatment effect of bilateral genioglossus muscle stimulation on upper airway collapsibility during drug-induced sleep endoscopy in patients implanted with the Inspire hypoglossal nerve stimulator.
- Trial name
- BLISS (NCT06661629)
- Testing
- Nerve stimulation
- Sponsor
- University of Pennsylvania
Hypoxia, Pars Plana Vitrectomy
Influence of HFNO on Spontaneous Breathing Support in Patients of Different ASA Risk During Moderate Multimodal Analgo-sedation for Pars Plana Vitrectomy
Pars plana vitrectomy is minimally invasive endoscopic procedure which is usually performed in moderate analgo-sedation given by anesthesiologist combined with topical anesthesia and regional eye anesthesia (retrobulbar or…
- Conditions
- Hypoxia, Pars Plana Vitrectomy, Respiratory Complications
- Trial name
- NCT04055077
- Testing
- Low-flow nasal oxygenation (LFNO) ASA I, Low-flow nasal oxygenation (LFNO) ASA II, Low-flow nasal oxygenation (LFNO) ASA III
- Where
- Croatia
- Volunteers
- 176 people
- Sponsor
- University of Split, School of Medicine
Palliative Sedation
Measuring Comfort During Palliative Sedation
Background. In case of untreatable suffering at the end of life, palliative sedation may be chosen to assure comfort by reducing the patient's level of consciousness.
- Trial name
- COMPAS (NCT03273244)
- Testing
- NeuroSense monitoring and ANI monitoring
- Where
- 2 sites in Belgium
- Volunteers
- 12 people
- Sponsor
- Vrije Universiteit Brussel
Hypoxia, Esophageal Cancer
COMBO Endoscopy Oropharyngeal Airway Reduces Hypoxia During Sedated Gastrointestinal Endoscopy in Obese Patients: A Multicenter, Randomized, Controlled Clinical Trial
Hypoxia represents the prevailing adverse occurrence during the sedation of patients undergoing gastrointestinal endoscopy with propofol. This is particularly true for obese patients, who have a higher incidence of hypoxia.
- Conditions
- Hypoxia, Esophageal Cancer, Gastric Cancer
- Trial name
- NCT06796764
- Testing
- the COMBO Endoscopy Oropharyngeal Airway Group, Regular Nasal Cannula
- Where
- 3 sites in China
- Volunteers
- 580 people
- Sponsor
- Zhejiang University
Hypoxemia
Procedural Oxygen Mask vs Nasal Cannula in Pediatric Endoscopy
Upper gastrointestinal endoscopy is a commonly performed diagnostic and, when necessary, therapeutic procedure in pediatric patients for the evaluation of the esophagus, stomach, and duodenum.
- Trial name
- NCT07234175
- Testing
- Procedural Oxygen Mask, Nasal Cannula
- Where
- Turkey (Türkiye)
- Volunteers
- 114 people
- Sponsor
- Bedirhan Günel
Hypoxia, Anesthetics
Acute Ventilatory Response to Hypoxia During Sedation With Dexmedetomidine Compared to Propofol in Healthy Male Volunteers
The overall aim with this project is to investigate the effect of dexmedetomidine on control of breathing in healthy volunteers and to compare it with propofol at the same degree of sedation.
- Conditions
- Hypoxia, Anesthetics, Conscious Sedation, Hypercapnia
- Trial name
- NCT01873612
- Testing
- Hypoxic ventilatory response, Hypercapnic ventilatory response
- Where
- Sweden
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Karolinska University Hospital
Sedation for Patients Undergoing Peribulbar Block
A Comparative Study of Oral Gabapentin, Oral Alprazolam and Intravenous Dexmedetomidine on Perioperative Anxiety and Pain During Posterior Segment Eye Surgery Under Peribulbar Block : a Randomized, Double-blind Study.
We hypothesized that gabapentin when given orally as a premedication in patients who perform posterior segment eye surgery under peribulbar block would provide adequate anxiolysis and arousable sedation as alprazolam and…
- Trial name
- NCT04658732
- Testing
- Administration of Alprazolam , Gabapentin , Dexmedetomidine
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Ehab Tarek Fahmy
Transcutaneous Electric Nerve Stimulation, Oocyte Retrieval
Transcutaneous Electrical Nerve Stimulation During Transvaginal Oocyte Retrieval
This randomized double-blinded control trial aims to compare the pain levels experienced by the women using the standard conscious sedation and those who had transcutaneous electrical nerve stimulation (TENS) in addition to…
- Trial name
- NCT03472430
- Testing
- Transcutaneous electrical nerve stimulation, TENS machine with electrodes not emitting any impulses.
- Where
- China
- Volunteers
- 160 people
- Sponsor
- The University of Hong Kong
Preoperative Anxiety, Emergence Agitation
Effects of Nasal Administration of Dexmedetomidine on Pre-anesthesia Sedation, Intraoperative Brain Electrical Activity, and Incidence of Agitation During Recovery in Children
Pre - operative anxiety and emergence agitation are common issues among pediatric patients, which have various influences on the recovery progress and prognosis of children.
- Trial name
- NCT06896721
- Testing
- Preoperative sedation with dexmedetomidine was administered nasal before surgery, Preoperative sedation with normal saline was administered nasal before surgery
- Volunteers
- 627 people, healthy volunteers welcome
- Sponsor
- Fuzhou Hua
Pharmacokinetics, Sedation
Pharmacokinetics of Dexmedetomidine During Prolonged Infusion in ICU
The study will examine dexmedetomidine levels in the blood of critically ill intensive care patients to understand how it is broken down by the body.
- Trial name
- DEX PK (NCT00747721)
- Testing
- Dexmedetomidine
- Where
- Finland
- Volunteers
- 13 people
- Sponsor
- Orion Corporation, Orion Pharma
Healthy
Cortico-cortical Connectivity During Midazolam Sedation in Humans; a TMS/EEG Study
The aim of the proposed research is to measure the effect of drug-induced sedation on the functional connectivity between brain regions as indicated by EEG signal transmission within the human brain.
- Trial name
- NCT00734006
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Analgesia, Sedation
Intranasal Dexmedetomidine for Procedural Pain Management in Elderly Adults in Palliative Care
Dexmedetomidine is allowed in Switzerland for intravenous (IV) medication in the intensive care unit in the adult patient. Its active molecule, Dexmedetomidine (Dex), is a selective and powerful α2-Adrenoreceptors (AR) agonist…
- Conditions
- Analgesia, Sedation, Anxiolysis
- Trial name
- INDEX (NCT03151863)
- Testing
- Opioids, Dexmedetomidine
- Where
- Switzerland
- Volunteers
- 33 people
- Sponsor
- Walid HABRE
Critical Illness
Evaluation of Pain Levels by Quantitative Pupillometry During the Placement of Deep Venous Catheters in Sedated Patients in Intensive Care Unit (PUPICAT)
Pain is common in intensive care and gives rise to multiple consequences that can impact the future of patients. The placement of deep venous catheters are painful gestures of common practice in intensive care.
- Trial name
- PUPICAT (NCT05962996)
- Testing
- Pupillometry
- Where
- 2 sites in France
- Volunteers
- 90 people
- Sponsor
- Centre Hospitalier Régional Universitaire de Tours
Pain, Colorectal Adenomas
Comparison of Methods to Distend the Colon During Insertion: CO2, Air Insufflation, Water-aided Colonoscopy
Insufflation of the colon, usually with room air, is necessary to distend the lumen for exploration. Carbon dioxide (CO2) insufflation instead of room air insufflation (AI) has been shown to decrease symptoms of abdominal pain or…
- Conditions
- Pain, Colorectal Adenomas, Colorectal Cancer
- Trial name
- NCT01954862
- Testing
- Air Insufflation method., CO2 insufflation, Water Immersion/CO2
- Where
- 3 sites in United States, Czechia and 1 more
- Volunteers
- 624 people
- Sponsor
- Presidio Ospedaliero Santa Barbara
Sedation and Analgesia Management in Patients Undergoing Flexible Bronchoscopy
Midazolam Alone Versus Midazolam With Ketorolac for Sedation During Flexible Bronchoscopy.
Flexible bronchoscopy has evolved into a vital diagnostic and therapeutic intervention in respiratory medicine due to its frequent and diverse applications.
- Trial name
- NCT07352059
- Testing
- Midazolam Alone, Midazolam + ketorolac
- Volunteers
- 50 people
- Sponsor
- SYED HAIDER ALI
Hypercapnia, Sedation Complication
Ventilatory Effects of THRIVE During EBUS
High flow nasal cannula (HFNC) is used in interventional procedures to prevent hypoxia during sedation. In patients with a patent airway, HFNC reduces dead space ventilation as well.
- Conditions
- Hypercapnia, Sedation Complication, High Flow Nasal Cannula
- Trial name
- NCT05505279
- Testing
- THRIVE (High Flow Nasal Cannula)
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Rijnstate Hospital